Trans-synaptic degeneration in the visual pathway: Neural connectivity, pathophysiology, and clinical implications in neurodegenerative disorders

There is a strong interrelationship between eye and brain diseases. It has been shown that neurodegenerative changes can spread bidirectionally in the visual pathway along neuronal projections. For example, damage to retinal ganglion cells in the retina leads to degeneration of the visual cortex (an...

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Bibliographic Details
Published in:	Survey of ophthalmology Vol. 67; no. 2; pp. 411 - 426
Main Authors:	Sharma, Samridhi, Chitranshi, Nitin, Wall, Roshana Vander, Basavarajappa, Devaraj, Gupta, Vivek, Mirzaei, Mehdi, Graham, Stuart L, Klistorner, Alexander, You, Yuyi
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01.03.2022
Subjects:	anterograde axonal loss bidirectional trans-synaptic degeneration Humans Neurodegenerative Diseases - complications Neurodegenerative Diseases - pathology neurodegenerative disorders Retinal Ganglion Cells - pathology retrograde Retrograde Degeneration - pathology synapse dysfunction Synapses - pathology Trans-synaptic degeneration visual pathway Visual Pathways - pathology Trans-synaptic degeneration retrograde bidirectional trans-synaptic degeneration neurodegenerative disorders anterograde visual pathway axonal loss synapse dysfunction
ISSN:	0039-6257, 1879-3304, 1879-3304
Online Access:	Get full text
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