Clinical and Treatment Considerations for the Pediatric and Aging Patients with Multiple Sclerosis
Chronologic aging is associated with multiple pathologic and immunologic changes that impact the clinical course of multiple sclerosis (MS). Clinical phenotypes evolve across the lifespan, from a highly inflammatory course in the very young to a predominantly neurodegenerative phenotype in older pat...
Gespeichert in:
| Veröffentlicht in: | Neurologic clinics Jg. 42; H. 1; S. 255 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Journal Article |
| Sprache: | Englisch |
| Veröffentlicht: |
01.02.2024
|
| ISSN: | 1557-9875, 1557-9875 |
| Online-Zugang: | Weitere Angaben |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| Abstract | Chronologic aging is associated with multiple pathologic and immunologic changes that impact the clinical course of multiple sclerosis (MS). Clinical phenotypes evolve across the lifespan, from a highly inflammatory course in the very young to a predominantly neurodegenerative phenotype in older patients. Thus, unique clinical considerations arise for the diagnosis and management of the two age extremes of pediatric and geriatric MS populations. This review covers epidemiology, diagnosis, and treatment strategies for these populations with nuanced discussions on therapeutic approaches to effectively care for patients living with MS at critical transition points during their lifespan.Chronologic aging is associated with multiple pathologic and immunologic changes that impact the clinical course of multiple sclerosis (MS). Clinical phenotypes evolve across the lifespan, from a highly inflammatory course in the very young to a predominantly neurodegenerative phenotype in older patients. Thus, unique clinical considerations arise for the diagnosis and management of the two age extremes of pediatric and geriatric MS populations. This review covers epidemiology, diagnosis, and treatment strategies for these populations with nuanced discussions on therapeutic approaches to effectively care for patients living with MS at critical transition points during their lifespan. |
|---|---|
| AbstractList | Chronologic aging is associated with multiple pathologic and immunologic changes that impact the clinical course of multiple sclerosis (MS). Clinical phenotypes evolve across the lifespan, from a highly inflammatory course in the very young to a predominantly neurodegenerative phenotype in older patients. Thus, unique clinical considerations arise for the diagnosis and management of the two age extremes of pediatric and geriatric MS populations. This review covers epidemiology, diagnosis, and treatment strategies for these populations with nuanced discussions on therapeutic approaches to effectively care for patients living with MS at critical transition points during their lifespan.Chronologic aging is associated with multiple pathologic and immunologic changes that impact the clinical course of multiple sclerosis (MS). Clinical phenotypes evolve across the lifespan, from a highly inflammatory course in the very young to a predominantly neurodegenerative phenotype in older patients. Thus, unique clinical considerations arise for the diagnosis and management of the two age extremes of pediatric and geriatric MS populations. This review covers epidemiology, diagnosis, and treatment strategies for these populations with nuanced discussions on therapeutic approaches to effectively care for patients living with MS at critical transition points during their lifespan. |
| Author | Hua, Le H Graves, Jennifer S Yang, Jennifer H Siddiqui, Areeba |
| Author_xml | – sequence: 1 givenname: Areeba surname: Siddiqui fullname: Siddiqui, Areeba – sequence: 2 givenname: Jennifer H surname: Yang fullname: Yang, Jennifer H – sequence: 3 givenname: Le H surname: Hua fullname: Hua, Le H – sequence: 4 givenname: Jennifer S surname: Graves fullname: Graves, Jennifer S |
| BookMark | eNpNjMtOwzAURC1UJNrCB7Dzkk2C73UcO8sq4iUVUYmyrpzYaV25Tokd8ftEwILVHI3OzILMQh8sIbfAcmBQ3h_z0PocGfKcyZwxfkHmIITMKiXF7B9fkUWMR8ZAAONz0tTeBddqT3UwdDtYnU42JFr3ITpjB53cRLTrB5oOlm6scToNrv3RV3sX9nQzOdMk0i-XDvR19MmdvaXvrbdDH128Jped9tHe_OWSfDw-bOvnbP329FKv1llbcJEywSQvK6N1U3KDHVQoheHaQMEt8kIhCATFm2JqlQZUnVKSNaJEBhobjkty9_t7HvrP0ca0O7nYWu91sP0Yd6gqkIIDk_gNEExbAQ |
| CitedBy_id | crossref_primary_10_1016_j_msard_2024_106162 crossref_primary_10_1016_j_neurot_2025_e00603 |
| ContentType | Journal Article |
| Copyright | Copyright © 2023 Elsevier Inc. All rights reserved. |
| Copyright_xml | – notice: Copyright © 2023 Elsevier Inc. All rights reserved. |
| DBID | 7X8 |
| DOI | 10.1016/j.ncl.2023.07.003 |
| DatabaseName | MEDLINE - Academic |
| DatabaseTitle | MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | no_fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1557-9875 |
| GroupedDBID | --- -RU .1- .FO 0R~ 123 1P~ 34G 39C 4.4 457 53G 5RE 7X8 AAEDT AAEDW AALRI AAWTL AAXUO ABCQX ABFRF ABIVO ABJNI ABQZK ABTEW ACGFO ACGFS ADBBV AEFWE AENEX AEVXI AFRHN AFTJW AJUYK ALMA_UNASSIGNED_HOLDINGS AMRAJ AXIYT B08 COIAO CS3 DAHGL DU5 EBS EX3 F5P FDB L7B O9- OP~ P2P SEL SES TWZ UNMZH WH7 WOW Z5R |
| ID | FETCH-LOGICAL-c435t-507369daab63d2f19275d3ad143e23482152183b45d38a128f8870b56201a2b32 |
| IEDL.DBID | 7X8 |
| ISICitedReferencesCount | 2 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=001165553500001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1557-9875 |
| IngestDate | Wed Oct 01 17:07:09 EDT 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c435t-507369daab63d2f19275d3ad143e23482152183b45d38a128f8870b56201a2b32 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 |
| PQID | 2891753107 |
| PQPubID | 23479 |
| ParticipantIDs | proquest_miscellaneous_2891753107 |
| PublicationCentury | 2000 |
| PublicationDate | 2024-02-01 |
| PublicationDateYYYYMMDD | 2024-02-01 |
| PublicationDate_xml | – month: 02 year: 2024 text: 2024-02-01 day: 01 |
| PublicationDecade | 2020 |
| PublicationTitle | Neurologic clinics |
| PublicationYear | 2024 |
| SSID | ssj0015103 |
| Score | 2.3880272 |
| SecondaryResourceType | review_article |
| Snippet | Chronologic aging is associated with multiple pathologic and immunologic changes that impact the clinical course of multiple sclerosis (MS). Clinical... |
| SourceID | proquest |
| SourceType | Aggregation Database |
| StartPage | 255 |
| Title | Clinical and Treatment Considerations for the Pediatric and Aging Patients with Multiple Sclerosis |
| URI | https://www.proquest.com/docview/2891753107 |
| Volume | 42 |
| WOSCitedRecordID | wos001165553500001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1LSwMxEB7UinjxLb6J4DW4bvZ5kiIWD7YUrLC3kicUZGvd6u93Jpu1eBO8LoENyWTmmwffB3DjSouBTRpeEANhgjGGK6NKXkqXamcjfFKeMv85H42KqirHoeDWhLHKzid6R23mmmrkt5gYEKkkZiv37wtOqlHUXQ0SGuvQEwhlyKrzatVFILY4z5ea5hxz67Travr5rlpT5yEWnrvTa2b99sU-wAx2_7u1PdgJ0JL1W1vYhzVbH8DWMDTPD0EFDtA3JmvDJt2EOes0O9vaHUMUyxAVsh8RD7-8T2JGbNyysDaMyrdsGIYR2Qv-D6PtrDmC18Hj5OGJB4kFrhEnLTmiQZGVRkqVCRM7hHt5aoQ0iKJsTLw3FN4LoRL8WkiMZQ6dUqQQNEV3MlYiPoaNel7bE2BOW43ZXY4XnKFjkCpNVBGblISQbFFmp3Ddnd4UTZj6ErK2889mujq_sz-sOYdtvLaknZy-gJ7DZ2ovYVN_LWfNx5W3gG_t67pF |
| linkProvider | ProQuest |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Clinical+and+Treatment+Considerations+for+the+Pediatric+and+Aging+Patients+with+Multiple+Sclerosis&rft.jtitle=Neurologic+clinics&rft.au=Siddiqui%2C+Areeba&rft.au=Yang%2C+Jennifer+H&rft.au=Hua%2C+Le+H&rft.au=Graves%2C+Jennifer+S&rft.date=2024-02-01&rft.issn=1557-9875&rft.eissn=1557-9875&rft.volume=42&rft.issue=1&rft.spage=255&rft_id=info:doi/10.1016%2Fj.ncl.2023.07.003&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1557-9875&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1557-9875&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1557-9875&client=summon |