Sensing mitochondrial DNA stress in cardiotoxicity

Cytoplasmic mitochondrial DNA (mtDNA) can trigger the interferon response to promote disease progression, but mtDNA sensing mechanisms remain elusive. Lei et al. have shown that Z-DNA binding protein1 (ZBP1) cooperates with cyclic GMP-AMP synthase (cGAS) to sense Z-form mtDNA and transmit mtDNA stre...

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Veröffentlicht in:Trends in endocrinology and metabolism Jg. 34; H. 11; S. 688 - 690
Hauptverfasser: Ding, Yang-Nan, Tang, Xiaoqiang
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Elsevier Ltd 01.11.2023
Schlagworte:
cardiotoxicity
cGAS
Endocrinology and Metabolism
mtDNA
Z-DNA
ZBP1
ZBP1
cGAS
cardiotoxicity
mtDNA
Z-DNA
ISSN:1043-2760, 1879-3061, 1879-3061
Online-Zugang:Volltext
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Zusammenfassung:Cytoplasmic mitochondrial DNA (mtDNA) can trigger the interferon response to promote disease progression, but mtDNA sensing mechanisms remain elusive. Lei et al. have shown that Z-DNA binding protein1 (ZBP1) cooperates with cyclic GMP-AMP synthase (cGAS) to sense Z-form mtDNA and transmit mtDNA stress signals to promote diseases such as cardiotoxicity, providing an important piece of the mtDNA stress landscape. Cytoplasmic mitochondrial DNA (mtDNA) can trigger the interferon response to promote disease progression, but mtDNA sensing mechanisms remain elusive. Lei et al. have shown that Z-DNA binding protein1 (ZBP1) cooperates with cyclic GMP-AMP synthase (cGAS) to sense Z-form mtDNA and transmit mtDNA stress signals to promote diseases such as cardiotoxicity, providing an important piece of the mtDNA stress landscape.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1043-2760
1879-3061
1879-3061
DOI:10.1016/j.tem.2023.08.012