CD4 + T Cell Help Confers a Cytotoxic T Cell Effector Program Including Coinhibitory Receptor Downregulation and Increased Tissue Invasiveness

CD4 T cells optimize the cytotoxic T cell (CTL) response in magnitude and quality, by unknown molecular mechanisms. We here present the transcriptomic changes in CTLs resulting from CD4 T cell help after anti-cancer vaccination or virus infection. The gene expression signatures revealed that CD4 T c...

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Bibliographic Details
Published in:	Immunity (Cambridge, Mass.) Vol. 47; no. 5; p. 848
Main Authors:	Ahrends, Tomasz, Spanjaard, Aldo, Pilzecker, Bas, Bąbała, Nikolina, Bovens, Astrid, Xiao, Yanling, Jacobs, Heinz, Borst, Jannie
Format:	Journal Article
Language:	English
Published:	United States 21.11.2017
Subjects:	Animals CD27 Ligand - physiology CD4-Positive T-Lymphocytes - physiology Cell Differentiation Cell Movement CX3C Chemokine Receptor 1 - physiology Down-Regulation Mice Mice, Inbred C57BL Receptors, CXCR4 - physiology T-Lymphocytes, Cytotoxic - immunology Tumor Necrosis Factor Receptor Superfamily, Member 7 - physiology CD4 T cell help CD8 T cell costimulation CTL differentiation transcriptome migration coinhibition tumor immunity vaccination virus infection
ISSN:	1097-4180, 1097-4180
Online Access:	Get more information
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