Topical oral cavity pharmacokinetic modeling of a stannous fluoride dentifrice: an unusual two compartment model

A pharmacokinetic model was developed describing the pharmacokinetics of stannous fluoride in human subjects after oral topical application of a stannous fluoride dentifrice. Twenty subjects participated in an investigation of an experimental dentifrice. Subjects rinsed their mouths with the experim...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Journal of pharmaceutical sciences Ročník 98; číslo 10; s. 3862
Hlavní autoři: Scott, Douglas C, Coggan, John W, Cruze, Charles A, He, Tao, Johnson, Robert D
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 01.10.2009
Témata:
Algorithms
Dental Caries - prevention & control
Dental Plaque - metabolism
Dentifrices - administration & dosage
Dentifrices - pharmacokinetics
Dentifrices - therapeutic use
Fluorides, Topical - administration & dosage
Fluorides, Topical - pharmacokinetics
Fluorides, Topical - therapeutic use
Half-Life
Humans
Models, Biological
Mouthwashes
Saliva - metabolism
Tin - pharmacokinetics
Tin Fluorides - administration & dosage
Tin Fluorides - pharmacokinetics
Tin Fluorides - therapeutic use
ISSN:1520-6017, 1520-6017
On-line přístup:Zjistit podrobnosti o přístupu
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Popis
Shrnutí:A pharmacokinetic model was developed describing the pharmacokinetics of stannous fluoride in human subjects after oral topical application of a stannous fluoride dentifrice. Twenty subjects participated in an investigation of an experimental dentifrice. Subjects rinsed their mouths with the experimental dentifrice slurry. Saliva and plaque samples were obtained from the subjects at various times up to 6 h after administration. Samples were analyzed for total tin content, used as an analytical marker for the active stannous fluoride ingredient, using a graphite furnace atomic absorption spectrometer. The modeling indicates that there is an obvious kinetic relationship between saliva and plaque compartments and that stannous fluoride is very well retained in and slowly released from plaque (and oral surfaces) into saliva. Additionally, both compartments are simultaneously loaded during administration unlike typical systemic drug behavior, and the elimination rate "constant" from the central compartment (saliva) changes due to changes in salivary flow. Stannous fluoride is cleared from saliva rapidly but very well retained in gingival plaque. The model with simultaneous loading of plaque and saliva describes these observations and may account for the prolonged antiplaque and antigingivitis benefits of stannous fluoride.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1520-6017
1520-6017
DOI:10.1002/jps.21691