Axon initial segment Kv1 channels control axonal action potential waveform and synaptic efficacy

Action potentials are binary signals that transmit information via their rate and temporal pattern. In this context, the axon is thought of as a transmission line, devoid of a role in neuronal computation. Here, we show a highly localized role of axonal Kv1 potassium channels in shaping the action p...

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Bibliographic Details
Published in:	Neuron (Cambridge, Mass.) Vol. 55; no. 4; p. 633
Main Authors:	Kole, Maarten H P, Letzkus, Johannes J, Stuart, Greg J
Format:	Journal Article
Language:	English
Published:	United States 16.08.2007
Subjects:	4-Aminopyridine - pharmacology Action Potentials - drug effects Action Potentials - physiology Action Potentials - radiation effects Animals Axons - drug effects Axons - physiology Axons - radiation effects Cerebral Cortex - cytology Dose-Response Relationship, Drug Dose-Response Relationship, Radiation Elapid Venoms - pharmacology Electric Stimulation - methods Excitatory Postsynaptic Potentials - drug effects Excitatory Postsynaptic Potentials - physiology Excitatory Postsynaptic Potentials - radiation effects Female In Vitro Techniques Lysine - analogs & derivatives Lysine - metabolism Male Models, Neurological Patch-Clamp Techniques Potassium Channel Blockers - pharmacology Pyramidal Cells - cytology Rats Rats, Wistar Shaker Superfamily of Potassium Channels - physiology Synapses - drug effects Synapses - physiology Synapses - radiation effects
ISSN:	0896-6273
Online Access:	Get more information
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