An in vitro platform for characterizing axonal electrophysiology of individual human iPSC-derived nociceptors

Neuropathic pain is characterized by aberrant activity of specific nociceptor populations, as demonstrated through functional assessments such as microneurography. Current treatments against severe forms of neuropathic pain demonstrate insufficient efficacy or lead to unwanted side effects as they f...

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Bibliographic Details
Published in:	Biosensors & bioelectronics Vol. 281; p. 117418
Main Authors:	Clément, Blandine F., Petrella, Lorenzo, Wallimann, Lea, Duru, Jens, Tringides, Christina M., Vörös, János, Ruff, Tobias
Format:	Journal Article
Language:	English
Published:	England Elsevier B.V 01.08.2025
Subjects:	Activity-dependent slowing agonists Axonal conduction axons Axons - drug effects Axons - physiology Biosensing Techniques - instrumentation biosensors capsaicin Capsaicin - pharmacology Cells, Cultured CMOS-based microelectrode array Electrophysiological Phenomena electrophysiology Equipment Design Human iPSC-derived sensory neurons Humans In vitro model Induced Pluripotent Stem Cells - cytology Microelectrodes microstructure Nociception Nociceptors - cytology Nociceptors - drug effects Nociceptors - physiology pain PDMS microstructures polydimethylsiloxane sensory neurons sowing therapeutics transient receptor potential vanilloid channels TRPV Cation Channels - agonists Nociception Human iPSC-derived sensory neurons Axonal conduction CMOS-based microelectrode array In vitro model Activity-dependent slowing PDMS microstructures
ISSN:	0956-5663, 1873-4235, 1873-4235
Online Access:	Get full text
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