Dynamically enhancing plaque targeting via a positive feedback loop using multifunctional biomimetic nanoparticles for plaque regression

A paradigm shift from preventive therapy to aggressive plaque regression and eventual eradication is much needed to address increasing atherosclerotic burden and risks. Herein, we report a biologically inspired dual-targeting multifunctional recombinant high-density lipoprotein (rHDL)-mimicking core...

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Veröffentlicht in:	Journal of controlled release Jg. 308; S. 71 - 85
Hauptverfasser:	Jiang, Cuiping, Qi, Zitong, He, Wanhua, Li, Zhuoting, Tang, Yuqi, Wang, Yunbo, Huang, Yilei, Zang, Haojing, Yang, Hu, Liu, Jianping
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Netherlands Elsevier B.V 28.08.2019
Schlagworte:	Atherosclerosis biomimetics catalase cholesterol Dual-targeting high density lipoprotein macrophages Nanocarrier nanoparticles Plaque regression Plaque targeting Positive feedback loop risk small interfering RNA therapeutics Dual-targeting Nanocarrier Plaque regression Positive feedback loop Atherosclerosis Plaque targeting
ISSN:	0168-3659, 1873-4995, 1873-4995
Online-Zugang:	Volltext
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