Phagocytosis: An Immunobiologic Process

It has been a century since the death of Élie Metchnikoff, who championed the role of phagocytosis in cellular immunity. Whereas others had observed the uptake of particles by cells from simple to complex organisms, he grasped its significance in the host response to injury and infection and establi...

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Bibliographic Details
Published in:Immunity (Cambridge, Mass.) Vol. 44; no. 3; p. 463
Main Author: Gordon, Siamon
Format: Journal Article
Language:English
Published: United States 15.03.2016
Subjects:
Adaptive Immunity
Animals
Homeostasis
Humans
Immunity, Cellular
Immunity, Innate
Inflammation - immunology
Phagocytes - immunology
Phagocytosis - immunology
ISSN:1097-4180, 1097-4180
Online Access:Get more information
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Summary:It has been a century since the death of Élie Metchnikoff, who championed the role of phagocytosis in cellular immunity. Whereas others had observed the uptake of particles by cells from simple to complex organisms, he grasped its significance in the host response to injury and infection and established a firm basis for our understanding of inflammation and tissue homeostasis. The past century has brought improved tools of cellular and molecular biology to the study of phagocytosis and its contribution to physiological and pathological processes, including receptor function in innate and acquired immunity. In this review, I assess our present knowledge and consider opportunities for future research and therapeutic targeting.
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ISSN:1097-4180
1097-4180
DOI:10.1016/j.immuni.2016.02.026