LAG-3 expression on peripheral blood cells identifies patients with poorer outcomes after immune checkpoint blockade

Immune checkpoint blocking antibodies are a cornerstone in cancer treatment; however, they benefit only a subset of patients and biomarkers to guide immune checkpoint blockade (ICB) treatment choices are lacking. We designed this study to identify blood-based correlates of clinical outcome in ICB-tr...

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Vydáno v:	Science translational medicine Ročník 13; číslo 608
Hlavní autoři:	Shen, Ronglai, Postow, Michael A, Adamow, Matthew, Arora, Arshi, Hannum, Margaret, Maher, Colleen, Wong, Phillip, Curran, Michael A, Hollmann, Travis J, Jia, Liwei, Al-Ahmadie, Hikmat, Keegan, Niamh, Funt, Samuel A, Iyer, Gopa, Rosenberg, Jonathan E, Bajorin, Dean F, Chapman, Paul B, Shoushtari, Alexander N, Betof, Allison S, Momtaz, Parisa, Merghoub, Taha, Wolchok, Jedd D, Panageas, Katherine S, Callahan, Margaret K
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 25.08.2021
Témata:	Biomarkers, Tumor Carcinoma, Transitional Cell Humans Immune Checkpoint Inhibitors T-Lymphocytes Urinary Bladder Neoplasms
ISSN:	1946-6242, 1946-6242
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