Substrate stiffness modulates cardiac fibroblast activation, senescence, and proinflammatory secretory phenotype

In vitro cultures of primary cardiac fibroblasts (CFs), the major extracellular matrix (ECM)-producing cells of the heart, are used to determine molecular mechanisms of cardiac fibrosis. However, the supraphysiologic stiffness of tissue culture polystyrene (TCPS) triggers the conversion of CFs into...

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Bibliographic Details

Published in:	American journal of physiology. Heart and circulatory physiology Vol. 326; no. 1; p. H61
Main Authors:	Felisbino, Marina B, Rubino, Marcello, Travers, Joshua G, Schuetze, Katherine B, Lemieux, Madeleine E, Anseth, Kristi S, Aguado, Brian A, McKinsey, Timothy A
Format:	Journal Article
Language:	English
Published:	United States 01.01.2024
Subjects:	Cells, Cultured Cellular Senescence Extracellular Matrix - metabolism Fibroblasts - metabolism Hydrogels - analysis Hydrogels - metabolism Myocardium - metabolism Myofibroblasts Phenotype senescence fibrosis fibroblast hydrogel inflammation culture substrate
ISSN:	1522-1539, 1522-1539
Online Access:	Get more information
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