Anaplastic large cell (CD30/Ki-1+) lymphoma in HIV+ patients: clinical and pathological findings in a group of ten patients

We compared the clinical and pathological features of 10 HIV+ CD30+ anaplastic large cell lymphoma (ALCL) patients with 28 HIV+ CD30- non-Hodgkin's lymphoma (NHL) patients. The incidence of ALCL among 38 HIV+ systemic NHL patients was 26%. Clinical features were similar in all the HIV-related N...

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Vydáno v:British journal of haematology Ročník 95; číslo 3; s. 508
Hlavní autoři: Nosari, A, Cantoni, S, Oreste, P, Schiantarelli, C, Landonio, G, Alexiadis, S, Gargantini, L, Caggese, L, Gambacorta, M, Morra, E
Médium: Journal Article
Jazyk:angličtina
Vydáno: England 01.12.1996
Témata:
Adult
Antigens, CD20 - metabolism
Female
Humans
Immunophenotyping
Ki-1 Antigen - metabolism
Leukocyte Common Antigens - metabolism
Lewis X Antigen - metabolism
Lymphoma, AIDS-Related - metabolism
Lymphoma, AIDS-Related - pathology
Lymphoma, Large-Cell, Anaplastic - pathology
Lymphoma, Non-Hodgkin - metabolism
Lymphoma, Non-Hodgkin - pathology
Male
Middle Aged
Survival Rate
ISSN:0007-1048
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Shrnutí:We compared the clinical and pathological features of 10 HIV+ CD30+ anaplastic large cell lymphoma (ALCL) patients with 28 HIV+ CD30- non-Hodgkin's lymphoma (NHL) patients. The incidence of ALCL among 38 HIV+ systemic NHL patients was 26%. Clinical features were similar in all the HIV-related NHL cases, but ALCL patients seemed to differ from HIV+ CD30- systemic NHL only in the greater frequency of lung tumours (40% v 21%) without concomitant mediastinal mass, bone marrow (75% v 18%) and gastroenteric involvement (40% v 25%). Among the HIV+ ALCL patients, histologic subtypes did not differ in frequency from ALCL in the general population. The B phenotype was predominant (50%) as in other HIV-related NHL. EBV genoma, studied in all HIV+ ALCL patients, was present in 3/10 by in situ hybridization (ISH) and in 5/10 cases using PCR. The clinical course of lymphomas was similar in CD30 positive and negative NHL patients. Overall survival also was short in our series, particularly in HIV+ ALCL (84 v 188 d), probably because of profound immunodepression of the ALCL patients. Our findings suggest that severe immunodepression due to HIV infection determines-more than any other factor-the clinical features of HIV+ ALCL, making them very similar to those of other high-grade systemic HIV+ NHL.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0007-1048
DOI:10.1046/j.1365-2141.1996.d01-1940.x