Hemostatic and hepatoprotective bioactivity of Junci Medulla Carbonisata-derived Carbon Dots

To explore the hemostatic and hepatoprotective bioactivity of Junci Medulla Carbonisata-derived Carbon Dots (JMC-CDs). The JMC-CDs were characterized using transmission electron microscopy, HPLC, Fourier transform IR, UV, fluorescence and x-ray photoelectron spectroscopy. The hemostatic effect of JM...

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Vydané v:Nanomedicine (London, England) Ročník 14; číslo 4; s. 431 - 446
Hlavní autori: Cheng, Jinjun, Zhang, Meiling, Sun, Ziwei, Lu, Fang, Xiong, Wei, Luo, Juan, Kong, Hui, Wang, Qingguo, Qu, Huihua, Zhao, Yan
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: England Future Medicine Ltd 01.02.2019
Predmet:
Biological activity
Carbon
carbon dots
Fourier transforms
Hemorrhage
hemostatic bioactivity
Junci Medulla Carbonisata
Laboratory animals
liver protection
Nanocrystals
Quantum dots
Snakes
Traditional Chinese medicine
Trauma
Venom
Beijing China
United States > US
China
Japan
carbon dots
liver protection
Junci Medulla Carbonisata
hemostatic bioactivity
ISSN:1743-5889, 1748-6963, 1748-6963
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Abstract To explore the hemostatic and hepatoprotective bioactivity of Junci Medulla Carbonisata-derived Carbon Dots (JMC-CDs). The JMC-CDs were characterized using transmission electron microscopy, HPLC, Fourier transform IR, UV, fluorescence and x-ray photoelectron spectroscopy. The hemostatic effect of JMC-CDs was evaluated and confirmed by trauma hemorrhagic animal models and internal hemorrhage animal model induced by venom. The JMC-CDs ranged in diameter from 1.0 to 8 nm and had a yield of 0.12%. Moreover, JMC-CDs not only possessed remarkable hemostatic efficacy but could also prevent hemorrhage-induced liver injury, as demonstrated by the reduced serum levels of biochemical indicators of liver damage such as aspartate aminotransferase, alanine amino transferase, alkaline phosphatase, total bilirubin and direct bilirubin. The JMC-CDs may have great potentials in clinical practice.
AbstractList To explore the hemostatic and hepatoprotective bioactivity of Junci Medulla Carbonisata-derived Carbon Dots (JMC-CDs).AIMTo explore the hemostatic and hepatoprotective bioactivity of Junci Medulla Carbonisata-derived Carbon Dots (JMC-CDs).The JMC-CDs were characterized using transmission electron microscopy, HPLC, Fourier transform IR, UV, fluorescence and x-ray photoelectron spectroscopy. The hemostatic effect of JMC-CDs was evaluated and confirmed by trauma hemorrhagic animal models and internal hemorrhage animal model induced by Deinagkistrodon acutus venom.MATERIALS & METHODSThe JMC-CDs were characterized using transmission electron microscopy, HPLC, Fourier transform IR, UV, fluorescence and x-ray photoelectron spectroscopy. The hemostatic effect of JMC-CDs was evaluated and confirmed by trauma hemorrhagic animal models and internal hemorrhage animal model induced by Deinagkistrodon acutus venom.The JMC-CDs ranged in diameter from 1.0 to 8 nm and had a yield of 0.12%. Moreover, JMC-CDs not only possessed remarkable hemostatic efficacy but could also prevent hemorrhage-induced liver injury, as demonstrated by the reduced serum levels of biochemical indicators of liver damage such as aspartate aminotransferase, alanine amino transferase, alkaline phosphatase, total bilirubin and direct bilirubin.RESULTSThe JMC-CDs ranged in diameter from 1.0 to 8 nm and had a yield of 0.12%. Moreover, JMC-CDs not only possessed remarkable hemostatic efficacy but could also prevent hemorrhage-induced liver injury, as demonstrated by the reduced serum levels of biochemical indicators of liver damage such as aspartate aminotransferase, alanine amino transferase, alkaline phosphatase, total bilirubin and direct bilirubin.The JMC-CDs may have great potentials in clinical practice.CONCLUSIONThe JMC-CDs may have great potentials in clinical practice.
To explore the hemostatic and hepatoprotective bioactivity of Junci Medulla Carbonisata-derived Carbon Dots (JMC-CDs). The JMC-CDs were characterized using transmission electron microscopy, HPLC, Fourier transform IR, UV, fluorescence and x-ray photoelectron spectroscopy. The hemostatic effect of JMC-CDs was evaluated and confirmed by trauma hemorrhagic animal models and internal hemorrhage animal model induced by venom. The JMC-CDs ranged in diameter from 1.0 to 8 nm and had a yield of 0.12%. Moreover, JMC-CDs not only possessed remarkable hemostatic efficacy but could also prevent hemorrhage-induced liver injury, as demonstrated by the reduced serum levels of biochemical indicators of liver damage such as aspartate aminotransferase, alanine amino transferase, alkaline phosphatase, total bilirubin and direct bilirubin. The JMC-CDs may have great potentials in clinical practice.
To explore the hemostatic and hepatoprotective bioactivity of Junci Medulla Carbonisata-derived Carbon Dots (JMC-CDs). The JMC-CDs were characterized using transmission electron microscopy, HPLC, Fourier transform IR, UV, fluorescence and x-ray photoelectron spectroscopy. The hemostatic effect of JMC-CDs was evaluated and confirmed by trauma hemorrhagic animal models and internal hemorrhage animal model induced by Deinagkistrodon acutus venom. The JMC-CDs ranged in diameter from 1.0 to 8 nm and had a yield of 0.12%. Moreover, JMC-CDs not only possessed remarkable hemostatic efficacy but could also prevent hemorrhage-induced liver injury, as demonstrated by the reduced serum levels of biochemical indicators of liver damage such as aspartate aminotransferase, alanine amino transferase, alkaline phosphatase, total bilirubin and direct bilirubin. The JMC-CDs may have great potentials in clinical practice.
Aim: To explore the hemostatic and hepatoprotective bioactivity of Junci Medulla Carbonisata-derived Carbon Dots (JMC-CDs). Materials & methods: The JMC-CDs were characterized using transmission electron microscopy, HPLC, Fourier transform IR, UV, fluorescence and x-ray photoelectron spectroscopy. The hemostatic effect of JMC-CDs was evaluated and confirmed by trauma hemorrhagic animal models and internal hemorrhage animal model induced by Deinagkistrodon acutus venom. Results: The JMC-CDs ranged in diameter from 1.0 to 8 nm and had a yield of 0.12%. Moreover, JMC-CDs not only possessed remarkable hemostatic efficacy but could also prevent hemorrhage-induced liver injury, as demonstrated by the reduced serum levels of biochemical indicators of liver damage such as aspartate aminotransferase, alanine amino transferase, alkaline phosphatase, total bilirubin and direct bilirubin. Conclusion: The JMC-CDs may have great potentials in clinical practice.
Author Kong, Hui
Cheng, Jinjun
Sun, Ziwei
Zhang, Meiling
Lu, Fang
Luo, Juan
Wang, Qingguo
Qu, Huihua
Zhao, Yan
Xiong, Wei
AuthorAffiliation 3Beijing Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China
2School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China
1School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China
AuthorAffiliation_xml – name: 1School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China
– name: 2School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China
– name: 3Beijing Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China
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Keywords carbon dots
liver protection
Junci Medulla Carbonisata
hemostatic bioactivity
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Snippet To explore the hemostatic and hepatoprotective bioactivity of Junci Medulla Carbonisata-derived Carbon Dots (JMC-CDs). The JMC-CDs were characterized using...
Aim: To explore the hemostatic and hepatoprotective bioactivity of Junci Medulla Carbonisata-derived Carbon Dots (JMC-CDs). Materials & methods: The JMC-CDs...
To explore the hemostatic and hepatoprotective bioactivity of Junci Medulla Carbonisata-derived Carbon Dots (JMC-CDs).AIMTo explore the hemostatic and...
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SubjectTerms Biological activity
Carbon
carbon dots
Fourier transforms
Hemorrhage
hemostatic bioactivity
Junci Medulla Carbonisata
Laboratory animals
liver protection
Nanocrystals
Quantum dots
Snakes
Traditional Chinese medicine
Trauma
Venom
Title Hemostatic and hepatoprotective bioactivity of Junci Medulla Carbonisata-derived Carbon Dots
URI http://dx.doi.org/10.2217/nnm-2018-0285
https://www.ncbi.nlm.nih.gov/pubmed/30698498
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