Preclinical platforms to study therapeutic efficacy of human γδ T cells

Background Gamma delta (γδ) T lymphocytes are promising candidate for adoptive T cell therapy, however, their treatment efficacy is not satisfactory. Vδ2 T cells are unique to primates and few suitable models are available to assay their anti‐tumour function. Methods We tested human γδ T cell activa...

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Bibliographic Details
Published in:	Clinical and translational medicine Vol. 12; no. 6; pp. e814 - n/a
Main Authors:	Ou, Lingling, Wang, Huaishan, Huang, Hui, Zhou, Zhiyan, Lin, Qiang, Guo, Yeye, Mitchell, Tara, Huang, Alexander C., Karakousis, Giorgos, Schuchter, Lynn, Amaravadi, Ravi, Guo, Wei, Salvino, Joseph, Herlyn, Meenhard, Xu, Xiaowei
Format:	Journal Article
Language:	English
Published:	United States John Wiley & Sons, Inc 01.06.2022 John Wiley and Sons Inc Wiley
Subjects:	B7-H1 Antigen Cancer Clinical medicine Cytotoxicity Cytotoxicity, Immunologic epigenetic modifiers Extracellular matrix Fibroblasts Humans immune checkpoint blockade Immunotherapy Immunotherapy - methods Lymphocytes Melanoma Melanoma - drug therapy melanoma 3D models Programmed Cell Death 1 Receptor Receptors, Antigen, T-Cell, gamma-delta - metabolism Spheroids γδ T cells melanoma 3D models epigenetic modifiers γδ T cells immunotherapy immune checkpoint blockade
ISSN:	2001-1326, 2001-1326
Online Access:	Get full text
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