Antineoplastic effect of pectic polysaccharides from green sweet pepper (Capsicum annuum) on mammary tumor cells in vivo and in vitro
[Display omitted] •The polysaccharides from green sweet pepper (CAP) presented antineoplastic effects against mammary tumor lineages.•CAP treatment reduced the gene expression of VEGF in tumor cells in vivo and in vitro.•CAP treatment reduced the area of vessels in Ehrlich tumor.•CAP treatment induc...
Uloženo v:
| Vydáno v: | Carbohydrate polymers Ročník 201; s. 280 - 292 |
|---|---|
| Hlavní autoři: | , , , , , , , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
England
Elsevier Ltd
01.12.2018
|
| Témata: | |
| ISSN: | 0144-8617, 1879-1344, 1879-1344 |
| On-line přístup: | Získat plný text |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|
| Abstract | [Display omitted]
•The polysaccharides from green sweet pepper (CAP) presented antineoplastic effects against mammary tumor lineages.•CAP treatment reduced the gene expression of VEGF in tumor cells in vivo and in vitro.•CAP treatment reduced the area of vessels in Ehrlich tumor.•CAP treatment induced necrosis in Ehrlich solid tumors.•CAP treatment increased the levels of IL-6 in Ehrlich tumors in mice.
The present study investigated the antineoplastic effects of pectic polysaccharides that were extracted from green sweet pepper (Capsicum annuum [CAP]) in the Ehrlich carcinoma in mice and in human mammary tumor lineages. After the subcutaneous inoculation of 2 × 106 Ehrlich tumor cells, Female Swiss mice received 50, 100, or 150 mg/kg CAP or vehicle orally once daily or methotrexate (2.5 mg/kg, i.p., every 5 days) for 21 days. CAP dose-dependently reduced Ehrlich tumor growth. It also reduced the viability of MCF-7, MDA-MB-231, and MDA-MB-436 human mammary cell lineages. Treatment with CAP reduced the gene expression of vascular endothelial growth factor in vivo and in vitro, reduced vessel areas of the tumors, and induced necrosis in Ehrlich solid tumors. CAP treatment significantly increased Interleukin-6 in tumors. The antineoplastic effect of CAP appears to depend on the regulation of inflammation and angiogenesis. Further studies are encouraged to better understand the CAP potential for the treatment of breast tumors. |
|---|---|
| AbstractList | The present study investigated the antineoplastic effects of pectic polysaccharides that were extracted from green sweet pepper (Capsicum annuum [CAP]) in the Ehrlich carcinoma in mice and in human mammary tumor lineages. After the subcutaneous inoculation of 2 × 106 Ehrlich tumor cells, Female Swiss mice received 50, 100, or 150 mg/kg CAP or vehicle orally once daily or methotrexate (2.5 mg/kg, i.p., every 5 days) for 21 days. CAP dose-dependently reduced Ehrlich tumor growth. It also reduced the viability of MCF-7, MDA-MB-231, and MDA-MB-436 human mammary cell lineages. Treatment with CAP reduced the gene expression of vascular endothelial growth factor in vivo and in vitro, reduced vessel areas of the tumors, and induced necrosis in Ehrlich solid tumors. CAP treatment significantly increased Interleukin-6 in tumors. The antineoplastic effect of CAP appears to depend on the regulation of inflammation and angiogenesis. Further studies are encouraged to better understand the CAP potential for the treatment of breast tumors.The present study investigated the antineoplastic effects of pectic polysaccharides that were extracted from green sweet pepper (Capsicum annuum [CAP]) in the Ehrlich carcinoma in mice and in human mammary tumor lineages. After the subcutaneous inoculation of 2 × 106 Ehrlich tumor cells, Female Swiss mice received 50, 100, or 150 mg/kg CAP or vehicle orally once daily or methotrexate (2.5 mg/kg, i.p., every 5 days) for 21 days. CAP dose-dependently reduced Ehrlich tumor growth. It also reduced the viability of MCF-7, MDA-MB-231, and MDA-MB-436 human mammary cell lineages. Treatment with CAP reduced the gene expression of vascular endothelial growth factor in vivo and in vitro, reduced vessel areas of the tumors, and induced necrosis in Ehrlich solid tumors. CAP treatment significantly increased Interleukin-6 in tumors. The antineoplastic effect of CAP appears to depend on the regulation of inflammation and angiogenesis. Further studies are encouraged to better understand the CAP potential for the treatment of breast tumors. [Display omitted] •The polysaccharides from green sweet pepper (CAP) presented antineoplastic effects against mammary tumor lineages.•CAP treatment reduced the gene expression of VEGF in tumor cells in vivo and in vitro.•CAP treatment reduced the area of vessels in Ehrlich tumor.•CAP treatment induced necrosis in Ehrlich solid tumors.•CAP treatment increased the levels of IL-6 in Ehrlich tumors in mice. The present study investigated the antineoplastic effects of pectic polysaccharides that were extracted from green sweet pepper (Capsicum annuum [CAP]) in the Ehrlich carcinoma in mice and in human mammary tumor lineages. After the subcutaneous inoculation of 2 × 106 Ehrlich tumor cells, Female Swiss mice received 50, 100, or 150 mg/kg CAP or vehicle orally once daily or methotrexate (2.5 mg/kg, i.p., every 5 days) for 21 days. CAP dose-dependently reduced Ehrlich tumor growth. It also reduced the viability of MCF-7, MDA-MB-231, and MDA-MB-436 human mammary cell lineages. Treatment with CAP reduced the gene expression of vascular endothelial growth factor in vivo and in vitro, reduced vessel areas of the tumors, and induced necrosis in Ehrlich solid tumors. CAP treatment significantly increased Interleukin-6 in tumors. The antineoplastic effect of CAP appears to depend on the regulation of inflammation and angiogenesis. Further studies are encouraged to better understand the CAP potential for the treatment of breast tumors. The present study investigated the antineoplastic effects of pectic polysaccharides that were extracted from green sweet pepper (Capsicum annuum [CAP]) in the Ehrlich carcinoma in mice and in human mammary tumor lineages. After the subcutaneous inoculation of 2 × 10 Ehrlich tumor cells, Female Swiss mice received 50, 100, or 150 mg/kg CAP or vehicle orally once daily or methotrexate (2.5 mg/kg, i.p., every 5 days) for 21 days. CAP dose-dependently reduced Ehrlich tumor growth. It also reduced the viability of MCF-7, MDA-MB-231, and MDA-MB-436 human mammary cell lineages. Treatment with CAP reduced the gene expression of vascular endothelial growth factor in vivo and in vitro, reduced vessel areas of the tumors, and induced necrosis in Ehrlich solid tumors. CAP treatment significantly increased Interleukin-6 in tumors. The antineoplastic effect of CAP appears to depend on the regulation of inflammation and angiogenesis. Further studies are encouraged to better understand the CAP potential for the treatment of breast tumors. The present study investigated the antineoplastic effects of pectic polysaccharides that were extracted from green sweet pepper (Capsicum annuum [CAP]) in the Ehrlich carcinoma in mice and in human mammary tumor lineages. After the subcutaneous inoculation of 2 × 10⁶ Ehrlich tumor cells, Female Swiss mice received 50, 100, or 150 mg/kg CAP or vehicle orally once daily or methotrexate (2.5 mg/kg, i.p., every 5 days) for 21 days. CAP dose-dependently reduced Ehrlich tumor growth. It also reduced the viability of MCF-7, MDA-MB-231, and MDA-MB-436 human mammary cell lineages. Treatment with CAP reduced the gene expression of vascular endothelial growth factor in vivo and in vitro, reduced vessel areas of the tumors, and induced necrosis in Ehrlich solid tumors. CAP treatment significantly increased Interleukin-6 in tumors. The antineoplastic effect of CAP appears to depend on the regulation of inflammation and angiogenesis. Further studies are encouraged to better understand the CAP potential for the treatment of breast tumors. |
| Author | Klassen, Giseli Galindo, Claudia Martins Chequin, Andressa Dittrich, Rosangela Locatelli Acco, Alexandra Adami, Eliana Rezende Stipp, Maria Caroline do Nascimento, Georgia Erdmann Turin-Oliveira, Natalia Mulinari de Andrade, Sérgio Faloni Corso, Claudia Rita Milani, Letícia Queiroz-Telles, José Ederaldo da Silva, Luisa Mota Cordeiro, Lucimara M.C. Ramos, Edneia A.S. |
| Author_xml | – sequence: 1 givenname: Eliana Rezende surname: Adami fullname: Adami, Eliana Rezende organization: Department of Pharmacology, Federal University of Paraná, Curitiba, PR, Brazil – sequence: 2 givenname: Claudia Rita surname: Corso fullname: Corso, Claudia Rita organization: Department of Pharmacology, Federal University of Paraná, Curitiba, PR, Brazil – sequence: 3 givenname: Natalia Mulinari surname: Turin-Oliveira fullname: Turin-Oliveira, Natalia Mulinari organization: Department of Pharmacology, Federal University of Paraná, Curitiba, PR, Brazil – sequence: 4 givenname: Claudia Martins surname: Galindo fullname: Galindo, Claudia Martins organization: Department of Pharmacology, Federal University of Paraná, Curitiba, PR, Brazil – sequence: 5 givenname: Letícia surname: Milani fullname: Milani, Letícia organization: Department of Pharmacology, Federal University of Paraná, Curitiba, PR, Brazil – sequence: 6 givenname: Maria Caroline surname: Stipp fullname: Stipp, Maria Caroline organization: Department of Pharmacology, Federal University of Paraná, Curitiba, PR, Brazil – sequence: 7 givenname: Georgia Erdmann surname: do Nascimento fullname: do Nascimento, Georgia Erdmann organization: Department of Biochemistry and Molecular Biology, Federal University of Paraná, Curitiba, PR, Brazil – sequence: 8 givenname: Andressa surname: Chequin fullname: Chequin, Andressa organization: Department of Basic Pathology, Federal University of Paraná, Curitiba, PR, Brazil – sequence: 9 givenname: Luisa Mota surname: da Silva fullname: da Silva, Luisa Mota organization: Postgraduate Program in Pharmaceutical Sciences, University Vale of Itajaí, Itajaí, SC, Brazil – sequence: 10 givenname: Sérgio Faloni orcidid: 0000-0001-9294-7290 surname: de Andrade fullname: de Andrade, Sérgio Faloni organization: Postgraduate Program in Pharmaceutical Sciences, University Vale of Itajaí, Itajaí, SC, Brazil – sequence: 11 givenname: Rosangela Locatelli surname: Dittrich fullname: Dittrich, Rosangela Locatelli organization: Department of Veterinary Medicine, Federal University of Paraná, Curitiba, PR, Brazil – sequence: 12 givenname: José Ederaldo surname: Queiroz-Telles fullname: Queiroz-Telles, José Ederaldo organization: Department of Medical Pathology, Clinical Hospital, Federal University of Paraná, Curitiba, PR, Brazil – sequence: 13 givenname: Giseli surname: Klassen fullname: Klassen, Giseli organization: Department of Basic Pathology, Federal University of Paraná, Curitiba, PR, Brazil – sequence: 14 givenname: Edneia A.S. surname: Ramos fullname: Ramos, Edneia A.S. organization: Department of Basic Pathology, Federal University of Paraná, Curitiba, PR, Brazil – sequence: 15 givenname: Lucimara M.C. orcidid: 0000-0001-6680-8967 surname: Cordeiro fullname: Cordeiro, Lucimara M.C. organization: Department of Biochemistry and Molecular Biology, Federal University of Paraná, Curitiba, PR, Brazil – sequence: 16 givenname: Alexandra orcidid: 0000-0003-3977-687X surname: Acco fullname: Acco, Alexandra email: aleacco@ufpr.br organization: Department of Pharmacology, Federal University of Paraná, Curitiba, PR, Brazil |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30241820$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNkc9u1DAQxi1URLeFRwD5WA5ZPIljJ-KAqhX_pEpc4Gw59gS8SuxgO1v1AXhvvNqFA5cyGmks6_eNx_NdkQsfPBLyEtgWGIg3-63RcVjCtK0ZdFtWUsITsoFO9hU0nF-QDQPOq06AvCRXKe1ZCQHsGblsWM2hq9mG_Lr12XkMy6RTdobiOKLJNIx0KbVclBcekjbmh47OYqJjDDP9HhE9TfeIuXDLgpHe7PSSnFlnqr1f1_k1DZ7Oep51fKB5nUOkBqcpUefpwR1CwezpnGN4Tp6Oekr44lyvybcP77_uPlV3Xz5-3t3eVYY3ba5ajXLQA-uttlYMZhys1JYPxkBTN7qVkgvdi5GDNNJYZEz2ti7DgxCCCWyuyc2p7xLDzxVTVrNLx7F0WcGaVA0NdF0LTfMfaAnet1IU9NUZXYcZrVqiO_5a_dlyAdoTYGJIKeL4FwGmjm6qvTq7qY5uKlZSQtG9_UdnXNbZBZ-jdtOj6ncnNZaNHhxGlYxDb9C6WLxVNrhHOvwGKFjBAw |
| CitedBy_id | crossref_primary_10_1016_j_bcdf_2025_100469 crossref_primary_10_1016_j_carbpol_2025_124287 crossref_primary_10_1080_17460441_2023_2293152 crossref_primary_10_1016_j_cbi_2023_110480 crossref_primary_10_3389_fnut_2021_688897 crossref_primary_10_1016_j_carbpol_2019_01_064 crossref_primary_10_1016_j_scitotenv_2024_176872 crossref_primary_10_3390_molecules26175341 crossref_primary_10_1016_j_tifs_2021_03_008 crossref_primary_10_3390_ph18010024 crossref_primary_10_12677_TCM_2023_123108 crossref_primary_10_1016_j_ijbiomac_2024_134590 crossref_primary_10_1016_j_foodres_2023_113743 crossref_primary_10_1016_j_jnutbio_2022_109253 crossref_primary_10_1111_ijfs_14363 crossref_primary_10_1016_j_ijbiomac_2020_05_001 crossref_primary_10_1016_j_ijbiomac_2024_132807 crossref_primary_10_1016_j_jpain_2021_03_142 crossref_primary_10_1007_s13197_020_04663_4 crossref_primary_10_1016_j_cpt_2024_07_003 crossref_primary_10_3390_nu13062008 crossref_primary_10_1080_10408398_2019_1672037 crossref_primary_10_1016_j_carbpol_2024_122457 crossref_primary_10_1016_j_foodres_2020_109510 crossref_primary_10_1002_ptr_7660 crossref_primary_10_1016_j_ijbiomac_2025_140617 crossref_primary_10_1016_j_arabjc_2022_104448 crossref_primary_10_1016_j_ijbiomac_2023_127692 crossref_primary_10_3390_ijms242316653 |
| Cites_doi | 10.1016/S0076-6879(84)05016-3 10.1038/nprot.2006.339 10.4049/jimmunol.151.12.7273 10.1186/s12957-015-0529-2 10.1139/Y09-111 10.1385/1-59259-869-2:021 10.1016/S0090-6980(98)00078-1 10.1016/j.foodchem.2003.09.020 10.1016/j.carbpol.2017.05.029 10.3109/1547691X.2014.978055 10.1155/2015/924028 10.11606/issn.1678-4456.v53i2p138-145 10.1371/journal.pone.0111960 10.3390/md15120376 10.1016/j.pharep.2014.07.010 10.1016/j.ijbiomac.2017.05.137 10.1007/s10735-008-9196-8 10.1016/S0302-4598(98)00072-5 10.1038/scientificamerican0193-82 10.1007/s10549-013-2488-z 10.3892/ol.2016.4686 10.1016/j.ijbiomac.2016.10.102 10.5344/ajev.1965.16.3.144 10.1093/jnci/djv073 10.1016/j.smim.2014.01.008 10.1186/s12906-017-1885-y 10.1016/j.jep.2006.11.013 10.1016/0003-2697(82)90118-X 10.1111/1523-1747.ep12506462 10.3349/ymj.2014.55.5.1196 10.1016/j.freeradbiomed.2017.06.011 10.1093/intimm/dxn109 10.1016/j.phymed.2017.06.007 10.1038/nature04478 10.1016/0003-2697(76)90527-3 10.1016/S0092-8674(00)81683-9 10.3390/molecules23020508 10.1211/002235702760345464 10.1007/BF02536169 10.1016/j.biopha.2013.12.012 10.1016/S0021-9258(19)42083-8 10.1007/s00284-008-9233-6 10.1016/j.carbpol.2016.12.047 10.1016/0003-2697(68)90092-4 10.1186/bcr1639 10.1016/j.ijbiomac.2018.01.168 |
| ContentType | Journal Article |
| Copyright | 2018 Elsevier Ltd Copyright © 2018 Elsevier Ltd. All rights reserved. |
| Copyright_xml | – notice: 2018 Elsevier Ltd – notice: Copyright © 2018 Elsevier Ltd. All rights reserved. |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 7S9 L.6 |
| DOI | 10.1016/j.carbpol.2018.08.071 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic AGRICOLA AGRICOLA - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic AGRICOLA AGRICOLA - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE AGRICOLA |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Chemistry |
| EISSN | 1879-1344 |
| EndPage | 292 |
| ExternalDocumentID | 30241820 10_1016_j_carbpol_2018_08_071 S0144861718309792 |
| Genre | Journal Article |
| GroupedDBID | --K --M .~1 0R~ 1B1 1RT 1~. 1~5 29B 4.4 457 4G. 5GY 5VS 6J9 7-5 71M 8P~ 9JM 9JN AABNK AABVA AACTN AAEDT AAEDW AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AARLI AATLK AAXUO ABFNM ABFRF ABGRD ABGSF ABJNI ABMAC ABUDA ABYKQ ACDAQ ACGFO ACGFS ACIUM ACRLP ADBBV ADECG ADEZE ADQTV ADUVX AEBSH AEFWE AEHWI AEKER AENEX AEQOU AFKWA AFTJW AFXIZ AFZHZ AGHFR AGUBO AGYEJ AHHHB AIEXJ AIKHN AITUG AJOXV AJSZI ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ AXJTR BKOJK BLXMC CBWCG CS3 DOVZS DU5 EBS EFJIC EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FIRID FLBIZ FNPLU FYGXN G-Q GBLVA IHE J1W KOM LW9 M24 M2Y M41 MO0 N9A O-L O9- OAUVE OZT P-8 P-9 P2P PC. Q38 RIG RNS ROL RPZ SAB SDF SDG SDP SES SPC SPCBC SSA SSK SSU SSZ T5K Y6R ~G- ~KM 53G 9DU AAHBH AALCJ AAQXK AATTM AAXKI AAYWO AAYXX ABWVN ABXDB ACLOT ACNNM ACRPL ACVFH ADCNI ADMUD ADNMO AEIPS AEUPX AFJKZ AFPUW AGQPQ AGRDE AIGII AIIUN AKBMS AKRWK AKYEP ANKPU APXCP ASPBG AVWKF AZFZN CITATION EFKBS FEDTE FGOYB G-2 HLV HMS HVGLF HZ~ R2- SCB SEW SMS SOC WUQ XPP ~HD CGR CUY CVF ECM EIF NPM 7X8 7S9 L.6 |
| ID | FETCH-LOGICAL-c435t-5ae7bab09dadd6bcfbd7ad4bcc1323a57746a96f417c7cde0079d2acc166606e3 |
| ISICitedReferencesCount | 33 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000445030100030&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 0144-8617 1879-1344 |
| IngestDate | Thu Oct 02 05:56:34 EDT 2025 Sat Sep 27 20:54:00 EDT 2025 Wed Feb 19 02:43:22 EST 2025 Sat Nov 29 07:28:13 EST 2025 Tue Nov 18 22:17:27 EST 2025 Fri Feb 23 02:47:45 EST 2024 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | Ehrlich solid tumor Green sweet pepper Pectic polysaccharide VEGF Mammary tumor cells Interleukin-6 |
| Language | English |
| License | Copyright © 2018 Elsevier Ltd. All rights reserved. |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c435t-5ae7bab09dadd6bcfbd7ad4bcc1323a57746a96f417c7cde0079d2acc166606e3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ORCID | 0000-0003-3977-687X 0000-0001-6680-8967 0000-0001-9294-7290 |
| PMID | 30241820 |
| PQID | 2111149576 |
| PQPubID | 23479 |
| PageCount | 13 |
| ParticipantIDs | proquest_miscellaneous_2131885133 proquest_miscellaneous_2111149576 pubmed_primary_30241820 crossref_primary_10_1016_j_carbpol_2018_08_071 crossref_citationtrail_10_1016_j_carbpol_2018_08_071 elsevier_sciencedirect_doi_10_1016_j_carbpol_2018_08_071 |
| PublicationCentury | 2000 |
| PublicationDate | 2018-12-01 |
| PublicationDateYYYYMMDD | 2018-12-01 |
| PublicationDate_xml | – month: 12 year: 2018 text: 2018-12-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | England |
| PublicationPlace_xml | – name: England |
| PublicationTitle | Carbohydrate polymers |
| PublicationTitleAlternate | Carbohydr Polym |
| PublicationYear | 2018 |
| Publisher | Elsevier Ltd |
| Publisher_xml | – name: Elsevier Ltd |
| References | Dethlefsen, Højfeldt, Hojman (bib0070) 2013; 138 Mizuno, M., Minato, K., Ito, H., Kawade, M., & Terai, H. (1999). LIQUID-CULTURED A g a r i c u s blazei M i l l 1Graduate School of Science and Technology, Kobe University, Kobe 657-8501, Japan 2School of Medicine, Mie University, Tsu 514-8507, Japan 3Iwade Mushroom Institute, Tsu 514-0012, Japan, 47(4), 707–714. Jiang, Woollard, Wolff (bib0140) 1991; 26 Stipp, Bezerra, de, Corso, dos Reis Livero, Lomba, Caillot, Acco (bib0240) 2017; 160 Sánchez, Moreno (bib0205) 1999; 57 Carmeliet (bib0050) 2005; 438 de Fátima Pereira, Mara da Costa, Cristina Magalhães Santos, Carmo Horta Pinto, Rodrigues Da Silva (bib0065) 2014; 68 Gentile, Queiroz-Hazarbassanov, Massoco, Fecchio (bib0110) 2015 Jumes, Lugarini, Pereira, de Oliveira, Christoff, de, Linde, Acco (bib0145) 2010; 88 Gao, Yuan, Zhao, Gao (bib0105) 1998; 45 Zhu, Chen, Lin (bib0265) 2007; 111 Dunnwald, Rossing, Li (bib0080) 2007; 9 Lee, Oesterreich, Davidson (bib0155) 2015; 107 Hanahan, Weinberg (bib0135) 2000; 100 Alves de Souza, Alves de Souza, de, Stipp, Corso, Galindo, Cardoso, Acco (bib0020) 2017; 110 Franken, Rodermond, Stap, Haveman, van Bree (bib0100) 2006; 1 Fisher, Appenheimer, Evans (bib0095) 2014; 26 Zarnescu, Brehar, Chivu, Ciurea (bib0250) 2008; 39 Riss, Moravec, Niles (bib0195) 2013 Bradley, Priebat, Christensen, Rothstein (bib0045) 1982; 78 Zhang, Liu, Wang, Liu, Zhang, Zhao, Cheng (bib0255) 2017; 95 Song, Hui, Kou, Xin, Jia, Wang, Liu (bib0235) 2008; 57 Kobayashi, Rassenti, Meisenholder, Carson, Kipps (bib0150) 1993; 151 Bhattacharjee, Acharya, Ghosh, Sarkar, Chatterjee, Kumar, Chaudhuri (bib0035) 2008; 20 Shirazi (bib0225) 2011 Chen, Wu, Chen (bib0055) 2004; 86 Singleton, Rossi (bib0230) 1965; 16 Varghese, Joseph, Sreelekha (bib0245) 2017; 103 Raso, Pacilio, Carlo (bib0190) 2002; 54 Green, Wagner, Glogowski, Skipper, Wishnok, Tannenbaum (bib0120) 1982; 126 El-Sisi, Sokar, Salem, Abu Risha (bib0085) 2015; 12 Abdin, Soliman, Saied (bib0010) 2014; 66 Li, Su, Chen, Zhao, Wang, Ding, Huang (bib0160) 2018; 23 Bassiony, Sabet, El-Din, Mohamed, El-Ghor (bib0030) 2014; 9 Bradford (bib0040) 1976; 72 Gopinathan, Milagre, Pearce, Reynolds, Leinster, Zhong, Hollingsworth (bib0115) 2016; 75 Ma, Xie, Du, Zhang, Hao, Wang, Cao (bib0170) 2017; 15 Sanguinetti, Santini, Bonafè, Taffurelli, Avenia (bib0210) 2015; 13 Rui, Pan, Shao, Xu (bib0200) 2017; 17 Habig, Papst, Jakoby (bib0130) 1974; 249 Sharon, Lis (bib0220) 1993; 268 Sedlak, Lindsay (bib0005) 1968; 25 Guo, Chen, Liu, Tian, Zhang, Li (bib0125) 2014; 55 Santos, Oliveira, Hastreiter, Silva, Beltran, Borelli (bib0215) 2016; 539 Liu, Kuang, Wu, Jin, Sun (bib0165) 2016; 6 Podar, Fan, Schimming, Jaeger (bib0185) 2012 Aebi (bib0015) 1984; 105 Fan, Yu, Nie, Jin, Chen, Chen (bib0090) 2018 Zhang, Yang, Li, Xu, Yan, Gao, Jia, Duan (bib0260) 2017; 33 do Nascimento, Iacomini, Cordeiro (bib0075) 2017; 171 Comşa, Cîmpean, Raica (bib0060) 2015; 35 Munshi, Hobbs, Meyn (bib0180) 2018; 110 Bao, Liu, Jiang, Zhang, Xie, Wang, Gong (bib0025) 2016; 12 Dethlefsen (10.1016/j.carbpol.2018.08.071_bib0070) 2013; 138 Abdin (10.1016/j.carbpol.2018.08.071_bib0010) 2014; 66 Li (10.1016/j.carbpol.2018.08.071_bib0160) 2018; 23 Riss (10.1016/j.carbpol.2018.08.071_bib0195) 2013 Bhattacharjee (10.1016/j.carbpol.2018.08.071_bib0035) 2008; 20 Gentile (10.1016/j.carbpol.2018.08.071_bib0110) 2015 Zhang (10.1016/j.carbpol.2018.08.071_bib0255) 2017; 95 Lee (10.1016/j.carbpol.2018.08.071_bib0155) 2015; 107 Gao (10.1016/j.carbpol.2018.08.071_bib0105) 1998; 45 Bradley (10.1016/j.carbpol.2018.08.071_bib0045) 1982; 78 Shirazi (10.1016/j.carbpol.2018.08.071_bib0225) 2011 Rui (10.1016/j.carbpol.2018.08.071_bib0200) 2017; 17 Munshi (10.1016/j.carbpol.2018.08.071_bib0180) 2018; 110 Jiang (10.1016/j.carbpol.2018.08.071_bib0140) 1991; 26 Comşa (10.1016/j.carbpol.2018.08.071_bib0060) 2015; 35 Aebi (10.1016/j.carbpol.2018.08.071_bib0015) 1984; 105 Liu (10.1016/j.carbpol.2018.08.071_bib0165) 2016; 6 Ma (10.1016/j.carbpol.2018.08.071_bib0170) 2017; 15 Sánchez (10.1016/j.carbpol.2018.08.071_bib0205) 1999; 57 Varghese (10.1016/j.carbpol.2018.08.071_bib0245) 2017; 103 Stipp (10.1016/j.carbpol.2018.08.071_bib0240) 2017; 160 Raso (10.1016/j.carbpol.2018.08.071_bib0190) 2002; 54 Sanguinetti (10.1016/j.carbpol.2018.08.071_bib0210) 2015; 13 Santos (10.1016/j.carbpol.2018.08.071_bib0215) 2016; 539 El-Sisi (10.1016/j.carbpol.2018.08.071_bib0085) 2015; 12 Green (10.1016/j.carbpol.2018.08.071_bib0120) 1982; 126 Singleton (10.1016/j.carbpol.2018.08.071_bib0230) 1965; 16 Dunnwald (10.1016/j.carbpol.2018.08.071_bib0080) 2007; 9 Fan (10.1016/j.carbpol.2018.08.071_bib0090) 2018 de Fátima Pereira (10.1016/j.carbpol.2018.08.071_bib0065) 2014; 68 Bradford (10.1016/j.carbpol.2018.08.071_bib0040) 1976; 72 Chen (10.1016/j.carbpol.2018.08.071_bib0055) 2004; 86 Habig (10.1016/j.carbpol.2018.08.071_bib0130) 1974; 249 Podar (10.1016/j.carbpol.2018.08.071_bib0185) 2012 Fisher (10.1016/j.carbpol.2018.08.071_bib0095) 2014; 26 Hanahan (10.1016/j.carbpol.2018.08.071_bib0135) 2000; 100 Guo (10.1016/j.carbpol.2018.08.071_bib0125) 2014; 55 Jumes (10.1016/j.carbpol.2018.08.071_bib0145) 2010; 88 do Nascimento (10.1016/j.carbpol.2018.08.071_bib0075) 2017; 171 Zhu (10.1016/j.carbpol.2018.08.071_bib0265) 2007; 111 Sharon (10.1016/j.carbpol.2018.08.071_bib0220) 1993; 268 Alves de Souza (10.1016/j.carbpol.2018.08.071_bib0020) 2017; 110 Bao (10.1016/j.carbpol.2018.08.071_bib0025) 2016; 12 10.1016/j.carbpol.2018.08.071_bib0175 Sedlak (10.1016/j.carbpol.2018.08.071_bib0005) 1968; 25 Zhang (10.1016/j.carbpol.2018.08.071_bib0260) 2017; 33 Gopinathan (10.1016/j.carbpol.2018.08.071_bib0115) 2016; 75 Zarnescu (10.1016/j.carbpol.2018.08.071_bib0250) 2008; 39 Carmeliet (10.1016/j.carbpol.2018.08.071_bib0050) 2005; 438 Kobayashi (10.1016/j.carbpol.2018.08.071_bib0150) 1993; 151 Bassiony (10.1016/j.carbpol.2018.08.071_bib0030) 2014; 9 Song (10.1016/j.carbpol.2018.08.071_bib0235) 2008; 57 Franken (10.1016/j.carbpol.2018.08.071_bib0100) 2006; 1 |
| References_xml | – volume: 75 start-page: 3098 year: 2016 end-page: 3107 ident: bib0115 publication-title: Europe PMC Funders Group Interleukin-6 stimulates defective angiogenesis – volume: 33 start-page: 21 year: 2017 end-page: 27 ident: bib0260 article-title: Angelica polysaccharides inhibit the growth and promote the apoptosis of U251 glioma cells in vitro and in vivo publication-title: Phytomedicine – year: 2018 ident: bib0090 article-title: Antitumor activity and underlying mechanism of Sargassum fusiforme polysaccharides in CNE-bearing mice publication-title: International Journal of Biological Macromolecules – volume: 26 start-page: 38 year: 2014 end-page: 47 ident: bib0095 article-title: The two faces of IL-6 in the tumor microenvironment. NIH Public Access publication-title: Seminars in Immunology – reference: Mizuno, M., Minato, K., Ito, H., Kawade, M., & Terai, H. (1999). LIQUID-CULTURED A g a r i c u s blazei M i l l 1Graduate School of Science and Technology, Kobe University, Kobe 657-8501, Japan 2School of Medicine, Mie University, Tsu 514-8507, Japan 3Iwade Mushroom Institute, Tsu 514-0012, Japan, 47(4), 707–714. – volume: 539 start-page: 138 year: 2016 end-page: 145 ident: bib0215 article-title: Hematological and biochemical reference values for C57BL/6, Swiss Webster and BALB/c mice publication-title: Brazilian Journal of Veterinary Research and Animal Science – volume: 151 start-page: 7273 year: 1993 end-page: 7283 ident: bib0150 article-title: Autoantigen inhibits apoptosis of a human B cell leukemia that produces pathogenic rheumatoid factor publication-title: Journal of Immunology (Baltimore, Md : 1950) – volume: 268 start-page: 82 year: 1993 end-page: 89 ident: bib0220 article-title: Carbohydrates in cell recognition publication-title: Scientific American – volume: 9 start-page: 1 year: 2007 end-page: 10 ident: bib0080 article-title: Hormone receptor status, tumor characteristics, and prognosis: A prospective cohort of breast cancer patients publication-title: Breast Cancer Research – volume: 68 start-page: 365 year: 2014 end-page: 368 ident: bib0065 article-title: Evaluation of the effects of methotrexate released from polymeric implants in solid Ehrlich tumor publication-title: Biomedecine & Pharmacotherapy – volume: 45 start-page: 41 year: 1998 end-page: 45 ident: bib0105 article-title: Mechanism of pyrogallol autoxidation and determination of superoxide dismutase enzyme activity publication-title: Bioelectrochemistry and Bioenergetics (Lausanne, Switzerland) – volume: 126 start-page: 131 year: 1982 end-page: 138 ident: bib0120 article-title: Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids publication-title: Analytical Biochemistry – volume: 110 start-page: 228 year: 2017 end-page: 239 ident: bib0020 article-title: Ruthenium complex exerts antineoplastic effects that are mediated by oxidative stress without inducing toxicity in Walker-256 tumor-bearing rats publication-title: Free Radical Biology & Medicine – volume: 12 start-page: 1058 year: 2016 end-page: 1066 ident: bib0025 article-title: Huaier polysaccharide induces apoptosis in hepatocellular carcinoma cells through p38 MAPK publication-title: Oncology Letters – volume: 23 year: 2018 ident: bib0160 article-title: Physicochemical characterization and functional analysis of the polysaccharide from the edible microalga nostoc sphaeroides publication-title: Molecules – volume: 110 start-page: 021 year: 2018 end-page: 028 ident: bib0180 article-title: Clonogenic cell survival assay publication-title: Chemosensitivity – volume: 88 start-page: 21 year: 2010 end-page: 27 ident: bib0145 article-title: Effects of publication-title: Canadian Journal of Physiology and Pharmacology – volume: 20 start-page: 1489 year: 2008 end-page: 1505 ident: bib0035 article-title: Bax and Bid act in synergy to bring about T11TS-mediated glioma apoptosis via the release of mitochondrial cytochrome c and subsequent caspase activation publication-title: International Immunology – volume: 9 start-page: 1 year: 2014 end-page: 9 ident: bib0030 article-title: Magnetite nanoparticles inhibit tumor growth and upregulate the expression of P53/P16 in Ehrlich solid carcinoma bearing mice publication-title: PloS One – start-page: 95 year: 2011 ident: bib0225 article-title: Remarks in successful cellular investigations for fighting breast Cancer Using novel synthetic compounds publication-title: Breast Cancer – Focusing Tumor Microenvironment, Stem Cells and Metastasis – volume: 35 start-page: 3147 year: 2015 end-page: 3154 ident: bib0060 article-title: The story of MCF-7 breast cancer cell line: 40 Years of experience in research publication-title: Anticancer Research – volume: 54 start-page: 1379 year: 2002 end-page: 1383 ident: bib0190 article-title: In‐vivo and in‐vitro anti‐inflammatory effect of Echinacea purpurea and Hypericum perforatum publication-title: The Journal of Pharmacy and Pharmacology – volume: 57 start-page: 119 year: 1999 end-page: 131 ident: bib0205 article-title: Role of prostaglandin H synthase isoforms in murine ear edema induced by phorbol ester application on skin publication-title: Prostaglandins & Other Lipid Mediators – volume: 171 start-page: 292 year: 2017 end-page: 299 ident: bib0075 article-title: New findings on green sweet pepper (Capsicum annum) pectins: Rhamnogalacturonan and type I and II arabinogalactans publication-title: Carbohydrate Polymers – volume: 86 start-page: 479 year: 2004 end-page: 484 ident: bib0055 article-title: The influence of different treatments on the free radical scavenging activity of burdock and variations of its active components publication-title: Food Chemistry – volume: 107 start-page: 1 year: 2015 end-page: 4 ident: bib0155 article-title: MCF-7 Cells - Changing the Course of Breast Cancer Research and Care for 45 Years publication-title: Journal of the National Cancer Institute – year: 2012 ident: bib0185 article-title: Targeting the tumor microenvironment: Focus on angiogenesis publication-title: Journal of Oncology – volume: 39 start-page: 561 year: 2008 end-page: 569 ident: bib0250 article-title: Immunohistochemical localization of caspase-3, caspase-9 and Bax in U87 glioblastoma xenografts publication-title: Journal of Molecular Histology – volume: 1 start-page: 2315 year: 2006 end-page: 2319 ident: bib0100 article-title: Clonogenic assay of cells in vitro publication-title: Nature Protocols – volume: 25 start-page: 192 year: 1968 end-page: 205 ident: bib0005 article-title: Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman’s reagent publication-title: Analytical Biochemistry – volume: 12 start-page: 308 year: 2015 end-page: 316 ident: bib0085 article-title: PPARγ-dependent anti-tumor and immunomodulatory actions of pioglitazone publication-title: Journal of Immunotoxicology – volume: 17 start-page: 1 year: 2017 end-page: 8 ident: bib0200 article-title: Anti-tumor and anti-angiogenic effects of Fucoidan on prostate cancer: Possible JAK-STAT3 pathway publication-title: BMC Complementary and Alternative Medicine – volume: 15 year: 2017 ident: bib0170 article-title: The anti-inflammatory effect and structure of epcp1-2 from crypthecodinium cohnii via modulation of tlr4-nf-κb pathways in lps-induced raw 264.7 cells publication-title: Marine Drugs – volume: 95 start-page: 1119 year: 2017 end-page: 1125 ident: bib0255 article-title: In vitro antioxidative and immunological activities of polysaccharides from Zizyphus Jujuba cv. Muzao publication-title: International Journal of Biological Macromolecules – volume: 160 start-page: 123 year: 2017 end-page: 133 ident: bib0240 article-title: Necroptosis mediates the antineoplastic effects of the soluble fraction of polysaccharide from red wine in Walker-256 tumor-bearing rats publication-title: Carbohydrate Polymers – year: 2015 ident: bib0110 article-title: Modulation of cytokines production by indomethacin acute dose during the evolution of Ehrlich Ascites tumor in mice publication-title: Mediators of Inflammation – volume: 57 start-page: 454 year: 2008 end-page: 462 ident: bib0235 article-title: Identification of Inonotus obliquus and analysis of antioxidation and antitumor activities of polysaccharides publication-title: Current Microbiology – start-page: 2004 year: 2013 ident: bib0195 article-title: Cell viability assays publication-title: Updated 2016 july 1]. assay guidance manual [internet] – volume: 78 start-page: 206 year: 1982 end-page: 209 ident: bib0045 article-title: Measurement of cutaneous inflammation: Estimation of neutrophil content with an enzyme marker publication-title: The Journal of Investigative Dermatology – volume: 111 start-page: 219 year: 2007 end-page: 226 ident: bib0265 article-title: Ganoderma lucidum polysaccharides enhance the function of immunological effector cells in immunosuppressed mice publication-title: Journal of Ethnopharmacology – volume: 66 start-page: 1114 year: 2014 end-page: 1121 ident: bib0010 article-title: Effect of propranolol on IL-10, visfatin, Hsp70, iNOS, TLR2, and survivin in amelioration of tumor progression and survival in solid ehrlich carcinoma-bearing mice publication-title: Pharmacological R reports – volume: 13 start-page: 4 year: 2015 end-page: 9 ident: bib0210 article-title: Interleukin-6 and pro inflammatory status in the breast tumor microenvironment publication-title: World Journal of Surgical Oncology – volume: 26 start-page: 853 year: 1991 end-page: 856 ident: bib0140 article-title: Lipid hydroperoxide measurement by oxidation of Fe2+in the presence of xylenol orange. Comparison with the TBA assay and an iodometric method publication-title: Lipids – volume: 6 start-page: 1 year: 2016 end-page: 12 ident: bib0165 article-title: A novel polysaccharide from Sargassum integerrimum induces apoptosis in A549 cells and prevents angiogensis in vitro and in vivo publication-title: Scientific Reports – volume: 105 start-page: 121 year: 1984 end-page: 126 ident: bib0015 article-title: Catalase in vitro. Oxygen radicals in biological systems publication-title: Methods in Enzymology – volume: 16 start-page: 144 year: 1965 end-page: 158 ident: bib0230 article-title: Colorimetry of total phenolics with phosphomolybdic-phosphotungstic acid reagents publication-title: American Journal of Enology and Viticulture – volume: 438 start-page: 932 year: 2005 end-page: 936 ident: bib0050 article-title: Angiogenesis in life, disease and medicine publication-title: Nature – volume: 55 start-page: 1196 year: 2014 end-page: 1205 ident: bib0125 article-title: LRIG1 enhances chemosensitivity by modulating BCL-2 expression and receptor tyrosine kinase signaling in glioma cells publication-title: Yonsei Medical Journal – volume: 72 start-page: 248 year: 1976 end-page: 254 ident: bib0040 article-title: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding publication-title: Analytical Biochemistry – volume: 103 start-page: 1000 year: 2017 end-page: 1010 ident: bib0245 article-title: The inhibitory effect of anti- tumor polysaccharide from Punica granatum on metastasis publication-title: International Journal of Biological Macromolecules – volume: 249 start-page: 7130 year: 1974 end-page: 7139 ident: bib0130 article-title: Glutathione S-transferases: the first enzymatic step in mercapturic acid formation publication-title: The Journal of Biological Chemistry – volume: 100 start-page: 57 year: 2000 end-page: 70 ident: bib0135 article-title: The hallmarks of cancer publication-title: Cell – volume: 138 start-page: 657 year: 2013 end-page: 664 ident: bib0070 article-title: The role of intratumoral and systemic IL-6 in breast cancer publication-title: Breast Cancer Research and Treatment – ident: 10.1016/j.carbpol.2018.08.071_bib0175 – volume: 105 start-page: 121 year: 1984 ident: 10.1016/j.carbpol.2018.08.071_bib0015 article-title: Catalase in vitro. Oxygen radicals in biological systems publication-title: Methods in Enzymology doi: 10.1016/S0076-6879(84)05016-3 – volume: 1 start-page: 2315 issue: 5 year: 2006 ident: 10.1016/j.carbpol.2018.08.071_bib0100 article-title: Clonogenic assay of cells in vitro publication-title: Nature Protocols doi: 10.1038/nprot.2006.339 – volume: 151 start-page: 7273 issue: 12 year: 1993 ident: 10.1016/j.carbpol.2018.08.071_bib0150 article-title: Autoantigen inhibits apoptosis of a human B cell leukemia that produces pathogenic rheumatoid factor publication-title: Journal of Immunology (Baltimore, Md : 1950) doi: 10.4049/jimmunol.151.12.7273 – volume: 13 start-page: 4 issue: 1 year: 2015 ident: 10.1016/j.carbpol.2018.08.071_bib0210 article-title: Interleukin-6 and pro inflammatory status in the breast tumor microenvironment publication-title: World Journal of Surgical Oncology doi: 10.1186/s12957-015-0529-2 – volume: 88 start-page: 21 issue: 1 year: 2010 ident: 10.1016/j.carbpol.2018.08.071_bib0145 article-title: Effects of Agaricus brasiliensis mushroom in Walker-256 tumor-bearing rats publication-title: Canadian Journal of Physiology and Pharmacology doi: 10.1139/Y09-111 – volume: 110 start-page: 021 year: 2018 ident: 10.1016/j.carbpol.2018.08.071_bib0180 article-title: Clonogenic cell survival assay publication-title: Chemosensitivity doi: 10.1385/1-59259-869-2:021 – volume: 57 start-page: 119 issue: 2–3 year: 1999 ident: 10.1016/j.carbpol.2018.08.071_bib0205 article-title: Role of prostaglandin H synthase isoforms in murine ear edema induced by phorbol ester application on skin publication-title: Prostaglandins & Other Lipid Mediators doi: 10.1016/S0090-6980(98)00078-1 – volume: 35 start-page: 3147 issue: 6 year: 2015 ident: 10.1016/j.carbpol.2018.08.071_bib0060 article-title: The story of MCF-7 breast cancer cell line: 40 Years of experience in research publication-title: Anticancer Research – volume: 75 start-page: 3098 issue: 15 year: 2016 ident: 10.1016/j.carbpol.2018.08.071_bib0115 publication-title: Europe PMC Funders Group Interleukin-6 stimulates defective angiogenesis – volume: 86 start-page: 479 issue: 4 year: 2004 ident: 10.1016/j.carbpol.2018.08.071_bib0055 article-title: The influence of different treatments on the free radical scavenging activity of burdock and variations of its active components publication-title: Food Chemistry doi: 10.1016/j.foodchem.2003.09.020 – volume: 171 start-page: 292 year: 2017 ident: 10.1016/j.carbpol.2018.08.071_bib0075 article-title: New findings on green sweet pepper (Capsicum annum) pectins: Rhamnogalacturonan and type I and II arabinogalactans publication-title: Carbohydrate Polymers doi: 10.1016/j.carbpol.2017.05.029 – volume: 12 start-page: 308 issue: 4 year: 2015 ident: 10.1016/j.carbpol.2018.08.071_bib0085 article-title: PPARγ-dependent anti-tumor and immunomodulatory actions of pioglitazone publication-title: Journal of Immunotoxicology doi: 10.3109/1547691X.2014.978055 – year: 2015 ident: 10.1016/j.carbpol.2018.08.071_bib0110 article-title: Modulation of cytokines production by indomethacin acute dose during the evolution of Ehrlich Ascites tumor in mice publication-title: Mediators of Inflammation doi: 10.1155/2015/924028 – volume: 539 start-page: 138 issue: 2 year: 2016 ident: 10.1016/j.carbpol.2018.08.071_bib0215 article-title: Hematological and biochemical reference values for C57BL/6, Swiss Webster and BALB/c mice publication-title: Brazilian Journal of Veterinary Research and Animal Science doi: 10.11606/issn.1678-4456.v53i2p138-145 – volume: 9 start-page: 1 issue: 11 year: 2014 ident: 10.1016/j.carbpol.2018.08.071_bib0030 article-title: Magnetite nanoparticles inhibit tumor growth and upregulate the expression of P53/P16 in Ehrlich solid carcinoma bearing mice publication-title: PloS One doi: 10.1371/journal.pone.0111960 – volume: 15 issue: 12 year: 2017 ident: 10.1016/j.carbpol.2018.08.071_bib0170 article-title: The anti-inflammatory effect and structure of epcp1-2 from crypthecodinium cohnii via modulation of tlr4-nf-κb pathways in lps-induced raw 264.7 cells publication-title: Marine Drugs doi: 10.3390/md15120376 – volume: 66 start-page: 1114 issue: 6 year: 2014 ident: 10.1016/j.carbpol.2018.08.071_bib0010 article-title: Effect of propranolol on IL-10, visfatin, Hsp70, iNOS, TLR2, and survivin in amelioration of tumor progression and survival in solid ehrlich carcinoma-bearing mice publication-title: Pharmacological R reports doi: 10.1016/j.pharep.2014.07.010 – volume: 103 start-page: 1000 year: 2017 ident: 10.1016/j.carbpol.2018.08.071_bib0245 article-title: The inhibitory effect of anti- tumor polysaccharide from Punica granatum on metastasis publication-title: International Journal of Biological Macromolecules doi: 10.1016/j.ijbiomac.2017.05.137 – volume: 39 start-page: 561 issue: 6 year: 2008 ident: 10.1016/j.carbpol.2018.08.071_bib0250 article-title: Immunohistochemical localization of caspase-3, caspase-9 and Bax in U87 glioblastoma xenografts publication-title: Journal of Molecular Histology doi: 10.1007/s10735-008-9196-8 – volume: 45 start-page: 41 issue: 1 year: 1998 ident: 10.1016/j.carbpol.2018.08.071_bib0105 article-title: Mechanism of pyrogallol autoxidation and determination of superoxide dismutase enzyme activity publication-title: Bioelectrochemistry and Bioenergetics (Lausanne, Switzerland) doi: 10.1016/S0302-4598(98)00072-5 – volume: 268 start-page: 82 issue: 1 year: 1993 ident: 10.1016/j.carbpol.2018.08.071_bib0220 article-title: Carbohydrates in cell recognition publication-title: Scientific American doi: 10.1038/scientificamerican0193-82 – volume: 138 start-page: 657 issue: 3 year: 2013 ident: 10.1016/j.carbpol.2018.08.071_bib0070 article-title: The role of intratumoral and systemic IL-6 in breast cancer publication-title: Breast Cancer Research and Treatment doi: 10.1007/s10549-013-2488-z – volume: 12 start-page: 1058 issue: 2 year: 2016 ident: 10.1016/j.carbpol.2018.08.071_bib0025 article-title: Huaier polysaccharide induces apoptosis in hepatocellular carcinoma cells through p38 MAPK publication-title: Oncology Letters doi: 10.3892/ol.2016.4686 – volume: 95 start-page: 1119 year: 2017 ident: 10.1016/j.carbpol.2018.08.071_bib0255 article-title: In vitro antioxidative and immunological activities of polysaccharides from Zizyphus Jujuba cv. Muzao publication-title: International Journal of Biological Macromolecules doi: 10.1016/j.ijbiomac.2016.10.102 – year: 2012 ident: 10.1016/j.carbpol.2018.08.071_bib0185 article-title: Targeting the tumor microenvironment: Focus on angiogenesis publication-title: Journal of Oncology – volume: 16 start-page: 144 year: 1965 ident: 10.1016/j.carbpol.2018.08.071_bib0230 article-title: Colorimetry of total phenolics with phosphomolybdic-phosphotungstic acid reagents publication-title: American Journal of Enology and Viticulture doi: 10.5344/ajev.1965.16.3.144 – volume: 107 start-page: 1 issue: 7 year: 2015 ident: 10.1016/j.carbpol.2018.08.071_bib0155 article-title: MCF-7 Cells - Changing the Course of Breast Cancer Research and Care for 45 Years publication-title: Journal of the National Cancer Institute doi: 10.1093/jnci/djv073 – volume: 26 start-page: 38 issue: 1 year: 2014 ident: 10.1016/j.carbpol.2018.08.071_bib0095 article-title: The two faces of IL-6 in the tumor microenvironment. NIH Public Access publication-title: Seminars in Immunology doi: 10.1016/j.smim.2014.01.008 – volume: 17 start-page: 1 issue: 1 year: 2017 ident: 10.1016/j.carbpol.2018.08.071_bib0200 article-title: Anti-tumor and anti-angiogenic effects of Fucoidan on prostate cancer: Possible JAK-STAT3 pathway publication-title: BMC Complementary and Alternative Medicine doi: 10.1186/s12906-017-1885-y – volume: 111 start-page: 219 issue: 2 year: 2007 ident: 10.1016/j.carbpol.2018.08.071_bib0265 article-title: Ganoderma lucidum polysaccharides enhance the function of immunological effector cells in immunosuppressed mice publication-title: Journal of Ethnopharmacology doi: 10.1016/j.jep.2006.11.013 – volume: 126 start-page: 131 year: 1982 ident: 10.1016/j.carbpol.2018.08.071_bib0120 article-title: Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids publication-title: Analytical Biochemistry doi: 10.1016/0003-2697(82)90118-X – start-page: 95 year: 2011 ident: 10.1016/j.carbpol.2018.08.071_bib0225 article-title: Remarks in successful cellular investigations for fighting breast Cancer Using novel synthetic compounds publication-title: Breast Cancer – Focusing Tumor Microenvironment, Stem Cells and Metastasis – volume: 78 start-page: 206 issue: 3 year: 1982 ident: 10.1016/j.carbpol.2018.08.071_bib0045 article-title: Measurement of cutaneous inflammation: Estimation of neutrophil content with an enzyme marker publication-title: The Journal of Investigative Dermatology doi: 10.1111/1523-1747.ep12506462 – volume: 6 start-page: 1 issue: March year: 2016 ident: 10.1016/j.carbpol.2018.08.071_bib0165 article-title: A novel polysaccharide from Sargassum integerrimum induces apoptosis in A549 cells and prevents angiogensis in vitro and in vivo publication-title: Scientific Reports – volume: 55 start-page: 1196 issue: 5 year: 2014 ident: 10.1016/j.carbpol.2018.08.071_bib0125 article-title: LRIG1 enhances chemosensitivity by modulating BCL-2 expression and receptor tyrosine kinase signaling in glioma cells publication-title: Yonsei Medical Journal doi: 10.3349/ymj.2014.55.5.1196 – volume: 110 start-page: 228 year: 2017 ident: 10.1016/j.carbpol.2018.08.071_bib0020 article-title: Ruthenium complex exerts antineoplastic effects that are mediated by oxidative stress without inducing toxicity in Walker-256 tumor-bearing rats publication-title: Free Radical Biology & Medicine doi: 10.1016/j.freeradbiomed.2017.06.011 – volume: 20 start-page: 1489 issue: 12 year: 2008 ident: 10.1016/j.carbpol.2018.08.071_bib0035 article-title: Bax and Bid act in synergy to bring about T11TS-mediated glioma apoptosis via the release of mitochondrial cytochrome c and subsequent caspase activation publication-title: International Immunology doi: 10.1093/intimm/dxn109 – start-page: 2004 year: 2013 ident: 10.1016/j.carbpol.2018.08.071_bib0195 article-title: Cell viability assays – volume: 33 start-page: 21 issue: March year: 2017 ident: 10.1016/j.carbpol.2018.08.071_bib0260 article-title: Angelica polysaccharides inhibit the growth and promote the apoptosis of U251 glioma cells in vitro and in vivo publication-title: Phytomedicine doi: 10.1016/j.phymed.2017.06.007 – volume: 438 start-page: 932 issue: 7070 year: 2005 ident: 10.1016/j.carbpol.2018.08.071_bib0050 article-title: Angiogenesis in life, disease and medicine publication-title: Nature doi: 10.1038/nature04478 – volume: 72 start-page: 248 year: 1976 ident: 10.1016/j.carbpol.2018.08.071_bib0040 article-title: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding publication-title: Analytical Biochemistry doi: 10.1016/0003-2697(76)90527-3 – volume: 100 start-page: 57 issue: 1 year: 2000 ident: 10.1016/j.carbpol.2018.08.071_bib0135 article-title: The hallmarks of cancer publication-title: Cell doi: 10.1016/S0092-8674(00)81683-9 – volume: 23 issue: 2 year: 2018 ident: 10.1016/j.carbpol.2018.08.071_bib0160 article-title: Physicochemical characterization and functional analysis of the polysaccharide from the edible microalga nostoc sphaeroides publication-title: Molecules doi: 10.3390/molecules23020508 – volume: 54 start-page: 1379 year: 2002 ident: 10.1016/j.carbpol.2018.08.071_bib0190 article-title: In‐vivo and in‐vitro anti‐inflammatory effect of Echinacea purpurea and Hypericum perforatum publication-title: The Journal of Pharmacy and Pharmacology doi: 10.1211/002235702760345464 – volume: 26 start-page: 853 issue: 10 year: 1991 ident: 10.1016/j.carbpol.2018.08.071_bib0140 article-title: Lipid hydroperoxide measurement by oxidation of Fe2+in the presence of xylenol orange. Comparison with the TBA assay and an iodometric method publication-title: Lipids doi: 10.1007/BF02536169 – volume: 68 start-page: 365 issue: 3 year: 2014 ident: 10.1016/j.carbpol.2018.08.071_bib0065 article-title: Evaluation of the effects of methotrexate released from polymeric implants in solid Ehrlich tumor publication-title: Biomedecine & Pharmacotherapy doi: 10.1016/j.biopha.2013.12.012 – volume: 249 start-page: 7130 year: 1974 ident: 10.1016/j.carbpol.2018.08.071_bib0130 article-title: Glutathione S-transferases: the first enzymatic step in mercapturic acid formation publication-title: The Journal of Biological Chemistry doi: 10.1016/S0021-9258(19)42083-8 – volume: 57 start-page: 454 issue: 5 year: 2008 ident: 10.1016/j.carbpol.2018.08.071_bib0235 article-title: Identification of Inonotus obliquus and analysis of antioxidation and antitumor activities of polysaccharides publication-title: Current Microbiology doi: 10.1007/s00284-008-9233-6 – volume: 160 start-page: 123 year: 2017 ident: 10.1016/j.carbpol.2018.08.071_bib0240 article-title: Necroptosis mediates the antineoplastic effects of the soluble fraction of polysaccharide from red wine in Walker-256 tumor-bearing rats publication-title: Carbohydrate Polymers doi: 10.1016/j.carbpol.2016.12.047 – volume: 25 start-page: 192 year: 1968 ident: 10.1016/j.carbpol.2018.08.071_bib0005 article-title: Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman’s reagent publication-title: Analytical Biochemistry doi: 10.1016/0003-2697(68)90092-4 – volume: 9 start-page: 1 issue: 1 year: 2007 ident: 10.1016/j.carbpol.2018.08.071_bib0080 article-title: Hormone receptor status, tumor characteristics, and prognosis: A prospective cohort of breast cancer patients publication-title: Breast Cancer Research doi: 10.1186/bcr1639 – year: 2018 ident: 10.1016/j.carbpol.2018.08.071_bib0090 article-title: Antitumor activity and underlying mechanism of Sargassum fusiforme polysaccharides in CNE-bearing mice publication-title: International Journal of Biological Macromolecules doi: 10.1016/j.ijbiomac.2018.01.168 |
| SSID | ssj0000610 |
| Score | 2.4340787 |
| Snippet | [Display omitted]
•The polysaccharides from green sweet pepper (CAP) presented antineoplastic effects against mammary tumor lineages.•CAP treatment reduced the... The present study investigated the antineoplastic effects of pectic polysaccharides that were extracted from green sweet pepper (Capsicum annuum [CAP]) in the... |
| SourceID | proquest pubmed crossref elsevier |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 280 |
| SubjectTerms | angiogenesis Animals Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology breast neoplasms Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Breast Neoplasms - pathology Capsicum - chemistry Capsicum annuum carcinoma Carcinoma, Ehrlich Tumor - drug therapy Carcinoma, Ehrlich Tumor - metabolism Carcinoma, Ehrlich Tumor - pathology Drug Screening Assays, Antitumor Ehrlich solid tumor epithelial cells Female females Green sweet pepper Humans inflammation Interleukin-6 laboratory animals mammary glands mammary neoplasms (animal) Mammary Neoplasms, Experimental - drug therapy Mammary Neoplasms, Experimental - metabolism Mammary tumor cells MCF-7 Cells methotrexate Mice necrosis neoplasm cells Pectic polysaccharide pectins Pectins - chemistry Pectins - isolation & purification Pectins - pharmacology sweet peppers vascular endothelial growth factors VEGF viability |
| Title | Antineoplastic effect of pectic polysaccharides from green sweet pepper (Capsicum annuum) on mammary tumor cells in vivo and in vitro |
| URI | https://dx.doi.org/10.1016/j.carbpol.2018.08.071 https://www.ncbi.nlm.nih.gov/pubmed/30241820 https://www.proquest.com/docview/2111149576 https://www.proquest.com/docview/2131885133 |
| Volume | 201 |
| WOSCitedRecordID | wos000445030100030&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVESC databaseName: Elsevier SD Freedom Collection Journals 2021 customDbUrl: eissn: 1879-1344 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000610 issn: 0144-8617 databaseCode: AIEXJ dateStart: 19950101 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lj9MwELa6uwj2gnhTHisjcQBVWZpXnRyrahEgsSBUpN4ix3YhqzaJ2qTscuef8cOYsZ20BcrCgUsUJbab5Ps6nrHnQchTP1BeKkOwToIwdQJXpCAHwUqZgnYuUyFACTHFJtjpaTSZxO87ne9NLMxqxvI8Oj-Py_8KNVwDsDF09h_gbgeFC3AOoMMRYIfjXwE_xNoP6BfOMQWzddjQjs0o2wSWZbhYcoHhVplUSxNg8gndb3rLL7hDXaqyxAQTXjTiJYCI7st5XmNB5Bj3FuZcx7v1qnpeLHq48q99alfZqrC5nOC8WhSbeu-IL9Li84XExBT6CeZqvY00lHyeWR8znnOA_CsuzLfbIwUYBXpBd8ZroHPvQ1a1k8kYdwucdzMQ2pkumYTu17h203tb61jjrPUwgqu53BrI5FDYWvlwow0vEmWkdcRix_VNAslGnHu2iRXIpk7ULxOFWbM4Oxbw-vDW6OMX6VyupiDMBk_KuSaKD8oMJrtfz5utN2Nza48ceCyMQbYeDF-fTN5saARufx099uK3v3pIrjbj7FKRdplAWhUa3yDXrQ1Dh4Z7N0lH5bfItVFTOvA2-bbNQWo4SIspNRykP3GQIgep5iDVHKSGg_RZw0BqGPicFjm1_KOaf1Tzj2Y5Rf5BM2nOgX93yMeXJ-PRK8fW-3AEKO2VE3LFUp72YwmT7iAV01QyLgOUGL7n8xAslQGPB9PAZYIJqUC9jaUHD4tb3_2B8u-S_bzI1X1CZYS2v8-x_EIgFYwkQA8PpyqSzFMu75Kg-cSJsMnwsSbLLGm8Hs8SC1KCICVYq5W5XXLcditNNpjLOkQNfolVaY2qmgARL-v6pME7Afjwa3JArl4mHqo5QRyywZ_awGQdYfGmLrlnyNI-ccOzBzvvPCSH6z_cI7JfLWr1mFwRqypbLo7IHptER5bkPwDiG-Yd |
| linkProvider | Elsevier |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Antineoplastic+effect+of+pectic+polysaccharides+from+green+sweet+pepper+%28Capsicum+annuum%29+on+mammary+tumor+cells+in+vivo+and+in+vitro&rft.jtitle=Carbohydrate+polymers&rft.au=Adami%2C+Eliana+Rezende&rft.au=Corso%2C+Claudia+Rita&rft.au=Turin-Oliveira%2C+Natalia+Mulinari&rft.au=Galindo%2C+Claudia+Martins&rft.date=2018-12-01&rft.eissn=1879-1344&rft.volume=201&rft.spage=280&rft_id=info:doi/10.1016%2Fj.carbpol.2018.08.071&rft_id=info%3Apmid%2F30241820&rft.externalDocID=30241820 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0144-8617&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0144-8617&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0144-8617&client=summon |