Sensing mitochondrial DNA stress in cardiotoxicity

Cytoplasmic mitochondrial DNA (mtDNA) can trigger the interferon response to promote disease progression, but mtDNA sensing mechanisms remain elusive. Lei et al. have shown that Z-DNA binding protein1 (ZBP1) cooperates with cyclic GMP-AMP synthase (cGAS) to sense Z-form mtDNA and transmit mtDNA stre...

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Bibliographic Details
Published in:Trends in endocrinology and metabolism Vol. 34; no. 11; pp. 688 - 690
Main Authors: Ding, Yang-Nan, Tang, Xiaoqiang
Format: Journal Article
Language:English
Published: Elsevier Ltd 01.11.2023
Subjects:
cardiotoxicity
cGAS
Endocrinology and Metabolism
mtDNA
Z-DNA
ZBP1
ZBP1
cGAS
cardiotoxicity
mtDNA
Z-DNA
ISSN:1043-2760, 1879-3061, 1879-3061
Online Access:Get full text
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Summary:Cytoplasmic mitochondrial DNA (mtDNA) can trigger the interferon response to promote disease progression, but mtDNA sensing mechanisms remain elusive. Lei et al. have shown that Z-DNA binding protein1 (ZBP1) cooperates with cyclic GMP-AMP synthase (cGAS) to sense Z-form mtDNA and transmit mtDNA stress signals to promote diseases such as cardiotoxicity, providing an important piece of the mtDNA stress landscape. Cytoplasmic mitochondrial DNA (mtDNA) can trigger the interferon response to promote disease progression, but mtDNA sensing mechanisms remain elusive. Lei et al. have shown that Z-DNA binding protein1 (ZBP1) cooperates with cyclic GMP-AMP synthase (cGAS) to sense Z-form mtDNA and transmit mtDNA stress signals to promote diseases such as cardiotoxicity, providing an important piece of the mtDNA stress landscape.
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ISSN:1043-2760
1879-3061
1879-3061
DOI:10.1016/j.tem.2023.08.012