Online clearance measurement in high-efficiency hemodiafiltration

The measurement of ionic dialysance by conductivity variation is an established method in diffusive hemodialysis. To extend the validity of this method for use in highly convective therapies, such as online hemodiafiltration, we derived a new model for the measurement of ionic dialysance. This metho...

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Veröffentlicht in:Kidney international Jg. 72; H. 12; S. 1550 - 1553
Hauptverfasser: Gross, M., Maierhofer, A., Tetta, C., Sénecal, L., Canaud, B.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: New York, NY Elsevier Inc 01.12.2007
Nature Publishing
Elsevier Limited
Schlagworte:
Biological and medical sciences
clearance
convection
dialysis efficiency
hemodiafiltration
Hemodiafiltration - methods
Hemodiafiltration - standards
Humans
Kidney Failure, Chronic - therapy
Medical sciences
Models, Biological
Nephrology. Urinary tract diseases
Reproducibility of Results
Urea - metabolism
convection
dialysis efficiency
clearance
hemodiafiltration
Measurement
Nephrology
Hemodiafiltration
Efficiency
High efficiency
Dialysis
Clearance
Convection
Urology
Quantitative analysis
ISSN:0085-2538, 1523-1755
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Beschreibung
Zusammenfassung:The measurement of ionic dialysance by conductivity variation is an established method in diffusive hemodialysis. To extend the validity of this method for use in highly convective therapies, such as online hemodiafiltration, we derived a new model for the measurement of ionic dialysance. This method was validated in a study involving 12 patients on pre- and postdilution online hemodiafiltration under various conditions. Clinically, there was a very good agreement between the dialysance determined by conductivity variation and blood side urea clearance. Neither the dilution modes nor the flow rate of the substitution fluid was found to significantly influence this agreement. Our results show that ionic dialysance can be easily and precisely measured by conductivity variation, and this provides an excellent surrogate for urea clearance even in highly convective therapies.
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ISSN:0085-2538
1523-1755
DOI:10.1038/sj.ki.5002551