Aberrations of m6A regulators are associated with tumorigenesis and metastasis in head and neck squamous cell carcinoma
•The m6A regulatory genes play critical roles in RNA processing via m6A modification.•We found dysregulation of m6A regulatory genes associated with tumorigenesis and metastasis in HNSCC patients.•Our findings may provide clues to identify new therapeutic targets for HNSCC. N6-Methyladenosine (m6A)...
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| Published in: | Archives of oral biology Vol. 122; p. 105030 |
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| Main Authors: | , , |
| Format: | Journal Article |
| Language: | English |
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Elsevier Ltd
01.02.2021
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| ISSN: | 0003-9969, 1879-1506, 1879-1506 |
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| Abstract | •The m6A regulatory genes play critical roles in RNA processing via m6A modification.•We found dysregulation of m6A regulatory genes associated with tumorigenesis and metastasis in HNSCC patients.•Our findings may provide clues to identify new therapeutic targets for HNSCC.
N6-Methyladenosine (m6A) is the most common RNA modification in eukaryotic mRNAs and growing evidence suggests that m6A modification and its regulators play crucial roles in human cancers. However, the role of m6A regulators and their molecular mechanisms in head and neck squamous cell carcinoma (HNSCC) remains largely unclear.
We therefore assessed m6A regulatory genes alterations and their mRNAs expression in HNSCC using openly available data from The Cancer Genome Atlas (TCGA). Further, we have validated the expression level of m6A regulatory gene in HNSCC tissue samples using real-time PCR. In addition, we also analyzed the protein interaction network, and functional enrichment of m6A regulatory genes.
Analysis of TCGA data revealed that m6A regulatory genes were altered in many HNSCC patients. Importantly, we found for the first time that m6A “writer” KIAA1429 (VIRMA) was frequently amplified and mutated (8 %), which contributes to the overexpression of KIAA1429 mRNA, and the overexpression of KIAA1429 could be remarkably related to cancer stages, tumor grade, and nodal metastasis (P < 0.05). In addition, the overexpression of KIAA1429 was successfully validated using HNSCC tissue samples.
Our findings suggest that the genetic alterations of m6A regulatory genes are associated with tumorigenesis and metastasis in HNSCC, which may provide clues to identify new therapeutic targets for HNSCC. |
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| AbstractList | N6-Methyladenosine (m6A) is the most common RNA modification in eukaryotic mRNAs and growing evidence suggests that m6A modification and its regulators play crucial roles in human cancers. However, the role of m6A regulators and their molecular mechanisms in head and neck squamous cell carcinoma (HNSCC) remains largely unclear.
We therefore assessed m6A regulatory genes alterations and their mRNAs expression in HNSCC using openly available data from The Cancer Genome Atlas (TCGA). Further, we have validated the expression level of m6A regulatory gene in HNSCC tissue samples using real-time PCR. In addition, we also analyzed the protein interaction network, and functional enrichment of m6A regulatory genes.
Analysis of TCGA data revealed that m6A regulatory genes were altered in many HNSCC patients. Importantly, we found for the first time that m6A "writer" KIAA1429 (VIRMA) was frequently amplified and mutated (8 %), which contributes to the overexpression of KIAA1429 mRNA, and the overexpression of KIAA1429 could be remarkably related to cancer stages, tumor grade, and nodal metastasis (P < 0.05). In addition, the overexpression of KIAA1429 was successfully validated using HNSCC tissue samples.
Our findings suggest that the genetic alterations of m6A regulatory genes are associated with tumorigenesis and metastasis in HNSCC, which may provide clues to identify new therapeutic targets for HNSCC. N6-Methyladenosine (m6A) is the most common RNA modification in eukaryotic mRNAs and growing evidence suggests that m6A modification and its regulators play crucial roles in human cancers. However, the role of m6A regulators and their molecular mechanisms in head and neck squamous cell carcinoma (HNSCC) remains largely unclear.OBJECTIVEN6-Methyladenosine (m6A) is the most common RNA modification in eukaryotic mRNAs and growing evidence suggests that m6A modification and its regulators play crucial roles in human cancers. However, the role of m6A regulators and their molecular mechanisms in head and neck squamous cell carcinoma (HNSCC) remains largely unclear.We therefore assessed m6A regulatory genes alterations and their mRNAs expression in HNSCC using openly available data from The Cancer Genome Atlas (TCGA). Further, we have validated the expression level of m6A regulatory gene in HNSCC tissue samples using real-time PCR. In addition, we also analyzed the protein interaction network, and functional enrichment of m6A regulatory genes.METHODSWe therefore assessed m6A regulatory genes alterations and their mRNAs expression in HNSCC using openly available data from The Cancer Genome Atlas (TCGA). Further, we have validated the expression level of m6A regulatory gene in HNSCC tissue samples using real-time PCR. In addition, we also analyzed the protein interaction network, and functional enrichment of m6A regulatory genes.Analysis of TCGA data revealed that m6A regulatory genes were altered in many HNSCC patients. Importantly, we found for the first time that m6A "writer" KIAA1429 (VIRMA) was frequently amplified and mutated (8 %), which contributes to the overexpression of KIAA1429 mRNA, and the overexpression of KIAA1429 could be remarkably related to cancer stages, tumor grade, and nodal metastasis (P < 0.05). In addition, the overexpression of KIAA1429 was successfully validated using HNSCC tissue samples.RESULTSAnalysis of TCGA data revealed that m6A regulatory genes were altered in many HNSCC patients. Importantly, we found for the first time that m6A "writer" KIAA1429 (VIRMA) was frequently amplified and mutated (8 %), which contributes to the overexpression of KIAA1429 mRNA, and the overexpression of KIAA1429 could be remarkably related to cancer stages, tumor grade, and nodal metastasis (P < 0.05). In addition, the overexpression of KIAA1429 was successfully validated using HNSCC tissue samples.Our findings suggest that the genetic alterations of m6A regulatory genes are associated with tumorigenesis and metastasis in HNSCC, which may provide clues to identify new therapeutic targets for HNSCC.CONCLUSIONSOur findings suggest that the genetic alterations of m6A regulatory genes are associated with tumorigenesis and metastasis in HNSCC, which may provide clues to identify new therapeutic targets for HNSCC. •The m6A regulatory genes play critical roles in RNA processing via m6A modification.•We found dysregulation of m6A regulatory genes associated with tumorigenesis and metastasis in HNSCC patients.•Our findings may provide clues to identify new therapeutic targets for HNSCC. N6-Methyladenosine (m6A) is the most common RNA modification in eukaryotic mRNAs and growing evidence suggests that m6A modification and its regulators play crucial roles in human cancers. However, the role of m6A regulators and their molecular mechanisms in head and neck squamous cell carcinoma (HNSCC) remains largely unclear. We therefore assessed m6A regulatory genes alterations and their mRNAs expression in HNSCC using openly available data from The Cancer Genome Atlas (TCGA). Further, we have validated the expression level of m6A regulatory gene in HNSCC tissue samples using real-time PCR. In addition, we also analyzed the protein interaction network, and functional enrichment of m6A regulatory genes. Analysis of TCGA data revealed that m6A regulatory genes were altered in many HNSCC patients. Importantly, we found for the first time that m6A “writer” KIAA1429 (VIRMA) was frequently amplified and mutated (8 %), which contributes to the overexpression of KIAA1429 mRNA, and the overexpression of KIAA1429 could be remarkably related to cancer stages, tumor grade, and nodal metastasis (P < 0.05). In addition, the overexpression of KIAA1429 was successfully validated using HNSCC tissue samples. Our findings suggest that the genetic alterations of m6A regulatory genes are associated with tumorigenesis and metastasis in HNSCC, which may provide clues to identify new therapeutic targets for HNSCC. |
| ArticleNumber | 105030 |
| Author | Jayaseelan, Vijayashree Priyadharsini Arumugam, Paramasivam George, Rinku |
| Author_xml | – sequence: 1 givenname: Paramasivam surname: Arumugam fullname: Arumugam, Paramasivam email: paramasivama.sdc@saveetha.com organization: Cellular and Molecular Research Centre, Saveetha Dental College & Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, India – sequence: 2 givenname: Rinku surname: George fullname: George, Rinku organization: Department of Oral Oncology, Saveetha Dental College & Hospital, Saveetha Institute of Medical and Technical Sciences [SIMATS], Saveetha University, Chennai, India – sequence: 3 givenname: Vijayashree Priyadharsini surname: Jayaseelan fullname: Jayaseelan, Vijayashree Priyadharsini organization: Cellular and Molecular Research Centre, Saveetha Dental College & Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, India |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33383437$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.2147/OTT.S180954 10.1186/s13045-017-0410-6 10.1038/s41423-020-0387-x 10.1073/pnas.1812536116 10.1093/nar/gkw937 10.3389/fonc.2019.00332 10.18632/aging.101856 10.1186/s12885-019-5538-z 10.1038/s41440-019-0338-z 10.1038/s41556-018-0045-z 10.1126/scisignal.2004088 10.1093/nar/gkaa048 10.3390/jcm8111896 10.1158/1541-7786.MCR-18-0056 10.1038/s41423-019-0307-0 10.1038/s41419-019-1769-9 10.1016/j.neo.2017.05.002 10.1186/s12943-019-1109-9 |
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| References | Paramasivam, Priyadharsini (bib0060) 2020; 17 Anita, Paramasivam, Vijayashree Priyadharsini, Chitra (bib0010) 2020; 10 Bai, Yang, Wu, Huang, Song, Li (bib0015) 2019; 9 Nisa, Barras, Medová, Aebersold, Medo, Poliaková (bib0055) 2018; 16 Paramasivam, Priyadharsini, Raghunandhakumar (bib0065) 2020; 17 He, Li, Wu, Peng, Shu, Yin (bib0035) 2019; 18 Huang, Weng, Sun, Qin, Shi, Wu (bib0040) 2018; 20 Pérez Sayáns, Chamorro Petronacci, Lorenzo Pouso, Padín Iruegas, Blanco Carrión, Suárez Peñaranda (bib0075) 2019; 8 Paramasivam, Priyadharsini, Raghunandhakumar (bib0070) 2020; 43 Alsahafi, Begg, Amelio, Raulf, Lucarelli, Sauter (bib0005) 2019; 10 Cheng, Li, Rao, Zhang, Li, Wang (bib0025) 2019; 12 Wu, Wu, Ning, Liu, Zhang (bib0085) 2019; 19 Kwok, Marshall, Rasko, Wong (bib0045) 2017; 10 Gao, Aksoy, Dogrusoz, Dresdner, Gross, Sumer (bib0030) 2013; 6 Zhang, Wang, Zhang, Wang, Ma, Zhang (bib0090) 2019; 116 Chandrashekar, Bashel, Balasubramanya, Creighton, Ponce-Rodriguez, Chakravarthi (bib0020) 2017; 19 Szklarczyk, Morris, Cook, Kuhn, Wyder, Simonovic (bib0080) 2016; 45 Liu, Wei, Jin, Luo, Liu, Yang (bib0050) 2020; 48 Zhou, Wang, Hong, Ma, Xie, Li (bib0095) 2019; 11 Liu (10.1016/j.archoralbio.2020.105030_bib0050) 2020; 48 Alsahafi (10.1016/j.archoralbio.2020.105030_bib0005) 2019; 10 Cheng (10.1016/j.archoralbio.2020.105030_bib0025) 2019; 12 Chandrashekar (10.1016/j.archoralbio.2020.105030_bib0020) 2017; 19 Wu (10.1016/j.archoralbio.2020.105030_bib0085) 2019; 19 Kwok (10.1016/j.archoralbio.2020.105030_bib0045) 2017; 10 Paramasivam (10.1016/j.archoralbio.2020.105030_bib0070) 2020; 43 Paramasivam (10.1016/j.archoralbio.2020.105030_bib0060) 2020; 17 Szklarczyk (10.1016/j.archoralbio.2020.105030_bib0080) 2016; 45 Paramasivam (10.1016/j.archoralbio.2020.105030_bib0065) 2020; 17 Zhang (10.1016/j.archoralbio.2020.105030_bib0090) 2019; 116 Huang (10.1016/j.archoralbio.2020.105030_bib0040) 2018; 20 Zhou (10.1016/j.archoralbio.2020.105030_bib0095) 2019; 11 Bai (10.1016/j.archoralbio.2020.105030_bib0015) 2019; 9 Pérez Sayáns (10.1016/j.archoralbio.2020.105030_bib0075) 2019; 8 He (10.1016/j.archoralbio.2020.105030_bib0035) 2019; 18 Anita (10.1016/j.archoralbio.2020.105030_bib0010) 2020; 10 Nisa (10.1016/j.archoralbio.2020.105030_bib0055) 2018; 16 Gao (10.1016/j.archoralbio.2020.105030_bib0030) 2013; 6 |
| References_xml | – volume: 10 start-page: 2546 year: 2020 end-page: 2554 ident: bib0010 article-title: The m6A readers YTHDF1 and YTHDF3 aberrations associated with metastasis and predict poor prognosis in breast cancer patients publication-title: American Journal of Cancer Research – volume: 12 start-page: 3421 year: 2019 end-page: 3428 ident: bib0025 article-title: KIAA1429 regulates the migration and invasion of hepatocellular carcinoma by altering m6A modification of ID2 mRNA publication-title: Onco Targets and Therapy – volume: 8 start-page: 1896 year: 2019 ident: bib0075 article-title: Comprehensive genomic review of TCGA head and neck squamous cell carcinomas (HNSCC) publication-title: Journal of Clinical Medicine – volume: 20 start-page: 285 year: 2018 end-page: 295 ident: bib0040 article-title: Recognition of RNA N 6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation publication-title: Nature Cell Biology – volume: 17 start-page: 668 year: 2020 end-page: 669 ident: bib0060 article-title: Novel insights into m6A modification in circular RNA and implications for immunity publication-title: Cellular & Molecular Immunology – volume: 45 start-page: D362 year: 2016 end-page: D368 ident: bib0080 article-title: The STRING database in 2017: Quality -controlled protein–Protein association networks, made broadly accessible publication-title: Nucleic Acids Research – volume: 9 start-page: 332 year: 2019 ident: bib0015 article-title: YTHDF1 regulates tumorigenicity and cancer stem cell-like activity in human colorectal carcinoma publication-title: Frontiers in Oncology – volume: 19 start-page: 649 year: 2017 end-page: 658 ident: bib0020 article-title: UALCAN: A portal for facilitating tumor subgroup gene expression and survival analyses publication-title: Neoplasia – volume: 48 start-page: 3816 year: 2020 end-page: 3831 ident: bib0050 article-title: The m6A reader YTHDF1 promotes ovarian cancer progression via augmenting EIF3C translation publication-title: Nucleic Acids Research – volume: 16 start-page: 1912 year: 2018 end-page: 1926 ident: bib0055 article-title: Comprehensive genomic profiling of patient matched head and neck cancer cells: A preclinical pipeline for metastatic and recurrent disease publication-title: Molecular Cancer Research – volume: 6 start-page: l1 year: 2013 ident: bib0030 article-title: Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal publication-title: Science Signaling – volume: 116 start-page: 976 year: 2019 end-page: 981 ident: bib0090 article-title: RNA-binding protein YTHDF3 suppresses interferon-dependent antiviral responses by promoting FOXO3 translation publication-title: Proceedings of the National academy of Sciences of the United States of America – volume: 10 start-page: 540 year: 2019 ident: bib0005 article-title: Clinical update on head and neck cancer: Molecular biology and ongoing challenges publication-title: Cell Death & Disease – volume: 17 start-page: 550 year: 2020 end-page: 551 ident: bib0065 article-title: Implications of m6A modification in autoimmune disorders publication-title: Cellular & Molecular Immunology – volume: 43 start-page: 153 year: 2020 end-page: 154 ident: bib0070 article-title: N6-adenosine methylation (m6A): A promising new molecular target in hypertension and cardiovascular diseases publication-title: Hypertension Research – volume: 19 start-page: 326 year: 2019 ident: bib0085 article-title: Changes of N6-methyladenosine modulators promote breast cancer progression publication-title: BMC Cancer – volume: 11 start-page: 1633 year: 2019 end-page: 1647 ident: bib0095 article-title: Gene signatures and prognostic values of m6A regulators in clear cell renal cell carcinoma – A retrospective study using TCGA database publication-title: Aging – volume: 18 start-page: 176 year: 2019 ident: bib0035 article-title: Functions of N6-methyladenosine and its role in cancer publication-title: Molecular Cancer – volume: 10 start-page: 39 year: 2017 ident: bib0045 article-title: Genetic alterations of m6A regulators predict poorer survival in acute myeloid leukemia publication-title: Journal of Hematology & Oncology – volume: 12 start-page: 3421 year: 2019 ident: 10.1016/j.archoralbio.2020.105030_bib0025 article-title: KIAA1429 regulates the migration and invasion of hepatocellular carcinoma by altering m6A modification of ID2 mRNA publication-title: Onco Targets and Therapy doi: 10.2147/OTT.S180954 – volume: 10 start-page: 39 year: 2017 ident: 10.1016/j.archoralbio.2020.105030_bib0045 article-title: Genetic alterations of m6A regulators predict poorer survival in acute myeloid leukemia publication-title: Journal of Hematology & Oncology doi: 10.1186/s13045-017-0410-6 – volume: 17 start-page: 668 year: 2020 ident: 10.1016/j.archoralbio.2020.105030_bib0060 article-title: Novel insights into m6A modification in circular RNA and implications for immunity publication-title: Cellular & Molecular Immunology doi: 10.1038/s41423-020-0387-x – volume: 116 start-page: 976 year: 2019 ident: 10.1016/j.archoralbio.2020.105030_bib0090 article-title: RNA-binding protein YTHDF3 suppresses interferon-dependent antiviral responses by promoting FOXO3 translation publication-title: Proceedings of the National academy of Sciences of the United States of America doi: 10.1073/pnas.1812536116 – volume: 45 start-page: D362 year: 2016 ident: 10.1016/j.archoralbio.2020.105030_bib0080 article-title: The STRING database in 2017: Quality -controlled protein–Protein association networks, made broadly accessible publication-title: Nucleic Acids Research doi: 10.1093/nar/gkw937 – volume: 9 start-page: 332 year: 2019 ident: 10.1016/j.archoralbio.2020.105030_bib0015 article-title: YTHDF1 regulates tumorigenicity and cancer stem cell-like activity in human colorectal carcinoma publication-title: Frontiers in Oncology doi: 10.3389/fonc.2019.00332 – volume: 11 start-page: 1633 year: 2019 ident: 10.1016/j.archoralbio.2020.105030_bib0095 article-title: Gene signatures and prognostic values of m6A regulators in clear cell renal cell carcinoma – A retrospective study using TCGA database publication-title: Aging doi: 10.18632/aging.101856 – volume: 19 start-page: 326 year: 2019 ident: 10.1016/j.archoralbio.2020.105030_bib0085 article-title: Changes of N6-methyladenosine modulators promote breast cancer progression publication-title: BMC Cancer doi: 10.1186/s12885-019-5538-z – volume: 43 start-page: 153 year: 2020 ident: 10.1016/j.archoralbio.2020.105030_bib0070 article-title: N6-adenosine methylation (m6A): A promising new molecular target in hypertension and cardiovascular diseases publication-title: Hypertension Research doi: 10.1038/s41440-019-0338-z – volume: 20 start-page: 285 year: 2018 ident: 10.1016/j.archoralbio.2020.105030_bib0040 article-title: Recognition of RNA N 6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation publication-title: Nature Cell Biology doi: 10.1038/s41556-018-0045-z – volume: 6 start-page: l1 year: 2013 ident: 10.1016/j.archoralbio.2020.105030_bib0030 article-title: Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal publication-title: Science Signaling doi: 10.1126/scisignal.2004088 – volume: 10 start-page: 2546 year: 2020 ident: 10.1016/j.archoralbio.2020.105030_bib0010 article-title: The m6A readers YTHDF1 and YTHDF3 aberrations associated with metastasis and predict poor prognosis in breast cancer patients publication-title: American Journal of Cancer Research – volume: 48 start-page: 3816 year: 2020 ident: 10.1016/j.archoralbio.2020.105030_bib0050 article-title: The m6A reader YTHDF1 promotes ovarian cancer progression via augmenting EIF3C translation publication-title: Nucleic Acids Research doi: 10.1093/nar/gkaa048 – volume: 8 start-page: 1896 year: 2019 ident: 10.1016/j.archoralbio.2020.105030_bib0075 article-title: Comprehensive genomic review of TCGA head and neck squamous cell carcinomas (HNSCC) publication-title: Journal of Clinical Medicine doi: 10.3390/jcm8111896 – volume: 16 start-page: 1912 year: 2018 ident: 10.1016/j.archoralbio.2020.105030_bib0055 article-title: Comprehensive genomic profiling of patient matched head and neck cancer cells: A preclinical pipeline for metastatic and recurrent disease publication-title: Molecular Cancer Research doi: 10.1158/1541-7786.MCR-18-0056 – volume: 17 start-page: 550 year: 2020 ident: 10.1016/j.archoralbio.2020.105030_bib0065 article-title: Implications of m6A modification in autoimmune disorders publication-title: Cellular & Molecular Immunology doi: 10.1038/s41423-019-0307-0 – volume: 10 start-page: 540 year: 2019 ident: 10.1016/j.archoralbio.2020.105030_bib0005 article-title: Clinical update on head and neck cancer: Molecular biology and ongoing challenges publication-title: Cell Death & Disease doi: 10.1038/s41419-019-1769-9 – volume: 19 start-page: 649 year: 2017 ident: 10.1016/j.archoralbio.2020.105030_bib0020 article-title: UALCAN: A portal for facilitating tumor subgroup gene expression and survival analyses publication-title: Neoplasia doi: 10.1016/j.neo.2017.05.002 – volume: 18 start-page: 176 year: 2019 ident: 10.1016/j.archoralbio.2020.105030_bib0035 article-title: Functions of N6-methyladenosine and its role in cancer publication-title: Molecular Cancer doi: 10.1186/s12943-019-1109-9 |
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| Snippet | •The m6A regulatory genes play critical roles in RNA processing via m6A modification.•We found dysregulation of m6A regulatory genes associated with... N6-Methyladenosine (m6A) is the most common RNA modification in eukaryotic mRNAs and growing evidence suggests that m6A modification and its regulators play... |
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| SubjectTerms | Adenosine - analogs & derivatives Adenosine - genetics Carcinogenesis - genetics Cell Transformation, Neoplastic Gene Expression Regulation, Neoplastic Head and Neck Neoplasms - genetics HNSCC Humans m6A modification m6A regulators RNA, Messenger RNA-Binding Proteins - genetics Squamous Cell Carcinoma of Head and Neck - genetics TCGA data |
| Title | Aberrations of m6A regulators are associated with tumorigenesis and metastasis in head and neck squamous cell carcinoma |
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