Stable knockout of lanthionine synthase C-like protein-1 (LanCL1) from HeLa cells indicates a role for LanCL1 in redox regulation of deubiquitinating enzymes

Lanthionine synthase C-like protein-1 (LanCL1) is a glutathione (GSH)-binding protein of uncertain function, widely expressed in mammalian cells. Recent data suggests that LanCL1 has glutathione S-transferase (GST)-like activity, while other reports claim that LanCL1 suppresses mitogen-activated kin...

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Bibliographic Details
Published in:	Free radical biology & medicine Vol. 161; pp. 115 - 124
Main Authors:	Downey, Aaron, Olcott, Melissa, Spector, Daniel, Bird, Kayla, Ter Doest, Amanda, Pierce, Zachary, Quach, Evan, Sparks, Sawyer, Super, Christa, Naifeh, Jefferey, Powers, Andrea, White, Matthew, Hensley, Kenneth
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01.12.2020
Subjects:	Deubiquitinase Deubiquitinating Enzymes Free radical Glutathione HeLa Cells Humans Hydro-Lyases Hydrogen Peroxide Lanthionine cyclase Multienzyme Complexes Oxidation-Reduction Proteasome Receptors, G-Protein-Coupled - metabolism Ubiquitin Thiolesterase Lanthionine cyclase Deubiquitinase Free radical Glutathione Proteasome
ISSN:	0891-5849, 1873-4596, 1873-4596
Online Access:	Get full text
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