Hydroxyisohexyl 3-cyclohexene carboxaldehyde allergy: relationship between patch test and repeated open application test thresholds

Summary Background  Hydroxyisohexyl 3‐cyclohexene carboxaldehyde (HICC) is a synthetic fragrance ingredient. Case reports of allergy to HICC appeared in the 1980s, and HICC has recently been included in the European baseline series. Human elicitation dose–response studies performed with different al...

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Vydané v:British journal of dermatology (1951) Ročník 161; číslo 3; s. 560 - 567
Hlavní autori: Fischer, L.A., Menné, T., Avnstorp, C., Kasting, G.B., Johansen, J.D.
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Oxford, UK Blackwell Publishing Ltd 01.09.2009
Wiley-Blackwell
Predmet:
Adult
Aldehydes - adverse effects
Allergens - administration & dosage
Allergens - adverse effects
Biological and medical sciences
Cyclohexanes - adverse effects
Cyclohexenes - adverse effects
Dermatitis, Allergic Contact - diagnosis
Dermatitis, Allergic Contact - etiology
Dermatology
dose-response
Dose-Response Relationship, Drug
elicitation
Female
HICC allergy
Humans
Logistic Models
Male
Medical sciences
Middle Aged
patch test
Patch Tests - methods
Perfume - adverse effects
Perfume - chemistry
repeated exposure
ROAT
Young Adult
elicitation
Immunopathology
Allergy
Dermatology
ROAT
dose-response
patch test
Dose
Patch
repeated exposure
HICC allergy
ISSN:0007-0963, 1365-2133, 1365-2133
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Shrnutí:Summary Background  Hydroxyisohexyl 3‐cyclohexene carboxaldehyde (HICC) is a synthetic fragrance ingredient. Case reports of allergy to HICC appeared in the 1980s, and HICC has recently been included in the European baseline series. Human elicitation dose–response studies performed with different allergens have shown a significant relationship between the patch‐test threshold and the repeated open application test (ROAT) threshold, which mimics some real‐life exposure situations. Fragrance ingredients are special as significant amounts of allergen may evaporate from the skin. Objectives  The study aimed to investigate the relationship between elicitation threshold doses at the patch test and the ROAT, using HICC as the allergen. The expected evaporation rate was calculated. Materials and methods  Seventeen HICC‐allergic persons were tested with a dilution series of HICC in a patch test and a ROAT (duration up to 21 days). Seventeen persons with no HICC allergy were included as control group for the ROAT. Results  The response frequency to the ROAT (in μg HICC cm−2 per application) was significantly higher than the response frequency to the patch test at one of the tested doses. Furthermore the response rate to the accumulated ROAT dose was significantly lower at half of the doses compared with the patch test. The evaporation rate of HICC was calculated to be 72% over a 24‐h period. Conclusions  The ROAT threshold in dose per area per application is lower than the patch test threshold; furthermore the accumulated ROAT threshold is higher than the patch test threshold, which can probably be explained by the evaporation of HICC from the skin in the open test.
Bibliografia:ark:/67375/WNG-MJH35CGS-C
ArticleID:BJD9256
istex:6247C082F4CB39531188E99E5614A607CE20BCC6
Conflicts of interest None declared.
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0007-0963
1365-2133
1365-2133
DOI:10.1111/j.1365-2133.2009.09256.x