Circular polarization biomicroscopy: a method for determining human corneal stromal lamellar organization in vivo

The theory of polarization biomicroscopy is explored using Stokes vectors and Mueller matrices. It is established that circular polarization can be used to simultaneously detect birefringent elements at any orientation unlike orientation‐sensitive techniques using linear polarized light alone. A met...

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Vydané v:	Ophthalmic & physiological optics Ročník 27; číslo 3; s. 256 - 264
Hlavný autor:	Misson, Gary P.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Oxford, UK Blackwell Publishing Ltd 01.05.2007 Blackwell
Predmet:	Adult Aged Aged, 80 and over Biological and medical sciences biomicroscopy circular polarized light Collagen - ultrastructure collagen lamellae cornea Cornea - physiology Corneal Stroma - ultrastructure corneal stromal structure Eye and associated structures. Visual pathways and centers. Vision Female Fundamental and applied biological sciences. Psychology Humans Male Microscopy, Polarization - methods Middle Aged Models, Biological Mueller matrices Ocular Physiological Phenomena Vertebrates: nervous system and sense organs Biomicroscopy Human Polarization Cornea Organization corneal stromal structure Stroma Method Polarized light In vivo Mueller matrices collagen lamellae Collagen Ophthalmology Structure circular polarized light
ISSN:	0275-5408, 1475-1313
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Shrnutí:	The theory of polarization biomicroscopy is explored using Stokes vectors and Mueller matrices. It is established that circular polarization can be used to simultaneously detect birefringent elements at any orientation unlike orientation‐sensitive techniques using linear polarized light alone. A method of biomicroscopy using circular polarized light is described and tested in a physical model. The method is then used to investigate the lamellar structure of human corneas in vivo in pairs of eyes of 38 subjects. An approximate confocal elliptic/hyperbolic distribution of stromal fibrils, presumed to be collagen, is clearly identified within central and intermediate areas of the cornea. All subjects tested demonstrate approximate mirror symmetry between pairs of eyes typically with a preferred orientation of central fibrils at approximately 15° to the horizontal in a superotemporal–inferonasal direction.
Bibliografia:	ArticleID:OPO482 istex:87C1C1347704D8F47EC7412BBCEA349E4C8BF313 ark:/67375/WNG-12J8RZLF-0 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0275-5408 1475-1313
DOI:	10.1111/j.1475-1313.2007.00482.x