Diagnostic potential and future directions of biomarkers in gingival crevicular fluid and saliva of periodontal diseases: Review of the current evidence

•Oral biomarkers can be used as an adjunctive method for diagnosis & monitoring of periodontal disease progression.•No clinical or laboratory test is routinely employed in monitoring patients with periodontal disease.•High-quality research designs targeting sensitivity & specificity are stil...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	Archives of oral biology Ročník 87; s. 115 - 124
Hlavní autor:	Ghallab, Noha Ayman
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	England Elsevier Ltd 01.03.2018
Témata:	Biomarkers Biomarkers - analysis Disease Progression GCF Gingival Crevicular Fluid - chemistry Humans Periodontal disease Periodontal Diseases - diagnosis Proteomics - trends Saliva Saliva - chemistry Sensitivity and Specificity Biomarkers Periodontal disease GCF Saliva
ISSN:	0003-9969, 1879-1506, 1879-1506
On-line přístup:	Získat plný text
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Abstract	•Oral biomarkers can be used as an adjunctive method for diagnosis & monitoring of periodontal disease progression.•No clinical or laboratory test is routinely employed in monitoring patients with periodontal disease.•High-quality research designs targeting sensitivity & specificity are still warranted to recognize GCF & salivary biomarkers with the clinical utility to identify current & future periodontal disease activity.•Future developments in proteomic analysis will pave the way for providing individual “signatures” for risk of periodontal disease. The holy grail of biomarker research in periodontology is to develop a high impact diagnostics which have a significant impact on clinical decision-making, patient outcomes and healthcare providers. In the field of periodontal diagnostics, oral fluid-based biomarkers have been studied mainly in the gingival crevicular fluid (GCF) and saliva. A literature search was performed using the Cochrane library and PubMed databases from 2000 to January 2017. Currently, there are more than 90 different components in the GCF that have been investigated as diagnostic and prognostic markers of periodontal disease progression involving; inflammatory mediators, markers of oxidative stress, host-derived enzymes, tissue-breakdown products and mediators of bone homeostasis. Furthermore, various biomarkers in saliva have been proposed which reveal a promising outlook for saliva as a key diagnostic medium for periodontal disease. Recent systematic reviews with high value of evidence have shown that potential salivary biomarkers can provide important complimentary diagnostic information and can be used as tests for screening diagnosis, prognosis and predicting periodontal disease progression. Future developments in proteomic analysis and personalized medicine will pave the way allowing novel diagnostic tools. Still, the application into the field of dentistry will depend on how practitioners will apply this into their daily clinical practice. Still, the application into the field of dentistry will depend on how practitioners will apply this into their daily clinical practice.
AbstractList	•Oral biomarkers can be used as an adjunctive method for diagnosis & monitoring of periodontal disease progression.•No clinical or laboratory test is routinely employed in monitoring patients with periodontal disease.•High-quality research designs targeting sensitivity & specificity are still warranted to recognize GCF & salivary biomarkers with the clinical utility to identify current & future periodontal disease activity.•Future developments in proteomic analysis will pave the way for providing individual “signatures” for risk of periodontal disease. The holy grail of biomarker research in periodontology is to develop a high impact diagnostics which have a significant impact on clinical decision-making, patient outcomes and healthcare providers. In the field of periodontal diagnostics, oral fluid-based biomarkers have been studied mainly in the gingival crevicular fluid (GCF) and saliva. A literature search was performed using the Cochrane library and PubMed databases from 2000 to January 2017. Currently, there are more than 90 different components in the GCF that have been investigated as diagnostic and prognostic markers of periodontal disease progression involving; inflammatory mediators, markers of oxidative stress, host-derived enzymes, tissue-breakdown products and mediators of bone homeostasis. Furthermore, various biomarkers in saliva have been proposed which reveal a promising outlook for saliva as a key diagnostic medium for periodontal disease. Recent systematic reviews with high value of evidence have shown that potential salivary biomarkers can provide important complimentary diagnostic information and can be used as tests for screening diagnosis, prognosis and predicting periodontal disease progression. Future developments in proteomic analysis and personalized medicine will pave the way allowing novel diagnostic tools. Still, the application into the field of dentistry will depend on how practitioners will apply this into their daily clinical practice. Still, the application into the field of dentistry will depend on how practitioners will apply this into their daily clinical practice. The holy grail of biomarker research in periodontology is to develop a high impact diagnostics which have a significant impact on clinical decision-making, patient outcomes and healthcare providers. In the field of periodontal diagnostics, oral fluid-based biomarkers have been studied mainly in the gingival crevicular fluid (GCF) and saliva. A literature search was performed using the Cochrane library and PubMed databases from 2000 to January 2017. Currently, there are more than 90 different components in the GCF that have been investigated as diagnostic and prognostic markers of periodontal disease progression involving; inflammatory mediators, markers of oxidative stress, host-derived enzymes, tissue-breakdown products and mediators of bone homeostasis. Furthermore, various biomarkers in saliva have been proposed which reveal a promising outlook for saliva as a key diagnostic medium for periodontal disease. Recent systematic reviews with high value of evidence have shown that potential salivary biomarkers can provide important complimentary diagnostic information and can be used as tests for screening diagnosis, prognosis and predicting periodontal disease progression. Future developments in proteomic analysis and personalized medicine will pave the way allowing novel diagnostic tools. Still, the application into the field of dentistry will depend on how practitioners will apply this into their daily clinical practice. Still, the application into the field of dentistry will depend on how practitioners will apply this into their daily clinical practice. The holy grail of biomarker research in periodontology is to develop a high impact diagnostics which have a significant impact on clinical decision-making, patient outcomes and healthcare providers. In the field of periodontal diagnostics, oral fluid-based biomarkers have been studied mainly in the gingival crevicular fluid (GCF) and saliva.OBJECTIVESThe holy grail of biomarker research in periodontology is to develop a high impact diagnostics which have a significant impact on clinical decision-making, patient outcomes and healthcare providers. In the field of periodontal diagnostics, oral fluid-based biomarkers have been studied mainly in the gingival crevicular fluid (GCF) and saliva.A literature search was performed using the Cochrane library and PubMed databases from 2000 to January 2017.METHODSA literature search was performed using the Cochrane library and PubMed databases from 2000 to January 2017.Currently, there are more than 90 different components in the GCF that have been investigated as diagnostic and prognostic markers of periodontal disease progression involving; inflammatory mediators, markers of oxidative stress, host-derived enzymes, tissue-breakdown products and mediators of bone homeostasis. Furthermore, various biomarkers in saliva have been proposed which reveal a promising outlook for saliva as a key diagnostic medium for periodontal disease. Recent systematic reviews with high value of evidence have shown that potential salivary biomarkers can provide important complimentary diagnostic information and can be used as tests for screening diagnosis, prognosis and predicting periodontal disease progression.RESULTSCurrently, there are more than 90 different components in the GCF that have been investigated as diagnostic and prognostic markers of periodontal disease progression involving; inflammatory mediators, markers of oxidative stress, host-derived enzymes, tissue-breakdown products and mediators of bone homeostasis. Furthermore, various biomarkers in saliva have been proposed which reveal a promising outlook for saliva as a key diagnostic medium for periodontal disease. Recent systematic reviews with high value of evidence have shown that potential salivary biomarkers can provide important complimentary diagnostic information and can be used as tests for screening diagnosis, prognosis and predicting periodontal disease progression.Future developments in proteomic analysis and personalized medicine will pave the way allowing novel diagnostic tools. Still, the application into the field of dentistry will depend on how practitioners will apply this into their daily clinical practice.CONCLUSIONFuture developments in proteomic analysis and personalized medicine will pave the way allowing novel diagnostic tools. Still, the application into the field of dentistry will depend on how practitioners will apply this into their daily clinical practice.Still, the application into the field of dentistry will depend on how practitioners will apply this into their daily clinical practice.CLINICAL RELEVANCEStill, the application into the field of dentistry will depend on how practitioners will apply this into their daily clinical practice.
Author	Ghallab, Noha Ayman
Author_xml	– sequence: 1 givenname: Noha Ayman surname: Ghallab fullname: Ghallab, Noha Ayman email: noha.ghallab@dentistry.cu.edu.eg organization: Periodontology and Oral Medicine, Faculty of Dentistry, Cairo University, Egypt
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/29288920$$D View this record in MEDLINE/PubMed
BookMark	eNqNkc1uFDEQhC0URDaBV0DmxmUmtuefC4qWnyBFQkJwtjx2z6Y3XnuxPYnyJjwuHjYglNOe3LarvpaqzsiJ8w4IecNZyRlvL7alCvrGB2VH9KVgvCu5KJkQz8iK991Q8Ia1J2TFGKuKYWiHU3IW4zZfm7blL8ipGETfD4KtyK8PqDbOx4Sa7n0Cl1BZqpyh05zmANRgAJ3Qu0j9RPO-nQq3ECJFRzfoNniX9TrAHerZqkAnO6P5A4jK5s_FtYeA3niXstRgBBUhvqPfsgful_90A1TPIeTtND8acBpekueTshFePZ7n5Menj9_XV8X1189f1pfXha6rJhUVH7uOi3GCKQ9dN01VB0oJgEZ09Tg1PReKtUPPdd0Yzau2aro-j60wldFNdU7eHrj74H_OEJPcYdRgrXLg5yj50Iu-5nVdZ-nrR-k87sDIfcAcxoP8m2YWDAeBDj7GANM_CWdyaU5u5X_NyaU5yYXMzWXv-ydejUktwaeg0B5FWB8IkOPK0QYZNS5RHiqUxuNRlMsnFG3RoVb2Fh6OZPwGQGrWxQ
CitedBy_id	crossref_primary_10_3390_ijerph192114085 crossref_primary_10_1002_JPER_24_0715 crossref_primary_10_1016_j_jdent_2022_104065 crossref_primary_10_1111_jcpe_13202 crossref_primary_10_1016_j_cca_2019_04_076 crossref_primary_10_3390_medicina60122004 crossref_primary_10_1111_jcpe_13285 crossref_primary_10_1007_s00784_023_05484_3 crossref_primary_10_3390_ijms24020959 crossref_primary_10_3389_fimmu_2025_1590665 crossref_primary_10_3390_diagnostics12040919 crossref_primary_10_2147_JIR_S448963 crossref_primary_10_1002_JPER_18_0412 crossref_primary_10_1186_s12903_023_03023_w crossref_primary_10_3390_biomedicines8110515 crossref_primary_10_3390_ijms25158401 crossref_primary_10_1080_14789450_2020_1858056 crossref_primary_10_1111_jcpe_13854 crossref_primary_10_1111_jcpe_13173 crossref_primary_10_3390_dj9060073 crossref_primary_10_1002_JPER_21_0494 crossref_primary_10_29254_2077_4214_2022_2_1_164_46_54 crossref_primary_10_36377_1683_2981_2023_21_1_42_48 crossref_primary_10_1177_00033197221134757 crossref_primary_10_1186_s12903_021_01743_5 crossref_primary_10_1111_clr_13725 crossref_primary_10_1155_2021_1796204 crossref_primary_10_3390_ijms241512207 crossref_primary_10_2147_CCIDE_S362801 crossref_primary_10_3389_fphys_2021_798682 crossref_primary_10_1016_j_jprot_2018_07_019 crossref_primary_10_3390_membranes12070655 crossref_primary_10_1016_j_jobcr_2025_03_022 crossref_primary_10_3389_fmed_2023_1168625 crossref_primary_10_1016_j_cyto_2018_10_021 crossref_primary_10_1007_s13205_023_03572_5 crossref_primary_10_1111_prd_12595 crossref_primary_10_3390_diagnostics11060932 crossref_primary_10_1186_s12903_020_01246_9 crossref_primary_10_1016_j_archoralbio_2018_04_018 crossref_primary_10_1007_s00520_021_06194_w crossref_primary_10_2174_0109298673323591240923051742 crossref_primary_10_3390_ijms252312559 crossref_primary_10_1155_2022_8629680 crossref_primary_10_3390_life12040501 crossref_primary_10_3390_jcm9061720 crossref_primary_10_1016_j_archoralbio_2018_11_001 crossref_primary_10_1080_10408363_2021_1907298 crossref_primary_10_3390_diagnostics14192184 crossref_primary_10_3390_ijms232213939 crossref_primary_10_36377_1683_2981_2022_20_1_64_71 crossref_primary_10_3389_froh_2024_1434217 crossref_primary_10_3389_fnins_2021_668852 crossref_primary_10_3390_molecules26051208 crossref_primary_10_1016_j_drugalcdep_2019_06_013 crossref_primary_10_3390_app142412004 crossref_primary_10_3390_molecules28031075 crossref_primary_10_1111_jcpe_13896 crossref_primary_10_1186_s13005_023_00359_0 crossref_primary_10_1186_s12903_024_04299_2 crossref_primary_10_1111_jcpe_13099 crossref_primary_10_17656_sdj_10114 crossref_primary_10_1111_ocr_12687 crossref_primary_10_3390_jpm15090440 crossref_primary_10_4103_ijdr_ijdr_62_23 crossref_primary_10_1016_j_archoralbio_2024_106116 crossref_primary_10_1016_j_bbih_2019_100014 crossref_primary_10_1002_app_51432 crossref_primary_10_1080_1354750X_2021_1875506 crossref_primary_10_1016_j_archoralbio_2020_104949 crossref_primary_10_1016_j_genrep_2023_101845 crossref_primary_10_1111_jcpe_12930 crossref_primary_10_1111_jre_13166 crossref_primary_10_33808_clinexphealthsci_1050418 crossref_primary_10_1111_jre_13164 crossref_primary_10_1186_s12903_023_03383_3 crossref_primary_10_3390_antiox10111741 crossref_primary_10_1111_jcpe_13188 crossref_primary_10_1371_journal_pone_0230334 crossref_primary_10_1038_s41432_024_01070_y crossref_primary_10_1016_j_ortho_2025_101017 crossref_primary_10_3390_jcm10071488 crossref_primary_10_1111_odi_14686 crossref_primary_10_1155_2021_9967311 crossref_primary_10_3390_jcm12031003 crossref_primary_10_4103_jisp_jisp_511_23 crossref_primary_10_1111_jcpe_13630 crossref_primary_10_1002_bip_23573 crossref_primary_10_4103_jomfp_jomfp_170_23 crossref_primary_10_1016_j_archoralbio_2020_104955 crossref_primary_10_1016_j_snb_2021_129673 crossref_primary_10_1155_2021_9198249 crossref_primary_10_1186_s12951_023_02277_4 crossref_primary_10_1186_s40001_025_02891_y crossref_primary_10_7759_cureus_50654 crossref_primary_10_1016_j_jds_2022_04_031 crossref_primary_10_1111_cid_70002 crossref_primary_10_1016_j_archoralbio_2024_105880 crossref_primary_10_1016_j_etap_2018_05_016 crossref_primary_10_3389_fcimb_2022_933833 crossref_primary_10_3390_diagnostics14242878
Cites_doi	10.1111/jcpe.12194 10.1111/j.1600-0757.2005.00129.x 10.1111/jre.12088 10.1016/j.archoralbio.2014.03.012 10.1111/jcpe.12557 10.1016/j.archoralbio.2016.08.020 10.3389/fcimb.2015.00065 10.1111/j.1600-0757.2009.00319.x 10.2217/bmm.09.68 10.1155/2014/146974 10.1111/j.1600-051X.2010.01670.x 10.1155/2012/828049 10.1111/prd.12117 10.1111/prd.12006 10.1196/annals.1384.004 10.1111/j.1600-0757.2008.00288.x 10.1111/prd.12002 10.1155/2013/259273 10.1155/2011/512580 10.1111/adj.12294 10.1046/j.0906-6713.2002.003427.x 10.1111/odi.12261 10.1016/j.cyto.2014.02.007 10.14219/jada.archive.2006.0181 10.1902/jop.2016.150657 10.1111/prd.12011 10.1007/s10753-015-0176-3 10.1111/j.1600-051x.2004.00521.x 10.1902/jop.2010.090630 10.1111/jcpe.12037 10.1902/jop.2009.090397 10.1902/jop.2015.150293 10.1007/s00784-014-1216-3 10.1111/j.1749-6632.1993.tb18343.x 10.4103/0973-029X.92974 10.1196/annals.1384.035 10.1016/j.archoralbio.2009.08.007 10.1111/j.1600-051X.2008.01213.x 10.1177/0022034511399908 10.1902/jop.2014.130654 10.14219/jada.archive.2012.0341 10.1111/j.1600-051X.2007.01107.x 10.1111/jcpe.12479 10.1016/j.archoralbio.2016.08.016 10.1902/jop.2012.110616 10.1902/jop.2009.090327 10.4103/0970-9290.74226 10.1902/jop.2011.110420 10.1021/pr700764j 10.1034/j.1600-0757.2003.03103.x 10.1902/jop.2013.130092 10.4103/1305-7456.195179 10.14219/jada.archive.2013.0200 10.1111/jcpe.12012 10.1902/jop.2009.090510 10.1111/prd.12109 10.1111/j.1600-0765.2006.00948.x 10.1177/0022034516661142 10.1111/j.1834-7819.2009.01123.x 10.1902/jop.2009.080654 10.1111/prd.12107 10.1371/journal.pone.0075898 10.1111/j.1600-051X.2011.01805.x 10.1111/j.1600-051X.2011.01706.x 10.1021/pr900941z 10.1111/jcpe.12130 10.1111/j.1600-0757.2011.00437.x 10.1155/2014/593151 10.1111/j.1600-0757.2009.00315.x 10.1111/jre.12010 10.1902/jop.2009.080480 10.1111/j.1600-051X.2007.01061.x 10.1016/j.archoralbio.2011.09.011 10.1902/jop.2008.080139 10.1034/j.1600-051x.2000.027007453.x 10.1902/jop.2010.090643 10.1080/19424396.2013.12222285 10.1902/jop.2013.120595 10.1111/j.1600-051X.2010.01563.x 10.1902/jop.2013.130388 10.1902/jop.2015.150377 10.1902/jop.2014.140338 10.1590/S1806-83242012000700006 10.1111/jcpe.12223 10.1111/prd.12101 10.1007/s00784-014-1308-0 10.1111/j.1601-0825.2009.01610.x 10.1111/jicd.12072 10.1111/prd.12116 10.14219/jada.archive.2012.0339 10.1902/jop.2012.120195 10.2334/josnusd.57.67 10.1111/j.1600-051X.2011.01817.x 10.1111/prd.12103 10.1155/2013/803240 10.1373/clinchem.2005.051532 10.1111/j.1600-0765.2007.00968.x 10.1016/j.jobcr.2015.01.001 10.1177/154411130301400605 10.2334/josnusd.15-0731 10.1007/s00784-012-0801-6 10.1111/j.1600-0757.2006.00178.x 10.1038/nature13118 10.1016/j.cyto.2012.12.012 10.1111/j.1600-051X.2009.01525.x 10.1067/mcp.2001.113989 10.1155/2011/621484 10.1016/S0891-5849(02)00905-X 10.1111/prd.12113 10.1021/acs.analchem.5b03018 10.1902/jop.2010.100526 10.1902/jop.2015.140476 10.1007/s00784-014-1236-z
ContentType	Journal Article
Copyright	2017 Elsevier Ltd Copyright © 2017 Elsevier Ltd. All rights reserved.
Copyright_xml	– notice: 2017 Elsevier Ltd – notice: Copyright © 2017 Elsevier Ltd. All rights reserved.
DBID	AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8
DOI	10.1016/j.archoralbio.2017.12.022
DatabaseName	CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic
DatabaseTitleList	MEDLINE MEDLINE - Academic
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Zoology Dentistry
EISSN	1879-1506
EndPage	124
ExternalDocumentID	29288920 10_1016_j_archoralbio_2017_12_022 S0003996917304053
Genre	Journal Article Review
GroupedDBID	--- --K --M .1- .FO .GJ .~1 0R~ 1B1 1P~ 1RT 1~. 1~5 23N 4.4 457 4CK 4G. 53G 5GY 5RE 5VS 7-5 71M 8P~ 9JM AAEDT AAEDW AAGKA AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AATTM AAXKI AAXUO AAYWO ABBQC ABFNM ABJNI ABMAC ABMZM ABWVN ABXDB ACDAQ ACGFS ACIEU ACIUM ACLOT ACRLP ACRPL ACVFH ADBBV ADCNI ADEZE ADMUD ADNMO AEBSH AEIPS AEKER AENEX AEUPX AEVXI AFFNX AFJKZ AFPUW AFRHN AFTJW AFXIZ AGHFR AGQPQ AGUBO AGYEJ AHHHB AIEXJ AIGII AIIUN AIKHN AITUG AJRQY AJUYK AKBMS AKRWK AKYEP ALMA_UNASSIGNED_HOLDINGS AMRAJ ANKPU ANZVX APXCP ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC BNPGV CS3 EBS EFJIC EFKBS EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HDX HMK HMO HVGLF HZ~ IHE J1W KOM LH1 M29 M41 MO0 N9A O-L O9- OAUVE OB- OHT OM. OZT P-8 P-9 P2P PC. Q38 R2- ROL RPZ SAE SCC SDF SDG SDP SEL SES SEW SPCBC SSH SSZ T5K WUQ Z5R ZGI ~02 ~G- ~HD AACTN AAIAV ABLVK ABYKQ AFCTW AFKWA AJBFU AJOXV AMFUW LCYCR RIG 9DU AAYXX CITATION AGCQF AGRNS CGR CUY CVF ECM EIF NPM 7X8
ID	FETCH-LOGICAL-c435t-31b7712bfefb7777ff37eaa2ee5274bf5812a06981c45dc136357845d62d3dc53
ISICitedReferencesCount	116
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000427208700015&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	0003-9969 1879-1506
IngestDate	Sat Sep 27 22:06:23 EDT 2025 Mon Jul 21 06:05:34 EDT 2025 Sat Nov 29 07:29:42 EST 2025 Tue Nov 18 21:40:51 EST 2025 Fri Feb 23 02:47:55 EST 2024 Tue Oct 14 19:27:32 EDT 2025
IsPeerReviewed	true
IsScholarly	true
Keywords	Biomarkers Periodontal disease GCF Saliva
Language	English
License	Copyright © 2017 Elsevier Ltd. All rights reserved.
LinkModel	OpenURL
MergedId	FETCHMERGED-LOGICAL-c435t-31b7712bfefb7777ff37eaa2ee5274bf5812a06981c45dc136357845d62d3dc53
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23
PMID	29288920
PQID	1982841444
PQPubID	23479
PageCount	10
ParticipantIDs	proquest_miscellaneous_1982841444 pubmed_primary_29288920 crossref_primary_10_1016_j_archoralbio_2017_12_022 crossref_citationtrail_10_1016_j_archoralbio_2017_12_022 elsevier_sciencedirect_doi_10_1016_j_archoralbio_2017_12_022 elsevier_clinicalkey_doi_10_1016_j_archoralbio_2017_12_022
PublicationCentury	2000
PublicationDate	March 2018 2018-03-00 2018-Mar 20180301
PublicationDateYYYYMMDD	2018-03-01
PublicationDate_xml	– month: 03 year: 2018 text: March 2018
PublicationDecade	2010
PublicationPlace	England
PublicationPlace_xml	– name: England
PublicationTitle	Archives of oral biology
PublicationTitleAlternate	Arch Oral Biol
PublicationYear	2018
Publisher	Elsevier Ltd
Publisher_xml	– name: Elsevier Ltd
References	Denny, Hagen, Hardt, Liao, Yan, Arellanno (bib0140) 2008; 7 Oh, Hirano, Takai, Ogata (bib0400) 2015; 57 Baltacioglu, Yuva, Aydin, Alver, Kahraman, Karabulut (bib0050) 2014; 85 Zelko, Mariani, Folz (bib0590) 2002; 33 Wong (bib0580) 2012; 143 Griffiths (bib0200) 2003; 31 Kumari, Pradeep, Priyanka, Kalra, Naik (bib0330) 2014; 59 Almughrabi, Marzouk, Hasanato, Shafik (bib0010) 2013; 48 Wei, Zhang, Wang, Yang, Chen (bib0565) 2010; 55 Bostanci, Ilgenli, Emingil, Afacan, Han, Toz (bib0080) 2007; 34 Kuboniwa, Sakanaka, Hashino, Bamba, Fukusaki, Amano (bib0320) 2016 Sakallioglu, Sakallioglu, Lutfioglu, Pamuk, Kantarci (bib0460) 2015; 21 Herr, Hatch, Giannobile, Throckmorton, Tran, Brennan (bib0260) 2007; 1098 Wilkins, Pasquali, Appel, Ou, Golaz, Sanchez (bib0575) 1996; 14 Selvarajan, Perumalsamy, Emmadi, Thiagarajan, Namasivayam (bib0470) 2015; 9 Navazesh (bib0375) 1993; 694 Hernandez, Martinez, Tejerina, Valenzuela, Gamonal (bib0255) 2007; 34 Slots (bib0495) 2013; 62 Armitage (bib0030) 2013; 62 Hassan, El-Refai, Ghallab, Kasem, Shaker (bib0240) 2015 Zhang, Henson, Camargo, Wong (bib0595) 2009; 51 Gomez-Moreno, Guardia, Ferrera, Cutando, Reiter (bib0195) 2010; 16 Kim, Kim, Camargo (bib0295) 2013; 41 Akram, Rahim, Taiyeb-Ali, Shahdan, Baharuddin, Vaithilingam (bib0005) 2017; 73 Giannobile (bib0185) 2012; 143 Loos, Tjoa (bib0360) 2005; 39 Pradeep, Kathariya, Raghavendra, Sharma (bib0415) 2011; 82 Thomas, Branscum, Miller, Ebersole, Al-Sabbagh, Schuster (bib0535) 2009; 80 Miller, Foley, Bailey, Campell, Humphries, Christodoulides (bib0370) 2010; 4 Salazar, Jehmlich, Murr, Dhople, Holtfreter, Hammer (bib0465) 2013; 40 Rescala, Rosalem, Teles, Fischer, Haffajee, Socransky (bib0445) 2010; 81 Kwok, Caton, Polson, Hunter (bib0345) 2012; 59 Lequin (bib0355) 2005; 51 Romero, Mastromatteo-Alberga, Escalona, Correnti (bib0450) 2013; 54 Giannobile, Beikler, Kinney, Ramseier, Morelli, Wong (bib0175) 2009; 50 Proctor (bib0425) 2016; 70 Baliban, Sakellari, Li, Guzman, Garcia, Floudas (bib0045) 2013; 40 Wassall, Preshaw (bib0560) 2016; 70 Heikkinen, Nwhator, Rathnayake, Mantyla, Vatanen, Sorsa (bib0245) 2016; 87 Kumaresan, Balasundaram, Naik, Appukuttan (bib0325) 2016; 10 Kinane, Hart (bib0300) 2003; 14 Novakovic, Todorovic, Rakic, Milinkovic, Dozic, Jankovic (bib0395) 2014; 49 Chapple (bib0105) 2000; 51 Barros, Williams, Offenbacher, Morelli (bib0060) 2016; 70 Bertl, Schoiber, Haririan, Laky, Steiner, Rausch (bib0075) 2013; 17 Demmer, Behle, Wolf, Handfield, Kebschull, Celenti (bib0135) 2008; 79 Ji, Choi (bib0270) 2015; 5 Khalaf, Lonn, Bengtsson (bib0290) 2014; 67 de Lima Oliveira, de Faveri, Gursky, Mestnik, Feres, Haffajee (bib0605) 2012; 39 Ghallab, Hamdy, Shaker (bib0170) 2016; 61 Gupta, Chaturvedi, Jain (bib0215) 2013; 61 Wignarajah, Suaifan, Bizzarro, Bikker, Kaman, Zourob (bib0570) 2015; 87 Raghavendra, Pradeep, Kathariya, Sharma, Rao, Naik (bib0430) 2012; 32 Chaturvedi, Gupta, Jain, Das, Prashar (bib0110) 2015; 19 Taylor (bib0525) 2014; 2014 Costa, Trevisan, Macedo, Palioto, Souza, Grisi (bib0125) 2010; 81 Tabari, Azadmehr, Nohekhan, Naddafpour, Ghaedi (bib0520) 2014; 85 Kaufman, Lamster (bib0285) 2000; 27 Gumus, Buduneli, Biyikoglu, Aksu, Sarac, Nile (bib0210) 2013; 84 Ramseier, Kinney, Herr, Braun, Sugai, Shelburne (bib0435) 2009; 80 Leppilahti, Hernandez-Rios, Gamonal, Tervahartiala, Brignardello-Petersen, Mantyla (bib0350) 2014; 41 Ozcan, Saygun, Serdar, Kurt (bib0405) 2015; 19 Srinath, Acharya, Thakur (bib0505) 2010; 81 Kunjappu, Mathew, Hegde, Kashyap, Hosadurga (bib0335) 2012; 16 Silva-Boghossian, Colombo, Tanaka, Rayo, Xiao, Siqueira (bib0490) 2013; 8 Jaedicke, Preshaw, Taylor (bib0265) 2016; 70 Korte, Kinney (bib0315) 2016; 70 Miller, King, Langub, Kryscio, Thomas (bib0365) 2006; 137 Nomura, Shimada, Hanada, Numabe, Kamoi, Sato (bib0390) 2012; 57 Sharma, Pradeep (bib0485) 2007; 42 Kuru, Griffiths, Petrie, Olsen (bib0340) 2004; 31 Garg, Pradeep, Thorat (bib0160) 2009; 54 Cifcibasi, Koyuncuoglu, Ciblak, Badur, Kasali, Firatli (bib0120) 2015; 38 Kathariya, Jain, Gujar, Singh, Ajwani, Mandhyan (bib0280) 2013; 34 Wu, Chen, Wei, Luo, Yan (bib0585) 2015; 86 Baeza, Garrido, Hernandez-Rios, Dezerega, Garcia-Sesnich, Strauss (bib0035) 2016; 43 Pawar, Mehta (bib0410) 2015; 6 Kinney, Morelli, Oh, Braun, Ramseier, Sugai (bib0310) 2014; 41 Doğan, Balli, Dede, Sertoglu, Tazegul (bib0150) 2016; 87 Gokhale, Acharya, Patil, Trivedi, Setty, Thakur (bib0190) 2014; 85 Sackmann, Fulton, Beebe (bib0455) 2014; 507 Armitage (bib0025) 2004; 34 Cekici, Kantarci, Hasturk, Van Dyke (bib0095) 2014; 64 Sorsa, Gursoy, Nwhator, Hernandez, Tervahartiala, Leppilahti (bib0500) 2016; 70 Taba, Souza, Mariguela (bib0515) 2012; 26 Nicu, Loos (bib0385) 2016; 71 Buduneli, Kinane (bib0090) 2011; 38 Villa-Correa, Isaza-Guzman, Tobon-Arroyave (bib0555) 2015; 86 Gupta, Govila, Saini (bib0220) 2015; 5 Teles, Sakellari, Teles, Konstantinidis, Kent, Socransky (bib0530) 2010; 81 Bostanci, Heywood, Mills, Parkar, Nibali, Donos (bib0085) 2010; 9 Karthikeyan, Pradeep (bib0275) 2007; 42 Gursoy, Kononen, Pradhan-Palikhe, Tervahartiala, Pussinen, Suominen-Taipale (bib0225) 2010; 37 Gursoy, Kononen, Pussinen, Tervahartiala, Hyvarinen, Suominen (bib0230) 2011; 30 Stadler, Angst, Arce, Gomes, Oppermann, Susin (bib0510) 2016; 43 Christodoulides, Floriano, Miller, Ebersole, Mohanty, Dharshan (bib0115) 2007; 1098 Esen, Alkan, Kirnap, Akgul, Isikoglu, Erel (bib0155) 2012; 83 Hendek, Erdemir, Kisa, Ozcan (bib0250) 2015; 86 Tobon-Arroyave, Isaza-Guzman, Restrepo-Cadavid, Zapata-Molina, Martinez-Pabon (bib0540) 2012; 39 Zhang, Chen, Zhu, Yan (bib0600) 2016; 72 Becerik, Afacan, Ozturk, Atmaca, Emingil (bib0065) 2011; 31 Giannobile, Kornman, Williams (bib0180) 2013 Toker, Poyraz, Eren (bib0545) 2008; 35 Dede, Ozden, Avci (bib0130) 2013; 84 Sexton, Lin, Kryscio, Dawson, Ebersole, Miller (bib0475) 2011; 38 Nazar Majeed, Philip, Alabsi, Pushparajan, Swaminathan (bib0380) 2016 Anil, Vellappally, Preethanath, Mokeem, AlMoharib, Patil (bib0015) 2014; 2014 Becerik, Ozturk, Atmaca, Atilla, Emingil (bib0070) 2012; 83 Haigh, Stewart, Whelan, Barnett, Smolenski, Wheeler (bib0235) 2010; 37 Priyanka, Kumari, Kalra, Arjun, Naik, Pradeep (bib0420) 2013; 35 Rathnayake, Gieselmann, Heikkinen, Tervahartiala, Sorsa (bib0440) 2017; 7 Shaker, Ghallab (bib0480) 2012 Banasova, Kamodyova, Jansakova, Tothova, Stanko, Turna (bib0055) 2015; 19 Aral, Koseoglu, Saglam, Pekbagriyanik, Savran (bib0020) 2016; 39 Vijayalakshmi, Geetha, Ramakrishnan, Emmadi (bib0550) 2010; 21 Group (bib0205) 2001; 69 Ghallab, Shaker (bib0165) 2010; 81 Kinney, Morelli, Braun, Ramseier, Herr, Sugai (bib0305) 2011; 90 Chapple, Matthews (bib0100) 2007; 43 Doğan, Ongoz Dede, Balli, Sertoglu (bib0145) 2016; 58 Baliban, Sakellari, Li, DiMaggio, Garcia, Floudas (bib0040) 2012; 39 Becerik (10.1016/j.archoralbio.2017.12.022_bib0070) 2012; 83 Rathnayake (10.1016/j.archoralbio.2017.12.022_bib0440) 2017; 7 Leppilahti (10.1016/j.archoralbio.2017.12.022_bib0350) 2014; 41 Loos (10.1016/j.archoralbio.2017.12.022_bib0360) 2005; 39 Hassan (10.1016/j.archoralbio.2017.12.022_bib0240) 2015 Villa-Correa (10.1016/j.archoralbio.2017.12.022_bib0555) 2015; 86 Sakallioglu (10.1016/j.archoralbio.2017.12.022_bib0460) 2015; 21 Teles (10.1016/j.archoralbio.2017.12.022_bib0530) 2010; 81 Kuboniwa (10.1016/j.archoralbio.2017.12.022_bib0320) 2016 Priyanka (10.1016/j.archoralbio.2017.12.022_bib0420) 2013; 35 Proctor (10.1016/j.archoralbio.2017.12.022_bib0425) 2016; 70 Vijayalakshmi (10.1016/j.archoralbio.2017.12.022_bib0550) 2010; 21 Slots (10.1016/j.archoralbio.2017.12.022_bib0495) 2013; 62 de Lima Oliveira (10.1016/j.archoralbio.2017.12.022_bib0605) 2012; 39 Salazar (10.1016/j.archoralbio.2017.12.022_bib0465) 2013; 40 Tobon-Arroyave (10.1016/j.archoralbio.2017.12.022_bib0540) 2012; 39 Haigh (10.1016/j.archoralbio.2017.12.022_bib0235) 2010; 37 Gursoy (10.1016/j.archoralbio.2017.12.022_bib0230) 2011; 30 Doğan (10.1016/j.archoralbio.2017.12.022_bib0145) 2016; 58 Novakovic (10.1016/j.archoralbio.2017.12.022_bib0395) 2014; 49 Pradeep (10.1016/j.archoralbio.2017.12.022_bib0415) 2011; 82 Kathariya (10.1016/j.archoralbio.2017.12.022_bib0280) 2013; 34 Sackmann (10.1016/j.archoralbio.2017.12.022_bib0455) 2014; 507 Bostanci (10.1016/j.archoralbio.2017.12.022_bib0085) 2010; 9 Cifcibasi (10.1016/j.archoralbio.2017.12.022_bib0120) 2015; 38 Hernandez (10.1016/j.archoralbio.2017.12.022_bib0255) 2007; 34 Zhang (10.1016/j.archoralbio.2017.12.022_bib0600) 2016; 72 Giannobile (10.1016/j.archoralbio.2017.12.022_bib0180) 2013 Sexton (10.1016/j.archoralbio.2017.12.022_bib0475) 2011; 38 Chaturvedi (10.1016/j.archoralbio.2017.12.022_bib0110) 2015; 19 Barros (10.1016/j.archoralbio.2017.12.022_bib0060) 2016; 70 Griffiths (10.1016/j.archoralbio.2017.12.022_bib0200) 2003; 31 Bertl (10.1016/j.archoralbio.2017.12.022_bib0075) 2013; 17 Chapple (10.1016/j.archoralbio.2017.12.022_bib0100) 2007; 43 Armitage (10.1016/j.archoralbio.2017.12.022_bib0030) 2013; 62 Miller (10.1016/j.archoralbio.2017.12.022_bib0370) 2010; 4 Demmer (10.1016/j.archoralbio.2017.12.022_bib0135) 2008; 79 Taylor (10.1016/j.archoralbio.2017.12.022_bib0525) 2014; 2014 Sorsa (10.1016/j.archoralbio.2017.12.022_bib0500) 2016; 70 Cekici (10.1016/j.archoralbio.2017.12.022_bib0095) 2014; 64 Gomez-Moreno (10.1016/j.archoralbio.2017.12.022_bib0195) 2010; 16 Group (10.1016/j.archoralbio.2017.12.022_bib0205) 2001; 69 Gumus (10.1016/j.archoralbio.2017.12.022_bib0210) 2013; 84 Gokhale (10.1016/j.archoralbio.2017.12.022_bib0190) 2014; 85 Kumari (10.1016/j.archoralbio.2017.12.022_bib0330) 2014; 59 Anil (10.1016/j.archoralbio.2017.12.022_bib0015) 2014; 2014 Raghavendra (10.1016/j.archoralbio.2017.12.022_bib0430) 2012; 32 Kumaresan (10.1016/j.archoralbio.2017.12.022_bib0325) 2016; 10 Costa (10.1016/j.archoralbio.2017.12.022_bib0125) 2010; 81 Giannobile (10.1016/j.archoralbio.2017.12.022_bib0175) 2009; 50 Heikkinen (10.1016/j.archoralbio.2017.12.022_bib0245) 2016; 87 Baltacioglu (10.1016/j.archoralbio.2017.12.022_bib0050) 2014; 85 Kinane (10.1016/j.archoralbio.2017.12.022_bib0300) 2003; 14 Doğan (10.1016/j.archoralbio.2017.12.022_bib0150) 2016; 87 Baliban (10.1016/j.archoralbio.2017.12.022_bib0045) 2013; 40 Nomura (10.1016/j.archoralbio.2017.12.022_bib0390) 2012; 57 Baeza (10.1016/j.archoralbio.2017.12.022_bib0035) 2016; 43 Miller (10.1016/j.archoralbio.2017.12.022_bib0365) 2006; 137 Romero (10.1016/j.archoralbio.2017.12.022_bib0450) 2013; 54 Armitage (10.1016/j.archoralbio.2017.12.022_bib0025) 2004; 34 Zelko (10.1016/j.archoralbio.2017.12.022_bib0590) 2002; 33 Gursoy (10.1016/j.archoralbio.2017.12.022_bib0225) 2010; 37 Tabari (10.1016/j.archoralbio.2017.12.022_bib0520) 2014; 85 Buduneli (10.1016/j.archoralbio.2017.12.022_bib0090) 2011; 38 Ramseier (10.1016/j.archoralbio.2017.12.022_bib0435) 2009; 80 Thomas (10.1016/j.archoralbio.2017.12.022_bib0535) 2009; 80 Nicu (10.1016/j.archoralbio.2017.12.022_bib0385) 2016; 71 Silva-Boghossian (10.1016/j.archoralbio.2017.12.022_bib0490) 2013; 8 Hendek (10.1016/j.archoralbio.2017.12.022_bib0250) 2015; 86 Karthikeyan (10.1016/j.archoralbio.2017.12.022_bib0275) 2007; 42 Giannobile (10.1016/j.archoralbio.2017.12.022_bib0185) 2012; 143 Wu (10.1016/j.archoralbio.2017.12.022_bib0585) 2015; 86 Chapple (10.1016/j.archoralbio.2017.12.022_bib0105) 2000; 51 Christodoulides (10.1016/j.archoralbio.2017.12.022_bib0115) 2007; 1098 Kwok (10.1016/j.archoralbio.2017.12.022_bib0345) 2012; 59 Zhang (10.1016/j.archoralbio.2017.12.022_bib0595) 2009; 51 Becerik (10.1016/j.archoralbio.2017.12.022_bib0065) 2011; 31 Ozcan (10.1016/j.archoralbio.2017.12.022_bib0405) 2015; 19 Kuru (10.1016/j.archoralbio.2017.12.022_bib0340) 2004; 31 Aral (10.1016/j.archoralbio.2017.12.022_bib0020) 2016; 39 Wei (10.1016/j.archoralbio.2017.12.022_bib0565) 2010; 55 Esen (10.1016/j.archoralbio.2017.12.022_bib0155) 2012; 83 Kinney (10.1016/j.archoralbio.2017.12.022_bib0305) 2011; 90 Oh (10.1016/j.archoralbio.2017.12.022_bib0400) 2015; 57 Ji (10.1016/j.archoralbio.2017.12.022_bib0270) 2015; 5 Korte (10.1016/j.archoralbio.2017.12.022_bib0315) 2016; 70 Gupta (10.1016/j.archoralbio.2017.12.022_bib0215) 2013; 61 Navazesh (10.1016/j.archoralbio.2017.12.022_bib0375) 1993; 694 Banasova (10.1016/j.archoralbio.2017.12.022_bib0055) 2015; 19 Wong (10.1016/j.archoralbio.2017.12.022_bib0580) 2012; 143 Akram (10.1016/j.archoralbio.2017.12.022_bib0005) 2017; 73 Kim (10.1016/j.archoralbio.2017.12.022_bib0295) 2013; 41 Baliban (10.1016/j.archoralbio.2017.12.022_bib0040) 2012; 39 Kinney (10.1016/j.archoralbio.2017.12.022_bib0310) 2014; 41 Nazar Majeed (10.1016/j.archoralbio.2017.12.022_bib0380) 2016 Wassall (10.1016/j.archoralbio.2017.12.022_bib0560) 2016; 70 Wilkins (10.1016/j.archoralbio.2017.12.022_bib0575) 1996; 14 Kaufman (10.1016/j.archoralbio.2017.12.022_bib0285) 2000; 27 Rescala (10.1016/j.archoralbio.2017.12.022_bib0445) 2010; 81 Garg (10.1016/j.archoralbio.2017.12.022_bib0160) 2009; 54 Gupta (10.1016/j.archoralbio.2017.12.022_bib0220) 2015; 5 Khalaf (10.1016/j.archoralbio.2017.12.022_bib0290) 2014; 67 Ghallab (10.1016/j.archoralbio.2017.12.022_bib0165) 2010; 81 Taba (10.1016/j.archoralbio.2017.12.022_bib0515) 2012; 26 Herr (10.1016/j.archoralbio.2017.12.022_bib0260) 2007; 1098 Selvarajan (10.1016/j.archoralbio.2017.12.022_bib0470) 2015; 9 Dede (10.1016/j.archoralbio.2017.12.022_bib0130) 2013; 84 Pawar (10.1016/j.archoralbio.2017.12.022_bib0410) 2015; 6 Sharma (10.1016/j.archoralbio.2017.12.022_bib0485) 2007; 42 Srinath (10.1016/j.archoralbio.2017.12.022_bib0505) 2010; 81 Denny (10.1016/j.archoralbio.2017.12.022_bib0140) 2008; 7 Almughrabi (10.1016/j.archoralbio.2017.12.022_bib0010) 2013; 48 Jaedicke (10.1016/j.archoralbio.2017.12.022_bib0265) 2016; 70 Wignarajah (10.1016/j.archoralbio.2017.12.022_bib0570) 2015; 87 Kunjappu (10.1016/j.archoralbio.2017.12.022_bib0335) 2012; 16 Toker (10.1016/j.archoralbio.2017.12.022_bib0545) 2008; 35 Stadler (10.1016/j.archoralbio.2017.12.022_bib0510) 2016; 43 Bostanci (10.1016/j.archoralbio.2017.12.022_bib0080) 2007; 34 Ghallab (10.1016/j.archoralbio.2017.12.022_bib0170) 2016; 61 Shaker (10.1016/j.archoralbio.2017.12.022_bib0480) 2012 Lequin (10.1016/j.archoralbio.2017.12.022_bib0355) 2005; 51
References_xml	– volume: 81 start-page: 710 year: 2010 end-page: 717 ident: bib0165 article-title: Salivary-soluble CD44 levels in smokers and non-smokers with chronic periodontitis: A pilot study publication-title: Journal of Periodontology – volume: 4 start-page: 171 year: 2010 end-page: 189 ident: bib0370 article-title: Current developments in salivary diagnostics publication-title: Biomarkers in Medicine – volume: 82 start-page: 734 year: 2011 end-page: 741 ident: bib0415 article-title: Levels of pentraxin-3 in gingival crevicular fluid and plasma in periodontal health and disease publication-title: Journal of Periodontology – volume: 62 start-page: 7 year: 2013 end-page: 19 ident: bib0495 article-title: Periodontology: Past, present, perspectives publication-title: Periodontology 2000 – volume: 70 start-page: 53 year: 2016 end-page: 64 ident: bib0060 article-title: Gingival crevicular fluid as a source of biomarkers for periodontitis publication-title: Periodontology 2000 – volume: 51 start-page: 9 year: 2000 end-page: 24 ident: bib0105 article-title: Periodontal diagnosis and treatment–where does the future lie? publication-title: Periodontology 2000 – volume: 84 start-page: 821 year: 2013 end-page: 828 ident: bib0130 article-title: 8-hydroxy-deoxyguanosine levels in gingival crevicular fluid and saliva in patients with chronic periodontitis after initial periodontal treatment publication-title: Journal of Periodontology – volume: 54 start-page: 1046 year: 2009 end-page: 1051 ident: bib0160 article-title: Effect of nonsurgical periodontal therapy on crevicular fluid levels of Cathepsin K in periodontitis publication-title: Archives of Oral Biology – volume: 16 start-page: 54 year: 2012 end-page: 57 ident: bib0335 article-title: Assessment of the alkaline phosphatase level in gingival crevicular fluid, as a biomarker to evaluate the effect of scaling and root planing on chronic periodontitis: An in vivo study publication-title: Journal of Oral and Maxillofacial Pathology – volume: 59 start-page: 61 year: 2012 end-page: 74 ident: bib0345 article-title: Application of evidence-based dentistry: From research to clinical periodontal practice publication-title: Periodontology 2000 – volume: 70 start-page: 11 year: 2016 end-page: 25 ident: bib0425 article-title: The physiology of salivary secretion publication-title: Periodontology 2000 – volume: 81 start-page: 277 year: 2010 end-page: 283 ident: bib0505 article-title: Salivary and gingival crevicular fluid melatonin in periodontal health and disease publication-title: Journal of Periodontology – volume: 39 start-page: 203 year: 2012 end-page: 212 ident: bib0040 article-title: Novel protein identification methods for biomarker discovery via a proteomic analysis of periodontally healthy and diseased gingival crevicular fluid samples publication-title: Journal of Clinical Periodontology – volume: 50 start-page: 52 year: 2009 end-page: 64 ident: bib0175 article-title: Saliva as a diagnostic tool for periodontal disease: Current state and future directions publication-title: Periodontology 2000 – volume: 31 start-page: 32 year: 2003 end-page: 42 ident: bib0200 article-title: Formation, collection and significance of gingival crevice fluid publication-title: Periodontology 2000 – volume: 14 start-page: 61 year: 1996 end-page: 65 ident: bib0575 article-title: From proteins to proteomes: Large scale protein identification by two-dimensional electrophoresis and amino acid analysis publication-title: Biotechnology (N Y) – volume: 81 start-page: 1308 year: 2010 end-page: 1316 ident: bib0445 article-title: Immunologic and microbiologic profiles of chronic and aggressive periodontitis subjects publication-title: Journal of Periodontology – volume: 40 start-page: 131 year: 2013 end-page: 139 ident: bib0045 article-title: Discovery of biomarker combinations that predict periodontal health or disease with high accuracy from GCF samples based on high-throughput proteomic analysis and mixed-integer linear optimization publication-title: Journal of Clinical Periodontology – volume: 57 start-page: 413 year: 2012 end-page: 420 ident: bib0390 article-title: Salivary biomarkers for predicting the progression of chronic periodontitis publication-title: Archives of Oral Biology – volume: 81 start-page: 89 year: 2010 end-page: 98 ident: bib0530 article-title: Relationships among gingival crevicular fluid biomarkers, clinical parameters of periodontal disease, and the subgingival microbiota publication-title: Journal of Periodontology – volume: 38 start-page: 1959 year: 2015 end-page: 1968 ident: bib0120 article-title: Evaluation of local and systemic levels of interleukin-17, interleukin-23, and myeloperoxidase in response to periodontal therapy in patients with generalized aggressive periodontitis publication-title: Inflammation – volume: 34 start-page: 143 year: 2013 end-page: 151 ident: bib0280 article-title: Pentraxins as key disease markers for periodontal diagnosis publication-title: Disease Markers – volume: 90 start-page: 752 year: 2011 end-page: 758 ident: bib0305 article-title: Saliva/pathogen biomarker signatures and periodontal disease progression publication-title: Journal of Dental Research – volume: 19 start-page: 921 year: 2015 end-page: 928 ident: bib0405 article-title: Evaluation of the salivary levels of visfatin, chemerin, and progranulin in periodontal inflammation publication-title: Clinical Oral Investigations – volume: 70 start-page: 164 year: 2016 end-page: 183 ident: bib0265 article-title: Salivary cytokines as biomarkers of periodontal diseases publication-title: Periodontology 2000 – volume: 85 start-page: 610 year: 2014 end-page: 617 ident: bib0190 article-title: Resistin levels in gingival crevicular fluid of patients with chronic periodontitis and type 2 diabetes mellitus publication-title: Journal of Periodontology – volume: 32 start-page: 383 year: 2012 end-page: 388 ident: bib0430 article-title: Effect of non surgical periodontal therapy on gingival crevicular fluid and serum visfatin concentration in periodontal health and disease publication-title: Disease Markers – volume: 55 start-page: 70 year: 2010 end-page: 78 ident: bib0565 article-title: Lipid peroxidation levels, total oxidant status and superoxide dismutase in serum, saliva and gingival crevicular fluid in chronic periodontitis patients before and after periodontal therapy publication-title: Australian Dental Journal – volume: 86 start-page: 1260 year: 2015 end-page: 1267 ident: bib0555 article-title: Prognostic value of 8-Hydroxy-2′-Deoxyguanosine and human neutrophil elastase/alpha1-Proteinase inhibitor complex as salivary biomarkers of oxidative stress in chronic periodontitis publication-title: Journal of Periodontology – start-page: 174764 year: 2012 ident: bib0480 article-title: IL-17 and IL-11 GCF levels in aggressive and chronic periodontitis patients: Relation to PCR bacterial detection publication-title: Mediators of Inflammation – volume: 84 start-page: 1627 year: 2013 end-page: 1637 ident: bib0210 article-title: Gingival crevicular fluid, serum levels of receptor activator of nuclear factor-kappaB ligand, osteoprotegerin, and interleukin-17 in patients with rheumatoid arthritis and osteoporosis and with periodontal disease publication-title: Journal of Periodontology – volume: 43 start-page: 727 year: 2016 end-page: 745 ident: bib0510 article-title: Gingival crevicular fluid levels of cytokines/chemokines in chronic periodontitis: A meta-analysis publication-title: Journal of Clinical Periodontology – volume: 35 start-page: 389 year: 2013 end-page: 394 ident: bib0420 article-title: Crevicular fluid and serum concentrations of progranulin and high sensitivity CRP in chronic periodontitis and type 2 diabetes publication-title: Disease Markers – volume: 61 start-page: 53 year: 2016 end-page: 61 ident: bib0170 article-title: Malondialdehyde, superoxide dismutase and melatonin levels in gingival crevicular fluid of aggressive and chronic periodontitis patients publication-title: Australian Dental Journal – volume: 83 start-page: 773 year: 2012 end-page: 779 ident: bib0155 article-title: The effects of chronic periodontitis and rheumatoid arthritis on serum and gingival crevicular fluid total antioxidant/oxidant status and oxidative stress index publication-title: Journal of Periodontology – volume: 19 start-page: 201 year: 2015 end-page: 207 ident: bib0055 article-title: Salivary DNA and markers of oxidative stress in patients with chronic periodontitis publication-title: Clinical Oral Investigations – volume: 85 start-page: 1081 year: 2014 end-page: 1085 ident: bib0520 article-title: Salivary visfatin concentrations in patients with chronic periodontitis publication-title: Journal of Periodontology – volume: 39 start-page: 53 year: 2005 end-page: 72 ident: bib0360 article-title: Host-derived diagnostic markers for periodontitis: Do they exist in gingival crevice fluid? publication-title: Periodontology 2000 – volume: 79 start-page: 2112 year: 2008 end-page: 2124 ident: bib0135 article-title: Transcriptomes in healthy and diseased gingival tissues publication-title: Journal of Periodontology – volume: 51 start-page: 2415 year: 2005 end-page: 2418 ident: bib0355 article-title: Enzyme immunoassay (EIA)/enzyme-linked immunosorbent assay (ELISA) publication-title: Clinical Chemistry – volume: 57 start-page: 67 year: 2015 end-page: 71 ident: bib0400 article-title: Effects of initial periodontal therapy on interleukin-1beta level in gingival crevicular fluid and clinical periodontal parameters publication-title: Journal of Oral Science – volume: 67 start-page: 29 year: 2014 end-page: 35 ident: bib0290 article-title: Cytokines and chemokines are differentially expressed in patients with periodontitis: Possible role for TGF-beta1 as a marker for disease progression publication-title: Cytokine – volume: 14 start-page: 430 year: 2003 end-page: 449 ident: bib0300 article-title: Genes and gene polymorphisms associated with periodontal disease publication-title: Critical Reviews in Oral Biology and Medicine – volume: 30 start-page: 299 year: 2011 end-page: 305 ident: bib0230 article-title: Use of host- and bacteria-derived salivary markers in detection of periodontitis: A cumulative approach publication-title: Disease Markers – start-page: 1804727 year: 2016 ident: bib0380 article-title: Identification of gingival crevicular fluid sampling, analytical methods, and oral biomarkers for the diagnosis and monitoring of periodontal diseases: A systematic review publication-title: Disease Markers – volume: 507 start-page: 181 year: 2014 end-page: 189 ident: bib0455 article-title: The present and future role of microfluidics in biomedical research publication-title: Nature – volume: 73 start-page: 311 year: 2017 end-page: 320 ident: bib0005 article-title: Resistin as potential biomarker for chronic periodontitis: A systematic review and meta-analysis publication-title: Archives of Oral Biology – volume: 85 start-page: 1432 year: 2014 end-page: 1441 ident: bib0050 article-title: Lipid peroxidation levels and total oxidant/antioxidant status in serum and saliva from patients with chronic and aggressive periodontitis. Oxidative stress index: A new biomarker for periodontal disease? publication-title: Journal of Periodontology – volume: 42 start-page: 450 year: 2007 end-page: 455 ident: bib0485 article-title: Plasma and crevicular fluid osteopontin levels in periodontal health and disease publication-title: Journal of Periodontal Research – volume: 43 start-page: 34 year: 2016 end-page: 45 ident: bib0035 article-title: Diagnostic accuracy for apical and chronic periodontitis biomarkers in gingival crevicular fluid: An exploratory study publication-title: Journal of Clinical Periodontology – volume: 9 start-page: 2191 year: 2010 end-page: 2199 ident: bib0085 article-title: Application of label-free absolute quantitative proteomics in human gingival crevicular fluid by LC/MS E (gingival exudatome) publication-title: Journal of Proteome Research – volume: 80 start-page: 436 year: 2009 end-page: 446 ident: bib0435 article-title: Identification of pathogen and host-response markers correlated with periodontal disease publication-title: Journal of Periodontology – volume: 16 start-page: 242 year: 2010 end-page: 247 ident: bib0195 article-title: Melatonin in diseases of the oral cavity publication-title: Oral Diseases – start-page: 341259 year: 2015 ident: bib0240 article-title: Effect of periodontal surgery on osteoprotegerin levels in gingival crevicular fluid, saliva, and gingival tissues of chronic periodontitis patients publication-title: Disease Markers – volume: 41 start-page: 119 year: 2013 end-page: 124 ident: bib0295 article-title: Salivary biomarkers in the diagnosis of periodontal diseases publication-title: Journal of the California Dental Association – volume: 43 start-page: 160 year: 2007 end-page: 232 ident: bib0100 article-title: The role of reactive oxygen and antioxidant species in periodontal tissue destruction publication-title: Periodontology 2000 – volume: 71 start-page: 140 year: 2016 end-page: 163 ident: bib0385 article-title: Polymorphonuclear neutrophils in periodontitis and their possible modulation as a therapeutic approach publication-title: Periodontology 2000 – volume: 6 start-page: 118 year: 2015 end-page: 124 ident: bib0410 article-title: Effect of phase 1 periodontal therapy on gingival crevicular fluid levels of matrix metalloproteinases-3 and –13 in chronic periodontitis patients publication-title: Journal of Investigative and Clinical Dentistry – volume: 38 start-page: 434 year: 2011 end-page: 441 ident: bib0475 article-title: Salivary biomarkers of periodontal disease in response to treatment publication-title: Journal of Clinical Periodontology – volume: 70 start-page: 142 year: 2016 end-page: 163 ident: bib0500 article-title: 2016). Analysis of matrix metalloproteinases, especially MMP-8, in gingival creviclular fluid, mouthrinse and saliva for monitoring periodontal diseases publication-title: Periodontology 2000 – volume: 1098 start-page: 362 year: 2007 end-page: 374 ident: bib0260 article-title: Integrated microfluidic platform for oral diagnostics publication-title: Annals of the New York Academy of Sciences – volume: 27 start-page: 453 year: 2000 end-page: 465 ident: bib0285 article-title: Analysis of saliva for periodontal diagnosis–A review publication-title: Journal of Clinical Periodontology – volume: 38 start-page: 85 year: 2011 end-page: 105 ident: bib0090 article-title: Host-derived diagnostic markers related to soft tissue destruction and bone degradation in periodontitis publication-title: Journal Clinical Periodontology – volume: 7 start-page: 1994 year: 2008 end-page: 2006 ident: bib0140 article-title: The proteomes of human parotid and submandibular/sublingual gland salivas collected as the ductal secretions publication-title: Journal of Proteome Research – volume: 51 start-page: 25 year: 2009 end-page: 37 ident: bib0595 article-title: 2009). The clinical value of salivary biomarkers for periodontal disease publication-title: Periodontology 2000 – volume: 70 start-page: 65 year: 2016 end-page: 79 ident: bib0560 article-title: Clinical and technical considerations in the analysis of gingival crevicular fluid publication-title: Periodontology 2000 – volume: 10 start-page: 546 year: 2016 end-page: 550 ident: bib0325 article-title: Gingival crevicular fluid periostin levels in chronic periodontitis patients following nonsurgical periodontal treatment with low-level laser therapy publication-title: European Journal of Dentistry – volume: 54 start-page: 138 year: 2013 end-page: 148 ident: bib0450 article-title: MMP-3 and MMP-8 levels in patients with chronic periodontitis before and after nonsurgical periodontal therapy publication-title: Investigacion Clinica – volume: 9 start-page: Zc48 year: 2015 end-page: 53 ident: bib0470 article-title: Association between gingival crevicular fluid leptin levels and periodontal status − A biochemical study on indian patients publication-title: Journal of Clinical and Diagnostic Research – volume: 5 start-page: 65 year: 2015 ident: bib0270 article-title: Point-of-care diagnosis of periodontitis using saliva: Technically feasible but still a challenge publication-title: Frontiers in Cellular and Infection Microbiology – volume: 80 start-page: 1146 year: 2009 end-page: 1153 ident: bib0535 article-title: Within-subject variability in repeated measures of salivary analytes in healthy adults publication-title: Journal of Periodontology – volume: 17 start-page: 1219 year: 2013 end-page: 1225 ident: bib0075 article-title: Non-surgical periodontal therapy influences salivary melatonin levels publication-title: Clinical Oral Investigations – volume: 87 start-page: 12161 year: 2015 end-page: 12168 ident: bib0570 article-title: Colorimetric assay for the detection of typical biomarkers for periodontitis using a magnetic nanoparticle biosensor publication-title: Analytical Chemistry – volume: 40 start-page: 825 year: 2013 end-page: 832 ident: bib0465 article-title: Identification of periodontitis associated changes in the proteome of whole human saliva by mass spectrometric analysis publication-title: Journal of Clinical Periodontology – volume: 8 start-page: e75898 year: 2013 ident: bib0490 article-title: Quantitative proteomic analysis of gingival crevicular fluid in different periodontal conditions publication-title: PLoS One – volume: 19 start-page: 45 year: 2015 end-page: 52 ident: bib0110 article-title: Soluble CD40 ligand: A novel biomarker in the pathogenesis of periodontal disease publication-title: Clinical Oral Investigations – volume: 21 start-page: 568 year: 2010 end-page: 574 ident: bib0550 article-title: Genetic polymorphisms in periodontal diseases: An overview publication-title: Indian Journal of Dental Research – volume: 143 start-page: 6s year: 2012 end-page: 11s ident: bib0185 article-title: Salivary diagnostics for periodontal diseases publication-title: The Journal of the American Dental Association – volume: 2014 start-page: 146974 year: 2014 ident: bib0015 article-title: Hepatocyte growth factor levels in the saliva and gingival crevicular fluid in smokers with periodontitis publication-title: Disease Markers – volume: 59 start-page: 645 year: 2014 end-page: 653 ident: bib0330 article-title: Crevicular and serum levels of monocyte chemoattractant protein-4 and high-sensitivity C-reactive protein in periodontal health and disease publication-title: Archives of Oral Biology – start-page: 874 year: 2013 end-page: 876 ident: bib0180 article-title: Personalized medicine enters dentistry: What might this mean for clinical practice? publication-title: The Journal of the American Dental Association – volume: 70 start-page: 26 year: 2016 end-page: 37 ident: bib0315 article-title: Personalized medicine: An update of salivary biomarkers for periodontal diseases publication-title: Periodontology 2000 – volume: 143 start-page: 19s year: 2012 end-page: 24s ident: bib0580 article-title: Salivaomics publication-title: Journal of the American Dental Association – year: 2016 ident: bib0320 article-title: Prediction of periodontal inflammation via metabolic profiling of saliva publication-title: Journal of Dental Research – volume: 41 start-page: 348 year: 2014 end-page: 356 ident: bib0350 article-title: Matrix metalloproteinases and myeloperoxidase in gingival crevicular fluid provide site-specific diagnostic value for chronic periodontitis publication-title: Journal of Clinical Periodontology – volume: 26 start-page: 32 year: 2012 end-page: 38 ident: bib0515 article-title: Periodontal disease: A genetic perspective publication-title: Brazilian Oral Research – volume: 34 start-page: 729 year: 2007 end-page: 735 ident: bib0255 article-title: MMP-13 and TIMP-1 determinations in progressive chronic periodontitis publication-title: Journal of Clinical Periodontology – volume: 21 start-page: 263 year: 2015 end-page: 269 ident: bib0460 article-title: Vascular endothelial cadherin and vascular endothelial growth factor in periodontitis and smoking publication-title: Oral Diseases – volume: 69 start-page: 89 year: 2001 end-page: 95 ident: bib0205 article-title: Biomarkers and surrogate endpoints: Preferred definitions and conceptual framework publication-title: Clinical Pharmacology and Therapeutics – volume: 34 start-page: 109 year: 2004 end-page: 119 ident: bib0025 article-title: Analysis of gingival crevice fluid and risk of progression of periodontitis publication-title: Periodontology – volume: 33 start-page: 337 year: 2002 end-page: 349 ident: bib0590 article-title: Superoxide dismutase multigene family: A comparison of the CuZn-SOD (SOD1), Mn-SOD (SOD2), and EC-SOD (SOD3) gene structures, evolution, and expression publication-title: Free Radical Biology and Medicine – volume: 31 start-page: 343 year: 2011 end-page: 352 ident: bib0065 article-title: Gingival crevicular fluid calprotectin, osteocalcin and cross-linked N-terminal telopeptid levels in health and different periodontal diseases publication-title: Disease Markers – volume: 37 start-page: 241 year: 2010 end-page: 247 ident: bib0235 article-title: Alterations in the salivary proteome associated with periodontitis publication-title: Journal of Clinical Periodontology – volume: 37 start-page: 487 year: 2010 end-page: 493 ident: bib0225 article-title: Salivary MMP-8, TIMP-1, and ICTP as markers of advanced periodontitis publication-title: Journal of Clinical Periodontology – volume: 1098 start-page: 411 year: 2007 end-page: 428 ident: bib0115 article-title: Lab-on-a-chip methods for point-of-care measurements of salivary biomarkers of periodontitis publication-title: Annals of the New York Academy of Sciences – volume: 39 start-page: 1132 year: 2012 end-page: 1140 ident: bib0540 article-title: Association of salivary levels of the bone remodelling regulators sRANKL and OPG with periodontal clinical status publication-title: Journal of Clinical Periodontology – volume: 39 start-page: 295 year: 2012 end-page: 302 ident: bib0605 article-title: Effects of periodontal therapy on GCF cytokines in generalized aggressive periodontitis subjects publication-title: Journal of Clinical Periodontology – volume: 41 start-page: 113 year: 2014 end-page: 120 ident: bib0310 article-title: Crevicular fluid biomarkers and periodontal disease progression publication-title: Journal of Clinical Periodontology – volume: 49 start-page: 129 year: 2014 end-page: 136 ident: bib0395 article-title: Salivary antioxidants as periodontal biomarkers in evaluation of tissue status and treatment outcome publication-title: Journal of Periodontal Research – volume: 48 start-page: 315 year: 2013 end-page: 321 ident: bib0010 article-title: Melatonin levels in periodontal health and disease publication-title: Journal of Periodontal Research – volume: 87 start-page: 36 year: 2016 end-page: 40 ident: bib0245 article-title: Pilot study on oral health status as assessed by an active matrix metalloproteinase-8 chairside mouthrinse test in adolescents publication-title: Journal of Periodontology – volume: 31 start-page: 527 year: 2004 end-page: 533 ident: bib0340 article-title: Changes in transforming growth factor-beta1 in gingival crevicular fluid following periodontal surgery publication-title: Journal of Clinical Periodontology – volume: 62 start-page: 20 year: 2013 end-page: 36 ident: bib0030 article-title: Learned and unlearned concepts in periodontal diagnostics: A 50-year perspective publication-title: Periodontology 2000 – volume: 5 start-page: 46 year: 2015 end-page: 52 ident: bib0220 article-title: Proteomics − The research frontier in periodontics publication-title: Journal of Oral Biology and Craniofacial Research – volume: 2014 start-page: 593151 year: 2014 ident: bib0525 article-title: Protein biomarkers of periodontitis in saliva publication-title: ISRN Inflammation – volume: 86 start-page: 273 year: 2015 end-page: 282 ident: bib0250 article-title: Effect of initial periodontal therapy on oxidative stress markers in gingival crevicular fluid, saliva, and serum in smokers and non-smokers with chronic periodontitis publication-title: Journal of Periodontology – volume: 39 start-page: 986 year: 2016 end-page: 993 ident: bib0020 article-title: Gingival crevicular fluid and salivary periostin levels in non-smoker subjects with chronic and aggressive periodontitis: Periostin levels in chronic and aggressive periodontitis publication-title: Inflammation – volume: 83 start-page: 1304 year: 2012 end-page: 1313 ident: bib0070 article-title: Gingival crevicular fluid and plasma acute-phase cytokine levels in different periodontal diseases publication-title: Journal of Periodontology – volume: 58 start-page: 379 year: 2016 end-page: 389 ident: bib0145 article-title: Levels of vaspin and omentin-1 in gingival crevicular fluid as potential markers of inflammation in patients with chronic periodontitis and type 2 diabetes mellitus publication-title: Journal of Oral Science – volume: 72 start-page: 92 year: 2016 end-page: 98 ident: bib0600 article-title: Biomarker levels in gingival crevicular fluid of subjects with different periodontal conditions: A cross-sectional study publication-title: Archives of Oral Biology – volume: 42 start-page: 300 year: 2007 end-page: 304 ident: bib0275 article-title: Leptin levels in gingival crevicular fluid in periodontal health and disease publication-title: Journal of Periodontal Research – volume: 86 start-page: 795 year: 2015 end-page: 800 ident: bib0585 article-title: Effect of non-surgical periodontal treatment on visfatin concentrations in serum and gingival crevicular fluid of patients with chronic periodontitis and type 2 diabetes mellitus publication-title: Journal of Periodontology – volume: 137 start-page: 322 year: 2006 end-page: 329 ident: bib0365 article-title: Salivary biomarkers of existing periodontal disease: A cross-sectional study publication-title: Journal of the American Dental Association – volume: 7 year: 2017 ident: bib0440 article-title: Salivary Diagnostics-Point-of-Care diagnostics of MMP-8 in dentistry and medicine publication-title: Diagnostics (Basel) – volume: 61 start-page: 892 year: 2013 end-page: 897 ident: bib0215 article-title: Role of monocyte chemoattractant protein-1 (MCP-1) as an immune-diagnostic biomarker in the pathogenesis of chronic periodontal disease publication-title: Cytokine – volume: 81 start-page: 384 year: 2010 end-page: 391 ident: bib0125 article-title: Salivary interleukin-6, matrix metalloproteinase-8, and osteoprotegerin in patients with periodontitis and diabetes publication-title: Journal of Periodontology – volume: 35 start-page: 507 year: 2008 end-page: 513 ident: bib0545 article-title: Effect of periodontal treatment on IL-1beta, IL-1ra, and IL-10 levels in gingival crevicular fluid in patients with aggressive periodontitis publication-title: Journal of Clinical Periodontology – volume: 34 start-page: 370 year: 2007 end-page: 376 ident: bib0080 article-title: Gingival crevicular fluid levels of RANKL and OPG in periodontal diseases: Implications of their relative ratio publication-title: Journal of Clinical Periodontology – volume: 64 start-page: 57 year: 2014 end-page: 80 ident: bib0095 article-title: Inflammatory and immune pathways in the pathogenesis of periodontal disease publication-title: Periodontology 2000 – volume: 87 start-page: 923 year: 2016 end-page: 933 ident: bib0150 article-title: Chemerin as a novel crevicular fluid marker of patients with periodontitis and type 2 diabetes mellitus publication-title: Journal of Periodontology – volume: 694 start-page: 72 year: 1993 end-page: 77 ident: bib0375 article-title: Methods for collecting saliva publication-title: Annals of the New York Academy of Sciences – volume: 41 start-page: 113 issue: 2 year: 2014 ident: 10.1016/j.archoralbio.2017.12.022_bib0310 article-title: Crevicular fluid biomarkers and periodontal disease progression publication-title: Journal of Clinical Periodontology doi: 10.1111/jcpe.12194 – volume: 39 start-page: 53 year: 2005 ident: 10.1016/j.archoralbio.2017.12.022_bib0360 article-title: Host-derived diagnostic markers for periodontitis: Do they exist in gingival crevice fluid? publication-title: Periodontology 2000 doi: 10.1111/j.1600-0757.2005.00129.x – volume: 49 start-page: 129 issue: 1 year: 2014 ident: 10.1016/j.archoralbio.2017.12.022_bib0395 article-title: Salivary antioxidants as periodontal biomarkers in evaluation of tissue status and treatment outcome publication-title: Journal of Periodontal Research doi: 10.1111/jre.12088 – volume: 59 start-page: 645 issue: 6 year: 2014 ident: 10.1016/j.archoralbio.2017.12.022_bib0330 article-title: Crevicular and serum levels of monocyte chemoattractant protein-4 and high-sensitivity C-reactive protein in periodontal health and disease publication-title: Archives of Oral Biology doi: 10.1016/j.archoralbio.2014.03.012 – volume: 43 start-page: 727 issue: 9 year: 2016 ident: 10.1016/j.archoralbio.2017.12.022_bib0510 article-title: Gingival crevicular fluid levels of cytokines/chemokines in chronic periodontitis: A meta-analysis publication-title: Journal of Clinical Periodontology doi: 10.1111/jcpe.12557 – volume: 72 start-page: 92 year: 2016 ident: 10.1016/j.archoralbio.2017.12.022_bib0600 article-title: Biomarker levels in gingival crevicular fluid of subjects with different periodontal conditions: A cross-sectional study publication-title: Archives of Oral Biology doi: 10.1016/j.archoralbio.2016.08.020 – volume: 5 start-page: 65 year: 2015 ident: 10.1016/j.archoralbio.2017.12.022_bib0270 article-title: Point-of-care diagnosis of periodontitis using saliva: Technically feasible but still a challenge publication-title: Frontiers in Cellular and Infection Microbiology doi: 10.3389/fcimb.2015.00065 – volume: 14 start-page: 61 issue: 1 year: 1996 ident: 10.1016/j.archoralbio.2017.12.022_bib0575 article-title: From proteins to proteomes: Large scale protein identification by two-dimensional electrophoresis and amino acid analysis publication-title: Biotechnology (N Y) – volume: 51 start-page: 9 year: 2000 ident: 10.1016/j.archoralbio.2017.12.022_bib0105 article-title: Periodontal diagnosis and treatment–where does the future lie? publication-title: Periodontology 2000 doi: 10.1111/j.1600-0757.2009.00319.x – volume: 4 start-page: 171 issue: 1 year: 2010 ident: 10.1016/j.archoralbio.2017.12.022_bib0370 article-title: Current developments in salivary diagnostics publication-title: Biomarkers in Medicine doi: 10.2217/bmm.09.68 – volume: 2014 start-page: 146974 year: 2014 ident: 10.1016/j.archoralbio.2017.12.022_bib0015 article-title: Hepatocyte growth factor levels in the saliva and gingival crevicular fluid in smokers with periodontitis publication-title: Disease Markers doi: 10.1155/2014/146974 – volume: 38 start-page: 85 issue: Suppl. 11 year: 2011 ident: 10.1016/j.archoralbio.2017.12.022_bib0090 article-title: Host-derived diagnostic markers related to soft tissue destruction and bone degradation in periodontitis publication-title: Journal Clinical Periodontology doi: 10.1111/j.1600-051X.2010.01670.x – volume: 32 start-page: 383 issue: 6 year: 2012 ident: 10.1016/j.archoralbio.2017.12.022_bib0430 article-title: Effect of non surgical periodontal therapy on gingival crevicular fluid and serum visfatin concentration in periodontal health and disease publication-title: Disease Markers doi: 10.1155/2012/828049 – volume: 70 start-page: 164 issue: 1 year: 2016 ident: 10.1016/j.archoralbio.2017.12.022_bib0265 article-title: Salivary cytokines as biomarkers of periodontal diseases publication-title: Periodontology 2000 doi: 10.1111/prd.12117 – volume: 62 start-page: 20 issue: 1 year: 2013 ident: 10.1016/j.archoralbio.2017.12.022_bib0030 article-title: Learned and unlearned concepts in periodontal diagnostics: A 50-year perspective publication-title: Periodontology 2000 doi: 10.1111/prd.12006 – volume: 1098 start-page: 362 year: 2007 ident: 10.1016/j.archoralbio.2017.12.022_bib0260 article-title: Integrated microfluidic platform for oral diagnostics publication-title: Annals of the New York Academy of Sciences doi: 10.1196/annals.1384.004 – volume: 50 start-page: 52 year: 2009 ident: 10.1016/j.archoralbio.2017.12.022_bib0175 article-title: Saliva as a diagnostic tool for periodontal disease: Current state and future directions publication-title: Periodontology 2000 doi: 10.1111/j.1600-0757.2008.00288.x – volume: 64 start-page: 57 issue: 1 year: 2014 ident: 10.1016/j.archoralbio.2017.12.022_bib0095 article-title: Inflammatory and immune pathways in the pathogenesis of periodontal disease publication-title: Periodontology 2000 doi: 10.1111/prd.12002 – volume: 54 start-page: 138 issue: 2 year: 2013 ident: 10.1016/j.archoralbio.2017.12.022_bib0450 article-title: MMP-3 and MMP-8 levels in patients with chronic periodontitis before and after nonsurgical periodontal therapy publication-title: Investigacion Clinica – volume: 34 start-page: 143 issue: 3 year: 2013 ident: 10.1016/j.archoralbio.2017.12.022_bib0280 article-title: Pentraxins as key disease markers for periodontal diagnosis publication-title: Disease Markers doi: 10.1155/2013/259273 – volume: 31 start-page: 343 issue: 6 year: 2011 ident: 10.1016/j.archoralbio.2017.12.022_bib0065 article-title: Gingival crevicular fluid calprotectin, osteocalcin and cross-linked N-terminal telopeptid levels in health and different periodontal diseases publication-title: Disease Markers doi: 10.1155/2011/512580 – volume: 61 start-page: 53 issue: 1 year: 2016 ident: 10.1016/j.archoralbio.2017.12.022_bib0170 article-title: Malondialdehyde, superoxide dismutase and melatonin levels in gingival crevicular fluid of aggressive and chronic periodontitis patients publication-title: Australian Dental Journal doi: 10.1111/adj.12294 – volume: 34 start-page: 109 year: 2004 ident: 10.1016/j.archoralbio.2017.12.022_bib0025 article-title: Analysis of gingival crevice fluid and risk of progression of periodontitis publication-title: Periodontology doi: 10.1046/j.0906-6713.2002.003427.x – volume: 21 start-page: 263 issue: 2 year: 2015 ident: 10.1016/j.archoralbio.2017.12.022_bib0460 article-title: Vascular endothelial cadherin and vascular endothelial growth factor in periodontitis and smoking publication-title: Oral Diseases doi: 10.1111/odi.12261 – volume: 67 start-page: 29 issue: 1 year: 2014 ident: 10.1016/j.archoralbio.2017.12.022_bib0290 article-title: Cytokines and chemokines are differentially expressed in patients with periodontitis: Possible role for TGF-beta1 as a marker for disease progression publication-title: Cytokine doi: 10.1016/j.cyto.2014.02.007 – volume: 137 start-page: 322 issue: 3 year: 2006 ident: 10.1016/j.archoralbio.2017.12.022_bib0365 article-title: Salivary biomarkers of existing periodontal disease: A cross-sectional study publication-title: Journal of the American Dental Association doi: 10.14219/jada.archive.2006.0181 – volume: 87 start-page: 923 issue: 8 year: 2016 ident: 10.1016/j.archoralbio.2017.12.022_bib0150 article-title: Chemerin as a novel crevicular fluid marker of patients with periodontitis and type 2 diabetes mellitus publication-title: Journal of Periodontology doi: 10.1902/jop.2016.150657 – volume: 62 start-page: 7 issue: 1 year: 2013 ident: 10.1016/j.archoralbio.2017.12.022_bib0495 article-title: Periodontology: Past, present, perspectives publication-title: Periodontology 2000 doi: 10.1111/prd.12011 – volume: 38 start-page: 1959 issue: 5 year: 2015 ident: 10.1016/j.archoralbio.2017.12.022_bib0120 article-title: Evaluation of local and systemic levels of interleukin-17, interleukin-23, and myeloperoxidase in response to periodontal therapy in patients with generalized aggressive periodontitis publication-title: Inflammation doi: 10.1007/s10753-015-0176-3 – volume: 31 start-page: 527 issue: 7 year: 2004 ident: 10.1016/j.archoralbio.2017.12.022_bib0340 article-title: Changes in transforming growth factor-beta1 in gingival crevicular fluid following periodontal surgery publication-title: Journal of Clinical Periodontology doi: 10.1111/j.1600-051x.2004.00521.x – volume: 81 start-page: 710 issue: 5 year: 2010 ident: 10.1016/j.archoralbio.2017.12.022_bib0165 article-title: Salivary-soluble CD44 levels in smokers and non-smokers with chronic periodontitis: A pilot study publication-title: Journal of Periodontology doi: 10.1902/jop.2010.090630 – start-page: 1804727 year: 2016 ident: 10.1016/j.archoralbio.2017.12.022_bib0380 article-title: Identification of gingival crevicular fluid sampling, analytical methods, and oral biomarkers for the diagnosis and monitoring of periodontal diseases: A systematic review publication-title: Disease Markers – volume: 40 start-page: 131 issue: 2 year: 2013 ident: 10.1016/j.archoralbio.2017.12.022_bib0045 article-title: Discovery of biomarker combinations that predict periodontal health or disease with high accuracy from GCF samples based on high-throughput proteomic analysis and mixed-integer linear optimization publication-title: Journal of Clinical Periodontology doi: 10.1111/jcpe.12037 – volume: 81 start-page: 89 issue: 1 year: 2010 ident: 10.1016/j.archoralbio.2017.12.022_bib0530 article-title: Relationships among gingival crevicular fluid biomarkers, clinical parameters of periodontal disease, and the subgingival microbiota publication-title: Journal of Periodontology doi: 10.1902/jop.2009.090397 – volume: 86 start-page: 1260 issue: 11 year: 2015 ident: 10.1016/j.archoralbio.2017.12.022_bib0555 article-title: Prognostic value of 8-Hydroxy-2′-Deoxyguanosine and human neutrophil elastase/alpha1-Proteinase inhibitor complex as salivary biomarkers of oxidative stress in chronic periodontitis publication-title: Journal of Periodontology doi: 10.1902/jop.2015.150293 – volume: 19 start-page: 45 issue: 1 year: 2015 ident: 10.1016/j.archoralbio.2017.12.022_bib0110 article-title: Soluble CD40 ligand: A novel biomarker in the pathogenesis of periodontal disease publication-title: Clinical Oral Investigations doi: 10.1007/s00784-014-1216-3 – volume: 694 start-page: 72 year: 1993 ident: 10.1016/j.archoralbio.2017.12.022_bib0375 article-title: Methods for collecting saliva publication-title: Annals of the New York Academy of Sciences doi: 10.1111/j.1749-6632.1993.tb18343.x – volume: 16 start-page: 54 issue: 1 year: 2012 ident: 10.1016/j.archoralbio.2017.12.022_bib0335 article-title: Assessment of the alkaline phosphatase level in gingival crevicular fluid, as a biomarker to evaluate the effect of scaling and root planing on chronic periodontitis: An in vivo study publication-title: Journal of Oral and Maxillofacial Pathology doi: 10.4103/0973-029X.92974 – volume: 1098 start-page: 411 year: 2007 ident: 10.1016/j.archoralbio.2017.12.022_bib0115 article-title: Lab-on-a-chip methods for point-of-care measurements of salivary biomarkers of periodontitis publication-title: Annals of the New York Academy of Sciences doi: 10.1196/annals.1384.035 – volume: 54 start-page: 1046 issue: 11 year: 2009 ident: 10.1016/j.archoralbio.2017.12.022_bib0160 article-title: Effect of nonsurgical periodontal therapy on crevicular fluid levels of Cathepsin K in periodontitis publication-title: Archives of Oral Biology doi: 10.1016/j.archoralbio.2009.08.007 – volume: 35 start-page: 507 issue: 6 year: 2008 ident: 10.1016/j.archoralbio.2017.12.022_bib0545 article-title: Effect of periodontal treatment on IL-1beta, IL-1ra, and IL-10 levels in gingival crevicular fluid in patients with aggressive periodontitis publication-title: Journal of Clinical Periodontology doi: 10.1111/j.1600-051X.2008.01213.x – volume: 90 start-page: 752 issue: 6 year: 2011 ident: 10.1016/j.archoralbio.2017.12.022_bib0305 article-title: Saliva/pathogen biomarker signatures and periodontal disease progression publication-title: Journal of Dental Research doi: 10.1177/0022034511399908 – volume: 85 start-page: 1432 issue: 10 year: 2014 ident: 10.1016/j.archoralbio.2017.12.022_bib0050 article-title: Lipid peroxidation levels and total oxidant/antioxidant status in serum and saliva from patients with chronic and aggressive periodontitis. Oxidative stress index: A new biomarker for periodontal disease? publication-title: Journal of Periodontology doi: 10.1902/jop.2014.130654 – volume: 143 start-page: 6s issue: Suppl. 10 year: 2012 ident: 10.1016/j.archoralbio.2017.12.022_bib0185 article-title: Salivary diagnostics for periodontal diseases publication-title: The Journal of the American Dental Association doi: 10.14219/jada.archive.2012.0341 – volume: 34 start-page: 729 issue: 9 year: 2007 ident: 10.1016/j.archoralbio.2017.12.022_bib0255 article-title: MMP-13 and TIMP-1 determinations in progressive chronic periodontitis publication-title: Journal of Clinical Periodontology doi: 10.1111/j.1600-051X.2007.01107.x – volume: 43 start-page: 34 issue: 1 year: 2016 ident: 10.1016/j.archoralbio.2017.12.022_bib0035 article-title: Diagnostic accuracy for apical and chronic periodontitis biomarkers in gingival crevicular fluid: An exploratory study publication-title: Journal of Clinical Periodontology doi: 10.1111/jcpe.12479 – volume: 73 start-page: 311 year: 2017 ident: 10.1016/j.archoralbio.2017.12.022_bib0005 article-title: Resistin as potential biomarker for chronic periodontitis: A systematic review and meta-analysis publication-title: Archives of Oral Biology doi: 10.1016/j.archoralbio.2016.08.016 – volume: 83 start-page: 1304 issue: 10 year: 2012 ident: 10.1016/j.archoralbio.2017.12.022_bib0070 article-title: Gingival crevicular fluid and plasma acute-phase cytokine levels in different periodontal diseases publication-title: Journal of Periodontology doi: 10.1902/jop.2012.110616 – volume: 81 start-page: 277 issue: 2 year: 2010 ident: 10.1016/j.archoralbio.2017.12.022_bib0505 article-title: Salivary and gingival crevicular fluid melatonin in periodontal health and disease publication-title: Journal of Periodontology doi: 10.1902/jop.2009.090327 – volume: 21 start-page: 568 issue: 4 year: 2010 ident: 10.1016/j.archoralbio.2017.12.022_bib0550 article-title: Genetic polymorphisms in periodontal diseases: An overview publication-title: Indian Journal of Dental Research doi: 10.4103/0970-9290.74226 – volume: 39 start-page: 986 issue: 3 year: 2016 ident: 10.1016/j.archoralbio.2017.12.022_bib0020 article-title: Gingival crevicular fluid and salivary periostin levels in non-smoker subjects with chronic and aggressive periodontitis: Periostin levels in chronic and aggressive periodontitis publication-title: Inflammation – volume: 83 start-page: 773 issue: 6 year: 2012 ident: 10.1016/j.archoralbio.2017.12.022_bib0155 article-title: The effects of chronic periodontitis and rheumatoid arthritis on serum and gingival crevicular fluid total antioxidant/oxidant status and oxidative stress index publication-title: Journal of Periodontology doi: 10.1902/jop.2011.110420 – volume: 7 start-page: 1994 issue: 5 year: 2008 ident: 10.1016/j.archoralbio.2017.12.022_bib0140 article-title: The proteomes of human parotid and submandibular/sublingual gland salivas collected as the ductal secretions publication-title: Journal of Proteome Research doi: 10.1021/pr700764j – volume: 31 start-page: 32 year: 2003 ident: 10.1016/j.archoralbio.2017.12.022_bib0200 article-title: Formation, collection and significance of gingival crevice fluid publication-title: Periodontology 2000 doi: 10.1034/j.1600-0757.2003.03103.x – volume: 7 issue: 1 year: 2017 ident: 10.1016/j.archoralbio.2017.12.022_bib0440 article-title: Salivary Diagnostics-Point-of-Care diagnostics of MMP-8 in dentistry and medicine publication-title: Diagnostics (Basel) – volume: 85 start-page: 610 issue: 4 year: 2014 ident: 10.1016/j.archoralbio.2017.12.022_bib0190 article-title: Resistin levels in gingival crevicular fluid of patients with chronic periodontitis and type 2 diabetes mellitus publication-title: Journal of Periodontology doi: 10.1902/jop.2013.130092 – volume: 10 start-page: 546 issue: 4 year: 2016 ident: 10.1016/j.archoralbio.2017.12.022_bib0325 article-title: Gingival crevicular fluid periostin levels in chronic periodontitis patients following nonsurgical periodontal treatment with low-level laser therapy publication-title: European Journal of Dentistry doi: 10.4103/1305-7456.195179 – start-page: 874 year: 2013 ident: 10.1016/j.archoralbio.2017.12.022_bib0180 article-title: Personalized medicine enters dentistry: What might this mean for clinical practice? publication-title: The Journal of the American Dental Association doi: 10.14219/jada.archive.2013.0200 – volume: 39 start-page: 1132 issue: 12 year: 2012 ident: 10.1016/j.archoralbio.2017.12.022_bib0540 article-title: Association of salivary levels of the bone remodelling regulators sRANKL and OPG with periodontal clinical status publication-title: Journal of Clinical Periodontology doi: 10.1111/jcpe.12012 – volume: 81 start-page: 384 issue: 3 year: 2010 ident: 10.1016/j.archoralbio.2017.12.022_bib0125 article-title: Salivary interleukin-6, matrix metalloproteinase-8, and osteoprotegerin in patients with periodontitis and diabetes publication-title: Journal of Periodontology doi: 10.1902/jop.2009.090510 – volume: 70 start-page: 65 issue: 1 year: 2016 ident: 10.1016/j.archoralbio.2017.12.022_bib0560 article-title: Clinical and technical considerations in the analysis of gingival crevicular fluid publication-title: Periodontology 2000 doi: 10.1111/prd.12109 – volume: 42 start-page: 300 issue: 4 year: 2007 ident: 10.1016/j.archoralbio.2017.12.022_bib0275 article-title: Leptin levels in gingival crevicular fluid in periodontal health and disease publication-title: Journal of Periodontal Research doi: 10.1111/j.1600-0765.2006.00948.x – year: 2016 ident: 10.1016/j.archoralbio.2017.12.022_bib0320 article-title: Prediction of periodontal inflammation via metabolic profiling of saliva publication-title: Journal of Dental Research doi: 10.1177/0022034516661142 – volume: 55 start-page: 70 issue: 1 year: 2010 ident: 10.1016/j.archoralbio.2017.12.022_bib0565 article-title: Lipid peroxidation levels, total oxidant status and superoxide dismutase in serum, saliva and gingival crevicular fluid in chronic periodontitis patients before and after periodontal therapy publication-title: Australian Dental Journal doi: 10.1111/j.1834-7819.2009.01123.x – volume: 80 start-page: 1146 issue: 7 year: 2009 ident: 10.1016/j.archoralbio.2017.12.022_bib0535 article-title: Within-subject variability in repeated measures of salivary analytes in healthy adults publication-title: Journal of Periodontology doi: 10.1902/jop.2009.080654 – volume: 70 start-page: 53 issue: 1 year: 2016 ident: 10.1016/j.archoralbio.2017.12.022_bib0060 article-title: Gingival crevicular fluid as a source of biomarkers for periodontitis publication-title: Periodontology 2000 doi: 10.1111/prd.12107 – volume: 8 start-page: e75898 issue: 10 year: 2013 ident: 10.1016/j.archoralbio.2017.12.022_bib0490 article-title: Quantitative proteomic analysis of gingival crevicular fluid in different periodontal conditions publication-title: PLoS One doi: 10.1371/journal.pone.0075898 – volume: 39 start-page: 203 issue: 3 year: 2012 ident: 10.1016/j.archoralbio.2017.12.022_bib0040 article-title: Novel protein identification methods for biomarker discovery via a proteomic analysis of periodontally healthy and diseased gingival crevicular fluid samples publication-title: Journal of Clinical Periodontology doi: 10.1111/j.1600-051X.2011.01805.x – volume: 38 start-page: 434 issue: 5 year: 2011 ident: 10.1016/j.archoralbio.2017.12.022_bib0475 article-title: Salivary biomarkers of periodontal disease in response to treatment publication-title: Journal of Clinical Periodontology doi: 10.1111/j.1600-051X.2011.01706.x – volume: 9 start-page: 2191 issue: 5 year: 2010 ident: 10.1016/j.archoralbio.2017.12.022_bib0085 article-title: Application of label-free absolute quantitative proteomics in human gingival crevicular fluid by LC/MS E (gingival exudatome) publication-title: Journal of Proteome Research doi: 10.1021/pr900941z – volume: 40 start-page: 825 issue: 9 year: 2013 ident: 10.1016/j.archoralbio.2017.12.022_bib0465 article-title: Identification of periodontitis associated changes in the proteome of whole human saliva by mass spectrometric analysis publication-title: Journal of Clinical Periodontology doi: 10.1111/jcpe.12130 – volume: 59 start-page: 61 issue: 1 year: 2012 ident: 10.1016/j.archoralbio.2017.12.022_bib0345 article-title: Application of evidence-based dentistry: From research to clinical periodontal practice publication-title: Periodontology 2000 doi: 10.1111/j.1600-0757.2011.00437.x – volume: 2014 start-page: 593151 year: 2014 ident: 10.1016/j.archoralbio.2017.12.022_bib0525 article-title: Protein biomarkers of periodontitis in saliva publication-title: ISRN Inflammation doi: 10.1155/2014/593151 – volume: 51 start-page: 25 year: 2009 ident: 10.1016/j.archoralbio.2017.12.022_bib0595 article-title: 2009). The clinical value of salivary biomarkers for periodontal disease publication-title: Periodontology 2000 doi: 10.1111/j.1600-0757.2009.00315.x – volume: 48 start-page: 315 issue: 3 year: 2013 ident: 10.1016/j.archoralbio.2017.12.022_bib0010 article-title: Melatonin levels in periodontal health and disease publication-title: Journal of Periodontal Research doi: 10.1111/jre.12010 – volume: 80 start-page: 436 issue: 3 year: 2009 ident: 10.1016/j.archoralbio.2017.12.022_bib0435 article-title: Identification of pathogen and host-response markers correlated with periodontal disease publication-title: Journal of Periodontology doi: 10.1902/jop.2009.080480 – volume: 34 start-page: 370 issue: 5 year: 2007 ident: 10.1016/j.archoralbio.2017.12.022_bib0080 article-title: Gingival crevicular fluid levels of RANKL and OPG in periodontal diseases: Implications of their relative ratio publication-title: Journal of Clinical Periodontology doi: 10.1111/j.1600-051X.2007.01061.x – volume: 57 start-page: 413 issue: 4 year: 2012 ident: 10.1016/j.archoralbio.2017.12.022_bib0390 article-title: Salivary biomarkers for predicting the progression of chronic periodontitis publication-title: Archives of Oral Biology doi: 10.1016/j.archoralbio.2011.09.011 – volume: 79 start-page: 2112 issue: 11 year: 2008 ident: 10.1016/j.archoralbio.2017.12.022_bib0135 article-title: Transcriptomes in healthy and diseased gingival tissues publication-title: Journal of Periodontology doi: 10.1902/jop.2008.080139 – volume: 27 start-page: 453 issue: 7 year: 2000 ident: 10.1016/j.archoralbio.2017.12.022_bib0285 article-title: Analysis of saliva for periodontal diagnosis–A review publication-title: Journal of Clinical Periodontology doi: 10.1034/j.1600-051x.2000.027007453.x – volume: 81 start-page: 1308 issue: 9 year: 2010 ident: 10.1016/j.archoralbio.2017.12.022_bib0445 article-title: Immunologic and microbiologic profiles of chronic and aggressive periodontitis subjects publication-title: Journal of Periodontology doi: 10.1902/jop.2010.090643 – volume: 41 start-page: 119 issue: 2 year: 2013 ident: 10.1016/j.archoralbio.2017.12.022_bib0295 article-title: Salivary biomarkers in the diagnosis of periodontal diseases publication-title: Journal of the California Dental Association doi: 10.1080/19424396.2013.12222285 – volume: 84 start-page: 1627 issue: 11 year: 2013 ident: 10.1016/j.archoralbio.2017.12.022_bib0210 article-title: Gingival crevicular fluid, serum levels of receptor activator of nuclear factor-kappaB ligand, osteoprotegerin, and interleukin-17 in patients with rheumatoid arthritis and osteoporosis and with periodontal disease publication-title: Journal of Periodontology doi: 10.1902/jop.2013.120595 – volume: 37 start-page: 487 issue: 6 year: 2010 ident: 10.1016/j.archoralbio.2017.12.022_bib0225 article-title: Salivary MMP-8, TIMP-1, and ICTP as markers of advanced periodontitis publication-title: Journal of Clinical Periodontology doi: 10.1111/j.1600-051X.2010.01563.x – volume: 85 start-page: 1081 issue: 8 year: 2014 ident: 10.1016/j.archoralbio.2017.12.022_bib0520 article-title: Salivary visfatin concentrations in patients with chronic periodontitis publication-title: Journal of Periodontology doi: 10.1902/jop.2013.130388 – volume: 87 start-page: 36 issue: 1 year: 2016 ident: 10.1016/j.archoralbio.2017.12.022_bib0245 article-title: Pilot study on oral health status as assessed by an active matrix metalloproteinase-8 chairside mouthrinse test in adolescents publication-title: Journal of Periodontology doi: 10.1902/jop.2015.150377 – volume: 86 start-page: 273 issue: 2 year: 2015 ident: 10.1016/j.archoralbio.2017.12.022_bib0250 article-title: Effect of initial periodontal therapy on oxidative stress markers in gingival crevicular fluid, saliva, and serum in smokers and non-smokers with chronic periodontitis publication-title: Journal of Periodontology doi: 10.1902/jop.2014.140338 – volume: 26 start-page: 32 issue: Suppl. 1 year: 2012 ident: 10.1016/j.archoralbio.2017.12.022_bib0515 article-title: Periodontal disease: A genetic perspective publication-title: Brazilian Oral Research doi: 10.1590/S1806-83242012000700006 – volume: 41 start-page: 348 issue: 4 year: 2014 ident: 10.1016/j.archoralbio.2017.12.022_bib0350 article-title: Matrix metalloproteinases and myeloperoxidase in gingival crevicular fluid provide site-specific diagnostic value for chronic periodontitis publication-title: Journal of Clinical Periodontology doi: 10.1111/jcpe.12223 – volume: 70 start-page: 142 issue: 1 year: 2016 ident: 10.1016/j.archoralbio.2017.12.022_bib0500 article-title: 2016). Analysis of matrix metalloproteinases, especially MMP-8, in gingival creviclular fluid, mouthrinse and saliva for monitoring periodontal diseases publication-title: Periodontology 2000 doi: 10.1111/prd.12101 – volume: 19 start-page: 921 issue: 4 year: 2015 ident: 10.1016/j.archoralbio.2017.12.022_bib0405 article-title: Evaluation of the salivary levels of visfatin, chemerin, and progranulin in periodontal inflammation publication-title: Clinical Oral Investigations doi: 10.1007/s00784-014-1308-0 – volume: 16 start-page: 242 issue: 3 year: 2010 ident: 10.1016/j.archoralbio.2017.12.022_bib0195 article-title: Melatonin in diseases of the oral cavity publication-title: Oral Diseases doi: 10.1111/j.1601-0825.2009.01610.x – volume: 6 start-page: 118 issue: 2 year: 2015 ident: 10.1016/j.archoralbio.2017.12.022_bib0410 article-title: Effect of phase 1 periodontal therapy on gingival crevicular fluid levels of matrix metalloproteinases-3 and –13 in chronic periodontitis patients publication-title: Journal of Investigative and Clinical Dentistry doi: 10.1111/jicd.12072 – volume: 70 start-page: 11 issue: 1 year: 2016 ident: 10.1016/j.archoralbio.2017.12.022_bib0425 article-title: The physiology of salivary secretion publication-title: Periodontology 2000 doi: 10.1111/prd.12116 – volume: 143 start-page: 19s issue: Suppl. 10 year: 2012 ident: 10.1016/j.archoralbio.2017.12.022_bib0580 article-title: Salivaomics publication-title: Journal of the American Dental Association doi: 10.14219/jada.archive.2012.0339 – start-page: 174764 year: 2012 ident: 10.1016/j.archoralbio.2017.12.022_bib0480 article-title: IL-17 and IL-11 GCF levels in aggressive and chronic periodontitis patients: Relation to PCR bacterial detection publication-title: Mediators of Inflammation – volume: 84 start-page: 821 issue: 6 year: 2013 ident: 10.1016/j.archoralbio.2017.12.022_bib0130 article-title: 8-hydroxy-deoxyguanosine levels in gingival crevicular fluid and saliva in patients with chronic periodontitis after initial periodontal treatment publication-title: Journal of Periodontology doi: 10.1902/jop.2012.120195 – volume: 57 start-page: 67 issue: 2 year: 2015 ident: 10.1016/j.archoralbio.2017.12.022_bib0400 article-title: Effects of initial periodontal therapy on interleukin-1beta level in gingival crevicular fluid and clinical periodontal parameters publication-title: Journal of Oral Science doi: 10.2334/josnusd.57.67 – volume: 9 start-page: Zc48 issue: 5 year: 2015 ident: 10.1016/j.archoralbio.2017.12.022_bib0470 article-title: Association between gingival crevicular fluid leptin levels and periodontal status − A biochemical study on indian patients publication-title: Journal of Clinical and Diagnostic Research – volume: 39 start-page: 295 issue: 3 year: 2012 ident: 10.1016/j.archoralbio.2017.12.022_bib0605 article-title: Effects of periodontal therapy on GCF cytokines in generalized aggressive periodontitis subjects publication-title: Journal of Clinical Periodontology doi: 10.1111/j.1600-051X.2011.01817.x – volume: 70 start-page: 26 issue: 1 year: 2016 ident: 10.1016/j.archoralbio.2017.12.022_bib0315 article-title: Personalized medicine: An update of salivary biomarkers for periodontal diseases publication-title: Periodontology 2000 doi: 10.1111/prd.12103 – volume: 35 start-page: 389 issue: 5 year: 2013 ident: 10.1016/j.archoralbio.2017.12.022_bib0420 article-title: Crevicular fluid and serum concentrations of progranulin and high sensitivity CRP in chronic periodontitis and type 2 diabetes publication-title: Disease Markers doi: 10.1155/2013/803240 – volume: 51 start-page: 2415 issue: 12 year: 2005 ident: 10.1016/j.archoralbio.2017.12.022_bib0355 article-title: Enzyme immunoassay (EIA)/enzyme-linked immunosorbent assay (ELISA) publication-title: Clinical Chemistry doi: 10.1373/clinchem.2005.051532 – volume: 42 start-page: 450 issue: 5 year: 2007 ident: 10.1016/j.archoralbio.2017.12.022_bib0485 article-title: Plasma and crevicular fluid osteopontin levels in periodontal health and disease publication-title: Journal of Periodontal Research doi: 10.1111/j.1600-0765.2007.00968.x – volume: 5 start-page: 46 issue: 1 year: 2015 ident: 10.1016/j.archoralbio.2017.12.022_bib0220 article-title: Proteomics − The research frontier in periodontics publication-title: Journal of Oral Biology and Craniofacial Research doi: 10.1016/j.jobcr.2015.01.001 – start-page: 341259 year: 2015 ident: 10.1016/j.archoralbio.2017.12.022_bib0240 article-title: Effect of periodontal surgery on osteoprotegerin levels in gingival crevicular fluid, saliva, and gingival tissues of chronic periodontitis patients publication-title: Disease Markers – volume: 14 start-page: 430 issue: 6 year: 2003 ident: 10.1016/j.archoralbio.2017.12.022_bib0300 article-title: Genes and gene polymorphisms associated with periodontal disease publication-title: Critical Reviews in Oral Biology and Medicine doi: 10.1177/154411130301400605 – volume: 58 start-page: 379 issue: 3 year: 2016 ident: 10.1016/j.archoralbio.2017.12.022_bib0145 article-title: Levels of vaspin and omentin-1 in gingival crevicular fluid as potential markers of inflammation in patients with chronic periodontitis and type 2 diabetes mellitus publication-title: Journal of Oral Science doi: 10.2334/josnusd.15-0731 – volume: 17 start-page: 1219 issue: 4 year: 2013 ident: 10.1016/j.archoralbio.2017.12.022_bib0075 article-title: Non-surgical periodontal therapy influences salivary melatonin levels publication-title: Clinical Oral Investigations doi: 10.1007/s00784-012-0801-6 – volume: 43 start-page: 160 year: 2007 ident: 10.1016/j.archoralbio.2017.12.022_bib0100 article-title: The role of reactive oxygen and antioxidant species in periodontal tissue destruction publication-title: Periodontology 2000 doi: 10.1111/j.1600-0757.2006.00178.x – volume: 507 start-page: 181 issue: 7491 year: 2014 ident: 10.1016/j.archoralbio.2017.12.022_bib0455 article-title: The present and future role of microfluidics in biomedical research publication-title: Nature doi: 10.1038/nature13118 – volume: 61 start-page: 892 issue: 3 year: 2013 ident: 10.1016/j.archoralbio.2017.12.022_bib0215 article-title: Role of monocyte chemoattractant protein-1 (MCP-1) as an immune-diagnostic biomarker in the pathogenesis of chronic periodontal disease publication-title: Cytokine doi: 10.1016/j.cyto.2012.12.012 – volume: 37 start-page: 241 issue: 3 year: 2010 ident: 10.1016/j.archoralbio.2017.12.022_bib0235 article-title: Alterations in the salivary proteome associated with periodontitis publication-title: Journal of Clinical Periodontology doi: 10.1111/j.1600-051X.2009.01525.x – volume: 69 start-page: 89 issue: 3 year: 2001 ident: 10.1016/j.archoralbio.2017.12.022_bib0205 article-title: Biomarkers and surrogate endpoints: Preferred definitions and conceptual framework publication-title: Clinical Pharmacology and Therapeutics doi: 10.1067/mcp.2001.113989 – volume: 30 start-page: 299 issue: 6 year: 2011 ident: 10.1016/j.archoralbio.2017.12.022_bib0230 article-title: Use of host- and bacteria-derived salivary markers in detection of periodontitis: A cumulative approach publication-title: Disease Markers doi: 10.1155/2011/621484 – volume: 33 start-page: 337 issue: 3 year: 2002 ident: 10.1016/j.archoralbio.2017.12.022_bib0590 article-title: Superoxide dismutase multigene family: A comparison of the CuZn-SOD (SOD1), Mn-SOD (SOD2), and EC-SOD (SOD3) gene structures, evolution, and expression publication-title: Free Radical Biology and Medicine doi: 10.1016/S0891-5849(02)00905-X – volume: 71 start-page: 140 issue: 1 year: 2016 ident: 10.1016/j.archoralbio.2017.12.022_bib0385 article-title: Polymorphonuclear neutrophils in periodontitis and their possible modulation as a therapeutic approach publication-title: Periodontology 2000 doi: 10.1111/prd.12113 – volume: 87 start-page: 12161 issue: 24 year: 2015 ident: 10.1016/j.archoralbio.2017.12.022_bib0570 article-title: Colorimetric assay for the detection of typical biomarkers for periodontitis using a magnetic nanoparticle biosensor publication-title: Analytical Chemistry doi: 10.1021/acs.analchem.5b03018 – volume: 82 start-page: 734 issue: 5 year: 2011 ident: 10.1016/j.archoralbio.2017.12.022_bib0415 article-title: Levels of pentraxin-3 in gingival crevicular fluid and plasma in periodontal health and disease publication-title: Journal of Periodontology doi: 10.1902/jop.2010.100526 – volume: 86 start-page: 795 issue: 6 year: 2015 ident: 10.1016/j.archoralbio.2017.12.022_bib0585 article-title: Effect of non-surgical periodontal treatment on visfatin concentrations in serum and gingival crevicular fluid of patients with chronic periodontitis and type 2 diabetes mellitus publication-title: Journal of Periodontology doi: 10.1902/jop.2015.140476 – volume: 19 start-page: 201 issue: 2 year: 2015 ident: 10.1016/j.archoralbio.2017.12.022_bib0055 article-title: Salivary DNA and markers of oxidative stress in patients with chronic periodontitis publication-title: Clinical Oral Investigations doi: 10.1007/s00784-014-1236-z
SSID	ssj0005661
Score	2.519531
SecondaryResourceType	review_article
Snippet	•Oral biomarkers can be used as an adjunctive method for diagnosis & monitoring of periodontal disease progression.•No clinical or laboratory test is routinely... The holy grail of biomarker research in periodontology is to develop a high impact diagnostics which have a significant impact on clinical decision-making,...
SourceID	proquest pubmed crossref elsevier
SourceType	Aggregation Database Index Database Enrichment Source Publisher
StartPage	115
SubjectTerms	Biomarkers Biomarkers - analysis Disease Progression GCF Gingival Crevicular Fluid - chemistry Humans Periodontal disease Periodontal Diseases - diagnosis Proteomics - trends Saliva Saliva - chemistry Sensitivity and Specificity
Title	Diagnostic potential and future directions of biomarkers in gingival crevicular fluid and saliva of periodontal diseases: Review of the current evidence
URI	https://www.clinicalkey.com/#!/content/1-s2.0-S0003996917304053 https://dx.doi.org/10.1016/j.archoralbio.2017.12.022 https://www.ncbi.nlm.nih.gov/pubmed/29288920 https://www.proquest.com/docview/1982841444
Volume	87
WOSCitedRecordID	wos000427208700015&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVESC databaseName: Elsevier SD Freedom Collection Journals 2021 customDbUrl: eissn: 1879-1506 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0005661 issn: 0003-9969 databaseCode: AIEXJ dateStart: 19950101 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1da9swFBVpu6-XsXVbl30UFfYWXGLZjuSyl7B2bHsoe-gg7MXYksxSUtukSWj_yX7u7tWHbRiB7GEvwdjIsX2OpSvr3HMJ-SBCmeRaySCUYowpOVFQMM0DKRWDcF8XcpKbYhP88lLMZun3waDxuTCbBa8qcXeXNv8VatgHYGPq7D_A3Z4UdsA2gA6_ADv87gT8uRXPoRFrU69QDOTsAKx9yMgOYl7_hun3qNBZGl0sViyab9AyBNW_VqJaLtZz4-c6us1x3chopOFGYD5rMindEo-T1vlEGIxnpfN-0q5yaT8Q7jveGpMA5wbV6oGwyEtuF4vqX_loen_jeOw-UYSi02idatutCp4G6GXY73fdQGs7ztAmdf7VodtvC9enSAW8GrgY1ONx8w3XZjT3MG1uDKjAMiFSNu7GuFZ56A_tkQPGkxT6wYPp14vZt04WBAHLI3LS6QC3_DO6SLtzbQtptk1ZTOhy9Yw8dXMOOrVceU4Gujokj8-RGljq75A8_Fmbh_-C_O7YQ1v2UACfWvbQjj20LmnHHjqvqGcP7dhDDXvMCSx7sFWPPdSz54xa7uBx4A513KGeOy_Jj88XV5--BK54RyAhAl_B2F5wHrKi1CVscF6WEdd5zrROGI-LMoHIMh9PUugs4kTJMEJjRAGbE6YiJZPoFdmv6kq_JpSVZVxgwnUkVRxHvIBZtiyEUlExKZRSQyL888-kc7bHAiuLzEsYr7MeihmimIUsAxSHhLVNG2vvskujMw9y5vOXYcTNgLO7NP7YNnZBrkVu1-YnnlUZDAS4updXul7fZmEqINQM4zgekiNLt_aWPFPfbD3yljzp3tx3ZH-1XOv35IHcABOXx2SPz8Sxe1X-AK8u47k
linkProvider	Elsevier
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Diagnostic+potential+and+future+directions+of+biomarkers+in+gingival+crevicular+fluid+and+saliva+of+periodontal+diseases%3A+Review+of+the+current+evidence&rft.jtitle=Archives+of+oral+biology&rft.au=Ghallab%2C+Noha+Ayman&rft.date=2018-03-01&rft.eissn=1879-1506&rft.volume=87&rft.spage=115&rft_id=info:doi/10.1016%2Fj.archoralbio.2017.12.022&rft_id=info%3Apmid%2F29288920&rft.externalDocID=29288920
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0003-9969&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0003-9969&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0003-9969&client=summon