Synergistic QTL interactions between Rf-1 and Rf-3 increase renal damage susceptibility in double congenic rats

The FHH (fawn-hooded hypertensive) rat is a model of hypertension-associated chronic kidney damage. Five interacting quantitative trait loci (QTLs), named Rf-1–Rf-5, determine the high renal susceptibility. The aim of the present study was to investigate a possible interaction between Rf-1 and Rf-3....

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Vydané v:	Kidney international Ročník 69; číslo 8; s. 1369 - 1376
Hlavní autori:	Van Dijk, S.J., Specht, P.A.C., Lazar, J., Jacob, H.J., Provoost, A.P.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	New York, NY Elsevier Inc 01.04.2006 Nature Publishing Elsevier Limited
Predmet:	Administration, Oral Animals Animals, Congenic Biological and medical sciences Blood Pressure - genetics Chromosome Mapping Chromosomes, Mammalian congenic rats Enzyme Inhibitors - administration & dosage Follow-Up Studies Genetic Markers Genetic Predisposition to Disease Genome Homeostasis - genetics Homozygote Hypertension, Renal - etiology Hypertension, Renal - genetics Kidney Diseases - genetics Kidney Diseases - physiopathology L-NAME-hypertension Male Medical sciences Nephrectomy Nephrology. Urinary tract diseases NG-Nitroarginine Methyl Ester - administration & dosage proteinuria Proteinuria - genetics Quantitative Trait Loci Rats Rats, Inbred ACI Renal Circulation - genetics renal damage susceptibility Survival Analysis Time Factors unilateral nephrectomy Urinary system involvement in other diseases. Miscellaneous Urinary tract. Prostate gland renal damage susceptibility L-NAME-hypertension congenic rats unilateral nephrectomy proteinuria Nephrology Rat Quantitative character Cardiovascular disease Synergism Kidney Urology Nephrectomy Surgery Congenic Drug interaction Hypertension Urinary system disease Rodentia Vertebrata Mammalia Treatment Urinary system Animal Unilateral Lesion Proteinuria
ISSN:	0085-2538, 1523-1755
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