Low cardiac content of long-chain acylcarnitines in TMLHE knockout mice prevents ischaemia-reperfusion-induced mitochondrial and cardiac damage

Increased tissue content of long-chain acylcarnitines may induce mitochondrial and cardiac damage by stimulating ROS production. N6-trimethyllysine dioxygenase (TMLD) is the first enzyme in the carnitine/acylcarnitine biosynthesis pathway. Inactivation of the TMLHE gene (TMLHE KO) in mice is expecte...

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Bibliographic Details
Published in:	Free radical biology & medicine Vol. 177; pp. 370 - 380
Main Authors:	Liepinsh, Edgars, Kuka, Janis, Vilks, Karlis, Svalbe, Baiba, Stelfa, Gundega, Vilskersts, Reinis, Sevostjanovs, Eduards, Goldins, Niks Ricards, Groma, Valerija, Grinberga, Solveiga, Plaas, Mario, Makrecka-Kuka, Marina, Dambrova, Maija
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01.12.2021
Subjects:	Acylcarnitine Animals Carnitine - analogs & derivatives Fatty acid metabolism Gamma-butyrobetaine Ischemia Male Mice Mice, Knockout Mitochondria, Heart Myocardial infarction PUFA Reperfusion Trimethyllysine Myocardial infarction Acylcarnitine Trimethyllysine Gamma-butyrobetaine Fatty acid metabolism PUFA
ISSN:	0891-5849, 1873-4596, 1873-4596
Online Access:	Get full text
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