Antineoplastic effect of pectic polysaccharides from green sweet pepper (Capsicum annuum) on mammary tumor cells in vivo and in vitro

[Display omitted] •The polysaccharides from green sweet pepper (CAP) presented antineoplastic effects against mammary tumor lineages.•CAP treatment reduced the gene expression of VEGF in tumor cells in vivo and in vitro.•CAP treatment reduced the area of vessels in Ehrlich tumor.•CAP treatment induc...

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Vydáno v:	Carbohydrate polymers Ročník 201; s. 280 - 292
Hlavní autoři:	Adami, Eliana Rezende, Corso, Claudia Rita, Turin-Oliveira, Natalia Mulinari, Galindo, Claudia Martins, Milani, Letícia, Stipp, Maria Caroline, do Nascimento, Georgia Erdmann, Chequin, Andressa, da Silva, Luisa Mota, de Andrade, Sérgio Faloni, Dittrich, Rosangela Locatelli, Queiroz-Telles, José Ederaldo, Klassen, Giseli, Ramos, Edneia A.S., Cordeiro, Lucimara M.C., Acco, Alexandra
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	England Elsevier Ltd 01.12.2018
Témata:	angiogenesis Animals Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology breast neoplasms Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Breast Neoplasms - pathology Capsicum - chemistry Capsicum annuum carcinoma Carcinoma, Ehrlich Tumor - drug therapy Carcinoma, Ehrlich Tumor - metabolism Carcinoma, Ehrlich Tumor - pathology Drug Screening Assays, Antitumor Ehrlich solid tumor epithelial cells Female females Green sweet pepper Humans inflammation Interleukin-6 laboratory animals mammary glands mammary neoplasms (animal) Mammary Neoplasms, Experimental - drug therapy Mammary Neoplasms, Experimental - metabolism Mammary tumor cells MCF-7 Cells methotrexate Mice necrosis neoplasm cells Pectic polysaccharide pectins Pectins - chemistry Pectins - isolation & purification Pectins - pharmacology sweet peppers vascular endothelial growth factors VEGF viability Ehrlich solid tumor Green sweet pepper Pectic polysaccharide VEGF Mammary tumor cells Interleukin-6
ISSN:	0144-8617, 1879-1344, 1879-1344
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Shrnutí:	[Display omitted] •The polysaccharides from green sweet pepper (CAP) presented antineoplastic effects against mammary tumor lineages.•CAP treatment reduced the gene expression of VEGF in tumor cells in vivo and in vitro.•CAP treatment reduced the area of vessels in Ehrlich tumor.•CAP treatment induced necrosis in Ehrlich solid tumors.•CAP treatment increased the levels of IL-6 in Ehrlich tumors in mice. The present study investigated the antineoplastic effects of pectic polysaccharides that were extracted from green sweet pepper (Capsicum annuum [CAP]) in the Ehrlich carcinoma in mice and in human mammary tumor lineages. After the subcutaneous inoculation of 2 × 106 Ehrlich tumor cells, Female Swiss mice received 50, 100, or 150 mg/kg CAP or vehicle orally once daily or methotrexate (2.5 mg/kg, i.p., every 5 days) for 21 days. CAP dose-dependently reduced Ehrlich tumor growth. It also reduced the viability of MCF-7, MDA-MB-231, and MDA-MB-436 human mammary cell lineages. Treatment with CAP reduced the gene expression of vascular endothelial growth factor in vivo and in vitro, reduced vessel areas of the tumors, and induced necrosis in Ehrlich solid tumors. CAP treatment significantly increased Interleukin-6 in tumors. The antineoplastic effect of CAP appears to depend on the regulation of inflammation and angiogenesis. Further studies are encouraged to better understand the CAP potential for the treatment of breast tumors.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0144-8617 1879-1344 1879-1344
DOI:	10.1016/j.carbpol.2018.08.071