Patterning the vertebrate heart

The mammalian heart is crafted from a few progenitor cells that are subject to rapidly changing sets of instructions from their environment and from within. These instructions cause them to migrate, expand and diversify in lineage, and acquire form and function. Molecular information from various mo...

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Vydané v:Nature reviews. Genetics Ročník 3; číslo 7; s. 544 - 556
Hlavný autor: Harvey, Richard P.
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: England Nature Publishing Group 01.07.2002
Predmet:
Animals
Body Patterning - physiology
Coronary vessels
Embryonic and Fetal Development - physiology
Embryos
Functional Laterality
Heart
Heart - embryology
Humans
Lungs
Morphogenesis
Pulmonary arteries
Stem Cells - physiology
Veins & arteries
Vertebrates
Vertebrates - embryology
ISSN:1471-0056, 1471-0064
On-line prístup:Získať plný text
Tagy: Pridať tag
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Abstract The mammalian heart is crafted from a few progenitor cells that are subject to rapidly changing sets of instructions from their environment and from within. These instructions cause them to migrate, expand and diversify in lineage, and acquire form and function. Molecular information from various model systems, combined with increasingly detailed morphogenetic data, has provided insights into some of these key events. Many congenital heart abnormalities might arise from defects in the early stages of heart development, therefore it is important to understand the molecular pathways that underlie the lineage specification and patterning processes that shape this organ.
AbstractList The mammalian heart is crafted from a few progenitor cells that are subject to rapidly changing sets of instructions from their environment and from within. These instructions cause them to migrate, expand and diversify in lineage, and acquire form and function. Molecular information from various model systems, combined with increasingly detailed morphogenetic data, has provided insights into some of these key events. Many congenital heart abnormalities might arise from defects in the early stages of heart development, therefore it is important to understand the molecular pathways that underlie the lineage specification and patterning processes that shape this organ.
The mammalian heart is crafted from a few progenitor cells that are subject to rapidly changing sets of instructions from their environment and from within. These instructions cause them to migrate, expand and diversify in lineage, and acquire form and function. Molecular information from various model systems, combined with increasingly detailed morphogenetic data, has provided insights into some of these key events. Many congenital heart abnormalities might arise from defects in the early stages of heart development, therefore it is important to understand the molecular pathways that underlie the lineage specification and patterning processes that shape this organ. Summary The vertebrate heart is a highly modified muscular vessel, which is composed of numerous cell lineages. Heart patterning is a complex and spatially and temporally dynamic process. The cardiac precursor zone in the embryo gives rise to myocardial and endocardial cells of the forming heart tube, as well as to pericardial cells and to a distinct precursor population called the secondary heart field. Secondary heart field cells give rise to the outflow tract and possibly to the right ventricle of the heart after the primary heart tube has formed. The heart precursor zone is shaped by positive (BMP, Fgf and anti-Wnt) and negative (Wnt and anti-BMP) signals from surrounding tissues. Ventral migration of heart precursor cells to form a heart tube requires transcription factors Mesp1 and 2, secreted factors Fgf4 and Fgf8, signalling through the sphingosine-1-phosphate receptor and the graded distribution of the extracellular-matrix component fibronectin. Formation of the atrial component of the heart and its venous tributaries requires retinoic-acid signalling. Chamber muscle is formed on the outer surface of the primary heart tube in response to patterning information, and this process requires an endocardial signal from neuregulin 1, myocardial transcription factors Nkx2-5, Fast2 and Tbx2/5, and complex matrix components. The embryonic leftright asymmetry pathway specifies asymmetric morphogenesis of the atria and its venous components, although whether it also defines the direction of ventricular bending remains contentious.
The mammalian heart is crafted from a few progenitor cells that are subject to rapidly changing sets of instructions from their environment and from within. These instructions cause them to migrate, expand and diversify in lineage, and acquire form and function. Molecular information from various model systems, combined with increasingly detailed morphogenetic data, has provided insights into some of these key events. Many congenital heart abnormalities might arise from defects in the early stages of heart development, therefore it is important to understand the molecular pathways that underlie the lineage specification and patterning processes that shape this organ.The mammalian heart is crafted from a few progenitor cells that are subject to rapidly changing sets of instructions from their environment and from within. These instructions cause them to migrate, expand and diversify in lineage, and acquire form and function. Molecular information from various model systems, combined with increasingly detailed morphogenetic data, has provided insights into some of these key events. Many congenital heart abnormalities might arise from defects in the early stages of heart development, therefore it is important to understand the molecular pathways that underlie the lineage specification and patterning processes that shape this organ.
Audience Academic
Author Harvey, Richard P.
Author_xml – sequence: 1
  givenname: Richard P.
  surname: Harvey
  fullname: Harvey, Richard P.
BackLink https://www.ncbi.nlm.nih.gov/pubmed/12094232$$D View this record in MEDLINE/PubMed
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  publication-title: Nature
  doi: 10.1038/378394a0
– volume: 406
  start-page: 192
  year: 2000
  ident: BFnrg843_CR65
  publication-title: Nature
  doi: 10.1038/35018092
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Snippet The mammalian heart is crafted from a few progenitor cells that are subject to rapidly changing sets of instructions from their environment and from within....
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SubjectTerms Animals
Body Patterning - physiology
Coronary vessels
Embryonic and Fetal Development - physiology
Embryos
Functional Laterality
Heart
Heart - embryology
Humans
Lungs
Morphogenesis
Pulmonary arteries
Stem Cells - physiology
Veins & arteries
Vertebrates
Vertebrates - embryology
Title Patterning the vertebrate heart
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