New mechanism for Notch signaling to endothelium at a distance by Delta-like 4 incorporation into exosomes

Notch signaling is an evolutionary conserved pathway that is mediated by cell-cell contact. It is involved in a variety of developmental processes and has an essential role in vascular development and angiogenesis. Delta-like 4 (Dll4) is a Notch ligand that is up-regulated during angiogenesis. It is...

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Bibliographic Details
Published in:	Blood Vol. 116; no. 13; p. 2385
Main Authors:	Sheldon, Helen, Heikamp, Emily, Turley, Helen, Dragovic, Rebecca, Thomas, Peter, Oon, Chern Ein, Leek, Russell, Edelmann, Mariola, Kessler, Benedikt, Sainson, Richard C A, Sargent, Ian, Li, Ji-Liang, Harris, Adrian L
Format:	Journal Article
Language:	English
Published:	United States 30.09.2010
Subjects:	Adaptor Proteins, Signal Transducing Animals Calcium-Binding Proteins Cell Communication - physiology Cell Line, Tumor Cells, Cultured Endothelial Cells - physiology Endothelial Cells - ultrastructure Exosomes - physiology Exosomes - transplantation Humans Intercellular Signaling Peptides and Proteins - physiology Mice Mice, Inbred BALB C Mice, SCID Neoplasm Transplantation Neovascularization, Physiologic Receptors, Notch - physiology Signal Transduction - physiology Transplantation, Heterologous
ISSN:	1528-0020, 1528-0020
Online Access:	Get more information
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