Adoptive T Cell Therapy Targeting Different Gene Products Reveals Diverse and Context-Dependent Immune Evasion in Melanoma

Tumor immune escape limits durable responses to T cell therapy. Here, we examined how regulation and function of gene products that provide the target epitopes for CD8 T cell anti-tumor immunity influence therapeutic efficacy and resistance. We used a CRISPR-Cas9-based method (CRISPitope) in syngene...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Jg. 53; H. 3; S. 564
Hauptverfasser:	Effern, Maike, Glodde, Nicole, Braun, Matthias, Liebing, Jana, Boll, Helena N, Yong, Michelle, Bawden, Emma, Hinze, Daniel, van den Boorn-Konijnenberg, Debby, Daoud, Mila, Aymans, Pia, Landsberg, Jennifer, Smyth, Mark J, Flatz, Lukas, Tüting, Thomas, Bald, Tobias, Gebhardt, Thomas, Hölzel, Michael
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 15.09.2020
Schlagworte:	Adoptive Transfer - methods Animals CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - transplantation Cell Line, Tumor Cell- and Tissue-Based Therapy - methods Epitopes, T-Lymphocyte - genetics Epitopes, T-Lymphocyte - immunology Gene Knockout Techniques Immune Checkpoint Inhibitors - pharmacology Melanoma - immunology Melanoma - therapy Mice Mice, Inbred C57BL Myeloid Cells - cytology Myeloid Cells - immunology Tumor Escape - immunology Tumor Microenvironment - immunology adoptive T cell therapy antigen loss phenotype switching PD-L1 dedifferentiation melanoma plasticity immune escape epitope resistance
ISSN:	1097-4180, 1097-4180
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