Biomarkers in cancer immunotherapy

Antibodies against T cell checkpoint molecules have started to revolutionize cancer treatment. Nevertheless, less than half of all patients respond to these immunotherapies. Recent work supports the potential value of biomarkers that predict therapy outcome and inspires the development of assay syst...

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Published in:Cancer cell Vol. 27; no. 1; p. 12
Main Authors: Schumacher, Ton N, Kesmir, Can, van Buuren, Marit M
Format: Journal Article
Language:English
Published: United States 12.01.2015
Subjects:
Antibodies, Neoplasm - therapeutic use
Biomarkers, Tumor - genetics
Biomarkers, Tumor - immunology
Humans
Immunotherapy - methods
Neoplasms - genetics
Neoplasms - immunology
T-Lymphocytes - immunology
ISSN:1878-3686, 1878-3686
Online Access:Get more information
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Abstract Antibodies against T cell checkpoint molecules have started to revolutionize cancer treatment. Nevertheless, less than half of all patients respond to these immunotherapies. Recent work supports the potential value of biomarkers that predict therapy outcome and inspires the development of assay systems that interrogate other aspects of the cancer-immunity cycle.
AbstractList Antibodies against T cell checkpoint molecules have started to revolutionize cancer treatment. Nevertheless, less than half of all patients respond to these immunotherapies. Recent work supports the potential value of biomarkers that predict therapy outcome and inspires the development of assay systems that interrogate other aspects of the cancer-immunity cycle.Antibodies against T cell checkpoint molecules have started to revolutionize cancer treatment. Nevertheless, less than half of all patients respond to these immunotherapies. Recent work supports the potential value of biomarkers that predict therapy outcome and inspires the development of assay systems that interrogate other aspects of the cancer-immunity cycle.
Antibodies against T cell checkpoint molecules have started to revolutionize cancer treatment. Nevertheless, less than half of all patients respond to these immunotherapies. Recent work supports the potential value of biomarkers that predict therapy outcome and inspires the development of assay systems that interrogate other aspects of the cancer-immunity cycle.
Author van Buuren, Marit M
Kesmir, Can
Schumacher, Ton N
Author_xml – sequence: 1
  givenname: Ton N
  surname: Schumacher
  fullname: Schumacher, Ton N
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  organization: Division of Immunology, The Netherlands Cancer Institute, 1066 CX Amsterdam, the Netherlands. Electronic address: t.schumacher@nki.nl
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  givenname: Can
  surname: Kesmir
  fullname: Kesmir, Can
  organization: Department of Theoretical Biology and Bioinformatics, Utrecht University, 3584 CH Utrecht, the Netherlands
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  givenname: Marit M
  surname: van Buuren
  fullname: van Buuren, Marit M
  organization: Division of Immunology, The Netherlands Cancer Institute, 1066 CX Amsterdam, the Netherlands
BackLink https://www.ncbi.nlm.nih.gov/pubmed/25584891$$D View this record in MEDLINE/PubMed
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Snippet Antibodies against T cell checkpoint molecules have started to revolutionize cancer treatment. Nevertheless, less than half of all patients respond to these...
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SubjectTerms Antibodies, Neoplasm - therapeutic use
Biomarkers, Tumor - genetics
Biomarkers, Tumor - immunology
Humans
Immunotherapy - methods
Neoplasms - genetics
Neoplasms - immunology
T-Lymphocytes - immunology
Title Biomarkers in cancer immunotherapy
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