Evolution of Physical Status From Diagnosis to the End of First-Line Treatment in Breast, Lung, and Colorectal Cancer Patients: The PROTECT-01 Cohort Study Protocol
Background: Cancer cachexia and exacerbated fatigue represent two hallmarks in cancer patients, negatively impacting their exercise tolerance and ultimately their quality of life. However, the characterization of patients' physical status and exercise tolerance and, most importantly, their evol...
Gespeichert in:
| Veröffentlicht in: | Frontiers in oncology Jg. 10; S. 1304 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , |
| Format: | Journal Article |
| Sprache: | Englisch |
| Veröffentlicht: |
Frontiers Media S.A
07.08.2020
|
| Schlagworte: | |
| ISSN: | 2234-943X, 2234-943X |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| Abstract | Background: Cancer cachexia and exacerbated fatigue represent two hallmarks in cancer patients, negatively impacting their exercise tolerance and ultimately their quality of life. However, the characterization of patients' physical status and exercise tolerance and, most importantly, their evolution throughout cancer treatment may represent the first step in efficiently counteracting their development with prescribed and tailored exercise training. In this context, the aim of the PROTECT-01 study will be to investigate the evolution of physical status, from diagnosis to the end of first-line treatment, of patients with one of the three most common cancers (i.e., lung, breast, and colorectal). Methods: The PROTECT-01 cohort study will include 300 patients equally divided between lung, breast and colorectal cancer. Patients will perform a series of assessments at three visits throughout the treatment: (1) between the date of diagnosis and the start of treatment, (2) 8 weeks after the start of treatment, and (3) after the completion of first-line treatment or at the 6-months mark, whichever occurs first. For each of the three visits, subjective and objective fatigue, maximal voluntary force, body composition, cachexia, physical activity level, quality of life, respiratory function, overall physical performance, and exercise tolerance will be assessed. Discussion: The present study is aimed at identifying the nature and severity of maladaptation related to exercise intolerance in the three most common cancers. Therefore, our results should contribute to the delineation of the needs of each group of patients and to the determination of the most valuable exercise interventions in order to counteract these maladaptations. This descriptive and comprehensive approach is a prerequisite in order to elaborate, through future interventional research projects, tailored exercise strategies to counteract specific symptoms that are potentially cancer type-dependent and, in fine, to improve the health and quality of life of cancer patients. Moreover, our concomitant focus on fatigue and cachexia will provide insightful information about two factors that may have substantial interaction but require further investigation. Trial registration: This prospective study has been registered at ClinicalTrials.gov (NCT03956641), May, 2019.Background: Cancer cachexia and exacerbated fatigue represent two hallmarks in cancer patients, negatively impacting their exercise tolerance and ultimately their quality of life. However, the characterization of patients' physical status and exercise tolerance and, most importantly, their evolution throughout cancer treatment may represent the first step in efficiently counteracting their development with prescribed and tailored exercise training. In this context, the aim of the PROTECT-01 study will be to investigate the evolution of physical status, from diagnosis to the end of first-line treatment, of patients with one of the three most common cancers (i.e., lung, breast, and colorectal). Methods: The PROTECT-01 cohort study will include 300 patients equally divided between lung, breast and colorectal cancer. Patients will perform a series of assessments at three visits throughout the treatment: (1) between the date of diagnosis and the start of treatment, (2) 8 weeks after the start of treatment, and (3) after the completion of first-line treatment or at the 6-months mark, whichever occurs first. For each of the three visits, subjective and objective fatigue, maximal voluntary force, body composition, cachexia, physical activity level, quality of life, respiratory function, overall physical performance, and exercise tolerance will be assessed. Discussion: The present study is aimed at identifying the nature and severity of maladaptation related to exercise intolerance in the three most common cancers. Therefore, our results should contribute to the delineation of the needs of each group of patients and to the determination of the most valuable exercise interventions in order to counteract these maladaptations. This descriptive and comprehensive approach is a prerequisite in order to elaborate, through future interventional research projects, tailored exercise strategies to counteract specific symptoms that are potentially cancer type-dependent and, in fine, to improve the health and quality of life of cancer patients. Moreover, our concomitant focus on fatigue and cachexia will provide insightful information about two factors that may have substantial interaction but require further investigation. Trial registration: This prospective study has been registered at ClinicalTrials.gov (NCT03956641), May, 2019. |
|---|---|
| AbstractList | Background: Cancer cachexia and exacerbated fatigue represent two hallmarks in cancer patients, negatively impacting their exercise tolerance and ultimately their quality of life. However, the characterization of patients' physical status and exercise tolerance and, most importantly, their evolution throughout cancer treatment may represent the first step in efficiently counteracting their development with prescribed and tailored exercise training. In this context, the aim of the PROTECT-01 study will be to investigate the evolution of physical status, from diagnosis to the end of first-line treatment, of patients with one of the three most common cancers (i.e., lung, breast, and colorectal). Methods: The PROTECT-01 cohort study will include 300 patients equally divided between lung, breast and colorectal cancer. Patients will perform a series of assessments at three visits throughout the treatment: (1) between the date of diagnosis and the start of treatment, (2) 8 weeks after the start of treatment, and (3) after the completion of first-line treatment or at the 6-months mark, whichever occurs first. For each of the three visits, subjective and objective fatigue, maximal voluntary force, body composition, cachexia, physical activity level, quality of life, respiratory function, overall physical performance, and exercise tolerance will be assessed. Discussion: The present study is aimed at identifying the nature and severity of maladaptation related to exercise intolerance in the three most common cancers. Therefore, our results should contribute to the delineation of the needs of each group of patients and to the determination of the most valuable exercise interventions in order to counteract these maladaptations. This descriptive and comprehensive approach is a prerequisite in order to elaborate, through future interventional research projects, tailored exercise strategies to counteract specific symptoms that are potentially cancer type-dependent and, in fine, to improve the health and quality of life of cancer patients. Moreover, our concomitant focus on fatigue and cachexia will provide insightful information about two factors that may have substantial interaction but require further investigation. Trial registration: This prospective study has been registered at ClinicalTrials.gov (NCT03956641), May, 2019. Background: Cancer cachexia and exacerbated fatigue represent two hallmarks in cancer patients, negatively impacting their exercise tolerance and ultimately their quality of life. However, the characterization of patients' physical status and exercise tolerance and, most importantly, their evolution throughout cancer treatment may represent the first step in efficiently counteracting their development with prescribed and tailored exercise training. In this context, the aim of the PROTECT-01 study will be to investigate the evolution of physical status, from diagnosis to the end of first-line treatment, of patients with one of the three most common cancers (i.e., lung, breast, and colorectal). Methods: The PROTECT-01 cohort study will include 300 patients equally divided between lung, breast and colorectal cancer. Patients will perform a series of assessments at three visits throughout the treatment: (1) between the date of diagnosis and the start of treatment, (2) 8 weeks after the start of treatment, and (3) after the completion of first-line treatment or at the 6-months mark, whichever occurs first. For each of the three visits, subjective and objective fatigue, maximal voluntary force, body composition, cachexia, physical activity level, quality of life, respiratory function, overall physical performance, and exercise tolerance will be assessed. Discussion: The present study is aimed at identifying the nature and severity of maladaptation related to exercise intolerance in the three most common cancers. Therefore, our results should contribute to the delineation of the needs of each group of patients and to the determination of the most valuable exercise interventions in order to counteract these maladaptations. This descriptive and comprehensive approach is a prerequisite in order to elaborate, through future interventional research projects, tailored exercise strategies to counteract specific symptoms that are potentially cancer type-dependent and, in fine, to improve the health and quality of life of cancer patients. Moreover, our concomitant focus on fatigue and cachexia will provide insightful information about two factors that may have substantial interaction but require further investigation. Trial registration: This prospective study has been registered at ClinicalTrials.gov (NCT03956641), May, 2019.Background: Cancer cachexia and exacerbated fatigue represent two hallmarks in cancer patients, negatively impacting their exercise tolerance and ultimately their quality of life. However, the characterization of patients' physical status and exercise tolerance and, most importantly, their evolution throughout cancer treatment may represent the first step in efficiently counteracting their development with prescribed and tailored exercise training. In this context, the aim of the PROTECT-01 study will be to investigate the evolution of physical status, from diagnosis to the end of first-line treatment, of patients with one of the three most common cancers (i.e., lung, breast, and colorectal). Methods: The PROTECT-01 cohort study will include 300 patients equally divided between lung, breast and colorectal cancer. Patients will perform a series of assessments at three visits throughout the treatment: (1) between the date of diagnosis and the start of treatment, (2) 8 weeks after the start of treatment, and (3) after the completion of first-line treatment or at the 6-months mark, whichever occurs first. For each of the three visits, subjective and objective fatigue, maximal voluntary force, body composition, cachexia, physical activity level, quality of life, respiratory function, overall physical performance, and exercise tolerance will be assessed. Discussion: The present study is aimed at identifying the nature and severity of maladaptation related to exercise intolerance in the three most common cancers. Therefore, our results should contribute to the delineation of the needs of each group of patients and to the determination of the most valuable exercise interventions in order to counteract these maladaptations. This descriptive and comprehensive approach is a prerequisite in order to elaborate, through future interventional research projects, tailored exercise strategies to counteract specific symptoms that are potentially cancer type-dependent and, in fine, to improve the health and quality of life of cancer patients. Moreover, our concomitant focus on fatigue and cachexia will provide insightful information about two factors that may have substantial interaction but require further investigation. Trial registration: This prospective study has been registered at ClinicalTrials.gov (NCT03956641), May, 2019. |
| Author | Ben Abdelghani, Meher Hucteau, Elyse Kalish-Weindling, Michal Belletier, Christine Carinato, Hélène Fischbach, Cathie Chiappa, Pascale Favret, Fabrice Dufour, Stéphane Pagano, Allan F. Demarchi, Martin Pivot, Xavier Schott, Roland Mallard, Joris Petit, Thierry Bousinière, Audren Hureau, Thomas J. |
| AuthorAffiliation | 2 EA 3072: Mitochondria, Oxidative Stress and Muscular Protection Laboratory, Faculty of Medicine, Faculty of Sports Sciences, University of Strasbourg , Strasbourg , France 1 Institut de Cancérologie Strasbourg Europe (ICANS) , Strasbourg , France |
| AuthorAffiliation_xml | – name: 2 EA 3072: Mitochondria, Oxidative Stress and Muscular Protection Laboratory, Faculty of Medicine, Faculty of Sports Sciences, University of Strasbourg , Strasbourg , France – name: 1 Institut de Cancérologie Strasbourg Europe (ICANS) , Strasbourg , France |
| Author_xml | – sequence: 1 givenname: Joris surname: Mallard fullname: Mallard, Joris – sequence: 2 givenname: Elyse surname: Hucteau fullname: Hucteau, Elyse – sequence: 3 givenname: Roland surname: Schott fullname: Schott, Roland – sequence: 4 givenname: Thierry surname: Petit fullname: Petit, Thierry – sequence: 5 givenname: Martin surname: Demarchi fullname: Demarchi, Martin – sequence: 6 givenname: Christine surname: Belletier fullname: Belletier, Christine – sequence: 7 givenname: Meher surname: Ben Abdelghani fullname: Ben Abdelghani, Meher – sequence: 8 givenname: Hélène surname: Carinato fullname: Carinato, Hélène – sequence: 9 givenname: Pascale surname: Chiappa fullname: Chiappa, Pascale – sequence: 10 givenname: Cathie surname: Fischbach fullname: Fischbach, Cathie – sequence: 11 givenname: Michal surname: Kalish-Weindling fullname: Kalish-Weindling, Michal – sequence: 12 givenname: Audren surname: Bousinière fullname: Bousinière, Audren – sequence: 13 givenname: Stéphane surname: Dufour fullname: Dufour, Stéphane – sequence: 14 givenname: Fabrice surname: Favret fullname: Favret, Fabrice – sequence: 15 givenname: Xavier surname: Pivot fullname: Pivot, Xavier – sequence: 16 givenname: Thomas J. surname: Hureau fullname: Hureau, Thomas J. – sequence: 17 givenname: Allan F. surname: Pagano fullname: Pagano, Allan F. |
| BookMark | eNp1kstu1DAYhSNUREvpmq2XLJqpHV8Ss0CCMAOVRuoIgsTOcmxnxlVit7ZTad6HB8XTKRJFwhvfzvl8-c_r4sR5Z4riLYILjBt-NXinFhWs4AIiDMmL4qyqMCk5wT9P_hqfFhcx3sLcGIUI4lfFKa44xJSTs-LX8sGPc7LeAT-AzW4frZIj-J5kmiNYBT-Bz1ZunY82guRB2hmwdPogXtkQU7m2zoAuGJkm4xKwDnzKk5guwXp220sgs7j1ow9GpQxupVMmgI1MNsvje9Bl4ObbTbdsuxKiLN35kPL5s96DTfDJKz--KV4Ocozm4qk_L36sll37tVzffLluP65LRTBLJR2oriSrkW5kjSjqe00IwYPsTSPzP6le94pBRLGutRmGWjccEwUZZg1HjOPz4vrI1V7eirtgJxn2wksrHhd82AoZklWjEVzCgfNMJawhGDNJERkMpw3FUjNDM-vDkXU395PRKr82yPEZ9PmOszux9Q-iJripqzoD3j0Bgr-fTUxislGZcZTO-DmKihDEIG4YzlJ6lKrgYwxmEMrmAuaiZrIdBYLiEBhxCIw4BEY8Bib7rv7x_bne_xy_AVf2xMk |
| CitedBy_id | crossref_primary_10_3389_fonc_2021_762709 crossref_primary_10_1002_cncr_34533 crossref_primary_10_1016_j_ctcp_2023_101811 crossref_primary_10_1155_2024_4850745 crossref_primary_10_1002_jcsm_12991 crossref_primary_10_3389_fcell_2021_719643 crossref_primary_10_1002_ijc_35508 |
| Cites_doi | 10.1113/JP273895 10.1093/annonc/mdt551 10.1007/s13539-013-0105-y 10.1016/S0885-3924(00)00258-X 10.1136/bjsports-2013-093080 10.1016/j.ejso.2016.02.094 10.1038/ejcn.2012.160 10.1080/00016489.2019.1566779 10.1038/sj.bjc.6602012 10.7861/clinmedicine.6-2-140 10.1016/S1470-2045(03)01221-X 10.1016/j.lungcan.2011.10.009 10.1016/j.pmrj.2017.07.074 10.3322/caac.21492 10.1200/JCO.2001.19.14.3385 10.1200/JCO.2014.56.1894 10.3390/nu9070695 10.1249/MSS.0b013e3181e0c112 10.2217/fon.15.195 10.1080/09638288.2016.1260647 10.1093/gerona/55.4.M221 10.1177/0898264312438551 10.1002/jcsm.12206 10.1007/s13539-012-0096-0 10.1093/jnci/85.5.365 10.1093/annonc/mdr447 10.3389/fnut.2019.00075 10.1016/j.neuroimage.2011.11.038 10.1177/1559827617725283 10.1001/jamaoncol.2016.1867 10.1016/j.critrevonc.2013.07.001 10.1016/j.mam.2016.04.006 10.1007/s10389-006-0024-x 10.1002/cncr.28382 10.1249/MSS.0000000000000929 10.1007/s11764-015-0450-2 10.1634/theoncologist.12-S1-22 10.1249/MSS.0000000000000975 10.1186/s12885-018-4668-z 10.3389/fphys.2018.01819 10.1097/MD.0000000000011068 10.1016/j.ctrv.2016.11.010 10.1016/S0140-6736(03)14186-4 10.1111/j.1582-4934.2009.00864.x 10.1016/j.jpsychores.2012.10.011 10.1093/oxfordjournals.jncimonographs.a003451 10.1016/j.jpainsymman.2011.06.013 10.1016/S1470-2045(10)70218-7 10.1249/JSR.0b013e3181c22324 10.1152/physrev.2001.81.4.1725 10.1634/theoncologist.5-5-353 10.1016/j.bbrc.2013.05.018 10.1177/1479972315575715 10.1164/ajrccm.166.1.at1102 10.1007/s13539-010-0016-0 10.1093/oxfordjournals.eurheartj.a014971 10.4103/0253-7176.116232 10.1016/j.clnu.2008.06.013 10.1007/s00520-018-4320-0 10.1002/jcsm.12199 10.1016/j.rmed.2005.08.003 10.1067/mhj.2001.118468 10.1186/s12885-017-3687-5 10.1016/j.jsams.2019.05.003 10.1001/jamaoncol.2015.2378 10.1001/jamaoncol.2016.6914 10.1158/1055-9965.EPI-10-0988 10.1016/j.biocel.2013.06.011 10.1200/JCO.2012.41.6222 10.1093/epirev/mxx007 10.1136/ijgc-00009577-200209000-00002 10.5539/cco.v4n1p19 10.1016/S1470-2045(09)70031-2 10.1002/jcsm.12043 10.1093/annonc/mdw099 10.1038/sj.bjc.6605578 10.7573/dic.212265 10.1002/14651858.CD006145.pub2 10.1038/nrdp.2017.105 10.3390/jfmk2010004 10.1093/jnci/djy218 |
| ContentType | Journal Article |
| Copyright | Copyright © 2020 Mallard, Hucteau, Schott, Petit, Demarchi, Belletier, Ben Abdelghani, Carinato, Chiappa, Fischbach, Kalish-Weindling, Bousinière, Dufour, Favret, Pivot, Hureau and Pagano. Copyright © 2020 Mallard, Hucteau, Schott, Petit, Demarchi, Belletier, Ben Abdelghani, Carinato, Chiappa, Fischbach, Kalish-Weindling, Bousinière, Dufour, Favret, Pivot, Hureau and Pagano. 2020 Mallard, Hucteau, Schott, Petit, Demarchi, Belletier, Ben Abdelghani, Carinato, Chiappa, Fischbach, Kalish-Weindling, Bousinière, Dufour, Favret, Pivot, Hureau and Pagano |
| Copyright_xml | – notice: Copyright © 2020 Mallard, Hucteau, Schott, Petit, Demarchi, Belletier, Ben Abdelghani, Carinato, Chiappa, Fischbach, Kalish-Weindling, Bousinière, Dufour, Favret, Pivot, Hureau and Pagano. – notice: Copyright © 2020 Mallard, Hucteau, Schott, Petit, Demarchi, Belletier, Ben Abdelghani, Carinato, Chiappa, Fischbach, Kalish-Weindling, Bousinière, Dufour, Favret, Pivot, Hureau and Pagano. 2020 Mallard, Hucteau, Schott, Petit, Demarchi, Belletier, Ben Abdelghani, Carinato, Chiappa, Fischbach, Kalish-Weindling, Bousinière, Dufour, Favret, Pivot, Hureau and Pagano |
| DBID | AAYXX CITATION 7X8 5PM DOA |
| DOI | 10.3389/fonc.2020.01304 |
| DatabaseName | CrossRef MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 2234-943X |
| ExternalDocumentID | oai_doaj_org_article_9a0f99a204684336a514fe95853ad6e5 PMC7438727 10_3389_fonc_2020_01304 |
| GroupedDBID | 53G 5VS 9T4 AAFWJ AAKDD AAYXX ACGFO ACGFS ADBBV ADRAZ AFPKN ALMA_UNASSIGNED_HOLDINGS AOIJS BAWUL BCNDV CITATION DIK EBS EJD EMOBN GROUPED_DOAJ GX1 HYE KQ8 M48 M~E OK1 PGMZT RNS RPM 7X8 5PM |
| ID | FETCH-LOGICAL-c436t-5f5d2a671d8a7151bbd4443fabe8a202cbdbc60153d7deff7d8934c0636891693 |
| IEDL.DBID | DOA |
| ISICitedReferencesCount | 7 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000563447200001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 2234-943X |
| IngestDate | Fri Oct 03 12:37:46 EDT 2025 Tue Sep 30 17:00:32 EDT 2025 Thu Oct 02 10:49:11 EDT 2025 Sat Nov 29 01:49:25 EST 2025 Tue Nov 18 20:44:43 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Language | English |
| License | This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c436t-5f5d2a671d8a7151bbd4443fabe8a202cbdbc60153d7deff7d8934c0636891693 |
| Notes | ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3 Edited by: Yun Dai, Peking University First Hospital, China These authors have contributed equally to this work This article was submitted to Gastrointestinal Cancers, a section of the journal Frontiers in Oncology Reviewed by: Antonio Macciò, Ospedale Oncologico Armando Businco, Italy; Moritz Schumann, German Sport University Cologne, Germany |
| OpenAccessLink | https://doaj.org/article/9a0f99a204684336a514fe95853ad6e5 |
| PMID | 32903594 |
| PQID | 2441603863 |
| PQPubID | 23479 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_9a0f99a204684336a514fe95853ad6e5 pubmedcentral_primary_oai_pubmedcentral_nih_gov_7438727 proquest_miscellaneous_2441603863 crossref_citationtrail_10_3389_fonc_2020_01304 crossref_primary_10_3389_fonc_2020_01304 |
| PublicationCentury | 2000 |
| PublicationDate | 2020-08-07 |
| PublicationDateYYYYMMDD | 2020-08-07 |
| PublicationDate_xml | – month: 08 year: 2020 text: 2020-08-07 day: 07 |
| PublicationDecade | 2020 |
| PublicationTitle | Frontiers in oncology |
| PublicationYear | 2020 |
| Publisher | Frontiers Media S.A |
| Publisher_xml | – name: Frontiers Media S.A |
| References | Partridge (B85) 2001; 30 Raoof (B12) 2015; 4 Chopard (B21) 2009; 13 Gandevia (B62) 2001; 81 Fearon (B4) 2011; 12 Mathiowetz (B60) 1990 Storey (B78) 2012; 23 Evans (B24) 2008; 27 Mustian (B34) 2009; 7 Neefjes (B5) 2017; 8 Ferrario (B59) 2016; 42 Steens (B79) 2012; 59 Stout (B44) 2017; 9 Bray (B51) 2018; 68 Fess (B61) 1992 Stewart (B81) 2006; 6 Cella (B15) 2001; 19 Harridge (B80) 1996; 17 Madeddu (B25) 2015; 11 Abrahams (B74) 2016; 27 Pressoir (B9) 2010; 102 Bodine (B20) 2013; 45 Guralnik (B64) 2000; 55 Mustian (B86) 2009; 8 Kilgour (B72) 2010; 1 Molassiotis (B76) 2012; 30 Mustian (B77) 2017; 3 Dudgeon (B10) 2001; 21 Barnes (B1) 2002; 12 Demangel (B22) 2017; 595 Roberts (B32) 2013; 435 Freire (B63) 2012; 24 Arthur (B29) 2014; 3 Butt (B52) 2013; 74 Brown (B47) 2011; 20 Freitag (B57) 2018; 97 Ryan (B30) 2007; 12 Brioche (B19) 2016; 50 Ahlberg (B2) 2003; 362 Camarri (B70) 2006; 100 Enoka (B13) 2016; 48 Martin (B28) 2015; 33 van der Leeden (B49) 2018; 40 Ferriolli (B17) 2012; 43 Bosy-Westphal (B55) 2013; 67 Powers (B31) 2016; 48 Cormie (B48) 2017; 39 Wagner (B14) 2004; 91 Jones (B66) 2012; 76 Gould (B37) 2013; 4 Bye (B6) 2017; 8 Kelley (B33) 2017; 17 Bowen (B36) 2015; 6 Zick (B75) 2016; 2 Granger (B69) 2015; 12 (B40) 2019 Armstrong (B53) 2006; 14 Schmitz (B42) 2010; 42 Abdel-Qadir (B50) 2019; 111 Farkas (B27) 2013; 4 Buffart (B45) 2017; 52 (B65) 2002; 166 Macciò (B26) 2018; 9 Quinten (B11) 2014; 120 Demers (B67) 2001; 142 Twomey (B73) 2018; 18 Hayes (B41) 2019; 22 Prigerson (B7) 2015; 1 Benavides-Rodríguez (B56) 2017; 9 Lobelo (B82) 2014; 48 Curt (B16) 2000; 5 Oikawa (B23) 2019; 6 Lundberg (B58) 2019; 139 Charan (B68) 2013; 35 Cramp (B35) 2008; 11 Hardee (B38) 2019; 13 Aaronson (B54) 1993; 85 Stene (B84) 2013; 88 Baracos (B3) 2018; 4 Christensen (B18) 2014; 25 Veni (B71) 2019; 27 Lucía (B83) 2003; 4 (B39) 2015 Jones (B46) 2009; 10 Stefani (B43) 2017; 2 Jones (B8) 2016; 10 |
| References_xml | – volume: 595 start-page: 4301 year: 2017 ident: B22 article-title: Early structural and functional signature of 3-day human skeletal muscle disuse using the dry immersion model publication-title: J Physiol. doi: 10.1113/JP273895 – volume: 25 start-page: 947 year: 2014 ident: B18 article-title: Muscle dysfunction in cancer patients publication-title: Ann Oncol. doi: 10.1093/annonc/mdt551 – volume: 4 start-page: 173 year: 2013 ident: B27 article-title: Cachexia as a major public health problem: frequent, costly, and deadly publication-title: J Cachexia Sarcopenia Muscle. doi: 10.1007/s13539-013-0105-y – volume: 21 start-page: 95 year: 2001 ident: B10 article-title: Dyspnea in cancer patients: prevalence and associated factors publication-title: J Pain Symptom Manage. doi: 10.1016/S0885-3924(00)00258-X – volume: 48 start-page: 1627 year: 2014 ident: B82 article-title: The exercise is medicine global health initiative: a 2014 update publication-title: Br J Sports Med. doi: 10.1136/bjsports-2013-093080 – volume: 42 start-page: S23 year: 2016 ident: B59 article-title: Factors influencing the length of stay for breast cancer patients undergoing mastectomy: an independent sector perspective publication-title: Eur J Surg Oncol. doi: 10.1016/j.ejso.2016.02.094 – volume: 67 start-page: S14 year: 2013 ident: B55 article-title: What makes a BIA equation unique? Validity of eight-electrode multifrequency BIA to estimate body composition in a healthy adult population publication-title: Eur J Clin Nutr. doi: 10.1038/ejcn.2012.160 – volume: 139 start-page: 383 year: 2019 ident: B58 article-title: Low-phase angle in body composition measurements correlates with prolonged hospital stay in head and neck cancer patients publication-title: Acta Otolaryngol (Stockh). doi: 10.1080/00016489.2019.1566779 – start-page: 163 volume-title: Muscle Strength Testing: Instrumented and Non-Instrumented Systems year: 1990 ident: B60 article-title: Grip and pinch strength measurements – volume: 91 start-page: 822 year: 2004 ident: B14 article-title: Fatigue and cancer: causes, prevalence and treatment approaches publication-title: Br J Cancer. doi: 10.1038/sj.bjc.6602012 – volume: 6 start-page: 140 year: 2006 ident: B81 article-title: Cancer cachexia and fatigue publication-title: Clin Med Lond Engl. doi: 10.7861/clinmedicine.6-2-140 – volume: 4 start-page: 616 year: 2003 ident: B83 article-title: Cancer-related fatigue: can exercise physiology assist oncologists? publication-title: Lancet Oncol. doi: 10.1016/S1470-2045(03)01221-X – volume: 76 start-page: 248 year: 2012 ident: B66 article-title: Prognostic significance of functional capacity and exercise behavior in patients with metastatic non-small cell lung cancer publication-title: Lung Cancer. doi: 10.1016/j.lungcan.2011.10.009 – volume: 9 start-page: S347 year: 2017 ident: B44 article-title: A systematic review of exercise systematic reviews in the cancer literature (2005-2017) publication-title: PM R. doi: 10.1016/j.pmrj.2017.07.074 – start-page: 41 volume-title: Clinical Assessment Recommendations year: 1992 ident: B61 article-title: Grip strength – volume: 68 start-page: 394 year: 2018 ident: B51 article-title: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries publication-title: CA Cancer J Clin. doi: 10.3322/caac.21492 – volume: 19 start-page: 3385 year: 2001 ident: B15 article-title: Cancer-related fatigue: prevalence of proposed diagnostic criteria in a United States sample of cancer survivors publication-title: J Clin Oncol doi: 10.1200/JCO.2001.19.14.3385 – volume: 33 start-page: 90 year: 2015 ident: B28 article-title: Diagnostic criteria for the classification of cancer-associated weight loss publication-title: J Clin Oncol. doi: 10.1200/JCO.2014.56.1894 – volume: 9 start-page: 695 year: 2017 ident: B56 article-title: Relationship between handgrip strength and muscle mass in female survivors of breast cancer: a mediation analysis publication-title: Nutrients. doi: 10.3390/nu9070695 – volume: 42 start-page: 1409 year: 2010 ident: B42 article-title: American college of sports medicine roundtable on exercise guidelines for cancer survivors publication-title: Med Sci Sports Exerc. doi: 10.1249/MSS.0b013e3181e0c112 – volume: 11 start-page: 2697 year: 2015 ident: B25 article-title: Muscle wasting as main evidence of energy impairment in cancer cachexia: future therapeutic approaches publication-title: Future Oncol Lond Engl. doi: 10.2217/fon.15.195 – volume: 40 start-page: 486 year: 2018 ident: B49 article-title: Tailoring exercise interventions to comorbidities and treatment-induced adverse effects in patients with early stage breast cancer undergoing chemotherapy: a framework to support clinical decisions publication-title: Disabil Rehabil. doi: 10.1080/09638288.2016.1260647 – volume: 55 start-page: M221 year: 2000 ident: B64 article-title: Lower extremity function and subsequent disability: consistency across studies, predictive models, and value of gait speed alone compared with the short physical performance battery publication-title: J Gerontol A Biol Sci Med Sci. doi: 10.1093/gerona/55.4.M221 – volume: 24 start-page: 863 year: 2012 ident: B63 article-title: Validity and reliability of the short physical performance battery in two diverse older adult populations in Quebec and Brazil publication-title: J Aging Health. doi: 10.1177/0898264312438551 – volume: 8 start-page: 759 year: 2017 ident: B6 article-title: Muscle mass and association to quality of life in non-small cell lung cancer patients publication-title: J Cachexia Sarcopenia Muscle. doi: 10.1002/jcsm.12206 – volume: 4 start-page: 111 year: 2013 ident: B37 article-title: Cancer cachexia prevention via physical exercise: molecular mechanisms publication-title: J Cachexia Sarcopenia Muscle. doi: 10.1007/s13539-012-0096-0 – volume: 85 start-page: 365 year: 1993 ident: B54 article-title: The european organization for research and treatment of cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology publication-title: J Natl Cancer Inst. doi: 10.1093/jnci/85.5.365 – volume: 23 start-page: 1542 year: 2012 ident: B78 article-title: Clinically relevant fatigue in men with hormone-sensitive prostate cancer on long-term androgen deprivation therapy publication-title: Ann Oncol. doi: 10.1093/annonc/mdr447 – volume: 6 start-page: 75 year: 2019 ident: B23 article-title: The impact of step reduction on muscle health in aging: protein and exercise as countermeasures publication-title: Front Nutr. doi: 10.3389/fnut.2019.00075 – volume: 59 start-page: 3110 year: 2012 ident: B79 article-title: Mechanisms underlying muscle fatigue differ between multiple sclerosis patients and controls: a combined electrophysiological and neuroimaging study publication-title: NeuroImage. doi: 10.1016/j.neuroimage.2011.11.038 – volume: 13 start-page: 46 year: 2019 ident: B38 article-title: Understanding the role of exercise in cancer cachexia therapy publication-title: Am J Lifestyle Med. doi: 10.1177/1559827617725283 – volume: 2 start-page: 1470 year: 2016 ident: B75 article-title: Investigation of 2 types of self-administered acupressure for persistent cancer-related fatigue in breast cancer survivors: a randomized clinical trial publication-title: JAMA Oncol. doi: 10.1001/jamaoncol.2016.1867 – volume: 88 start-page: 573 year: 2013 ident: B84 article-title: Effect of physical exercise on muscle mass and strength in cancer patients during treatment—a systematic review publication-title: Crit Rev Oncol Hematol. doi: 10.1016/j.critrevonc.2013.07.001 – volume: 50 start-page: 56 year: 2016 ident: B19 article-title: Muscle wasting and aging: experimental models, fatty infiltrations, and prevention publication-title: Mol Aspects Med. doi: 10.1016/j.mam.2016.04.006 – volume: 14 start-page: 66 year: 2006 ident: B53 article-title: Development of the World Health Organization Global Physical Activity Questionnaire (GPAQ) publication-title: J Public Health. doi: 10.1007/s10389-006-0024-x – volume: 120 start-page: 302 year: 2014 ident: B11 article-title: A global analysis of multitrial data investigating quality of life and symptoms as prognostic factors for survival in different tumor sites publication-title: Cancer. doi: 10.1002/cncr.28382 – volume: 48 start-page: 2228 year: 2016 ident: B13 article-title: Translating fatigue to human performance publication-title: Med Sci Sports Exerc. doi: 10.1249/MSS.0000000000000929 – volume: 10 start-page: 51 year: 2016 ident: B8 article-title: Cancer-related fatigue and associated disability in post-treatment cancer survivors publication-title: J Cancer Surviv Res Pract. doi: 10.1007/s11764-015-0450-2 – volume: 12 start-page: 22 year: 2007 ident: B30 article-title: Mechanisms of cancer-related fatigue publication-title: Oncologist. doi: 10.1634/theoncologist.12-S1-22 – volume: 48 start-page: 2307 year: 2016 ident: B31 article-title: Disease-induced skeletal muscle atrophy and fatigue publication-title: Med Sci Sports Exerc. doi: 10.1249/MSS.0000000000000975 – volume: 18 start-page: 757 year: 2018 ident: B73 article-title: Tailored exercise interventions to reduce fatigue in cancer survivors: study protocol of a randomized controlled trial publication-title: BMC Cancer. doi: 10.1186/s12885-018-4668-z – volume: 9 start-page: 1819 year: 2018 ident: B26 article-title: Editorial: biological mechanism-based and patient-centered management of cancer-related symptoms and syndromes publication-title: Front Physiol. doi: 10.3389/fphys.2018.01819 – volume: 97 start-page: e11068 year: 2018 ident: B57 article-title: High-intensity interval training and hyperoxia during chemotherapy publication-title: Medicine (Baltimore). doi: 10.1097/MD.0000000000011068 – volume: 52 start-page: 91 year: 2017 ident: B45 article-title: Effects and moderators of exercise on quality of life and physical function in patients with cancer: an individual patient data meta-analysis of 34 RCTs publication-title: Cancer Treat Rev. doi: 10.1016/j.ctrv.2016.11.010 – volume: 362 start-page: 640 year: 2003 ident: B2 article-title: Assessment and management of cancer-related fatigue in adults publication-title: Lancet Lond Engl. doi: 10.1016/S0140-6736(03)14186-4 – volume: 13 start-page: 3032 year: 2009 ident: B21 article-title: Molecular events and signalling pathways involved in skeletal muscle disuse-induced atrophy and the impact of countermeasures publication-title: J Cell Mol Med. doi: 10.1111/j.1582-4934.2009.00864.x – volume-title: Activité Physique: Prévention et Traitement des Maladies Chroniques year: 2019 ident: B40 – volume: 74 start-page: 64 year: 2013 ident: B52 article-title: Measurement of fatigue in cancer, stroke, and HIV using the functional assessment of chronic illness therapy–fatigue (FACIT-F) scale publication-title: J Psychosom Res. doi: 10.1016/j.jpsychores.2012.10.011 – volume: 30 start-page: 135 year: 2001 ident: B85 article-title: Side effects of chemotherapy and combined chemohormonal therapy in women with early-stage breast cancer publication-title: J Natl Cancer Inst Monogr. doi: 10.1093/oxfordjournals.jncimonographs.a003451 – volume: 43 start-page: 1025 year: 2012 ident: B17 article-title: Physical activity monitoring: a responsive and meaningful patient-centered outcome for surgery, chemotherapy, or radiotherapy? publication-title: J Pain Symptom Manage. doi: 10.1016/j.jpainsymman.2011.06.013 – volume: 12 start-page: 489 year: 2011 ident: B4 article-title: Definition and classification of cancer cachexia: an international consensus publication-title: Lancet Oncol. doi: 10.1016/S1470-2045(10)70218-7 – volume: 8 start-page: 325 year: 2009 ident: B86 article-title: Exercise for the management of side effects and quality of life among cancer survivors publication-title: Curr Sports Med Rep. doi: 10.1249/JSR.0b013e3181c22324 – volume: 81 start-page: 1725 year: 2001 ident: B62 article-title: Spinal and supraspinal factors in human muscle fatigue publication-title: Physiol Rev. doi: 10.1152/physrev.2001.81.4.1725 – volume: 5 start-page: 353 year: 2000 ident: B16 article-title: Impact of cancer-related fatigue on the lives of patients: new findings from the fatigue coalition publication-title: Oncologist. doi: 10.1634/theoncologist.5-5-353 – volume: 435 start-page: 488 year: 2013 ident: B32 article-title: Cancer cachexia decreases specific force and accelerates fatigue in limb muscle publication-title: Biochem Biophys Res Commun. doi: 10.1016/j.bbrc.2013.05.018 – volume: 12 start-page: 146 year: 2015 ident: B69 article-title: Minimal important difference of the 6-minute walk distance in lung cancer publication-title: Chron Respir Dis. doi: 10.1177/1479972315575715 – volume: 166 start-page: 111 year: 2002 ident: B65 article-title: ATS statement: guidelines for the six-minute walk test publication-title: Am J Respir Crit Care Med. doi: 10.1164/ajrccm.166.1.at1102 – volume: 1 start-page: 177 year: 2010 ident: B72 article-title: Cancer-related fatigue: the impact of skeletal muscle mass and strength in patients with advanced cancer publication-title: J Cachexia Sarcopenia Muscle. doi: 10.1007/s13539-010-0016-0 – volume: 17 start-page: 896 year: 1996 ident: B80 article-title: Skeletal muscle contractile characteristics and fatigue resistance in patients with chronic heart failure publication-title: Eur Heart J. doi: 10.1093/oxfordjournals.eurheartj.a014971 – volume: 35 start-page: 121 year: 2013 ident: B68 article-title: How to calculate sample size for different study designs in medical research? publication-title: Indian J Psychol Med. doi: 10.4103/0253-7176.116232 – volume: 27 start-page: 793 year: 2008 ident: B24 article-title: Cachexia: a new definition publication-title: Clin Nutr Edinb Scotl. doi: 10.1016/j.clnu.2008.06.013 – volume: 27 start-page: 229 year: 2019 ident: B71 article-title: Handgrip fatiguing exercise can provide objective assessment of cancer-related fatigue: a pilot study publication-title: Support Care Cancer. doi: 10.1007/s00520-018-4320-0 – volume: 8 start-page: 623 year: 2017 ident: B5 article-title: Muscle mass as a target to reduce fatigue in patients with advanced cancer publication-title: J Cachexia Sarcopenia Muscle. doi: 10.1002/jcsm.12199 – volume: 100 start-page: 658 year: 2006 ident: B70 article-title: Six minute walk distance in healthy subjects aged 55-75 years publication-title: Respir Med. doi: 10.1016/j.rmed.2005.08.003 – volume: 142 start-page: 698 year: 2001 ident: B67 article-title: Reliability, validity, and responsiveness of the six-minute walk test in patients with heart failure publication-title: Am Heart J. doi: 10.1067/mhj.2001.118468 – volume: 17 start-page: 693 year: 2017 ident: B33 article-title: Exercise and cancer-related fatigue in adults: a systematic review of previous systematic reviews with meta-analyses publication-title: BMC Cancer. doi: 10.1186/s12885-017-3687-5 – volume: 7 start-page: 158 year: 2009 ident: B34 article-title: A 4-week home-based aerobic and resistance exercise program during radiation therapy: a pilot randomized clinical trial publication-title: J Support Oncol. – volume: 22 start-page: 1175 year: 2019 ident: B41 article-title: The exercise and sports science Australia position statement: exercise medicine in cancer management publication-title: J Sci Med Sport. doi: 10.1016/j.jsams.2019.05.003 – volume: 1 start-page: 778 year: 2015 ident: B7 article-title: Chemotherapy use, performance status, and quality of life at the end of life publication-title: JAMA Oncol. doi: 10.1001/jamaoncol.2015.2378 – volume: 3 start-page: 961 year: 2017 ident: B77 article-title: Comparison of pharmaceutical, psychological, and exercise treatments for cancer-related fatigue: a meta-analysis publication-title: JAMA Oncol. doi: 10.1001/jamaoncol.2016.6914 – volume: 20 start-page: 123 year: 2011 ident: B47 article-title: Efficacy of exercise interventions in modulating cancer-related fatigue among adult cancer survivors: a meta-analysis publication-title: Cancer Epidemiol Biomark Prev. doi: 10.1158/1055-9965.EPI-10-0988 – volume: 45 start-page: 2200 year: 2013 ident: B20 article-title: Disuse-induced muscle wasting publication-title: Int J Biochem Cell Biol. doi: 10.1016/j.biocel.2013.06.011 – volume: 30 start-page: 4470 year: 2012 ident: B76 article-title: Acupuncture for cancer-related fatigue in patients with breast cancer: a pragmatic randomized controlled trial publication-title: J Clin Oncol Off J Am Soc Clin Oncol. doi: 10.1200/JCO.2012.41.6222 – volume: 39 start-page: 71 year: 2017 ident: B48 article-title: The impact of exercise on cancer mortality, recurrence, and treatment-related adverse effects publication-title: Epidemiol Rev. doi: 10.1093/epirev/mxx007 – volume: 12 start-page: 424 year: 2002 ident: B1 article-title: Fatigue in patients with advanced cancer: a review publication-title: Int J Gynecol Cancer Off J Int Gynecol Cancer Soc. doi: 10.1136/ijgc-00009577-200209000-00002 – volume: 4 start-page: 19 year: 2015 ident: B12 article-title: Quality of life among cancer patients treated with chemotherapy or radiotherapy in erbil city an evaluation study publication-title: Cancer Clin Oncol. doi: 10.5539/cco.v4n1p19 – volume: 10 start-page: 598 year: 2009 ident: B46 article-title: Exercise intolerance in cancer and the role of exercise therapy to reverse dysfunction publication-title: Lancet Oncol. doi: 10.1016/S1470-2045(09)70031-2 – volume: 6 start-page: 197 year: 2015 ident: B36 article-title: Skeletal muscle wasting in cachexia and sarcopenia: molecular pathophysiology and impact of exercise training publication-title: J Cachexia Sarcopenia Muscle. doi: 10.1002/jcsm.12043 – volume: 27 start-page: 965 year: 2016 ident: B74 article-title: Risk factors, prevalence, and course of severe fatigue after breast cancer treatment: a meta-analysis involving 12 327 breast cancer survivors publication-title: Ann Oncol. doi: 10.1093/annonc/mdw099 – volume: 102 start-page: 966 year: 2010 ident: B9 article-title: Prevalence, risk factors and clinical implications of malnutrition in French comprehensive cancer centres publication-title: Br J Cancer. doi: 10.1038/sj.bjc.6605578 – volume: 3 start-page: 212265 year: 2014 ident: B29 article-title: One-year prevalence, comorbidities and cost of cachexia-related inpatient admissions in the USA publication-title: Drugs Context. doi: 10.7573/dic.212265 – volume: 11 start-page: CD006145 year: 2008 ident: B35 article-title: Exercise for the management of cancer-related fatigue in adults publication-title: Cochrane Database Syst Rev. doi: 10.1002/14651858.CD006145.pub2 – volume: 4 start-page: 17105 year: 2018 ident: B3 article-title: Cancer-associated cachexia publication-title: Nat Rev Dis Primer. doi: 10.1038/nrdp.2017.105 – volume: 2 start-page: 4 year: 2017 ident: B43 article-title: Clinical implementation of exercise guidelines for cancer patients: adaptation of ACSM's guidelines to the Italian model publication-title: J Funct Morphol Kinesiol. doi: 10.3390/jfmk2010004 – year: 2015 ident: B39 publication-title: Plan Cancer 2014–2019 – volume: 111 start-page: 854 year: 2019 ident: B50 article-title: The risk of heart failure and other cardiovascular hospitalizations after early stage breast cancer: a matched cohort study publication-title: J Natl Cancer Inst doi: 10.1093/jnci/djy218 |
| SSID | ssj0000650103 |
| Score | 2.2585027 |
| Snippet | Background: Cancer cachexia and exacerbated fatigue represent two hallmarks in cancer patients, negatively impacting their exercise tolerance and ultimately... |
| SourceID | doaj pubmedcentral proquest crossref |
| SourceType | Open Website Open Access Repository Aggregation Database Enrichment Source Index Database |
| StartPage | 1304 |
| SubjectTerms | cachexia cachexia-fatigue vicious cycle cancer-related fatigue exercise intolerance muscle wasting Oncology tumor |
| Title | Evolution of Physical Status From Diagnosis to the End of First-Line Treatment in Breast, Lung, and Colorectal Cancer Patients: The PROTECT-01 Cohort Study Protocol |
| URI | https://www.proquest.com/docview/2441603863 https://pubmed.ncbi.nlm.nih.gov/PMC7438727 https://doaj.org/article/9a0f99a204684336a514fe95853ad6e5 |
| Volume | 10 |
| WOSCitedRecordID | wos000563447200001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 2234-943X dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000650103 issn: 2234-943X databaseCode: DOA dateStart: 20110101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources (ISSN International Center) customDbUrl: eissn: 2234-943X dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000650103 issn: 2234-943X databaseCode: M~E dateStart: 20110101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Nb9QwELWgQohLxadYCtUgceDQtNnYiW1udNkVh7ZEaEF7ixzHViNBgpJsJS78Gn4oM0m22hwQFy45JJPEyTyP38ijN4y9KfLYKxmpIM5DFwgb8cCEiQ-sNpG2oQttXzz-9UJeXanNRqd7rb6oJmyQBx5-3Jk2odd4I-ZxSnCeGFzhvdPIcrkpEterlyLr2UumhhgcUwODQcsHszB95uuKFAuj8JT26sRkGerV-icUc1ogubfirB6yw5EqwvthiI_YHVc9Zvcvx83wJ-z38mbEDdQe0vGHA9HHbQurpv4OH4ZCurKFrgakerCsCjJelUj6AsxDHax3leZQVnBOJerdCVxgCDgBg8YLDI4UFPHBCwJIA-mgxNq-A4QYpJ8_rZeLdRDO0fQauTxQZeJPSJu6qxFkT9mX1XK9-BiMTRcCK3jSBbGPi8gkcl4oI5EO5HkhhODe5E6hFyKbF7nFLC7mhSyc97JAxiMsMp1EaVJ2ecYOqrpyzxk4zZPcJRiKkSfkUhhh4zlXymraHnV-xk53PsjsqEhOjTG-ZZiZkNMyclpGTst6p83Y29sbfgxiHH83PSen3pqRinZ_ArGVjdjK_oWtGXu9g0SGs462Ukzl6m2bISmi_twq4TMmJ1iZvHF6pSqve_1uJG04PeSL_zHEI_aAProvSZQv2UHXbN0rds_edGXbHLO7cqOO-6mBx8tfyz-mTBQA |
| linkProvider | Directory of Open Access Journals |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Evolution+of+Physical+Status+From+Diagnosis+to+the+End+of+First-Line+Treatment+in+Breast%2C+Lung%2C+and+Colorectal+Cancer+Patients%3A+The+PROTECT-01+Cohort+Study+Protocol&rft.jtitle=Frontiers+in+oncology&rft.au=Mallard%2C+Joris&rft.au=Hucteau%2C+Elyse&rft.au=Schott%2C+Roland&rft.au=Petit%2C+Thierry&rft.date=2020-08-07&rft.issn=2234-943X&rft.eissn=2234-943X&rft.volume=10&rft_id=info:doi/10.3389%2Ffonc.2020.01304&rft.externalDBID=n%2Fa&rft.externalDocID=10_3389_fonc_2020_01304 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2234-943X&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2234-943X&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2234-943X&client=summon |