ALT neuroblastoma chemoresistance due to telomere dysfunction-induced ATM activation is reversible with ATM inhibitor AZD0156

Cancers overcome replicative immortality by activating either telomerase or an alternative lengthening of telomeres (ALT) mechanism. ALT occurs in ~25% of high-risk neuroblastomas, and progression in patients with ALT neuroblastoma during or after front-line therapy is frequent and often fatal. Temo...

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Vydáno v:	Science translational medicine Ročník 13; číslo 607
Hlavní autoři:	Koneru, Balakrishna, Farooqi, Ahsan, Nguyen, Thinh H, Chen, Wan Hsi, Hindle, Ashly, Eslinger, Cody, Makena, Monish Ram, Burrow, Trevor A, Wilson, Joanne, Smith, Aaron, Pilla Reddy, Venkatesh, Cadogan, Elaine, Durant, Stephen T, Reynolds, C Patrick
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 18.08.2021
Témata:	Animals Ataxia Telangiectasia Ataxia Telangiectasia Mutated Proteins Drug Resistance, Neoplasm Humans Mice Neoplasm Recurrence, Local Neuroblastoma - drug therapy Pyridines Quinolines Telomere Telomere Homeostasis
ISSN:	1946-6242, 1946-6242
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