The insulin-regulated aminopeptidase IRAP is colocalised with GLUT4 in the mouse hippocampus - potential role in modulation of glucose uptake in neurones?

It is proposed that insulin‐regulated aminopeptidase (IRAP) is the site of action of two peptides, angiotensin IV and LVV‐hemorphin 7, which have facilitatory effects on learning and memory. In fat and muscles, IRAP codistributes with the insulin‐responsive glucose transporter GLUT4 in specialised v...

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Vydané v:	The European journal of neuroscience Ročník 28; číslo 3; s. 588 - 598
Hlavní autori:	Fernando, Ruani N., Albiston, Anthony L., Chai, Siew Y.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Oxford, UK Blackwell Publishing Ltd 01.08.2008
Predmet:	Angiotensin II - analogs & derivatives Angiotensin II - metabolism Animals Cerebellum - cytology Cerebellum - metabolism Cystinyl Aminopeptidase - metabolism Deoxyglucose - metabolism Glucose - metabolism Glucose Transport Proteins, Facilitative - metabolism glucose transporter Glucose Transporter Type 3 - metabolism Glucose Transporter Type 4 - metabolism Hemoglobins - metabolism Hippocampus - cytology Hippocampus - metabolism Humans Insulin - metabolism Male memory Mice Mice, Inbred C57BL Mice, Knockout Neurons - cytology Neurons - metabolism Peptide Fragments - metabolism
ISSN:	0953-816X, 1460-9568, 1460-9568
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Abstract	It is proposed that insulin‐regulated aminopeptidase (IRAP) is the site of action of two peptides, angiotensin IV and LVV‐hemorphin 7, which have facilitatory effects on learning and memory. In fat and muscles, IRAP codistributes with the insulin‐responsive glucose transporter GLUT4 in specialised vesicles, where it plays a role in the tethering and/or trafficking of these vesicles. This study investigated whether an analogous system exists in two functionally distinct regions of the brain, the hippocampus and the cerebellum. In the hippocampus, IRAP was found in the pyramidal neurones where it exhibited a high degree of colocalisation with GLUT4. Consistent with the role of GLUT4 in insulin‐responsive tissues, the glucose transporter was thought to be responsible for facilitating glucose uptake into these pyramidal neurones in response to potassium‐induced depolarisation or cAMP activation as the glucose influx was sensitive to indinavir treatment. Angiotensin IV and LVV‐hemorphin 7 enhanced this activity‐dependent glucose uptake in hippocampal slices. In contrast, in the cerebellum, where the distribution of IRAP was dissociated from GLUT4, the effect of the peptides on glucose uptake was absent. We propose that the modulation of glucose uptake by angiotensin IV and LVV‐hemorphin 7 is region‐specific and is critically dependent on a high degree of colocalisation between IRAP and GLUT4. These findings also confirm a role for IRAP and GLUT4 in activity‐dependent glucose uptake in hippocampal neurones.
AbstractList	It is proposed that insulin-regulated aminopeptidase (IRAP) is the site of action of two peptides, angiotensin IV and LVV-hemorphin 7, which have facilitatory effects on learning and memory. In fat and muscles, IRAP codistributes with the insulin-responsive glucose transporter GLUT4 in specialised vesicles, where it plays a role in the tethering and/or trafficking of these vesicles. This study investigated whether an analogous system exists in two functionally distinct regions of the brain, the hippocampus and the cerebellum. In the hippocampus, IRAP was found in the pyramidal neurones where it exhibited a high degree of colocalisation with GLUT4. Consistent with the role of GLUT4 in insulin-responsive tissues, the glucose transporter was thought to be responsible for facilitating glucose uptake into these pyramidal neurones in response to potassium-induced depolarisation or cAMP activation as the glucose influx was sensitive to indinavir treatment. Angiotensin IV and LVV-hemorphin 7 enhanced this activity-dependent glucose uptake in hippocampal slices. In contrast, in the cerebellum, where the distribution of IRAP was dissociated from GLUT4, the effect of the peptides on glucose uptake was absent. We propose that the modulation of glucose uptake by angiotensin IV and LVV-hemorphin 7 is region-specific and is critically dependent on a high degree of colocalisation between IRAP and GLUT4. These findings also confirm a role for IRAP and GLUT4 in activity-dependent glucose uptake in hippocampal neurones.It is proposed that insulin-regulated aminopeptidase (IRAP) is the site of action of two peptides, angiotensin IV and LVV-hemorphin 7, which have facilitatory effects on learning and memory. In fat and muscles, IRAP codistributes with the insulin-responsive glucose transporter GLUT4 in specialised vesicles, where it plays a role in the tethering and/or trafficking of these vesicles. This study investigated whether an analogous system exists in two functionally distinct regions of the brain, the hippocampus and the cerebellum. In the hippocampus, IRAP was found in the pyramidal neurones where it exhibited a high degree of colocalisation with GLUT4. Consistent with the role of GLUT4 in insulin-responsive tissues, the glucose transporter was thought to be responsible for facilitating glucose uptake into these pyramidal neurones in response to potassium-induced depolarisation or cAMP activation as the glucose influx was sensitive to indinavir treatment. Angiotensin IV and LVV-hemorphin 7 enhanced this activity-dependent glucose uptake in hippocampal slices. In contrast, in the cerebellum, where the distribution of IRAP was dissociated from GLUT4, the effect of the peptides on glucose uptake was absent. We propose that the modulation of glucose uptake by angiotensin IV and LVV-hemorphin 7 is region-specific and is critically dependent on a high degree of colocalisation between IRAP and GLUT4. These findings also confirm a role for IRAP and GLUT4 in activity-dependent glucose uptake in hippocampal neurones. It is proposed that insulin-regulated aminopeptidase (IRAP) is the site of action of two peptides, angiotensinIV and LVV-hemorphin7, which have facilitatory effects on learning and memory. In fat and muscles, IRAP codistributes with the insulin-responsive glucose transporter GLUT4 in specialised vesicles, where it plays a role in the tethering and-or trafficking of these vesicles. This study investigated whether an analogous system exists in two functionally distinct regions of the brain, the hippocampus and the cerebellum. In the hippocampus, IRAP was found in the pyramidal neurones where it exhibited a high degree of colocalisation with GLUT4. Consistent with the role of GLUT4 in insulin-responsive tissues, the glucose transporter was thought to be responsible for facilitating glucose uptake into these pyramidal neurones in response to potassium-induced depolarisation or cAMP activation as the glucose influx was sensitive to indinavir treatment. AngiotensinIV and LVV-hemorphin7 enhanced this activity-dependent glucose uptake in hippocampal slices. In contrast, in the cerebellum, where the distribution of IRAP was dissociated from GLUT4, the effect of the peptides on glucose uptake was absent. We propose that the modulation of glucose uptake by angiotensinIV and LVV-hemorphin7 is region-specific and is critically dependent on a high degree of colocalisation between IRAP and GLUT4. These findings also confirm a role for IRAP and GLUT4 in activity-dependent glucose uptake in hippocampal neurones. It is proposed that insulin‐regulated aminopeptidase (IRAP) is the site of action of two peptides, angiotensin IV and LVV‐hemorphin 7, which have facilitatory effects on learning and memory. In fat and muscles, IRAP codistributes with the insulin‐responsive glucose transporter GLUT4 in specialised vesicles, where it plays a role in the tethering and/or trafficking of these vesicles. This study investigated whether an analogous system exists in two functionally distinct regions of the brain, the hippocampus and the cerebellum. In the hippocampus, IRAP was found in the pyramidal neurones where it exhibited a high degree of colocalisation with GLUT4. Consistent with the role of GLUT4 in insulin‐responsive tissues, the glucose transporter was thought to be responsible for facilitating glucose uptake into these pyramidal neurones in response to potassium‐induced depolarisation or cAMP activation as the glucose influx was sensitive to indinavir treatment. Angiotensin IV and LVV‐hemorphin 7 enhanced this activity‐dependent glucose uptake in hippocampal slices. In contrast, in the cerebellum, where the distribution of IRAP was dissociated from GLUT4, the effect of the peptides on glucose uptake was absent. We propose that the modulation of glucose uptake by angiotensin IV and LVV‐hemorphin 7 is region‐specific and is critically dependent on a high degree of colocalisation between IRAP and GLUT4. These findings also confirm a role for IRAP and GLUT4 in activity‐dependent glucose uptake in hippocampal neurones.
Author	Albiston, Anthony L. Chai, Siew Y. Fernando, Ruani N.
Author_xml	– sequence: 1 givenname: Ruani N. surname: Fernando fullname: Fernando, Ruani N. organization: Howard Florey Institute, The University of Melbourne, Parkville, Vic. 3010, Australia – sequence: 2 givenname: Anthony L. surname: Albiston fullname: Albiston, Anthony L. organization: Howard Florey Institute, The University of Melbourne, Parkville, Vic. 3010, Australia – sequence: 3 givenname: Siew Y. surname: Chai fullname: Chai, Siew Y. organization: Howard Florey Institute, The University of Melbourne, Parkville, Vic. 3010, Australia
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/18702730$$D View this record in MEDLINE/PubMed
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Snippet	It is proposed that insulin‐regulated aminopeptidase (IRAP) is the site of action of two peptides, angiotensin IV and LVV‐hemorphin 7, which have facilitatory... It is proposed that insulin-regulated aminopeptidase (IRAP) is the site of action of two peptides, angiotensin IV and LVV-hemorphin 7, which have facilitatory... It is proposed that insulin-regulated aminopeptidase (IRAP) is the site of action of two peptides, angiotensinIV and LVV-hemorphin7, which have facilitatory...
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SubjectTerms	Angiotensin II - analogs & derivatives Angiotensin II - metabolism Animals Cerebellum - cytology Cerebellum - metabolism Cystinyl Aminopeptidase - metabolism Deoxyglucose - metabolism Glucose - metabolism Glucose Transport Proteins, Facilitative - metabolism glucose transporter Glucose Transporter Type 3 - metabolism Glucose Transporter Type 4 - metabolism Hemoglobins - metabolism Hippocampus - cytology Hippocampus - metabolism Humans Insulin - metabolism Male memory Mice Mice, Inbred C57BL Mice, Knockout Neurons - cytology Neurons - metabolism Peptide Fragments - metabolism
Title	The insulin-regulated aminopeptidase IRAP is colocalised with GLUT4 in the mouse hippocampus - potential role in modulation of glucose uptake in neurones?
URI	https://api.istex.fr/ark:/67375/WNG-1H7JTCCH-8/fulltext.pdf https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fj.1460-9568.2008.06347.x https://www.ncbi.nlm.nih.gov/pubmed/18702730 https://www.proquest.com/docview/20872501 https://www.proquest.com/docview/69436083
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