Topical oral cavity pharmacokinetic modeling of a stannous fluoride dentifrice: an unusual two compartment model

A pharmacokinetic model was developed describing the pharmacokinetics of stannous fluoride in human subjects after oral topical application of a stannous fluoride dentifrice. Twenty subjects participated in an investigation of an experimental dentifrice. Subjects rinsed their mouths with the experim...

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Bibliographic Details
Published in:	Journal of pharmaceutical sciences Vol. 98; no. 10; p. 3862
Main Authors:	Scott, Douglas C, Coggan, John W, Cruze, Charles A, He, Tao, Johnson, Robert D
Format:	Journal Article
Language:	English
Published:	United States 01.10.2009
Subjects:	Algorithms Dental Caries - prevention & control Dental Plaque - metabolism Dentifrices - administration & dosage Dentifrices - pharmacokinetics Dentifrices - therapeutic use Fluorides, Topical - administration & dosage Fluorides, Topical - pharmacokinetics Fluorides, Topical - therapeutic use Half-Life Humans Models, Biological Mouthwashes Saliva - metabolism Tin - pharmacokinetics Tin Fluorides - administration & dosage Tin Fluorides - pharmacokinetics Tin Fluorides - therapeutic use
ISSN:	1520-6017, 1520-6017
Online Access:	Get more information
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