An integrative view on the carotid artery alterations in metabolic syndrome

Eur J Clin Invest 2012; 42 (5): 496–502 Backgrounds  Metabolic syndrome (MetS) is a multiple risk factor paradigm widely considered in risk management. We aimed to investigate carotid artery alterations in MetS and the underlying risk factors. Materials and methods  A total of 400 Chinese subjects w...

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Vydáno v:European journal of clinical investigation Ročník 42; číslo 5; s. 496 - 502
Hlavní autoři: Wang, Zhi-Hao, Gong, Hui-Ping, Shang, Yuan-Yuan, Tang, Meng-Xiong, Fang, Ning-Ning, Jiang, Gui-Hua, Zhang, Yun, Zhong, Ming, Zhang, Wei
Médium: Journal Article
Jazyk:angličtina
Vydáno: Oxford, UK Blackwell Publishing Ltd 01.05.2012
Wiley-Blackwell
Témata:
Adult
Asian Continental Ancestry Group
Biological and medical sciences
Body Mass Index
Cardiovascular Diseases - diagnostic imaging
Cardiovascular Diseases - etiology
Carotid alterations
Carotid Arteries - diagnostic imaging
Carotid Intima-Media Thickness
Case-Control Studies
Cholesterol, HDL
Female
General aspects
Humans
Male
Medical sciences
Metabolic diseases
metabolic syndrome
Metabolic Syndrome - complications
Metabolic Syndrome - diagnostic imaging
Middle Aged
Miscellaneous
Other metabolic disorders
Regression Analysis
Risk Factors
ultrasonography
Waist Circumference
Endocrinopathy
Sonography
ultrasonography
Metabolic diseases
Cardiovascular disease
Metabolic syndrome
Artery
Carotid alterations
Medicine
Blood vessel
Carotid
Echography
Circulatory system
ISSN:0014-2972, 1365-2362, 1365-2362
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Shrnutí:Eur J Clin Invest 2012; 42 (5): 496–502 Backgrounds  Metabolic syndrome (MetS) is a multiple risk factor paradigm widely considered in risk management. We aimed to investigate carotid artery alterations in MetS and the underlying risk factors. Materials and methods  A total of 400 Chinese subjects were recruited, divided into control (n = 200) and MetS (n = 200) groups. Clinical and laboratory characteristics were collected. All subjects underwent carotid ultrasonography. Results  Cardiovascular risk profiles were worse in the MetS than control group (all P < 0·05). After adjusting for MetS and age, the MetS group showed significantly increased mean intima‐media thickness (IMTmean) and significantly impaired carotid elastic properties (all P < 0·05), as compared to control group. Waist circumference (WC) was positively correlated with IMTmean (r = 0·130, P = 0·038), systolic carotid diameter (r = 0·139, P = 0·026) and diastolic carotid diameter (r = 0·168, P = 0·007). systolic blood pressure (SBP) and diastolic blood pressure were positively correlated with IMTmean (r = 0·201, P = 0·004; r = 0·168, P = 0·008, respectively), but negatively with arterial compliance coefficient (r = −0·421, P < 0·001; r = −0·230, P < 0·001, respectively). Serum level of high‐density lipoprotein (HDL) negatively correlated with IMTmean (r = −0·195, P = 0·002). Plaque index was positively correlated with fasting blood glucose (r = 0·205, P = 0·001) after adjusting for the other risk factors. Significantly impaired carotid elastic properties (all P < 0·05) independently correlated with IMTmean. Furthermore, age (β = 0·255, P < 0·001), SBP (β = 0·224, P < 0·001), WC (β = 0·202, P < 0·001) and high‐density lipoprotein cholesterol (HDL‐C) (β = −0·163, P = 0·001) were independently associated with IMTmean. Conclusion  Carotid alterations consequent upon MetS ultimately developed subclinical and clinical atherosclerosis, the underlying risk factors for which were abdominal obesity, hypertension, ageing and low level of HDL‐C.
Bibliografie:ArticleID:ECI2605
ark:/67375/WNG-VZFPHL8P-8
istex:891247B49B1193A77F94D814C948D8E892352538
Present Address: Emergency Department, Qilu Hospital of Shandong University, Ji’nan, China.
ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
ISSN:0014-2972
1365-2362
1365-2362
DOI:10.1111/j.1365-2362.2011.02605.x