Protein Microarrays for High Throughput Hydrogen/Deuterium Exchange Monitored by FTIR Imaging

Proteins form the fastest-growing therapeutic class. Due to their intrinsic instability, loss of native structure is common. Structure alteration must be carefully evaluated as structural changes may jeopardize the efficiency and safety of the protein-based drugs. Hydrogen deuterium exchange (HDX) h...

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Bibliographic Details
Published in:	International journal of molecular sciences Vol. 25; no. 18; p. 9989
Main Authors:	De Meutter, Joëlle, Goormaghtigh, Erik
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 16.09.2024 MDPI
Subjects:	Biological research Biology, Experimental Chemical reactions Conformation Deuterium Exchange Measurement - methods Experiments Fourier transform infrared spectroscopy Fourier transforms Hydrogen - chemistry Ligands Mass spectrometry NMR Nuclear magnetic resonance Protein Array Analysis - methods Proteins Proteins - chemistry Scientific imaging Spectroscopy, Fourier Transform Infrared - methods protein microarrays hydrogen deuterium exchange FTIR spectroscopy
ISSN:	1422-0067, 1661-6596, 1422-0067
Online Access:	Get full text
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