A subset of N-substituted phenothiazines inhibits NADPH oxidases

NADPH oxidases (NOXs) constitute a family of enzymes generating reactive oxygen species (ROS) and are increasingly recognized as interesting drug targets. Here we investigated the effects of 10 phenothiazine compounds on NOX activity using an extensive panel of assays to measure production of ROS (A...

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Vydáno v:	Free radical biology & medicine Ročník 86; s. 239 - 249
Hlavní autoři:	Seredenina, Tamara, Chiriano, Gianpaolo, Filippova, Aleksandra, Nayernia, Zeynab, Mahiout, Zahia, Fioraso-Cartier, Laetitia, Plastre, Olivier, Scapozza, Leonardo, Krause, Karl-Heinz, Jaquet, Vincent
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Elsevier Inc 01.09.2015
Témata:	Animals Cell Differentiation - drug effects CHO Cells Cricetinae Cricetulus Drug Evaluation, Preclinical Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Fibrosis Free radicals HEK293 Cells Humans Inhibitory Concentration 50 Myofibroblasts - drug effects Myofibroblasts - physiology NADPH oxidase NADPH Oxidases - antagonists & inhibitors NADPH Oxidases - chemistry NADPH Oxidases - metabolism NOX inhibitor Oxidation-Reduction Oxidative Stress Oxygen Consumption Phenothiazine Phenothiazines - chemistry Phenothiazines - pharmacology Reactive Oxygen Species - metabolism ROS SAR Structure-Activity Relationship Thioridazine DMSO SAR NOX inhibitor NOXO1 CHO GFP DMEM FBS NADPH oxidase DUOX Phenothiazine PBS ESP Free radicals PMA PKC WST-1 HEK MCLA Thioridazine NOX ROS Fibrosis HBSS DPI RPMI
ISSN:	0891-5849, 1873-4596
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