Polymorphisms and Haplotypes of the Estrogen Receptor-β Gene (ESR2) and Cardiovascular Disease in Men and Women

Background: Cohort studies suggest an association between variation in the estrogen receptor-α gene (ESR1) and cardiovascular disease (CVD), but data are lacking for the effect of variation in the estrogen receptor-β gene (ESR2). Methods: Three polymorphisms of the ESR2 gene, and their associated ha...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	Clinical chemistry (Baltimore, Md.) Ročník 53; číslo 10; s. 1749 - 1756
Hlavní autoři:	Rexrode, Kathryn M, Ridker, Paul M, Hegener, Hillary H, Buring, Julie E, Manson, JoAnn E, Zee, Robert YL
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Washington, DC American Association for Clinical Chemistry 01.10.2007
Témata:	Adult Aged Aged, 80 and over Analytical, structural and metabolic biochemistry Biological and medical sciences Brain Ischemia - complications Cardiovascular Diseases - etiology Cardiovascular Diseases - genetics Case-Control Studies Cohort Studies Estrogen Receptor beta - genetics Female Fundamental and applied biological sciences. Psychology Haplotypes Humans Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Middle Aged Myocardial Infarction - genetics Polymorphism, Genetic Promoter Regions, Genetic Risk Sex Factors Stroke - etiology Stroke - genetics White People Estrogen receptor β Genetic variability Gene Clinical biology Sex Cardiovascular disease Genotype Genetics Biochemistry Molecular biology Haplotype Polymorphism
ISSN:	0009-9147, 1530-8561
On-line přístup:	Získat plný text
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Abstract	Background: Cohort studies suggest an association between variation in the estrogen receptor-α gene (ESR1) and cardiovascular disease (CVD), but data are lacking for the effect of variation in the estrogen receptor-β gene (ESR2). Methods: Three polymorphisms of the ESR2 gene, and their associated haplotypes, were evaluated in 296 white women from the Women’s Health Study and 566 white men from the Physicians’ Health Study who developed CVD [myocardial infarction (MI) or ischemic stroke], each matched 1:1 to a member of the cohort study who remained free from CVD. Blood samples and cardiovascular risk information were collected at baseline. Results: Women, but not men, who developed CVD or MI, but not ischemic stroke, were more likely to have the rs1271572 polymorphism variant T allele (P = 0.05 and 0.02) and less likely to have the rs1256049 polymorphism variant A allele (P = 0.003 and 0.004). No associations were observed for rs4986938. In conditional logistic multivariate regression, the rs1271572 variant was associated with increased odds of CVD [odds ratio (OR) = 1.49, 95% CI: 1.10–2.01] and MI (OR = 1.46, 95% CI: 0.96–2.23), whereas the rs1256049 variant was associated with decreased odds of CVD (OR = 0.37, 95% CI: 0.17–0.79) and MI (OR = 0.25, 95% CI: 0.09–0.73) in women. A common haplotype that included the rs1271572 variant was associated with a 7-fold increased risk of MI in women. Conclusions: Two tightly linked polymorphisms of ESR2 were associated with risk of CVD, particularly MI, in women but not men. Additional studies of ESR2 genetic variation and risk of CVD are warranted.
AbstractList	Background: Cohort studies suggest an association between variation in the estrogen receptor-α gene (ESR1) and cardiovascular disease (CVD), but data are lacking for the effect of variation in the estrogen receptor-β gene (ESR2). Methods: Three polymorphisms of the ESR2 gene, and their associated haplotypes, were evaluated in 296 white women from the Women’s Health Study and 566 white men from the Physicians’ Health Study who developed CVD [myocardial infarction (MI) or ischemic stroke], each matched 1:1 to a member of the cohort study who remained free from CVD. Blood samples and cardiovascular risk information were collected at baseline. Results: Women, but not men, who developed CVD or MI, but not ischemic stroke, were more likely to have the rs1271572 polymorphism variant T allele (P = 0.05 and 0.02) and less likely to have the rs1256049 polymorphism variant A allele (P = 0.003 and 0.004). No associations were observed for rs4986938. In conditional logistic multivariate regression, the rs1271572 variant was associated with increased odds of CVD [odds ratio (OR) = 1.49, 95% CI: 1.10–2.01] and MI (OR = 1.46, 95% CI: 0.96–2.23), whereas the rs1256049 variant was associated with decreased odds of CVD (OR = 0.37, 95% CI: 0.17–0.79) and MI (OR = 0.25, 95% CI: 0.09–0.73) in women. A common haplotype that included the rs1271572 variant was associated with a 7-fold increased risk of MI in women. Conclusions: Two tightly linked polymorphisms of ESR2 were associated with risk of CVD, particularly MI, in women but not men. Additional studies of ESR2 genetic variation and risk of CVD are warranted. Cohort studies suggest an association between variation in the estrogen receptor-alpha gene (ESR1) and cardiovascular disease (CVD), but data are lacking for the effect of variation in the estrogen receptor-beta gene (ESR2). Three polymorphisms of the ESR2 gene, and their associated haplotypes, were evaluated in 296 white women from the Women's Health Study and 566 white men from the Physicians' Health Study who developed CVD [myocardial infarction (MI) or ischemic stroke], each matched 1:1 to a member of the cohort study who remained free from CVD. Blood samples and cardiovascular risk information were collected at baseline. Women, but not men, who developed CVD or MI, but not ischemic stroke, were more likely to have the rs1271572 polymorphism variant T allele (P = 0.05 and 0.02) and less likely to have the rs1256049 polymorphism variant A allele (P = 0.003 and 0.004). No associations were observed for rs4986938. In conditional logistic multivariate regression, the rs1271572 variant was associated with increased odds of CVD [odds ratio (OR) = 1.49, 95% CI: 1.10-2.01] and MI (OR = 1.46, 95% CI: 0.96-2.23), whereas the rs1256049 variant was associated with decreased odds of CVD (OR = 0.37, 95% CI: 0.17-0.79) and MI (OR = 0.25, 95% CI: 0.09-0.73) in women. A common haplotype that included the rs1271572 variant was associated with a 7-fold increased risk of MI in women. Two tightly linked polymorphisms of ESR2 were associated with risk of CVD, particularly MI, in women but not men. Additional studies of ESR2 genetic variation and risk of CVD are warranted. Cohort studies suggest an association between variation in the estrogen receptor-alpha gene (ESR1) and cardiovascular disease (CVD), but data are lacking for the effect of variation in the estrogen receptor-beta gene (ESR2).BACKGROUNDCohort studies suggest an association between variation in the estrogen receptor-alpha gene (ESR1) and cardiovascular disease (CVD), but data are lacking for the effect of variation in the estrogen receptor-beta gene (ESR2).Three polymorphisms of the ESR2 gene, and their associated haplotypes, were evaluated in 296 white women from the Women's Health Study and 566 white men from the Physicians' Health Study who developed CVD [myocardial infarction (MI) or ischemic stroke], each matched 1:1 to a member of the cohort study who remained free from CVD. Blood samples and cardiovascular risk information were collected at baseline.METHODSThree polymorphisms of the ESR2 gene, and their associated haplotypes, were evaluated in 296 white women from the Women's Health Study and 566 white men from the Physicians' Health Study who developed CVD [myocardial infarction (MI) or ischemic stroke], each matched 1:1 to a member of the cohort study who remained free from CVD. Blood samples and cardiovascular risk information were collected at baseline.Women, but not men, who developed CVD or MI, but not ischemic stroke, were more likely to have the rs1271572 polymorphism variant T allele (P = 0.05 and 0.02) and less likely to have the rs1256049 polymorphism variant A allele (P = 0.003 and 0.004). No associations were observed for rs4986938. In conditional logistic multivariate regression, the rs1271572 variant was associated with increased odds of CVD [odds ratio (OR) = 1.49, 95% CI: 1.10-2.01] and MI (OR = 1.46, 95% CI: 0.96-2.23), whereas the rs1256049 variant was associated with decreased odds of CVD (OR = 0.37, 95% CI: 0.17-0.79) and MI (OR = 0.25, 95% CI: 0.09-0.73) in women. A common haplotype that included the rs1271572 variant was associated with a 7-fold increased risk of MI in women.RESULTSWomen, but not men, who developed CVD or MI, but not ischemic stroke, were more likely to have the rs1271572 polymorphism variant T allele (P = 0.05 and 0.02) and less likely to have the rs1256049 polymorphism variant A allele (P = 0.003 and 0.004). No associations were observed for rs4986938. In conditional logistic multivariate regression, the rs1271572 variant was associated with increased odds of CVD [odds ratio (OR) = 1.49, 95% CI: 1.10-2.01] and MI (OR = 1.46, 95% CI: 0.96-2.23), whereas the rs1256049 variant was associated with decreased odds of CVD (OR = 0.37, 95% CI: 0.17-0.79) and MI (OR = 0.25, 95% CI: 0.09-0.73) in women. A common haplotype that included the rs1271572 variant was associated with a 7-fold increased risk of MI in women.Two tightly linked polymorphisms of ESR2 were associated with risk of CVD, particularly MI, in women but not men. Additional studies of ESR2 genetic variation and risk of CVD are warranted.CONCLUSIONSTwo tightly linked polymorphisms of ESR2 were associated with risk of CVD, particularly MI, in women but not men. Additional studies of ESR2 genetic variation and risk of CVD are warranted.
Author	Zee, Robert YL Rexrode, Kathryn M Manson, JoAnn E Hegener, Hillary H Buring, Julie E Ridker, Paul M
Author_xml	– sequence: 1 givenname: Kathryn M surname: Rexrode fullname: Rexrode, Kathryn M organization: Division of Preventive Medicine and the Center for Cardiovascular Disease Prevention – sequence: 2 givenname: Paul M surname: Ridker fullname: Ridker, Paul M organization: Division of Preventive Medicine and the Center for Cardiovascular Disease Prevention,, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA – sequence: 3 givenname: Hillary H surname: Hegener fullname: Hegener, Hillary H organization: Division of Preventive Medicine and the Center for Cardiovascular Disease Prevention,, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA – sequence: 4 givenname: Julie E surname: Buring fullname: Buring, Julie E organization: Division of Preventive Medicine and the Center for Cardiovascular Disease Prevention,, Department of Epidemiology, Harvard School of Public Health, Boston, MA, Department of Ambulatory Care and Prevention, Harvard Medical School, Boston, MA – sequence: 5 givenname: JoAnn E surname: Manson fullname: Manson, JoAnn E organization: Division of Preventive Medicine and the Center for Cardiovascular Disease Prevention,, Department of Epidemiology, Harvard School of Public Health, Boston, MA – sequence: 6 givenname: Robert YL surname: Zee fullname: Zee, Robert YL organization: Division of Preventive Medicine and the Center for Cardiovascular Disease Prevention,, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA
BackLink	http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19128196$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/17702854$$D View this record in MEDLINE/PubMed
BookMark	eNp9kc9uEzEQxi1URNPCGyDkCwgOG_xnvV5zQEIhtEhFoALiaDnecWPktRd7UymvxYPwTGxISoEDp9Foft83mvlO0FFMERB6SMmccsmf2-CjXUM_Z4TIOVG0FvUdNKOCk6oVDT1CM0KIqqaBPEYnpXyd2lq2zT10TKUkrBX1DA0fUtj2KQ9rX_qCTezwuRlCGrcDFJwcHteAl2XM6QoivgQLw5hy9eM7PoMI-Ony4yV79ku2MLnz6doUuwkm49e-gCmAfcTvJuWO-JJ6iPfRXWdCgQeHeoo-v1l-WpxXF-_P3i5eXVS25s1YMSncquOidYopZZWtpXVCULEiHDpmpVnV0CnqQHVGdYrJhroV70CqlnWO8FP0cu87bFY9dBbimE3QQ_a9yVudjNd_T6Jf66t0rRlpBZdsMnhyMMjp2wbKqHtfLIRgIqRN0U3LCaFSTOCjPzf9XnHz5Al4fACm55jgsonWl1tOUdZS1UxcvedsTqVkcLcI0bvM9U3mepe53mc-yV78I7N-NKNPu7t8-L_4J3HPtsE
CODEN	CLCHAU
CitedBy_id	crossref_primary_10_2459_JCM_0000000000000500 crossref_primary_10_3389_fendo_2019_00733 crossref_primary_10_1177_1933719110367829 crossref_primary_10_1007_s10072_011_0885_9 crossref_primary_10_1089_met_2008_0030 crossref_primary_10_2165_11635960_000000000_00000 crossref_primary_10_1016_j_clim_2008_09_017 crossref_primary_10_1016_j_psyneuen_2011_04_011 crossref_primary_10_1088_1742_6596_1246_1_012005 crossref_primary_10_1371_journal_pone_0034828 crossref_primary_10_1124_pr_107_08002 crossref_primary_10_3109_13697130902943287 crossref_primary_10_3389_fmed_2023_1047166 crossref_primary_10_1016_j_ijcard_2017_11_007 crossref_primary_10_1093_cvr_cvp187 crossref_primary_10_1371_journal_pone_0034112 crossref_primary_10_1016_j_arcmed_2017_03_015 crossref_primary_10_1016_j_cjca_2015_10_021 crossref_primary_10_1016_j_gene_2018_07_048 crossref_primary_10_1016_j_ijcard_2020_02_002 crossref_primary_10_1016_j_nicl_2021_102719 crossref_primary_10_1080_09513590802485038 crossref_primary_10_1016_j_genm_2011_05_010 crossref_primary_10_2217_WHE_10_53 crossref_primary_10_1186_1471_2156_10_55 crossref_primary_10_1038_srep43632 crossref_primary_10_1161_ATVBAHA_110_215087 crossref_primary_10_1192_bjp_bp_111_091751 crossref_primary_10_1186_s12872_021_02088_1 crossref_primary_10_1038_jhg_2009_122 crossref_primary_10_1210_jc_2017_00957 crossref_primary_10_1186_1423_0127_20_32 crossref_primary_10_1016_j_neurobiolaging_2013_09_026 crossref_primary_10_1016_j_phrs_2020_105163 crossref_primary_10_1038_cddis_2013_66 crossref_primary_10_1016_j_parkreldis_2010_02_012 crossref_primary_10_3389_fendo_2019_00310 crossref_primary_10_1016_j_meegid_2014_09_024 crossref_primary_10_1016_j_jalz_2012_12_008 crossref_primary_10_1007_s00296_012_2386_4 crossref_primary_10_1016_j_jns_2012_01_007 crossref_primary_10_1111_cen_13797 crossref_primary_10_1016_j_neuroimage_2020_117087 crossref_primary_10_1038_nrendo_2017_12 crossref_primary_10_1016_j_maturitas_2008_11_006 crossref_primary_10_1373_clinchem_2007_102400 crossref_primary_10_1007_s00296_011_1947_2 crossref_primary_10_1016_j_maturitas_2016_01_009 crossref_primary_10_1080_09513590802571118 crossref_primary_10_1007_s10552_008_9216_8 crossref_primary_10_1016_j_gene_2012_08_004 crossref_primary_10_1097_FJC_0b013e318226bd16 crossref_primary_10_1089_gtmb_2008_0129 crossref_primary_10_1177_0003319709351256 crossref_primary_10_1210_jc_2013_4472 crossref_primary_10_1016_j_jep_2013_09_018 crossref_primary_10_1016_j_arcmed_2010_10_011 crossref_primary_10_1089_gte_2008_0034
Cites_doi	10.1086/319501 10.1126/science.1065250 10.1210/jc.2005-2672 10.1093/hmg/ddg055 10.1161/01.STR.0000181088.76518.ec 10.1038/sj.ejhg.5201447 10.1007/s100380070002 10.1056/NEJM198907203210301 10.1053/meta.2001.27192 10.1016/j.amjmed.2006.07.009 10.1161/CIRCULATIONAHA.105.545913 10.1016/j.arcmed.2005.04.002 10.1097/00001573-199409000-00018 10.1161/01.CIR.101.15.1792 10.1016/j.amjhyper.2005.05.023 10.1001/jama.291.24.2969 10.1210/jc.2004-1211 10.1161/01.RES.83.2.224 10.1007/s00109-001-0311-5 10.1089/152460900318911 10.1016/S0306-3623(02)00133-7 10.1161/01.HYP.0000223064.62762.0b 10.1001/jama.290.17.2263 10.1056/NEJMoa050613 10.1590/S0100-879X2006000400004 10.1161/01.ATV.0000014424.18209.21 10.1161/01.RES.0000210578.62102.a6 10.1210/jcem.83.12.5471 10.1006/geno.1995.9003 10.1086/379378 10.1038/sj.tpj.6500272 10.1016/j.amjmed.2006.07.008
ContentType	Journal Article
Copyright	2007 INIST-CNRS
Copyright_xml	– notice: 2007 INIST-CNRS
DBID	AAYXX CITATION IQODW CGR CUY CVF ECM EIF NPM 7X8 5PM
DOI	10.1373/clinchem.2007.091454
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic
DatabaseTitleList	CrossRef MEDLINE MEDLINE - Academic
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Medicine
EISSN	1530-8561
EndPage	1756
ExternalDocumentID	PMC2085372 17702854 19128196 10_1373_clinchem_2007_091454
Genre	Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural
GrantInformation_xml	– fundername: NHLBI NIH HHS grantid: HL-26490 – fundername: NCI NIH HHS grantid: R01 CA040360 – fundername: NCI NIH HHS grantid: R01 CA047988 – fundername: NHLBI NIH HHS grantid: HL43851 – fundername: NCI NIH HHS grantid: R01 CA097193 – fundername: NCI NIH HHS grantid: CA-40360 – fundername: NCI NIH HHS grantid: R01 CA034944 – fundername: NCI NIH HHS grantid: CA047988 – fundername: NHLBI NIH HHS grantid: R01 HL043851 – fundername: NCI NIH HHS grantid: CA097193
GroupedDBID	--- -~X .55 04C 0R~ 18M 29B 2WC 4.4 53G 5GY 5RE 5VS 5WD 6J9 7RV 7X7 88E 88I 8AO 8C1 8FE 8FG 8FH 8FI 8FJ 8R4 8R5 AABZA AACZT AAPQZ AAPXW AAQQT AARHZ AAUAY AAVAP AAYXX ABCQX ABDFA ABEJV ABGNP ABJCF ABJNI ABMNT ABNHQ ABOCM ABPPZ ABPQP ABPTD ABQNK ABSQV ABUWG ABVGC ABWST ABXVV ABXZS ACGOD ACIHN ACIWK ACPRK ACUTJ ACYHN ADBBV ADGKP ADGZP ADIPN ADNBA ADQBN ADVEK AEAQA AELWJ AEMQT AENEX AETBJ AEUYN AFFHD AFFNX AFFZL AFGWE AFKRA AFRAH AFXAL AFYAG AGINJ AGQXC AGUTN AHMBA AHMMS AJBYB AJEEA AJNCP ALMA_UNASSIGNED_HOLDINGS ALXQX ATGXG AZQEC BAWUL BCRHZ BENPR BES BEYMZ BGLVJ BHPHI BKEYQ BKSAR BPHCQ BTFSW BVXVI C1A C45 CCPQU CITATION CS3 D1I DU5 DWQXO E3Z EBS EJD ENERS EX3 F5P F9R FECEO FHSFR FLUFQ FOEOM FOTVD FQBLK FYUFA GAUVT GNUQQ H13 HCIFZ HMCUK H~9 IH2 INIJC INR JXSIZ KB. KBUDW KOP KQ8 KSI KSN L7B LK5 M1P M2P M7R NAPCQ NOMLY NU- OAUYM OBOKY OCZFY OJZSN OPAEJ OVD OWPYF PCBAR PDBOC PHGZM PHGZT PJZUB PPXIY PQGLB PQQKQ PROAC PSQYO Q2X R0Z RHI RNS ROX RUSNO S0X TCC TEORI TR2 TWZ U5U UKHRP UNMZH W8F WH7 WOQ WOW X7M YBU YHG YSK YWH YXANX ZCG ZE2 ~V8 .GJ 1KJ AAPGJ AAWDT ABEFU ACFRR ACVCV ACZBC ADMTO AFFQV AGKRT AGMDO AGORE AHGBF AI. AJDVS ALIPV APJGH AQDSO AVNTJ BMSDO EBD EIHBH EIHJH EMOBN IQODW J5H ML- MVM OBFPC PV9 RZL SV3 TMA VH1 YQJ ZGI CGR CUY CVF ECM EIF NPM 7X8 ARBBW PUEGO 5PM
ID	FETCH-LOGICAL-c436t-275fbd358f9299c9c47cf5515b03ed2c7ab4ed91fe9da9d92761fb3de7982df03
ISICitedReferencesCount	70
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000249879200005&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	0009-9147
IngestDate	Tue Nov 04 01:56:27 EST 2025 Sun Sep 28 08:21:07 EDT 2025 Mon Jul 21 05:52:00 EDT 2025 Mon Jul 21 09:14:28 EDT 2025 Tue Nov 18 21:01:12 EST 2025 Sat Nov 29 02:19:11 EST 2025
IsDoiOpenAccess	false
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	10
Keywords	Estrogen receptor β Genetic variability Gene Clinical biology Sex Cardiovascular disease Genotype Genetics Biochemistry Molecular biology Haplotype Polymorphism
Language	English
License	https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model CC BY 4.0
LinkModel	OpenURL
MergedId	FETCHMERGED-LOGICAL-c436t-275fbd358f9299c9c47cf5515b03ed2c7ab4ed91fe9da9d92761fb3de7982df03
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
OpenAccessLink	https://academic.oup.com/clinchem/article-pdf/53/10/1749/32690387/clinchem1749.pdf
PMID	17702854
PQID	68300175
PQPubID	23479
PageCount	8
ParticipantIDs	pubmedcentral_primary_oai_pubmedcentral_nih_gov_2085372 proquest_miscellaneous_68300175 pubmed_primary_17702854 pascalfrancis_primary_19128196 crossref_primary_10_1373_clinchem_2007_091454 crossref_citationtrail_10_1373_clinchem_2007_091454
PublicationCentury	2000
PublicationDate	2007-10-01
PublicationDateYYYYMMDD	2007-10-01
PublicationDate_xml	– month: 10 year: 2007 text: 2007-10-01 day: 01
PublicationDecade	2000
PublicationPlace	Washington, DC
PublicationPlace_xml	– name: Washington, DC – name: England
PublicationTitle	Clinical chemistry (Baltimore, Md.)
PublicationTitleAlternate	Clin Chem
PublicationYear	2007
Publisher	American Association for Clinical Chemistry
Publisher_xml	– name: American Association for Clinical Chemistry
References	2020022802512602900_R4 2020022802512602900_R19 2020022802512602900_R5 2020022802512602900_R6 2020022802512602900_R7 2020022802512602900_R8 2020022802512602900_R15 2020022802512602900_R9 2020022802512602900_R16 2020022802512602900_R17 2020022802512602900_R18 2020022802512602900_R11 2020022802512602900_R12 2020022802512602900_R13 2020022802512602900_R14 2020022802512602900_R30 2020022802512602900_R31 2020022802512602900_R10 2020022802512602900_R32 2020022802512602900_R1 2020022802512602900_R2 2020022802512602900_R3 2020022802512602900_R26 2020022802512602900_R27 2020022802512602900_R28 2020022802512602900_R29 2020022802512602900_R22 2020022802512602900_R23 2020022802512602900_R24 2020022802512602900_R25 2020022802512602900_R20 2020022802512602900_R21
References_xml	– ident: 2020022802512602900_R20 doi: 10.1086/319501 – ident: 2020022802512602900_R29 doi: 10.1126/science.1065250 – ident: 2020022802512602900_R10 doi: 10.1210/jc.2005-2672 – ident: 2020022802512602900_R32 doi: 10.1093/hmg/ddg055 – ident: 2020022802512602900_R1 doi: 10.1161/01.STR.0000181088.76518.ec – ident: 2020022802512602900_R31 doi: 10.1038/sj.ejhg.5201447 – ident: 2020022802512602900_R30 doi: 10.1007/s100380070002 – ident: 2020022802512602900_R15 doi: 10.1056/NEJM198907203210301 – ident: 2020022802512602900_R27 doi: 10.1053/meta.2001.27192 – ident: 2020022802512602900_R26 doi: 10.1016/j.amjmed.2006.07.009 – ident: 2020022802512602900_R5 doi: 10.1161/CIRCULATIONAHA.105.545913 – ident: 2020022802512602900_R13 doi: 10.1016/j.arcmed.2005.04.002 – ident: 2020022802512602900_R24 doi: 10.1097/00001573-199409000-00018 – ident: 2020022802512602900_R9 doi: 10.1161/01.CIR.101.15.1792 – ident: 2020022802512602900_R12 doi: 10.1016/j.amjhyper.2005.05.023 – ident: 2020022802512602900_R8 doi: 10.1001/jama.291.24.2969 – ident: 2020022802512602900_R11 doi: 10.1210/jc.2004-1211 – ident: 2020022802512602900_R21 doi: 10.1161/01.RES.83.2.224 – ident: 2020022802512602900_R7 doi: 10.1007/s00109-001-0311-5 – ident: 2020022802512602900_R16 doi: 10.1089/152460900318911 – ident: 2020022802512602900_R25 doi: 10.1016/S0306-3623(02)00133-7 – ident: 2020022802512602900_R23 doi: 10.1161/01.HYP.0000223064.62762.0b – ident: 2020022802512602900_R3 doi: 10.1001/jama.290.17.2263 – ident: 2020022802512602900_R17 doi: 10.1056/NEJMoa050613 – ident: 2020022802512602900_R4 doi: 10.1590/S0100-879X2006000400004 – ident: 2020022802512602900_R6 doi: 10.1161/01.ATV.0000014424.18209.21 – ident: 2020022802512602900_R2 doi: 10.1161/01.RES.0000210578.62102.a6 – ident: 2020022802512602900_R14 doi: 10.1210/jcem.83.12.5471 – ident: 2020022802512602900_R18 doi: 10.1006/geno.1995.9003 – ident: 2020022802512602900_R19 doi: 10.1086/379378 – ident: 2020022802512602900_R22 doi: 10.1038/sj.tpj.6500272 – ident: 2020022802512602900_R28 doi: 10.1016/j.amjmed.2006.07.008
SSID	ssj0004786
Score	2.1717658
Snippet	Background: Cohort studies suggest an association between variation in the estrogen receptor-α gene (ESR1) and cardiovascular disease (CVD), but data are... Cohort studies suggest an association between variation in the estrogen receptor-alpha gene (ESR1) and cardiovascular disease (CVD), but data are lacking for...
SourceID	pubmedcentral proquest pubmed pascalfrancis crossref
SourceType	Open Access Repository Aggregation Database Index Database Enrichment Source
StartPage	1749
SubjectTerms	Adult Aged Aged, 80 and over Analytical, structural and metabolic biochemistry Biological and medical sciences Brain Ischemia - complications Cardiovascular Diseases - etiology Cardiovascular Diseases - genetics Case-Control Studies Cohort Studies Estrogen Receptor beta - genetics Female Fundamental and applied biological sciences. Psychology Haplotypes Humans Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Middle Aged Myocardial Infarction - genetics Polymorphism, Genetic Promoter Regions, Genetic Risk Sex Factors Stroke - etiology Stroke - genetics White People
Title	Polymorphisms and Haplotypes of the Estrogen Receptor-β Gene (ESR2) and Cardiovascular Disease in Men and Women
URI	https://www.ncbi.nlm.nih.gov/pubmed/17702854 https://www.proquest.com/docview/68300175 https://pubmed.ncbi.nlm.nih.gov/PMC2085372
Volume	53
WOSCitedRecordID	wos000249879200005&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVPQU databaseName: Earth, Atmospheric & Aquatic Science Database customDbUrl: eissn: 1530-8561 dateEnd: 20220430 omitProxy: false ssIdentifier: ssj0004786 issn: 0009-9147 databaseCode: PCBAR dateStart: 20021201 isFulltext: true titleUrlDefault: https://search.proquest.com/eaasdb providerName: ProQuest – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1530-8561 dateEnd: 20220430 omitProxy: false ssIdentifier: ssj0004786 issn: 0009-9147 databaseCode: 7X7 dateStart: 20021201 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: Materials Science Database customDbUrl: eissn: 1530-8561 dateEnd: 20220430 omitProxy: false ssIdentifier: ssj0004786 issn: 0009-9147 databaseCode: KB. dateStart: 20021201 isFulltext: true titleUrlDefault: http://search.proquest.com/materialsscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Nursing & Allied Health Database customDbUrl: eissn: 1530-8561 dateEnd: 20220430 omitProxy: false ssIdentifier: ssj0004786 issn: 0009-9147 databaseCode: 7RV dateStart: 20021201 isFulltext: true titleUrlDefault: https://search.proquest.com/nahs providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1530-8561 dateEnd: 20220430 omitProxy: false ssIdentifier: ssj0004786 issn: 0009-9147 databaseCode: BENPR dateStart: 20021201 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Public Health Database customDbUrl: eissn: 1530-8561 dateEnd: 20220430 omitProxy: false ssIdentifier: ssj0004786 issn: 0009-9147 databaseCode: 8C1 dateStart: 20021201 isFulltext: true titleUrlDefault: https://search.proquest.com/publichealth providerName: ProQuest – providerCode: PRVPQU databaseName: Science Database customDbUrl: eissn: 1530-8561 dateEnd: 20220430 omitProxy: false ssIdentifier: ssj0004786 issn: 0009-9147 databaseCode: M2P dateStart: 20021201 isFulltext: true titleUrlDefault: https://search.proquest.com/sciencejournals providerName: ProQuest
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3bjtMwELW6uwghIcSdcil-YCUQSklzc_xIS1El1KoqC-pblcQOVApJ1HZX5bf4EH6CH2HGiXNZVcA-8GK1qe00npPx2J45Q8iLAOdoOfCMwIoELFA82wgdKGQsAtfjYNA6oUo2wWYzf7nk807nl46FuUhYmvr7Pc__q6jhGggbQ2evIO6qU7gAn0HoUILYofwnwc-zBNbzMHzr7beCgHkS5EmGe61b7REw3u42GfSAVqPMYdltnI7Gp0NLsVCj0Tn-uLBwwwCbj9ouq--KIx3cKJnKwpVZpcFsmrkjHW8Z6Xxy2OkwSHZr7dg7Ff3GLsRC7kGTS-3fsfmevm7wa4vS9QPdGJvbt19kGa4zwdxJcJPq3Guooi91ALgs4y307gar_ORqjc1BIResnH2plbRp-G5B4q61eEE5rNFqNnQyrLl4Y34He8k7OHfYDDksMCAVx6Zkt4RbFyTXbaruS1No5diozgeZvdK9YJZPtip6OSInFnM5ql5_VPshOUylI60etIzvhF7eHPovLfvpZg6yD5K4yMFyaJF02de3YTyd3Sa3ylUPfVug9Q7pyPQuuT4t_TrukbwFWgqYojVoaRZTAC3VoKUVaH_-oAhY-hLh-ko1a4OVlmCl65QCWFUNBdb75NP78dloYpS5QIzIsb2dASMXh8J2_RjseR7xyGFRDNa-G5q2FFbEgtCRgg9iyUXABbeYN4hDW0gG-kbEpv2AHKdZKh8RantxEJmeEKC-nABq-2ZkCZiJYukFwmddYusRXkUlUT7ma0lWf5JulxhVq7wgivlL_V5LeHUjrg63vS55rqW5gjcVz_GCVGbn25Xn22hcul3ysJBt3ZYxE0Oiu4S1pF5VQDL59i_p-qsilcdcvTazHl_xMZ6QG_Vr-5Qc7zbn8hm5Fl3s1ttNjxyxxWcsl0yVfk9hv0dOhuPZfAHfPgz7UE6t-W_jHvIz
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Polymorphisms+and+Haplotypes+of+the+Estrogen+Receptor-%CE%B2+Gene+%28ESR2%29+and+Cardiovascular+Disease+in+Men+and+Women&rft.jtitle=Clinical+chemistry+%28Baltimore%2C+Md.%29&rft.au=Rexrode%2C+Kathryn+M&rft.au=Ridker%2C+Paul+M&rft.au=Hegener%2C+Hillary+H&rft.au=Buring%2C+Julie+E&rft.date=2007-10-01&rft.issn=0009-9147&rft.eissn=1530-8561&rft.volume=53&rft.issue=10&rft.spage=1749&rft.epage=1756&rft_id=info:doi/10.1373%2Fclinchem.2007.091454&rft.externalDBID=n%2Fa&rft.externalDocID=10_1373_clinchem_2007_091454
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0009-9147&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0009-9147&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0009-9147&client=summon