Evaluation of Jacalin lectin sorbents for the extraction of the human chorionic gonadotropin glycoforms prior to analysis by nano liquid chromatography-high resolution mass spectrometry

Human chorionic gonadotropin (hCG) is a dimeric, highly glycosylated hormone with a total of 4 N- and 4 O-glycosylation sites in its two subunits, hCGα and hCGβ. Recently, we developed a novel nano liquid chromatography coupled to high resolution mass spectrometry (nanoLC-HRMS) method for the analys...

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Bibliographic Details
Published in:	Journal of pharmaceutical and biomedical analysis Vol. 252; p. 116525
Main Authors:	Goumenou, Anastasia, Chendo, Christophe, Combès, Audrey, Fournier, Thierry, Pichon, Valérie, Delaunay, Nathalie
Format:	Journal Article
Language:	English
Published:	England Elsevier B.V 01.01.2025 Elsevier
Subjects:	Chemical Sciences Chorionic Gonadotropin - analysis Chorionic Gonadotropin - chemistry Chorionic Gonadotropin - urine Chromatography, Liquid - methods Glycosylation Human chorionic gonadotropin Humans Jacalin Lectin Liquid chromatography Mass spectrometry Mass Spectrometry - methods Nanotechnology - methods Plant Lectins - chemistry Solid phase extraction Solid Phase Extraction - methods Jacalin Lectin Solid phase extraction Liquid chromatography Mass spectrometry Human chorionic gonadotropin mass spectrometry liquid chromatography human chorionic gonadotropin solid phase extraction lectin
ISSN:	0731-7085, 1873-264X, 1873-264X
Online Access:	Get full text
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