Upregulated Expression of VLA Proteins and CD29 in Peripheral Blood Lymphocytes of Chronic Alcoholics Without Ethanol-Related Diseases

To analyze adhesion molecule expression on peripheral blood mononuclear cells (PBMCs) and on different lymphocyte subpopulations (CD2+, CD8+, CD19+, and CD56+ subsets) in chronic alcoholism, 30 well‐nourished chronic alcoholics without ethanol‐related diseases and 30 matched controls were included i...

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Vydané v:Alcoholism, clinical and experimental research Ročník 23; číslo 2; s. 371 - 375
Hlavní autori: Sacanella, E., Estruch, R., Gaya, A., Ferrer, K., Fernández-Sola, J., Alonso, J. R., Nicolás, J.M., Urbano-Márquez, A.
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Oxford, UK Blackwell Publishing Ltd 01.02.1999
Lippincott Williams & Wilkins
Predmet:
Adhesion Molecules
Adult
Alcohol-Related Disorders - metabolism
Alcoholism - metabolism
Alcoholism and acute alcohol poisoning
Antigens, CD19 - biosynthesis
B-Lymphocytes - drug effects
B-Lymphocytes - metabolism
Biological and medical sciences
CD50
CD56 Antigen - biosynthesis
Cell Adhesion Molecules - metabolism
Chronic Alcoholism
Humans
Integrin beta1 - biosynthesis
Integrins
Killer Cells, Natural - drug effects
Killer Cells, Natural - metabolism
Liver Function Tests
Lymphocytes - metabolism
Male
Medical sciences
Nutritional Status
Receptors, Very Late Antigen - drug effects
T-Lymphocytes - drug effects
T-Lymphocytes - metabolism
Toxicology
Up-Regulation - drug effects
VLA
Human
Integrin
Mononuclear cell
Ethanol
Toxicity
Alcoholism
Dependence
T-Lymphocyte
Mechanism of action
Adhesion
Immune system
ISSN:0145-6008, 1530-0277
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Popis
Shrnutí:To analyze adhesion molecule expression on peripheral blood mononuclear cells (PBMCs) and on different lymphocyte subpopulations (CD2+, CD8+, CD19+, and CD56+ subsets) in chronic alcoholism, 30 well‐nourished chronic alcoholics without ethanol‐related diseases and 30 matched controls were included in the study. Adhesion molecules that mediate adhesion to other cells and to extracellular matrix proteins, and whose cellular expression is modified during lymphocyte activation, were selected for study. A detailed clinical evaluation, laboratory analysis, nutritional assessment, and study of adhesion molecule expression was performed. A significant higher expression of CD29 (β1‐integrin) (p= 0.001), VIA‐3 (p= 0.002), VLA‐4 (p= 0.03), and VLA‐5 (p= 0.001) were observed on PBMCs of chronic alcoholics, compared with control subjects, whereas no changes were observed in CD18 (β2‐integrin) and CD50 (ICAM‐3) expression. The upregulation of CD29 and VLA proteins only affected T lymphocytes (CD2+/CD8+/CD4+ cells). These data confirm that T cells of chronic alcoholics are basally activated and that changes in adhesion molecule expression on PBMCs may be responsible of disturbances of adhesion processes in chronic alcoholics without ethanol‐related diseases.
Bibliografia:ark:/67375/WNG-WCDQV0BL-C
ArticleID:ACER371
istex:51AD086588884DFE0A1ADA6F6D019141FD2A93F8
This study was supported in part by Grant FIS 94/1114.
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0145-6008
1530-0277
DOI:10.1111/j.1530-0277.1999.tb04124.x