Evaluation of NADPH oxidases as drug targets in a mouse model of familial amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disease characterized by progressive loss of motor neurons, gliosis, neuroinflammation and oxidative stress. The aim of this study was to evaluate the involvement of NADPH oxidases (NOX) in the oxidative damage and progression of...

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Veröffentlicht in:	Free radical biology & medicine Jg. 97; S. 95 - 108
Hauptverfasser:	Seredenina, Tamara, Nayernia, Zeynab, Sorce, Silvia, Maghzal, Ghassan J., Filippova, Aleksandra, Ling, Shuo-Chien, Basset, Olivier, Plastre, Olivier, Daali, Youssef, Rushing, Elisabeth J., Giordana, Maria T., Cleveland, Don W., Aguzzi, Adriano, Stocker, Roland, Krause, Karl-Heinz, Jaquet, Vincent
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Elsevier Inc 01.08.2016
Schlagworte:	Adult Aged Amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis - drug therapy Amyotrophic Lateral Sclerosis - genetics Amyotrophic Lateral Sclerosis - pathology Animals Disease Models, Animal Female Gene Expression Regulation - drug effects Humans Male Mice Microglia Middle Aged Motor Neurons - metabolism Motor Neurons - pathology NADPH oxidase NADPH Oxidase 1 - genetics NADPH Oxidase 2 - genetics NADPH Oxidase 2 - metabolism NOX Perphenazine Perphenazine - administration & dosage Phenothiazine SOD1G93A mice Spinal Cord - drug effects Spinal Cord - pathology Superoxide Dismutase-1 - antagonists & inhibitors Superoxide Dismutase-1 - genetics Thioridazine Thioridazine - administration & dosage NADPH SOD1G93A mice BBB O2 DMSO E TDP 43 ALS CNS NOXO1 H2O2 MPO 2-Cl-E DMEM GM-CSF FBS NADPH oxidase FUS/TLS EC50 DUOX qPCR WT Perphenazine Phenothiazine PBS LC/MS/MS PMA SOD Amyotrophic lateral sclerosis WST-1 Microglia HOCl Thioridazine NC DNA NOX ROS HBSS DPI HE 2-OH-E SOD1(G93A) mice
ISSN:	0891-5849, 1873-4596, 1873-4596
Online-Zugang:	Volltext
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