Causes of hypercarbia with oxygen therapy in patients with chronic obstructive pulmonary disease
To compare data derived from a computer model of the pulmonary circulation with data from a case series of patients with chronic obstructive pulmonary disease (COPD). To evaluate the specific factors contributing to CO2 retention due to oxygen therapy in patients with acute exacerbations of COPD. Da...
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| Veröffentlicht in: | Critical care medicine Jg. 24; H. 1; S. 23 |
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| Hauptverfasser: | , , , |
| Format: | Journal Article |
| Sprache: | Englisch |
| Veröffentlicht: |
United States
01.01.1996
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| ISSN: | 0090-3493 |
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| Abstract | To compare data derived from a computer model of the pulmonary circulation with data from a case series of patients with chronic obstructive pulmonary disease (COPD). To evaluate the specific factors contributing to CO2 retention due to oxygen therapy in patients with acute exacerbations of COPD.
Data from a computer model of the pulmonary circulation were compared with a previous case series.
Patient data were derived from previous case series.
Simulated application of oxygen therapy.
The computer model of the pulmonary circulation generates data comparable with those data from a series of patients with COPD treated with supplemental oxygen and permits identification of the causes for hypercarbia. Therapy with supplemental oxygen alters hypoxic pulmonary vasoconstriction and modulates the Haldane effect, resulting in changes in physiologic deadspace.
Changes in physiologic deadspace are sufficient to account for the hypercarbia developed by patients with acute exacerbations of COPD when treated with supplemental oxygen. |
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| AbstractList | To compare data derived from a computer model of the pulmonary circulation with data from a case series of patients with chronic obstructive pulmonary disease (COPD). To evaluate the specific factors contributing to CO2 retention due to oxygen therapy in patients with acute exacerbations of COPD.OBJECTIVESTo compare data derived from a computer model of the pulmonary circulation with data from a case series of patients with chronic obstructive pulmonary disease (COPD). To evaluate the specific factors contributing to CO2 retention due to oxygen therapy in patients with acute exacerbations of COPD.Data from a computer model of the pulmonary circulation were compared with a previous case series.DESIGNData from a computer model of the pulmonary circulation were compared with a previous case series.Patient data were derived from previous case series.PATIENTSPatient data were derived from previous case series.Simulated application of oxygen therapy.INTERVENTIONSSimulated application of oxygen therapy.The computer model of the pulmonary circulation generates data comparable with those data from a series of patients with COPD treated with supplemental oxygen and permits identification of the causes for hypercarbia. Therapy with supplemental oxygen alters hypoxic pulmonary vasoconstriction and modulates the Haldane effect, resulting in changes in physiologic deadspace.MEASUREMENTS AND MAIN RESULTSThe computer model of the pulmonary circulation generates data comparable with those data from a series of patients with COPD treated with supplemental oxygen and permits identification of the causes for hypercarbia. Therapy with supplemental oxygen alters hypoxic pulmonary vasoconstriction and modulates the Haldane effect, resulting in changes in physiologic deadspace.Changes in physiologic deadspace are sufficient to account for the hypercarbia developed by patients with acute exacerbations of COPD when treated with supplemental oxygen.CONCLUSIONChanges in physiologic deadspace are sufficient to account for the hypercarbia developed by patients with acute exacerbations of COPD when treated with supplemental oxygen. To compare data derived from a computer model of the pulmonary circulation with data from a case series of patients with chronic obstructive pulmonary disease (COPD). To evaluate the specific factors contributing to CO2 retention due to oxygen therapy in patients with acute exacerbations of COPD. Data from a computer model of the pulmonary circulation were compared with a previous case series. Patient data were derived from previous case series. Simulated application of oxygen therapy. The computer model of the pulmonary circulation generates data comparable with those data from a series of patients with COPD treated with supplemental oxygen and permits identification of the causes for hypercarbia. Therapy with supplemental oxygen alters hypoxic pulmonary vasoconstriction and modulates the Haldane effect, resulting in changes in physiologic deadspace. Changes in physiologic deadspace are sufficient to account for the hypercarbia developed by patients with acute exacerbations of COPD when treated with supplemental oxygen. |
| Author | Marshall, B E Frasch, H F Marshall, C Hanson, 3rd, C W |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/8565533$$D View this record in MEDLINE/PubMed |
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| SubjectTerms | Blood Pressure Carbon Dioxide - blood Computer Simulation Humans Hypercapnia - etiology Hypercapnia - physiopathology Lung Diseases, Obstructive - blood Lung Diseases, Obstructive - physiopathology Lung Diseases, Obstructive - therapy Oxygen - blood Oxygen Inhalation Therapy - adverse effects Pulmonary Artery - physiopathology Pulmonary Circulation Vasoconstriction Ventilation-Perfusion Ratio |
| Title | Causes of hypercarbia with oxygen therapy in patients with chronic obstructive pulmonary disease |
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