Liver Immune Profiling Reveals Pathogenesis and Therapeutics for Biliary Atresia

Biliary atresia (BA) is a severe cholangiopathy that leads to liver failure in infants, but its pathogenesis remains to be fully characterized. By single-cell RNA profiling, we observed macrophage hypo-inflammation, Kupffer cell scavenger function defects, cytotoxic T cell expansion, and deficiency...

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Vydané v:	Cell Ročník 183; číslo 7; s. 1867
Hlavní autori:	Wang, Jun, Xu, Yanhui, Chen, Zhanghua, Liang, Jiankun, Lin, Zefeng, Liang, Huiying, Xu, Yiping, Wu, Qi, Guo, Xuanjie, Nie, Junli, Lu, Bingtai, Huang, Bing, Xian, Huifang, Wang, Xiaohui, Wu, Qiang, Zeng, Jixiao, Chai, Chengwei, Zhang, Meixue, Lin, Yuzhen, Zhang, Li, Zhao, Shanmeizi, Tong, Yanlu, Zeng, Liang, Gu, Xiaoqiong, Chen, Zhuang-Gui, Yi, Shuhong, Zhang, Tong, Delfouneso, David, Zhang, Yan, Nutt, Stephen L, Lew, Andrew M, Lu, Liwei, Bai, Fan, Xia, Huimin, Wen, Zhe, Zhang, Yuxia
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 23.12.2020
Predmet:	Animals Antigens, CD20 - metabolism B-Lymphocytes - immunology Biliary Atresia - blood Biliary Atresia - drug therapy Biliary Atresia - immunology Biliary Atresia - therapy Biopsy Cell Death Cell Line Cell Proliferation Cell Transdifferentiation Child Child, Preschool Cohort Studies CX3C Chemokine Receptor 1 - metabolism Cytotoxicity, Immunologic Disease Models, Animal Female Humans Immunoglobulin G - metabolism Infant Inflammation - pathology Killer Cells, Natural - immunology Kupffer Cells - pathology Liver - immunology Liver - pathology Liver Cirrhosis - blood Liver Cirrhosis - complications Liver Cirrhosis - immunology Liver Cirrhosis - pathology Lymphocyte Depletion Lymphopoiesis Male Mice, Inbred BALB C Phagocytosis Rituximab - administration & dosage Rituximab - pharmacology Rituximab - therapeutic use RNA - metabolism Rotavirus - physiology Single-Cell Analysis Th1 Cells - immunology Th17 Cells - immunology CX3CR1 B cell haematopoiesis biliary atresia scRNA-seq autoantibody hypo-inflammation Rituximab cytotoxicity TNFSF13B
ISSN:	1097-4172, 1097-4172
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