Applications of the Delay Stochastic Simulation Algorithm (DSSA) in Mathematical Epidemiology
The calculation of the probability of a minor outbreak is crucial in analyzing a stochastic epidemic model. For stochastic epidemic models with fixed delays, the linear chain trick is applied to transform the delayed models into a family of ODE models with increasing shape parameters. We then prove...
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| Vydané v: | Mathematics (Basel) Ročník 10; číslo 20; s. 3759 |
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01.10.2022
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| Abstract | The calculation of the probability of a minor outbreak is crucial in analyzing a stochastic epidemic model. For stochastic epidemic models with fixed delays, the linear chain trick is applied to transform the delayed models into a family of ODE models with increasing shape parameters. We then prove that the well-established results on the probability of a minor outbreak for continuous-time Markov chain (CTMC) epidemic models also hold for the stochastic epidemic models with fixed delays. All theoretical results are verified by numerical simulations implemented by the delay stochastic simulation algorithm (DSSA) in Python. It is shown that DSSA is able to generate exact realizations for underlying delayed models in the context of mathematical epidemiology, and therefore, provides insights into the effect of delays during the outbreak phases of epidemics. |
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| AbstractList | The calculation of the probability of a minor outbreak is crucial in analyzing a stochastic epidemic model. For stochastic epidemic models with fixed delays, the linear chain trick is applied to transform the delayed models into a family of ODE models with increasing shape parameters. We then prove that the well-established results on the probability of a minor outbreak for continuous-time Markov chain (CTMC) epidemic models also hold for the stochastic epidemic models with fixed delays. All theoretical results are verified by numerical simulations implemented by the delay stochastic simulation algorithm (DSSA) in Python. It is shown that DSSA is able to generate exact realizations for underlying delayed models in the context of mathematical epidemiology, and therefore, provides insights into the effect of delays during the outbreak phases of epidemics. |
| Audience | Academic |
| Author | Bai, Fan |
| Author_xml | – sequence: 1 givenname: Fan surname: Bai fullname: Bai, Fan |
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| Cites_doi | 10.1006/tpbi.2001.1525 10.1038/srep10371 10.1186/1471-2105-12-S1-S17 10.1196/annals.1408.006 10.1016/j.jtbi.2007.04.014 10.1007/978-1-4419-7646-8 10.1080/17513758.2018.1498984 10.1098/rsif.2009.0514 10.1007/978-3-540-78911-6_3 10.1021/j100540a008 10.1007/978-3-319-21554-9 10.1073/pnas.0503858102 10.1007/s00285-015-0961-5 10.1007/978-1-4614-1686-9 10.1016/0021-9991(76)90041-3 10.1007/978-3-642-65371-1 10.1371/journal.pone.0079345 10.1007/978-0-85729-115-8 10.1063/1.2799998 10.1371/journal.pcbi.0020117 10.1021/jp993732q 10.1063/1.2710253 10.1098/rspb.2001.1599 10.1063/5.0028972 10.1016/j.aml.2018.07.022 10.1007/978-1-4614-7320-6_189-1 10.1016/S0025-5564(98)10027-5 10.1140/epjp/s13360-022-02726-3 10.1111/j.2517-6161.1949.tb00031.x 10.1093/biomet/67.1.191 10.1007/1-4020-3647-7_13 |
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| SubjectTerms | Algorithms branching process Computer simulation delay differential equations Epidemics Epidemiology Food science Gene expression Infections Infectious diseases Learning models (Stochastic processes) Markov analysis Markov chain Markov chains Mathematical models numerical methods Outbreaks Population Probability probability of a minor epidemic outbreak Probability theory Random variables Signal transduction Simulation stochastic epidemic models with delays Stochastic models Viral infections |
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| Title | Applications of the Delay Stochastic Simulation Algorithm (DSSA) in Mathematical Epidemiology |
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