Chronic Stress Promotes Cancer Development

Stress is an inevitable part of life. Chronic stress on account of reasons like adversity, depression, anxiety, or loneliness/social isolation can endanger human health. Recent studies have shown that chronic stress can induce tumorigenesis and promote cancer development. This review describes the l...

Full description

Saved in:

Bibliographic Details
Published in:	Frontiers in oncology Vol. 10; p. 1492
Main Authors:	Dai, Shirui, Mo, Yongzhen, Wang, Yumin, Xiang, Bo, Liao, Qianjin, Zhou, Ming, Li, Xiaoling, Li, Yong, Xiong, Wei, Li, Guiyuan, Guo, Can, Zeng, Zhaoyang
Format:	Journal Article
Language:	English
Published:	Frontiers Media S.A 19.08.2020
Subjects:	cancer hormone hypothalamic-pituitary-adrenal axis immunity inflammation Oncology stress
ISSN:	2234-943X, 2234-943X
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Abstract	Stress is an inevitable part of life. Chronic stress on account of reasons like adversity, depression, anxiety, or loneliness/social isolation can endanger human health. Recent studies have shown that chronic stress can induce tumorigenesis and promote cancer development. This review describes the latest progress of research on the molecular mechanisms by which chronic stress promotes cancer development. Primarily, chronic stress activates the classic neuroendocrine system [the hypothalamic-pituitary-adrenal (HPA) axis] and the sympathetic nervous system (SNS) and leads to a decline and dysfunction of the prefrontal cortex and the hippocampus under stress. Stress hormones produced during the activation of both the HPA axis and the SNS can promote tumorigenesis and cancer development through a variety of mechanisms. Chronic stress can also cause corresponding changes in the body's immune function and inflammatory response, which is significant because a long-term inflammatory response and the decline of the body's immune surveillance capabilities are implicated in tumorigenesis. Stress management is essential for both healthy people and cancer patients. Whether drugs that limit the signaling pathways downstream of the HPA axis or the SNS can suppress chronic stress-induced cancers or prolong patient survival deserves further study.Stress is an inevitable part of life. Chronic stress on account of reasons like adversity, depression, anxiety, or loneliness/social isolation can endanger human health. Recent studies have shown that chronic stress can induce tumorigenesis and promote cancer development. This review describes the latest progress of research on the molecular mechanisms by which chronic stress promotes cancer development. Primarily, chronic stress activates the classic neuroendocrine system [the hypothalamic-pituitary-adrenal (HPA) axis] and the sympathetic nervous system (SNS) and leads to a decline and dysfunction of the prefrontal cortex and the hippocampus under stress. Stress hormones produced during the activation of both the HPA axis and the SNS can promote tumorigenesis and cancer development through a variety of mechanisms. Chronic stress can also cause corresponding changes in the body's immune function and inflammatory response, which is significant because a long-term inflammatory response and the decline of the body's immune surveillance capabilities are implicated in tumorigenesis. Stress management is essential for both healthy people and cancer patients. Whether drugs that limit the signaling pathways downstream of the HPA axis or the SNS can suppress chronic stress-induced cancers or prolong patient survival deserves further study.
AbstractList	Stress is an inevitable part of life. Chronic stress on account of reasons like adversity, depression, anxiety, or loneliness/social isolation can endanger human health. Recent studies have shown that chronic stress can induce tumorigenesis and promote cancer development. This review describes the latest progress of research on the molecular mechanisms by which chronic stress promotes cancer development. Primarily, chronic stress activates the classic neuroendocrine system [the hypothalamic-pituitary-adrenal (HPA) axis] and the sympathetic nervous system (SNS) and leads to a decline and dysfunction of the prefrontal cortex and the hippocampus under stress. Stress hormones produced during the activation of both the HPA axis and the SNS can promote tumorigenesis and cancer development through a variety of mechanisms. Chronic stress can also cause corresponding changes in the body's immune function and inflammatory response, which is significant because a long-term inflammatory response and the decline of the body's immune surveillance capabilities are implicated in tumorigenesis. Stress management is essential for both healthy people and cancer patients. Whether drugs that limit the signaling pathways downstream of the HPA axis or the SNS can suppress chronic stress-induced cancers or prolong patient survival deserves further study.Stress is an inevitable part of life. Chronic stress on account of reasons like adversity, depression, anxiety, or loneliness/social isolation can endanger human health. Recent studies have shown that chronic stress can induce tumorigenesis and promote cancer development. This review describes the latest progress of research on the molecular mechanisms by which chronic stress promotes cancer development. Primarily, chronic stress activates the classic neuroendocrine system [the hypothalamic-pituitary-adrenal (HPA) axis] and the sympathetic nervous system (SNS) and leads to a decline and dysfunction of the prefrontal cortex and the hippocampus under stress. Stress hormones produced during the activation of both the HPA axis and the SNS can promote tumorigenesis and cancer development through a variety of mechanisms. Chronic stress can also cause corresponding changes in the body's immune function and inflammatory response, which is significant because a long-term inflammatory response and the decline of the body's immune surveillance capabilities are implicated in tumorigenesis. Stress management is essential for both healthy people and cancer patients. Whether drugs that limit the signaling pathways downstream of the HPA axis or the SNS can suppress chronic stress-induced cancers or prolong patient survival deserves further study. Stress is an inevitable part of life. Chronic stress on account of reasons like adversity, depression, anxiety, or loneliness/social isolation can endanger human health. Recent studies have shown that chronic stress can induce tumorigenesis and promote cancer development. This review describes the latest progress of research on the molecular mechanisms by which chronic stress promotes cancer development. Primarily, chronic stress activates the classic neuroendocrine system [the hypothalamic-pituitary-adrenal (HPA) axis] and the sympathetic nervous system (SNS) and leads to a decline and dysfunction of the prefrontal cortex and the hippocampus under stress. Stress hormones produced during the activation of both the HPA axis and the SNS can promote tumorigenesis and cancer development through a variety of mechanisms. Chronic stress can also cause corresponding changes in the body's immune function and inflammatory response, which is significant because a long-term inflammatory response and the decline of the body's immune surveillance capabilities are implicated in tumorigenesis. Stress management is essential for both healthy people and cancer patients. Whether drugs that limit the signaling pathways downstream of the HPA axis or the SNS can suppress chronic stress-induced cancers or prolong patient survival deserves further study.
Author	Liao, Qianjin Li, Xiaoling Mo, Yongzhen Wang, Yumin Zeng, Zhaoyang Xiang, Bo Li, Yong Guo, Can Zhou, Ming Li, Guiyuan Dai, Shirui Xiong, Wei
AuthorAffiliation	3 Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Disease Genome Research Center, The Third Xiangya Hospital, Central South University , Changsha , China 1 NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Translational Radiation Oncology, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University , Changsha , China 2 Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University , Changsha , China 4 Department of Medicine, Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine , Houston, TX , United States
AuthorAffiliation_xml	– name: 4 Department of Medicine, Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine , Houston, TX , United States – name: 3 Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Disease Genome Research Center, The Third Xiangya Hospital, Central South University , Changsha , China – name: 2 Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University , Changsha , China – name: 1 NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Translational Radiation Oncology, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University , Changsha , China
Author_xml	– sequence: 1 givenname: Shirui surname: Dai fullname: Dai, Shirui – sequence: 2 givenname: Yongzhen surname: Mo fullname: Mo, Yongzhen – sequence: 3 givenname: Yumin surname: Wang fullname: Wang, Yumin – sequence: 4 givenname: Bo surname: Xiang fullname: Xiang, Bo – sequence: 5 givenname: Qianjin surname: Liao fullname: Liao, Qianjin – sequence: 6 givenname: Ming surname: Zhou fullname: Zhou, Ming – sequence: 7 givenname: Xiaoling surname: Li fullname: Li, Xiaoling – sequence: 8 givenname: Yong surname: Li fullname: Li, Yong – sequence: 9 givenname: Wei surname: Xiong fullname: Xiong, Wei – sequence: 10 givenname: Guiyuan surname: Li fullname: Li, Guiyuan – sequence: 11 givenname: Can surname: Guo fullname: Guo, Can – sequence: 12 givenname: Zhaoyang surname: Zeng fullname: Zeng, Zhaoyang
BookMark	eNp1kc1r3DAQxUVJaNLtnnPdYynsRpbGsnwJlE2TBgIJJIHehDweJQq2tZW8C_nvq_0oNIXORTOa935IvE_saAgDMXZW8IWUuj53YcCF4IIveAG1-MBOhZAwr0H-PPqrP2HTlF55LlXygsuP7ESKuoJC81P2dfkSw-Bx9jBGSml2H0MfRkqzpR2Q4uySNtSFVU_D-JkdO9slmh7OCXu6-v64_DG_vbu-WX67nSNINc7BtYpTLiFLJVRhayzKpgZqGy0s6AZrcDaP0rnSkUOoCMFCQ41r2rKSE3az57bBvppV9L2NbyZYb3YXIT4bG0ePHRlOtpUcrdBQAWKlWy04bxRyoSqpVWZd7FmrddNTi_kb0XbvoO83g38xz2FjKlAKRJ0BXw6AGH6tKY2m9wmp6-xAYZ2MgCxUUkvI0nIvxRhSiuQM-tGOPmzJvjMFN9vYzDY2s43N7GLLvvN_fH-e9z_Hb8jenGo
CitedBy_id	crossref_primary_10_3892_ol_2023_14106 crossref_primary_10_1172_JCI143776 crossref_primary_10_3390_ijms24054577 crossref_primary_10_3389_fcell_2020_601738 crossref_primary_10_3390_stresses3020033 crossref_primary_10_1158_2326_6066_CIR_23_0378 crossref_primary_10_1007_s11010_025_05376_y crossref_primary_10_3390_genes15121531 crossref_primary_10_1111_imm_13933 crossref_primary_10_1177_15598276221123764 crossref_primary_10_1007_s11357_025_01780_w crossref_primary_10_1007_s12035_021_02544_1 crossref_primary_10_1186_s12905_022_01671_8 crossref_primary_10_1001_jamanetworkopen_2024_49855 crossref_primary_10_3390_ijerph20043640 crossref_primary_10_1038_s41598_021_93506_z crossref_primary_10_1002_cncr_34789 crossref_primary_10_3389_fpsyt_2025_1580673 crossref_primary_10_1007_s00520_023_08143_1 crossref_primary_10_1016_j_jaim_2024_101069 crossref_primary_10_1016_j_psyneuen_2025_107478 crossref_primary_10_1016_j_mehy_2025_111683 crossref_primary_10_1016_j_semcancer_2022_01_008 crossref_primary_10_3390_ani12111337 crossref_primary_10_1016_j_bbcan_2021_188629 crossref_primary_10_1016_j_psyneuen_2024_107191 crossref_primary_10_1038_s41401_024_01441_2 crossref_primary_10_1186_s12967_022_03467_8 crossref_primary_10_1152_japplphysiol_00608_2024 crossref_primary_10_1007_s40615_025_02636_x crossref_primary_10_1007_s00520_021_06435_y crossref_primary_10_15407_oncology_2025_02_111 crossref_primary_10_1186_s40959_024_00240_2 crossref_primary_10_3390_cancers14081903 crossref_primary_10_3389_fphar_2025_1644315 crossref_primary_10_3390_cancers14235933 crossref_primary_10_1177_10732748241248363 crossref_primary_10_1080_10511482_2022_2099936 crossref_primary_10_31083_j_jin2305101 crossref_primary_10_1002_agm2_70026 crossref_primary_10_1002_wjs_70046 crossref_primary_10_1016_j_neubiorev_2024_105734 crossref_primary_10_3389_fendo_2024_1363748 crossref_primary_10_1186_s12935_025_03701_5 crossref_primary_10_3390_cancers16112044 crossref_primary_10_1016_j_biocel_2024_106733 crossref_primary_10_1186_s12974_023_02964_x crossref_primary_10_1016_j_ijbiomac_2022_03_065 crossref_primary_10_3389_fimmu_2022_1014296 crossref_primary_10_1080_07853890_2022_2131330 crossref_primary_10_1111_cns_13999 crossref_primary_10_1371_journal_pone_0323671 crossref_primary_10_1007_s12672_025_01744_8 crossref_primary_10_1016_j_jff_2024_106294 crossref_primary_10_1146_annurev_cancerbio_062822_105541 crossref_primary_10_1111_cns_14724 crossref_primary_10_1007_s11427_022_2269_7 crossref_primary_10_1186_s12905_023_02529_3 crossref_primary_10_3390_ijms241814104 crossref_primary_10_1007_s10943_025_02362_y crossref_primary_10_3389_fmed_2023_1190049 crossref_primary_10_1007_s12672_025_02747_1 crossref_primary_10_1016_j_jep_2023_117069 crossref_primary_10_1002_smi_3279 crossref_primary_10_1186_s13058_023_01754_w crossref_primary_10_1097_MD_0000000000037916 crossref_primary_10_3389_fonc_2025_1543872 crossref_primary_10_1111_imm_13448 crossref_primary_10_3389_fpubh_2024_1370399 crossref_primary_10_3390_ijerph18105092 crossref_primary_10_1016_j_intimp_2023_110825 crossref_primary_10_3390_ijms252312856 crossref_primary_10_1007_s12035_024_04444_6 crossref_primary_10_1016_j_cbi_2022_110278 crossref_primary_10_1002_bco2_237 crossref_primary_10_3390_ijms24076705 crossref_primary_10_1007_s11033_022_07847_7 crossref_primary_10_15252_embr_202357176 crossref_primary_10_3390_bs12060166 crossref_primary_10_2147_DDDT_S359451 crossref_primary_10_1002_cnr2_1571 crossref_primary_10_1007_s10552_022_01664_w crossref_primary_10_1080_15700763_2024_2373455 crossref_primary_10_1038_s41575_022_00669_9 crossref_primary_10_1002_pbc_31271 crossref_primary_10_3389_fonc_2021_744251 crossref_primary_10_3389_fimmu_2022_1032294 crossref_primary_10_1007_s40618_022_01751_4 crossref_primary_10_3389_fonc_2021_738252 crossref_primary_10_1016_j_jbc_2024_107753 crossref_primary_10_3390_cancers12123853 crossref_primary_10_1186_s12943_025_02402_x crossref_primary_10_1093_aje_kwaf038 crossref_primary_10_3389_fonc_2023_1090610 crossref_primary_10_1016_j_tvjl_2022_105788 crossref_primary_10_1161_JAHA_123_033295 crossref_primary_10_1186_s12903_023_03787_1 crossref_primary_10_3389_fpsyt_2024_1391403 crossref_primary_10_1080_2331186X_2023_2232686 crossref_primary_10_1186_s12943_024_02219_0 crossref_primary_10_1016_j_bbcan_2021_188665 crossref_primary_10_1016_j_ypmed_2023_107817 crossref_primary_10_3389_fcvm_2023_1072042 crossref_primary_10_1186_s12943_021_01409_4 crossref_primary_10_3390_cancers14081881 crossref_primary_10_3390_molecules27113470 crossref_primary_10_1080_00098655_2025_2475825 crossref_primary_10_1177_08445621241230099 crossref_primary_10_18282_po3596 crossref_primary_10_1111_luts_70018 crossref_primary_10_1158_2159_8290_CD_23_0397 crossref_primary_10_1002_cam4_6065 crossref_primary_10_1016_j_bbi_2024_10_012 crossref_primary_10_3390_cancers14133044 crossref_primary_10_1007_s00520_025_09366_0 crossref_primary_10_1007_s12020_025_04161_7 crossref_primary_10_3389_fpsyg_2023_1279561 crossref_primary_10_3390_nu14030568 crossref_primary_10_69601_meandrosmdj_1591577 crossref_primary_10_3390_ijerph21081077 crossref_primary_10_1016_j_jad_2021_10_119 crossref_primary_10_3390_biomedicines11082100 crossref_primary_10_1111_prd_12610 crossref_primary_10_3390_ijms232012653 crossref_primary_10_1016_j_bbih_2025_100995 crossref_primary_10_1002_cbf_4132 crossref_primary_10_1016_j_clindermatol_2023_03_008 crossref_primary_10_3390_cells12030418 crossref_primary_10_1089_cbr_2025_0108 crossref_primary_10_7717_peerj_16029 crossref_primary_10_1016_j_acthis_2022_151878 crossref_primary_10_3390_ani13111869 crossref_primary_10_1038_s41417_024_00830_3 crossref_primary_10_1136_bmjopen_2024_097084 crossref_primary_10_3390_biom14010096 crossref_primary_10_1002_hsr2_2282 crossref_primary_10_3389_fonc_2024_1227151 crossref_primary_10_4081_hls_2024_12402 crossref_primary_10_31083_j_fbl2709253 crossref_primary_10_1177_21650799231170872 crossref_primary_10_1016_j_prp_2024_155747 crossref_primary_10_1016_j_intimp_2024_112330 crossref_primary_10_1007_s00432_023_05300_1 crossref_primary_10_1200_EDBK_349825 crossref_primary_10_1097_CM9_0000000000002976 crossref_primary_10_3390_cancers16061201 crossref_primary_10_1016_j_nwh_2024_09_004 crossref_primary_10_1093_eurheartj_ehaf191 crossref_primary_10_3390_healthcare13101151 crossref_primary_10_1016_j_jopan_2021_08_008 crossref_primary_10_1016_j_bbih_2022_100558 crossref_primary_10_1186_s13046_021_01952_4 crossref_primary_10_3389_fpubh_2023_1117822 crossref_primary_10_1016_j_pop_2023_04_011 crossref_primary_10_1097_MS9_0000000000003304 crossref_primary_10_3390_ani14233536 crossref_primary_10_3390_ijms241612822 crossref_primary_10_1016_j_lfs_2025_123894 crossref_primary_10_3390_ph14010065 crossref_primary_10_1007_s00210_024_03205_5 crossref_primary_10_1016_j_jval_2022_08_005 crossref_primary_10_1016_j_jare_2025_08_052 crossref_primary_10_1038_s41416_022_02132_7 crossref_primary_10_1038_s41380_023_02006_1 crossref_primary_10_1038_s41467_023_43470_1 crossref_primary_10_3390_cancers14235950 crossref_primary_10_3390_ijms26136063 crossref_primary_10_1080_2162402X_2023_2255459 crossref_primary_10_3389_fphys_2023_1119095 crossref_primary_10_1007_s00432_024_05617_5 crossref_primary_10_1136_bmjopen_2022_067360 crossref_primary_10_1002_eji_202451299 crossref_primary_10_1007_s12094_022_02927_3 crossref_primary_10_1016_j_bandc_2024_106239 crossref_primary_10_3389_fpsyg_2023_1253266 crossref_primary_10_1016_j_isci_2025_112769 crossref_primary_10_3390_s21041030 crossref_primary_10_1002_advs_202400665 crossref_primary_10_3390_ph15121517 crossref_primary_10_1007_s44202_023_00089_z crossref_primary_10_3389_fpsyg_2024_1303721 crossref_primary_10_1053_j_gastro_2022_06_085 crossref_primary_10_3390_ijms24119565 crossref_primary_10_1158_0008_5472_CAN_24_1779 crossref_primary_10_1093_jnci_djaf043 crossref_primary_10_3389_fendo_2022_1076521 crossref_primary_10_3390_cancers16162891 crossref_primary_10_3389_fimmu_2025_1637144 crossref_primary_10_3390_diseases11030101 crossref_primary_10_1615_CritRevEukaryotGeneExpr_2025059382 crossref_primary_10_3390_biomedicines12091978 crossref_primary_10_3390_healthcare11091278 crossref_primary_10_1186_s40959_024_00254_w crossref_primary_10_1158_0008_5472_CAN_21_2463 crossref_primary_10_1073_pnas_2415042122 crossref_primary_10_1007_s12033_023_00872_2 crossref_primary_10_3390_healthcare13172169 crossref_primary_10_1007_s13105_024_01012_3 crossref_primary_10_1177_17588359251371826
Cites_doi	10.1158/1078-0432.CCR-10-2441 10.1038/ncomms2413 10.1200/JCO.2017.77.1097 10.1038/nri.2017.1 10.1177/0141076819890547 10.1002/cncr.31943 10.1126/scitranslmed.3008455 10.1016/j.jaad.2004.08.042 10.1053/j.gastro.2008.03.036 10.1016/j.biopsych.2016.02.026 10.1038/nrc3978 10.1126/science.168638 10.1016/j.ccr.2013.07.016 10.1038/nn.4087 10.1523/JNEUROSCI.2568-17.2018 10.1016/j.ejca.2005.08.016 10.1016/j.bbi.2016.06.011 10.1037/0033-2909.130.4.601 10.1016/j.ccell.2017.11.007 10.1038/nrd2656 10.1172/JCI31537 10.1016/S1470-2045(17)30677-0 10.1093/jnci/dji401 10.1200/JCO.2014.57.2198 10.1016/j.biopsych.2013.03.024 10.1016/j.eururo.2014.10.024 10.1038/nature10368 10.1172/JCI63324 10.1200/JCO.2015.65.7874 10.1158/1078-0432.CCR-17-0152 10.1016/j.biopsych.2008.06.026 10.1002/cncr.31594 10.1016/j.immuni.2019.06.025 10.1093/jnci/90.1.12 10.1016/j.biopsych.2011.10.007 10.1093/annonc/mdx264 10.1016/j.trecan.2017.11.008 10.1002/jcp.22011 10.1016/j.cell.2010.01.025 10.1016/S0140-6736(14)60093-3 10.1523/JNEUROSCI.0004-11.2011 10.1016/j.ccell.2017.11.015 10.1016/j.ygyno.2019.07.004 10.3390/jcm8050575 10.1016/j.bbi.2018.05.014 10.1038/nrn3918 10.1002/path.4988 10.1016/j.cell.2019.01.021 10.1038/nri1703 10.1016/j.bbi.2019.04.012 10.1200/JCO.2016.68.8788 10.1093/annonc/mds342 10.1136/gut.47.suppl_4.iv49 10.1038/s41419-019-2030-2 10.1038/nm1447 10.1016/j.bbi.2012.07.011 10.1016/j.bbi.2014.02.019 10.1038/ncomms10634 10.1186/1476-4598-10-146 10.1016/j.bbi.2018.07.007 10.1158/0008-5472.CAN-07-0858 10.1172/JCI121685 10.1007/s11481-019-09891-w 10.1186/1476-4598-8-30 10.1016/j.biopsych.2008.12.013 10.1158/0008-5472.CAN-16-0990 10.1038/s41586-019-1019-4 10.1038/nri.2017.142 10.1126/science.aah5072 10.1038/nature04870 10.1007/s13311-017-0600-5 10.1038/s41593-017-0010-3 10.1016/j.bbi.2017.02.008 10.1523/JNEUROSCI.0450-11.2011 10.1016/j.bbi.2009.02.003 10.1152/physrev.00018.2018 10.1186/1476-4598-9-261 10.1159/000288920 10.1073/pnas.1203930109 10.3892/ijo.2019.4753 10.1080/15548627.2019.1630222 10.1126/science.7233204 10.1038/s41591-019-0566-4 10.1016/S1470-2045(04)01597-9
ContentType	Journal Article
Copyright	Copyright © 2020 Dai, Mo, Wang, Xiang, Liao, Zhou, Li, Li, Xiong, Li, Guo and Zeng. Copyright © 2020 Dai, Mo, Wang, Xiang, Liao, Zhou, Li, Li, Xiong, Li, Guo and Zeng. 2020 Dai, Mo, Wang, Xiang, Liao, Zhou, Li, Li, Xiong, Li, Guo and Zeng
Copyright_xml	– notice: Copyright © 2020 Dai, Mo, Wang, Xiang, Liao, Zhou, Li, Li, Xiong, Li, Guo and Zeng. – notice: Copyright © 2020 Dai, Mo, Wang, Xiang, Liao, Zhou, Li, Li, Xiong, Li, Guo and Zeng. 2020 Dai, Mo, Wang, Xiang, Liao, Zhou, Li, Li, Xiong, Li, Guo and Zeng
DBID	AAYXX CITATION 7X8 5PM DOA
DOI	10.3389/fonc.2020.01492
DatabaseName	CrossRef MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals
DatabaseTitle	CrossRef MEDLINE - Academic
DatabaseTitleList	MEDLINE - Academic
Database_xml	– sequence: 1 dbid: DOA name: DOAJ Open Access Full Text url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Medicine
EISSN	2234-943X
ExternalDocumentID	oai_doaj_org_article_0ead30ca28474cc78d8200b6c0267386 PMC7466429 10_3389_fonc_2020_01492
GrantInformation_xml	– fundername: Natural Science Foundation ofÂHunan Province – fundername: National Natural Science Foundation of China – fundername: Hunan Provincial Innovation Foundation for Postgraduate – fundername: Fundamental Research Funds for Central Universities of the Central South University
GroupedDBID	53G 5VS 9T4 AAFWJ AAKDD AAYXX ACGFO ACGFS ADBBV ADRAZ AFPKN ALMA_UNASSIGNED_HOLDINGS AOIJS BAWUL BCNDV CITATION DIK EBS EJD EMOBN GROUPED_DOAJ GX1 HYE KQ8 M48 M~E OK1 PGMZT RNS RPM 7X8 5PM
ID	FETCH-LOGICAL-c436t-4fd60eeee2356261a9c15b94edb82a48bc94fa4ed3ff5fefc47ec4a4bebfbd573
IEDL.DBID	DOA
ISICitedReferencesCount	248
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000567828300001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	2234-943X
IngestDate	Fri Oct 03 12:40:01 EDT 2025 Thu Aug 21 13:12:57 EDT 2025 Wed Oct 01 13:12:01 EDT 2025 Tue Nov 18 20:27:50 EST 2025 Sat Nov 29 01:49:27 EST 2025
IsDoiOpenAccess	true
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Language	English
License	This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c436t-4fd60eeee2356261a9c15b94edb82a48bc94fa4ed3ff5fefc47ec4a4bebfbd573
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 Reviewed by: Ravi Manoharan, University of Madras, India; Aruljothi Muralidharan, University of California School of Medicine, Riverside, United States Edited by: Sridhar Muthusami, Karpagam Academy of Higher Education, India This article was submitted to Molecular and Cellular Oncology, a section of the journal Frontiers in Oncology
OpenAccessLink	https://doaj.org/article/0ead30ca28474cc78d8200b6c0267386
PMID	32974180
PQID	2446663834
PQPubID	23479
ParticipantIDs	doaj_primary_oai_doaj_org_article_0ead30ca28474cc78d8200b6c0267386 pubmedcentral_primary_oai_pubmedcentral_nih_gov_7466429 proquest_miscellaneous_2446663834 crossref_citationtrail_10_3389_fonc_2020_01492 crossref_primary_10_3389_fonc_2020_01492
PublicationCentury	2000
PublicationDate	2020-08-19
PublicationDateYYYYMMDD	2020-08-19
PublicationDate_xml	– month: 08 year: 2020 text: 2020-08-19 day: 19
PublicationDecade	2020
PublicationTitle	Frontiers in oncology
PublicationYear	2020
Publisher	Frontiers Media S.A
Publisher_xml	– name: Frontiers Media S.A
References	Farzi (B63) 2018; 15 Landen (B39) 2007; 67 Carayol (B70) 2013; 24 Shaashua (B84) 2017; 23 Moreno-Smith (B76) 2011; 17 Zhou (B5) 2011; 31 Thaker (B34) 2006; 12 Bondar (B45) 2013; 24 O'Mahony (B64) 2009; 65 Hara (B38) 2011; 477 Le (B60) 2016; 7 Armaiz-Pena (B36) 2013; 4 Menard (B6) 2017; 20 Karin (B53) 2005; 5 Segerstrom (B57) 2004; 130 Zhi (B13) 2019; 54 El-Kenawi (B52) 2017; 32 Cole (B30) 2015; 15 Chaudhary (B81) 2019; 8 Wohleb (B47) 2011; 31 Haldar (B82) 2018; 73 Chen (B15) 2018; 244 Nilsson (B78) 2020; 15 Parker (B18) 2004; 51 Niraula (B46) 2018; 38 Taniguchi (B55) 2018; 18 Cain (B77) 2017; 17 Saul (B17) 2005; 97 Breitbart (B69) 2015; 33 Curtin (B26) 2009; 23 Frick (B44) 2009; 65 Chambers (B74) 2017; 35 Hanke (B48) 2012; 26 Alonso (B3) 2008; 135 Riley (B19) 1981; 212 Kim-Fuchs (B33) 2014; 40 Santos (B4) 2000; 47 Jung (B21) 2019; 16 Renz (B35) 2018; 33 Jackson (B1) 2014; 383 Guarino (B37) 2010; 223 Hassan (B42) 2013; 123 Antoni (B49) 2012; 71 Lin (B51) 2007; 117 Zhang (B14) 2019; 10 Obradovic (B29) 2019; 567 McNeil (B12) 1998; 90 Arnsten (B20) 2015; 18 Reiche (B58) 2004; 5 Cryan (B62) 2019; 99 Lengacher (B73) 2016; 34 Greten (B24) 2019; 51 Biondi (B65) 1994; 62 Hodge (B56) 2005; 41 Ricon (B79) 2019; 125 Feng (B27) 2012; 109 Chang (B9) 2016; 57 Jang (B16) 2016; 76 Witek Janusek (B72) 2019; 80 Xu (B75) 2014; 6 Androulidaki (B10) 2009; 8 Salmaso (B22) 2016; 80 Ramondetta (B80) 2019; 154 Fidler (B7) 2017; 18 Spera (B83) 2017; 28 Sandi (B2) 2015; 16 Muthuswamy (B59) 2017; 62 Cui (B8) 2019; 129 Hondermarck (B32) 2018; 4 Grivennikov (B50) 2010; 140 Yang (B25) 2019; 25 Antoni (B66) 2019; 125 Zhang (B41) 2011; 10 Apte (B40) 2019; 176 Arranz (B43) 2010; 9 Rodin (B71) 2018; 36 Wootten (B68) 2015; 68 Zahalka (B31) 2017; 358 Karin (B54) 2006; 441 Bird (B67) 2020; 113 McKlveen (B23) 2013; 74 Vazquez (B28) 2008; 7 Riley (B11) 1975; 189 Vodicka (B61) 2018; 73
References_xml	– volume: 17 start-page: 3649 year: 2011 ident: B76 article-title: Dopamine blocks stress-mediated ovarian carcinoma growth publication-title: Clin Cancer Res. doi: 10.1158/1078-0432.CCR-10-2441 – volume: 4 start-page: 1403 year: 2013 ident: B36 article-title: Src activation by beta-adrenoreceptors is a key switch for tumour metastasis publication-title: Nat Commun. doi: 10.1038/ncomms2413 – volume: 36 start-page: 2422 year: 2018 ident: B71 article-title: Managing cancer and living meaningfully (CALM): a randomized controlled trial of a psychological intervention for patients with advanced cancer publication-title: J Clin Oncol. doi: 10.1200/JCO.2017.77.1097 – volume: 17 start-page: 233 year: 2017 ident: B77 article-title: Immune regulation by glucocorticoids publication-title: Nat Rev Immunol. doi: 10.1038/nri.2017.1 – volume: 113 start-page: 105 year: 2020 ident: B67 article-title: Reducing chronic stress to promote health in adults: the role of social prescriptions and social movements publication-title: J R Soc Med. doi: 10.1177/0141076819890547 – volume: 125 start-page: 1417 year: 2019 ident: B66 article-title: The impact of psychosocial stress and stress management on immune responses in patients with cancer publication-title: Cancer. doi: 10.1002/cncr.31943 – volume: 6 start-page: 242ra84 year: 2014 ident: B75 article-title: COX-2 inhibition potentiates antiangiogenic cancer therapy and prevents metastasis in preclinical models publication-title: Sci Transl Med. doi: 10.1126/scitranslmed.3008455 – volume: 51 start-page: 919 year: 2004 ident: B18 article-title: Chronic stress accelerates ultraviolet-induced cutaneous carcinogenesis publication-title: J Am Acad Dermatol. doi: 10.1016/j.jaad.2004.08.042 – volume: 135 start-page: 163 year: 2008 ident: B3 article-title: Maladaptive intestinal epithelial responses to life stress may predispose healthy women to gut mucosal inflammation publication-title: Gastroenterology. doi: 10.1053/j.gastro.2008.03.036 – volume: 80 start-page: 479 year: 2016 ident: B22 article-title: Fibroblast growth factor 2 modulates hypothalamic pituitary axis activity and anxiety behavior through glucocorticoid receptors publication-title: Biol Psychiatry. doi: 10.1016/j.biopsych.2016.02.026 – volume: 15 start-page: 563 year: 2015 ident: B30 article-title: Sympathetic nervous system regulation of the tumour microenvironment publication-title: Nat Rev Cancer. doi: 10.1038/nrc3978 – volume: 189 start-page: 465 year: 1975 ident: B11 article-title: Mouse mammary tumors: alteration of incidence as apparent function of stress publication-title: Science. doi: 10.1126/science.168638 – volume: 24 start-page: 143 year: 2013 ident: B45 article-title: The origins of tumor-promoting inflammation publication-title: Cancer Cell. doi: 10.1016/j.ccr.2013.07.016 – volume: 18 start-page: 1376 year: 2015 ident: B20 article-title: Stress weakens prefrontal networks: molecular insults to higher cognition publication-title: Nat Neurosci. doi: 10.1038/nn.4087 – volume: 38 start-page: 2328 year: 2018 ident: B46 article-title: Corticosterone production during repeated social defeat causes monocyte mobilization from the bone marrow, glucocorticoid resistance, and neurovascular adhesion molecule expression publication-title: J Neurosci. doi: 10.1523/JNEUROSCI.2568-17.2018 – volume: 41 start-page: 2502 year: 2005 ident: B56 article-title: The role of IL-6 and STAT3 in inflammation and cancer publication-title: Eur J Cancer. doi: 10.1016/j.ejca.2005.08.016 – volume: 57 start-page: 106 year: 2016 ident: B9 article-title: β2-Adrenoceptors on tumor cells play a critical role in stress-enhanced metastasis in a mouse model of breast cancer publication-title: Brain Behav Immun. doi: 10.1016/j.bbi.2016.06.011 – volume: 130 start-page: 601 year: 2004 ident: B57 article-title: Psychological stress and the human immune system: a meta-analytic study of 30 years of inquiry publication-title: Psychol Bull. doi: 10.1037/0033-2909.130.4.601 – volume: 33 start-page: 75 year: 2018 ident: B35 article-title: β2 Adrenergic-neurotrophin feedforward loop promotes pancreatic cancer publication-title: Cancer Cell. doi: 10.1016/j.ccell.2017.11.007 – volume: 7 start-page: 979 year: 2008 ident: B28 article-title: The genetics of the p53 pathway, apoptosis and cancer therapy publication-title: Nat Rev Drug Discov. doi: 10.1038/nrd2656 – volume: 117 start-page: 1175 year: 2007 ident: B51 article-title: A cytokine-mediated link between innate immunity, inflammation, and cancer publication-title: J Clin Invest. doi: 10.1172/JCI31537 – volume: 18 start-page: 1579 year: 2017 ident: B7 article-title: Cancer incidence and mortality among young adults aged 20-39 years worldwide in 2012: a population-based study publication-title: Lancet Oncol. doi: 10.1016/S1470-2045(17)30677-0 – volume: 97 start-page: 1760 year: 2005 ident: B17 article-title: Chronic stress and susceptibility to skin cancer publication-title: J Natl Cancer Inst. doi: 10.1093/jnci/dji401 – volume: 33 start-page: 749 year: 2015 ident: B69 article-title: Meaning-centered group psychotherapy: an effective intervention for improving psychological well-being in patients with advanced cancer publication-title: J Clin Oncol. doi: 10.1200/JCO.2014.57.2198 – volume: 74 start-page: 672 year: 2013 ident: B23 article-title: Role of prefrontal cortex glucocorticoid receptors in stress and emotion publication-title: Biol Psychiatry. doi: 10.1016/j.biopsych.2013.03.024 – volume: 68 start-page: 471 year: 2015 ident: B68 article-title: Preliminary results of a randomised controlled trial of an online psychological intervention to reduce distress in men treated for localised prostate cancer publication-title: Eur Urol. doi: 10.1016/j.eururo.2014.10.024 – volume: 477 start-page: 349 year: 2011 ident: B38 article-title: A stress response pathway regulates DNA damage through beta2-adrenoreceptors and beta-arrestin-1 publication-title: Nature. doi: 10.1038/nature10368 – volume: 123 start-page: 874 year: 2013 ident: B42 article-title: Behavioral stress accelerates prostate cancer development in mice publication-title: J Clin Invest. doi: 10.1172/JCI63324 – volume: 34 start-page: 2827 year: 2016 ident: B73 article-title: Examination of broad symptom improvement resulting from mindfulness-based stress reduction in breast cancer survivors: a randomized controlled trial publication-title: J Clin Oncol. doi: 10.1200/JCO.2015.65.7874 – volume: 23 start-page: 4651 year: 2017 ident: B84 article-title: Perioperative COX-2 and beta-adrenergic blockade improves metastatic biomarkers in breast cancer patients in a phase-II randomized trial publication-title: Clin Cancer Res. doi: 10.1158/1078-0432.CCR-17-0152 – volume: 65 start-page: 263 year: 2009 ident: B64 article-title: Early life stress alters behavior, immunity, and microbiota in rats: implications for irritable bowel syndrome and psychiatric illnesses publication-title: Biol Psychiatry. doi: 10.1016/j.biopsych.2008.06.026 – volume: 125 start-page: 45 year: 2019 ident: B79 article-title: Perioperative biobehavioral interventions to prevent cancer recurrence through combined inhibition of beta-adrenergic and cyclooxygenase 2 signaling publication-title: Cancer. doi: 10.1002/cncr.31594 – volume: 51 start-page: 27 year: 2019 ident: B24 article-title: Inflammation and cancer: triggers, mechanisms, and consequences publication-title: Immunity. doi: 10.1016/j.immuni.2019.06.025 – volume: 90 start-page: 12 year: 1998 ident: B12 article-title: Stress reduction: three trials test its impact on breast cancer progression publication-title: J Natl Cancer Inst. doi: 10.1093/jnci/90.1.12 – volume: 71 start-page: 366 year: 2012 ident: B49 article-title: Cognitive-behavioral stress management reverses anxiety-related leukocyte transcriptional dynamics publication-title: Biol Psychiatry. doi: 10.1016/j.biopsych.2011.10.007 – volume: 28 start-page: 1836 year: 2017 ident: B83 article-title: Beta blockers and improved progression-free survival in patients with advanced HER2 negative breast cancer: a retrospective analysis of the ROSE/TRIO-012 study publication-title: Ann Oncol. doi: 10.1093/annonc/mdx264 – volume: 4 start-page: 93 year: 2018 ident: B32 article-title: The sympathetic nervous system drives tumor angiogenesis publication-title: Trends Cancer. doi: 10.1016/j.trecan.2017.11.008 – volume: 223 start-page: 14 year: 2010 ident: B37 article-title: Src signaling in cancer invasion publication-title: J Cell Physiol. doi: 10.1002/jcp.22011 – volume: 140 start-page: 883 year: 2010 ident: B50 article-title: Immunity, inflammation, and cancer publication-title: Cell. doi: 10.1016/j.cell.2010.01.025 – volume: 383 start-page: 300 year: 2014 ident: B1 article-title: The stress of life: a modern complaint? publication-title: Lancet. doi: 10.1016/S0140-6736(14)60093-3 – volume: 31 start-page: 7579 year: 2011 ident: B5 article-title: Hippocampal neuronal nitric oxide synthase mediates the stress-related depressive behaviors of glucocorticoids by downregulating glucocorticoid receptor publication-title: J Neurosci. doi: 10.1523/JNEUROSCI.0004-11.2011 – volume: 32 start-page: 727 year: 2017 ident: B52 article-title: Inflammation, ROS, and mutagenesis publication-title: Cancer Cell. doi: 10.1016/j.ccell.2017.11.015 – volume: 154 start-page: 524 year: 2019 ident: B80 article-title: Prospective pilot trial with combination of propranolol with chemotherapy in patients with epithelial ovarian cancer and evaluation on circulating immune cell gene expression publication-title: Gynecol Oncol. doi: 10.1016/j.ygyno.2019.07.004 – volume: 8 start-page: 575 year: 2019 ident: B81 article-title: Effects of beta-adrenergic antagonists on chemoradiation therapy for locally advanced non-small cell lung cancer publication-title: J Clin Med. doi: 10.3390/jcm8050575 – volume: 73 start-page: 294 year: 2018 ident: B82 article-title: Perioperative inhibition of beta-adrenergic and COX2 signaling in a clinical trial in breast cancer patients improves tumor Ki-67 expression, serum cytokine levels, and PBMCs transcriptome publication-title: Brain Behav Immun. doi: 10.1016/j.bbi.2018.05.014 – volume: 16 start-page: 290 year: 2015 ident: B2 article-title: Stress and the social brain: behavioural effects and neurobiological mechanisms publication-title: Nat Rev Neurosci. doi: 10.1038/nrn3918 – volume: 244 start-page: 49 year: 2018 ident: B15 article-title: Chronic psychological stress promotes lung metastatic colonization of circulating breast cancer cells by decorating a pre-metastatic niche through activating beta-adrenergic signaling publication-title: J Pathol. doi: 10.1002/path.4988 – volume: 176 start-page: 1248 year: 2019 ident: B40 article-title: VEGF in signaling and disease: beyond discovery and development publication-title: Cell. doi: 10.1016/j.cell.2019.01.021 – volume: 5 start-page: 749 year: 2005 ident: B53 article-title: NF-kappaB: linking inflammation and immunity to cancer development and progression publication-title: Nat Rev Immunol. doi: 10.1038/nri1703 – volume: 80 start-page: 358 year: 2019 ident: B72 article-title: Mindfulness based stress reduction provides psychological benefit and restores immune function of women newly diagnosed with breast cancer: a randomized trial with active control publication-title: Brain Behav Immun. doi: 10.1016/j.bbi.2019.04.012 – volume: 35 start-page: 291 year: 2017 ident: B74 article-title: Mindfulness-based cognitive therapy in advanced prostate cancer: a randomized controlled trial publication-title: J Clin Oncol. doi: 10.1200/JCO.2016.68.8788 – volume: 24 start-page: 291 year: 2013 ident: B70 article-title: Psychological effect of exercise in women with breast cancer receiving adjuvant therapy: what is the optimal dose needed? publication-title: Ann Oncol. doi: 10.1093/annonc/mds342 – volume: 47 start-page: 49 year: 2000 ident: B4 article-title: Stress and neuroimmune regulation of gut mucosal function publication-title: Gut. doi: 10.1136/gut.47.suppl_4.iv49 – volume: 10 start-page: 788 year: 2019 ident: B14 article-title: Chronic stress promotes gastric cancer progression and metastasis: an essential role for ADRB2 publication-title: Cell Death Dis. doi: 10.1038/s41419-019-2030-2 – volume: 12 start-page: 939 year: 2006 ident: B34 article-title: Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma publication-title: Nat Med. doi: 10.1038/nm1447 – volume: 26 start-page: 1150 year: 2012 ident: B48 article-title: Beta adrenergic blockade decreases the immunomodulatory effects of social disruption stress publication-title: Brain Behav Immun. doi: 10.1016/j.bbi.2012.07.011 – volume: 40 start-page: 40 year: 2014 ident: B33 article-title: Chronic stress accelerates pancreatic cancer growth and invasion: a critical role for beta-adrenergic signaling in the pancreatic microenvironment publication-title: Brain Behav Immun. doi: 10.1016/j.bbi.2014.02.019 – volume: 7 start-page: 10634 year: 2016 ident: B60 article-title: Chronic stress in mice remodels lymph vasculature to promote tumour cell dissemination publication-title: Nat Commun. doi: 10.1038/ncomms10634 – volume: 10 start-page: 146 year: 2011 ident: B41 article-title: β2-adrenoceptor blockage induces G1/S phase arrest and apoptosis in pancreatic cancer cells via Ras/Akt/NFkappaB pathway publication-title: Mol Cancer. doi: 10.1186/1476-4598-10-146 – volume: 73 start-page: 615 year: 2018 ident: B61 article-title: Microbiota affects the expression of genes involved in HPA axis regulation and local metabolism of glucocorticoids in chronic psychosocial stress publication-title: Brain Behav Immun. doi: 10.1016/j.bbi.2018.07.007 – volume: 67 start-page: 10389 year: 2007 ident: B39 article-title: Neuroendocrine modulation of signal transducer and activator of transcription-3 in ovarian cancer publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-07-0858 – volume: 129 start-page: 1030 year: 2019 ident: B8 article-title: Stress-induced epinephrine enhances lactate dehydrogenase A and promotes breast cancer stem-like cells publication-title: J Clin Invest. doi: 10.1172/JCI121685 – volume: 15 start-page: 27 year: 2020 ident: B78 article-title: β-Adrenergic signaling in lung cancer: A potential role for beta-blockers publication-title: J Neuroimmune Pharmacol. doi: 10.1007/s11481-019-09891-w – volume: 8 start-page: 30 year: 2009 ident: B10 article-title: Corticotropin releasing factor promotes breast cancer cell motility and invasiveness publication-title: Mol Cancer. doi: 10.1186/1476-4598-8-30 – volume: 65 start-page: 935 year: 2009 ident: B44 article-title: Involvement of thyroid hormones in the alterations of T-cell immunity and tumor progression induced by chronic stress publication-title: Biol Psychiatry. doi: 10.1016/j.biopsych.2008.12.013 – volume: 76 start-page: 6607 year: 2016 ident: B16 article-title: Chronic stress facilitates lung tumorigenesis by promoting exocytosis of IGF2 in lung epithelial cells publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-16-0990 – volume: 567 start-page: 540 year: 2019 ident: B29 article-title: Glucocorticoids promote breast cancer metastasis publication-title: Nature. doi: 10.1038/s41586-019-1019-4 – volume: 18 start-page: 309 year: 2018 ident: B55 article-title: NF-kappaB, inflammation, immunity and cancer: coming of age publication-title: Nat Rev Immunol. doi: 10.1038/nri.2017.142 – volume: 358 start-page: 321 year: 2017 ident: B31 article-title: Adrenergic nerves activate an angio-metabolic switch in prostate cancer publication-title: Science. doi: 10.1126/science.aah5072 – volume: 441 start-page: 431 year: 2006 ident: B54 article-title: Nuclear factor-kappaB in cancer development and progression publication-title: Nature. doi: 10.1038/nature04870 – volume: 15 start-page: 5 year: 2018 ident: B63 article-title: Gut microbiota and the neuroendocrine system publication-title: Neurotherapeutics. doi: 10.1007/s13311-017-0600-5 – volume: 20 start-page: 1752 year: 2017 ident: B6 article-title: Social stress induces neurovascular pathology promoting depression publication-title: Nat Neurosci. doi: 10.1038/s41593-017-0010-3 – volume: 62 start-page: 78 year: 2017 ident: B59 article-title: Epinephrine promotes COX-2-dependent immune suppression in myeloid cells and cancer tissues publication-title: Brain Behav Immun. doi: 10.1016/j.bbi.2017.02.008 – volume: 31 start-page: 6277 year: 2011 ident: B47 article-title: β-Adrenergic receptor antagonism prevents anxiety-like behavior and microglial reactivity induced by repeated social defeat publication-title: J Neurosci. doi: 10.1523/JNEUROSCI.0450-11.2011 – volume: 23 start-page: 535 year: 2009 ident: B26 article-title: Psychological stress suppresses innate IFN-gamma production via glucocorticoid receptor activation: reversal by the anxiolytic chlordiazepoxide publication-title: Brain Behav Immun. doi: 10.1016/j.bbi.2009.02.003 – volume: 99 start-page: 1877 year: 2019 ident: B62 article-title: The microbiota-gut-brain axis publication-title: Physiol Rev. doi: 10.1152/physrev.00018.2018 – volume: 9 start-page: 261 year: 2010 ident: B43 article-title: The impact of stress on tumor growth: peripheral CRF mediates tumor-promoting effects of stress publication-title: Mol Cancer. doi: 10.1186/1476-4598-9-261 – volume: 62 start-page: 176 year: 1994 ident: B65 article-title: Personality, endocrine and immune changes after eight months in healthy individuals under normal daily stress publication-title: Psychother Psychosom. doi: 10.1159/000288920 – volume: 109 start-page: 7013 year: 2012 ident: B27 article-title: Chronic restraint stress attenuates p53 function and promotes tumorigenesis publication-title: Proc Natl Acad Sci USA. doi: 10.1073/pnas.1203930109 – volume: 54 start-page: 1625 year: 2019 ident: B13 article-title: Adrenergic modulation of AMPKdependent autophagy by chronic stress enhances cell proliferation and survival in gastric cancer publication-title: Int J Oncol. doi: 10.3892/ijo.2019.4753 – volume: 16 start-page: 512 year: 2019 ident: B21 article-title: Autophagic death of neural stem cells mediates chronic stress-induced decline of adult hippocampal neurogenesis and cognitive deficits publication-title: Autophagy. doi: 10.1080/15548627.2019.1630222 – volume: 212 start-page: 1100 year: 1981 ident: B19 article-title: Psychoneuroendocrine influences on immunocompetence and neoplasia publication-title: Science. doi: 10.1126/science.7233204 – volume: 25 start-page: 1428 year: 2019 ident: B25 article-title: Stress-glucocorticoid-TSC22D3 axis compromises therapy-induced antitumor immunity publication-title: Nat Med. doi: 10.1038/s41591-019-0566-4 – volume: 5 start-page: 617 year: 2004 ident: B58 article-title: Stress, depression, the immune system, and cancer publication-title: Lancet Oncol. doi: 10.1016/S1470-2045(04)01597-9
SSID	ssj0000650103
Score	2.6338482
SecondaryResourceType	review_article
Snippet	Stress is an inevitable part of life. Chronic stress on account of reasons like adversity, depression, anxiety, or loneliness/social isolation can endanger...
SourceID	doaj pubmedcentral proquest crossref
SourceType	Open Website Open Access Repository Aggregation Database Enrichment Source Index Database
StartPage	1492
SubjectTerms	cancer hormone hypothalamic-pituitary-adrenal axis immunity inflammation Oncology stress
Title	Chronic Stress Promotes Cancer Development
URI	https://www.proquest.com/docview/2446663834 https://pubmed.ncbi.nlm.nih.gov/PMC7466429 https://doaj.org/article/0ead30ca28474cc78d8200b6c0267386
Volume	10
WOSCitedRecordID	wos000567828300001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVAON databaseName: DOAJ Open Access Full Text customDbUrl: eissn: 2234-943X dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000650103 issn: 2234-943X databaseCode: DOA dateStart: 20110101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 2234-943X dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000650103 issn: 2234-943X databaseCode: M~E dateStart: 20110101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3NS8MwFH_oEPEifuL8GBU8iNCta9ImPerY8LIxUGG3kKQJDqSTfXj0bzcv7cZ6EC_2UOgXTX4vvLxf8_p7AHcqdyzZShNyzUhIuebODxLMsmLKpBgzpMoXm2CjEZ9MsvFWqS_MCSvlgUvgOpHrKom0RDdKtWY8d3NWpFKNpZMI92LbLurZIlOlD06wgEGp5eNYWNaxswIVC-OojaQgrk1DXq2_FmLWEyS3ZpzBERxWoWLwWDbxGHZMcQL7w2ox_BQeKmHb4MX_7xGMfWadWQQ9tOQ82MoHOoO3Qf-19xxWpQ9CTUm6DKnN08i4LSYuQEm7MtPdRGXU5IrHknKlM2qlOyTWJtZYTZnRVFJllFV5wsg5NIpZYS4gSLXjcEpLltuEkjxRzJJMdh1RSpSlMm1Ce42E0JUuOJan-BCOHyB0AqETCJ3w0DXhfvPAZymJ8futTwjt5jbUsvYnnIVFZWHxl4WbcLs2jHBjHxc0ZGFmq4WIcTHaORBCm8BqFqu9sX6lmL57FW2GwvpxdvkfTbyCA-w0fmvuZtfQWM5X5gb29Ndyupi3YJdNeMsPULcffvd_ALZK7Ac
linkProvider	Directory of Open Access Journals
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Chronic+Stress+Promotes+Cancer+Development&rft.jtitle=Frontiers+in+oncology&rft.au=Dai%2C+Shirui&rft.au=Mo%2C+Yongzhen&rft.au=Wang%2C+Yumin&rft.au=Xiang%2C+Bo&rft.date=2020-08-19&rft.issn=2234-943X&rft.eissn=2234-943X&rft.volume=10&rft_id=info:doi/10.3389%2Ffonc.2020.01492&rft.externalDBID=n%2Fa&rft.externalDocID=10_3389_fonc_2020_01492
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2234-943X&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2234-943X&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2234-943X&client=summon