Protein Microarrays for High Throughput Hydrogen/Deuterium Exchange Monitored by FTIR Imaging

Proteins form the fastest-growing therapeutic class. Due to their intrinsic instability, loss of native structure is common. Structure alteration must be carefully evaluated as structural changes may jeopardize the efficiency and safety of the protein-based drugs. Hydrogen deuterium exchange (HDX) h...

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Vydané v:	International journal of molecular sciences Ročník 25; číslo 18; s. 9989
Hlavní autori:	De Meutter, Joëlle, Goormaghtigh, Erik
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Switzerland MDPI AG 16.09.2024 MDPI
Predmet:	Biological research Biology, Experimental Chemical reactions Conformation Deuterium Exchange Measurement - methods Experiments Fourier transform infrared spectroscopy Fourier transforms Hydrogen - chemistry Ligands Mass spectrometry NMR Nuclear magnetic resonance Protein Array Analysis - methods Proteins Proteins - chemistry Scientific imaging Spectroscopy, Fourier Transform Infrared - methods protein microarrays hydrogen deuterium exchange FTIR spectroscopy
ISSN:	1422-0067, 1661-6596, 1422-0067
On-line prístup:	Získať plný text
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