Quantitative assessment of visual behavior in disorders of consciousness

The study of eye behavior is of paramount importance in the differential diagnosis of disorders of consciousness (DoC). In spite of this, assessment of eye movement patterns in patients with vegetative state (VS) or minimally conscious state (MCS) only relies on clinical evaluation. In this study we...

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Veröffentlicht in:Journal of neurology Jg. 259; H. 9; S. 1888 - 1895
Hauptverfasser: Trojano, L., Moretta, P., Loreto, V., Cozzolino, A., Santoro, L., Estraneo, A.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Berlin/Heidelberg Springer-Verlag 01.09.2012
Springer
Springer Nature B.V
Schlagworte:
Adult
Aged
Analysis of Variance
Biological and medical sciences
Color
Consciousness
Consciousness Disorders - complications
Diagnosis, Differential
Differential diagnosis
Dissolved organic carbon
Electroencephalography
Evoked Potentials, Visual - physiology
Eye
Eye movements
Eye Movements - physiology
Female
Fundamental and applied biological sciences. Psychology
General aspects
Humans
Male
Medical sciences
Medicine
Medicine & Public Health
Middle Aged
Neurology
Neuroradiology
Neurosciences
Original Communication
Patients
Pattern Recognition, Visual - physiology
Photic Stimulation
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Rehabilitation
Ulcers
Vision Disorders - diagnosis
Vision Disorders - etiology
Young Adult
Italy
Visual tracking
Visual behavior
Eye-tracker
Disorders of consciousness
Eye
Visual system
Nervous system diseases
Tracking
Consciousness impairment
Behavior
Neurological disorder
ISSN:0340-5354, 1432-1459, 1432-1459
Online-Zugang:Volltext
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Zusammenfassung:The study of eye behavior is of paramount importance in the differential diagnosis of disorders of consciousness (DoC). In spite of this, assessment of eye movement patterns in patients with vegetative state (VS) or minimally conscious state (MCS) only relies on clinical evaluation. In this study we aimed to provide a quantitative assessment of visual tracking behavior in response to moving stimuli in DoC patients. Nine VS patients and nine MCS patients were recruited in a Neurorehabilitation Unit for patients with chronic DoC; 11 matched healthy subjects were tested as the control group. All participants underwent a quantitative evaluation of eye-tracking pattern by means of a computerized infrared eye-tracker system; stimuli were represented by a red circle or a small color picture slowly moving on a PC monitor. The proportion of on- or off-target fixations differed significantly between MCS and VS. Most importantly, the distribution of fixations on or off the target in all VS patients was at or below the chance level, whereas in the MCS group seven out of nine patients showed a proportion of on-target fixations significantly higher than the chance level. Fixation length did not differ among the three groups significantly. The present quantitative assessment of visual behaviour in a tracking task demonstrated that MCS and VS patients differ in the proportion of on-target fixations. These results could have important clinical implications since the quantitative analysis of visual behavior might provide additional elements in the differential diagnosis of DoC.
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ISSN:0340-5354
1432-1459
1432-1459
DOI:10.1007/s00415-012-6435-4