Antineoplastic effect of pectic polysaccharides from green sweet pepper (Capsicum annuum) on mammary tumor cells in vivo and in vitro

[Display omitted] •The polysaccharides from green sweet pepper (CAP) presented antineoplastic effects against mammary tumor lineages.•CAP treatment reduced the gene expression of VEGF in tumor cells in vivo and in vitro.•CAP treatment reduced the area of vessels in Ehrlich tumor.•CAP treatment induc...

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Bibliographic Details
Published in:	Carbohydrate polymers Vol. 201; pp. 280 - 292
Main Authors:	Adami, Eliana Rezende, Corso, Claudia Rita, Turin-Oliveira, Natalia Mulinari, Galindo, Claudia Martins, Milani, Letícia, Stipp, Maria Caroline, do Nascimento, Georgia Erdmann, Chequin, Andressa, da Silva, Luisa Mota, de Andrade, Sérgio Faloni, Dittrich, Rosangela Locatelli, Queiroz-Telles, José Ederaldo, Klassen, Giseli, Ramos, Edneia A.S., Cordeiro, Lucimara M.C., Acco, Alexandra
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01.12.2018
Subjects:	angiogenesis Animals Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology breast neoplasms Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Breast Neoplasms - pathology Capsicum - chemistry Capsicum annuum carcinoma Carcinoma, Ehrlich Tumor - drug therapy Carcinoma, Ehrlich Tumor - metabolism Carcinoma, Ehrlich Tumor - pathology Drug Screening Assays, Antitumor Ehrlich solid tumor epithelial cells Female females Green sweet pepper Humans inflammation Interleukin-6 laboratory animals mammary glands mammary neoplasms (animal) Mammary Neoplasms, Experimental - drug therapy Mammary Neoplasms, Experimental - metabolism Mammary tumor cells MCF-7 Cells methotrexate Mice necrosis neoplasm cells Pectic polysaccharide pectins Pectins - chemistry Pectins - isolation & purification Pectins - pharmacology sweet peppers vascular endothelial growth factors VEGF viability Ehrlich solid tumor Green sweet pepper Pectic polysaccharide VEGF Mammary tumor cells Interleukin-6
ISSN:	0144-8617, 1879-1344, 1879-1344
Online Access:	Get full text
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