LAG-3 expression on peripheral blood cells identifies patients with poorer outcomes after immune checkpoint blockade

Immune checkpoint blocking antibodies are a cornerstone in cancer treatment; however, they benefit only a subset of patients and biomarkers to guide immune checkpoint blockade (ICB) treatment choices are lacking. We designed this study to identify blood-based correlates of clinical outcome in ICB-tr...

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Veröffentlicht in:	Science translational medicine Jg. 13; H. 608
Hauptverfasser:	Shen, Ronglai, Postow, Michael A, Adamow, Matthew, Arora, Arshi, Hannum, Margaret, Maher, Colleen, Wong, Phillip, Curran, Michael A, Hollmann, Travis J, Jia, Liwei, Al-Ahmadie, Hikmat, Keegan, Niamh, Funt, Samuel A, Iyer, Gopa, Rosenberg, Jonathan E, Bajorin, Dean F, Chapman, Paul B, Shoushtari, Alexander N, Betof, Allison S, Momtaz, Parisa, Merghoub, Taha, Wolchok, Jedd D, Panageas, Katherine S, Callahan, Margaret K
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 25.08.2021
Schlagworte:	Biomarkers, Tumor Carcinoma, Transitional Cell Humans Immune Checkpoint Inhibitors T-Lymphocytes Urinary Bladder Neoplasms
ISSN:	1946-6242, 1946-6242
Online-Zugang:	Weitere Angaben
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