Long-term safety and efficacy of emtricitabine and tenofovir alafenamide vs emtricitabine and tenofovir disoproxil fumarate for HIV-1 pre-exposure prophylaxis: week 96 results from a randomised, double-blind, placebo-controlled, phase 3 trial

In DISCOVER, a multinational, randomised controlled trial, emtricitabine and tenofovir alafenamide compared with emtricitabine and tenofovir disoproxil fumarate showed non-inferior efficacy for HIV prevention and improved bone mineral density and renal safety biomarkers at week 48. We report outcome...

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Veröffentlicht in:	The lancet HIV Jg. 8; H. 7; S. e397
Hauptverfasser:	Ogbuagu, Onyema, Ruane, Peter J, Podzamczer, Daniel, Salazar, Laura C, Henry, Keith, Asmuth, David M, Wohl, David, Gilson, Richard, Shao, Yongwu, Ebrahimi, Ramin, Cox, Stephanie, Kintu, Alexander, Carter, Christoph, Das, Moupali, Baeten, Jared M, Brainard, Diana M, Whitlock, Gary, Brunetta, Jason M, Kronborg, Gitte, Spinner, Christoph D
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Netherlands 01.07.2021
Schlagworte:	Adenine - adverse effects Adenine - analogs & derivatives Adenine - therapeutic use Adult Aged Alanine - adverse effects Alanine - therapeutic use Anti-HIV Agents - adverse effects Anti-HIV Agents - therapeutic use Double-Blind Method Drug Therapy, Combination - adverse effects Emtricitabine - adverse effects Emtricitabine - therapeutic use Female Follow-Up Studies HIV Infections - prevention & control HIV Infections - virology HIV-1 - drug effects HIV-1 - physiology Humans Male Middle Aged Organophosphonates - adverse effects Organophosphonates - therapeutic use Pre-Exposure Prophylaxis Tenofovir - adverse effects Tenofovir - therapeutic use Treatment Outcome Young Adult
ISSN:	2352-3018, 2352-3018
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