Nucleoside-modified mRNA vaccination partially overcomes maternal antibody inhibition of de novo immune responses in mice

Maternal antibodies provide short-term protection to infants against many infections. However, they can inhibit de novo antibody responses in infants elicited by infections or vaccination, leading to increased long-term susceptibility to infectious diseases. Thus, there is a need to develop vaccines...

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Bibliographic Details
Published in:	Science translational medicine Vol. 12; no. 525
Main Authors:	Willis, Elinor, Pardi, Norbert, Parkhouse, Kaela, Mui, Barbara L, Tam, Ying K, Weissman, Drew, Hensley, Scott E
Format:	Journal Article
Language:	English
Published:	United States 08.01.2020
Subjects:	Adjuvants, Immunologic - pharmacology Animals Antibodies, Viral - immunology Antibody Formation - immunology Disease Models, Animal Female Germinal Center Hemagglutinin Glycoproteins, Influenza Virus - immunology Influenza Vaccines - immunology Lipids - chemistry Mice Mice, Inbred BALB C Mice, Inbred C57BL Nanoparticles - chemistry Nucleosides - metabolism Orthomyxoviridae - immunology Orthomyxoviridae Infections - immunology Orthomyxoviridae Infections - prevention & control Orthomyxoviridae Infections - virology RNA, Messenger - immunology Vaccination
ISSN:	1946-6242, 1946-6242
Online Access:	Get more information
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